Transglutaminase core family

SCOP classification

• Root: SCOP hierarchy in SUPERFAMILY [ 0] (11)
• Class: Alpha and beta proteins (a+b) [ 53931] (376)
• Fold: Cysteine proteinases [ 54000]
• Superfamily: Cysteine proteinases [ 54001] (22)
• Family: Transglutaminase core [ 54044] (2)

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Family statistics

	Genomes (398)	Uniprot 2018_03 genome	PDB chains (SCOP 1.75)
Domains	1,304	3,919	10
Proteins	1,286	3,884	10

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Enzyme Commission (EC)

Highlighted in gray are those with FDR_all>0.001

	EC term	FDR (all)	IC level	SDEO level	Annotation (direct or inherited)
Enzyme Commission (EC)	In linear amides	0	1.21	--	DIRECT
Enzyme Commission (EC)	Acyltransferases	0	0.8778	--	DIRECT
Enzyme Commission (EC)	Protein-glutamine gamma-glutamyltransferase	0	2.264	--	DIRECT
Enzyme Commission (EC)	Peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagin	0	2.264	--	DIRECT
Enzyme Commission (EC)	Transferases	0.000485	0	--	DIRECT
Enzyme Commission (EC)	Hydrolases	0.0005665	0.01852	--	DIRECT
Enzyme Commission (EC)	Acting on carbon-nitrogen bonds, other than peptid	0	0.8435	Moderately Informative	DIRECT
Enzyme Commission (EC)	Aminoacyltransferases	0	1.662	Informative	DIRECT

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Disease Ontology (DO)

Highlighted in gray are those with FDR_all>0.001

	DO term	FDR (all)	IC level	SDDO level	Annotation (direct or inherited)
Disease Ontology (DO)	dermatitis herpetiformis	0.00000000001842	1.668	--	DIRECT
Disease Ontology (DO)	skin disease	0.00001032	1.022	--	DIRECT
Disease Ontology (DO)	autosomal genetic disease	0.002693	1.133	--	INHERITED FROM: autosomal recessive disease
Disease Ontology (DO)	monogenic disease	0.003233	1.115	--	INHERITED FROM: autosomal recessive disease
Disease Ontology (DO)	hypersensitivity reaction disease	0.009594	0.8505	--	INHERITED FROM: dermatitis herpetiformis || autoimmune disease of skin and connective tissue
Disease Ontology (DO)	disease of anatomical entity	0.02294	0.2414	--	INHERITED FROM: autoimmune disease of skin and connective tissue || integumentary system disease || bullous skin disease || dermatitis herpetiformis || skin disease
Disease Ontology (DO)	immune system disease	0.0688	0.8411	--	INHERITED FROM: autoimmune disease of skin and connective tissue || dermatitis herpetiformis
Disease Ontology (DO)	dermatitis	0.1077	1.283	--	INHERITED FROM: dermatitis herpetiformis || bullous skin disease
Disease Ontology (DO)	integumentary system disease	0.0001079	0.9817	Moderately Informative	DIRECT
Disease Ontology (DO)	genetic disease	0.005426	1.066	Moderately Informative	INHERITED FROM: autosomal recessive disease
Disease Ontology (DO)	hypersensitivity reaction type II disease	0.005763	0.8797	Moderately Informative	INHERITED FROM: dermatitis herpetiformis || autoimmune disease of skin and connective tissue
Disease Ontology (DO)	autoimmune disease of skin and connective tissue	0.00000001976	1.472	Informative	DIRECT
Disease Ontology (DO)	bullous skin disease	0.00000007109	1.472	Informative	DIRECT
Disease Ontology (DO)	autosomal recessive disease	0.0001915	1.472	Informative	DIRECT

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Human Phenotype (HP)

Highlighted in gray are those with FDR_all>0.001

	HP term	FDR (all)	IC level	SDHP level	Annotation (direct or inherited)
Phenotypic Abnormality (PA)	Abnormal corneal epithelium morphology	0.0002455	1.763	--	DIRECT
Phenotypic Abnormality (PA)	Abnormality of the coagulation cascade	0.0005244	1.684	--	DIRECT
Phenotypic Abnormality (PA)	Abnormal eye morphology	0.7048	0.7812	--	INHERITED FROM: Abnormal corneal epithelium morphology
Phenotypic Abnormality (PA)	Abnormality of the eye	0.1788	0.5703	Least Informative	INHERITED FROM: Abnormal corneal epithelium morphology
Phenotypic Abnormality (PA)	Abnormal anterior eye segment morphology	0.07036	1.12	Moderately Informative	INHERITED FROM: Abnormal corneal epithelium morphology
Phenotypic Abnormality (PA)	Abnormality of blood and blood-forming tissues	0.2843	0.9183	Moderately Informative	INHERITED FROM: Abnormality of the common coagulation pathway || Abnormality of the coagulation cascade
Phenotypic Abnormality (PA)	Abnormality of coagulation	0.001939	1.617	Informative	INHERITED FROM: Abnormality of the coagulation cascade || Abnormality of the common coagulation pathway
Phenotypic Abnormality (PA)	Abnormal cornea morphology	0.1929	1.383	Informative	INHERITED FROM: Abnormal corneal epithelium morphology
Phenotypic Abnormality (PA)	Abnormality of the common coagulation pathway	0.00003136	1.985	Highly Informative	DIRECT

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Xenopus Anatomy (XA)

Highlighted in gray are those with FDR_all>0.001

	XA term	FDR (all)	IC level	SDXA level	Annotation (direct or inherited)
Xenopus ANatomical entity (XAN)	anatomical structure	0	0	--	DIRECT
Xenopus ANatomical entity (XAN)	multicellular anatomical structure	0	0.1131	--	DIRECT
Xenopus ANatomical entity (XAN)	whole organism	1	0.0884	--	INHERITED FROM: multicellular anatomical structure
Xenopus DEvelopment stage (XDE)	NF stage	0	0.01895	--	DIRECT

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Enzyme Commission (EC)

Highlighted in gray are those with FDR_all>0.001

	EC term	FDR (all)	IC level	SDEC level	Annotation (direct or inherited)
Enzyme Commission (EC)	Protein-glutamine gamma-glutamyltransferase	0	2.753	--	DIRECT
Enzyme Commission (EC)	Peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidase	0	2.753	--	DIRECT
Enzyme Commission (EC)	Hydrolases	0.0002342	0.4043	Least Informative	DIRECT
Enzyme Commission (EC)	Transferases	0.0003873	0.3972	Least Informative	DIRECT
Enzyme Commission (EC)	Acyltransferases	0	1.034	Moderately Informative	DIRECT
Enzyme Commission (EC)	Acting on carbon-nitrogen bonds, other than peptide bonds	0.000000000000001826	1.213	Moderately Informative	DIRECT
Enzyme Commission (EC)	Aminoacyltransferases	0	1.391	Informative	DIRECT
Enzyme Commission (EC)	In linear amides	0	1.539	Informative	DIRECT

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