Fe-only hydrogenase superfamily

SCOP classification

• Root: SCOP hierarchy in SUPERFAMILY [ 0] (11)
• Class: Alpha and beta proteins (a/b) [ 51349] (147)
• Fold: Fe-only hydrogenase [ 53919]
• Superfamily: Fe-only hydrogenase [ 53920]
• Families: Fe-only hydrogenase [ 53921] (2)

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Superfamily statistics

	Genomes (765)	Uniprot 2018_03 genome	PDB chains (SCOP 1.75)
Domains	1,562	11,839	3
Proteins	1,540	11,794	3

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Functional annotation

• General category: Metabolism
• Detailed category: Other enzymes

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Enzyme Commission (EC)

Highlighted in gray are those with FDR_all>0.001

	EC term	FDR (all)	IC level	SDEC level	Annotation (direct or inherited)
Enzyme Commission (EC)	With an iron-sulfur protein as acceptor	0.0000898	2.952	--	DIRECT
Enzyme Commission (EC)	Oxidoreductases	0	0.6234	Least Informative	DIRECT
Enzyme Commission (EC)	Acting on hydrogen as donors	0	2.049	Highly Informative	DIRECT

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InterPro annotation

• Cross references: IPR009016 SSF53920 Protein matches
• Abstract:

  The iron-only hydrogenases catalyse the two-electron reduction of two protons to yield dihydrogen, as part of an energy cycle. Fe-only hydrogenases are restricted to strictly anaerobic microbes, and are often very sensitive to molecular oxygen. The cytoplasmic monomeric Fe hydrogenases are involved in hydrogen production, while the periplasmic, heterodimeric Fe hydrogenases are involved in hydrogen uptake. Fe hydrogenases consist of two, intertwined domains, the catalytic domain [9836629] and the larger subunit C domain [10368269]. The larger subunit C domain can be divided into three subdomains. There are five distinct metal clusters, one in the catalytic domain. This entry represents the two intertwined domains, the catalytic domain and the large subunit C domain.

InterPro database

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