Interleukin 8-like chemokines family

SCOP classification

• Root: SCOP hierarchy in SUPERFAMILY [ 0] (11)
• Class: Alpha and beta proteins (a+b) [ 53931] (376)
• Fold: IL8-like [ 54116] (2)
• Superfamily: Interleukin 8-like chemokines [ 54117]
• Family: Interleukin 8-like chemokines [ 54118] (24)

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Family statistics

	Genomes (50)	Uniprot 2018_03 genome	PDB chains (SCOP 1.75)
Domains	810	1,735	51
Proteins	809	1,731	51

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Disease Ontology (DO)

Highlighted in gray are those with FDR_all>0.001

	DO term	FDR (all)	IC level	SDDO level	Annotation (direct or inherited)
Disease Ontology (DO)	skin disease	0.00000000002912	1.022	--	DIRECT
Disease Ontology (DO)	bone inflammation disease	0.00000001724	1.309	--	DIRECT
Disease Ontology (DO)	primary bacterial infectious disease	0.00000002565	1.212	--	DIRECT
Disease Ontology (DO)	disease of anatomical entity	0.0000007824	0.2414	--	DIRECT
Disease Ontology (DO)	human immunodeficiency virus infectious disease	0.0003261	2.513	--	DIRECT
Disease Ontology (DO)	respiratory system disease	0.0004154	0.9334	--	DIRECT
Disease Ontology (DO)	aggressive systemic mastocytosis	0.0004613	2.513	--	DIRECT
Disease Ontology (DO)	musculoskeletal system disease	0.000652	0.89	--	DIRECT
Disease Ontology (DO)	demyelinating disease	0.0007677	1.367	--	DIRECT
Disease Ontology (DO)	periodontitis	0.0009729	1.559	--	DIRECT
Disease Ontology (DO)	systemic mastocytosis	0.001071	2.513	--	INHERITED FROM: aggressive systemic mastocytosis
Disease Ontology (DO)	tooth disease	0.002516	1.399	--	INHERITED FROM: periodontitis
Disease Ontology (DO)	bacterial infectious disease	0.00808	1.191	--	INHERITED FROM: primary bacterial infectious disease
Disease Ontology (DO)	immune system disease	0.01381	0.8411	--	INHERITED FROM: hypersensitivity reaction type II disease || scleroderma
Disease Ontology (DO)	intestinal disease	0.04041	1.399	--	INHERITED FROM: inflammatory bowel disease
Disease Ontology (DO)	mastocytosis	0.1109	2.513	--	INHERITED FROM: aggressive systemic mastocytosis
Disease Ontology (DO)	collagen disease	0.114	1.472	--	INHERITED FROM: scleroderma
Disease Ontology (DO)	hypersensitivity reaction disease	0.1194	0.8505	--	INHERITED FROM: scleroderma || hypersensitivity reaction type II disease
Disease Ontology (DO)	bone disease	0.1196	1.171	--	INHERITED FROM: bone inflammation disease || arthritis
Disease Ontology (DO)	central nervous system disease	0.1223	0.8698	--	INHERITED FROM: demyelinating disease || multiple sclerosis
Disease Ontology (DO)	rheumatic disease	0.1241	1.513	--	INHERITED FROM: scleroderma
Disease Ontology (DO)	immune system cancer	0.1779	0.89	--	INHERITED FROM: mature T-cell and NK-cell lymphoma
Disease Ontology (DO)	non-Hodgkin lymphoma	0.2128	1.814	--	INHERITED FROM: mature T-cell and NK-cell lymphoma
Disease Ontology (DO)	mouth disease	0.2501	1.399	--	INHERITED FROM: periodontitis
Disease Ontology (DO)	bronchial disease	0.4558	1.133	--	INHERITED FROM: asthma
Disease Ontology (DO)	cancer	0.482	0.2555	--	INHERITED FROM: mature T-cell and NK-cell lymphoma
Disease Ontology (DO)	disease of cellular proliferation	0.5353	0.2322	--	INHERITED FROM: mature T-cell and NK-cell lymphoma
Disease Ontology (DO)	viral infectious disease	0.8491	1.212	--	INHERITED FROM: human immunodeficiency virus infectious disease
Disease Ontology (DO)	organ system cancer	0.02529	0.4879	Least Informative	INHERITED FROM: mature T-cell and NK-cell lymphoma
Disease Ontology (DO)	nervous system disease	1	0.7279	Least Informative	INHERITED FROM: demyelinating disease || multiple sclerosis
Disease Ontology (DO)	disease by infectious agent	0.0000000001093	0.8142	Moderately Informative	DIRECT
Disease Ontology (DO)	integumentary system disease	0.0000002529	0.9817	Moderately Informative	DIRECT
Disease Ontology (DO)	lower respiratory tract disease	0.0000005399	0.9947	Moderately Informative	DIRECT
Disease Ontology (DO)	hypersensitivity reaction type II disease	0.000008414	0.8797	Moderately Informative	DIRECT
Disease Ontology (DO)	gastrointestinal system disease	0.00155	0.8797	Moderately Informative	INHERITED FROM: periodontitis || inflammatory bowel disease
Disease Ontology (DO)	hematologic cancer	0.02564	0.89	Moderately Informative	INHERITED FROM: mature T-cell and NK-cell lymphoma
Disease Ontology (DO)	hematopoietic system disease	0.1409	1.051	Moderately Informative	INHERITED FROM: aggressive systemic mastocytosis
Disease Ontology (DO)	connective tissue disease	0.2765	1.022	Moderately Informative	INHERITED FROM: bone inflammation disease || arthritis || scleroderma
Disease Ontology (DO)	neurodegenerative disease	0.3268	1.022	Moderately Informative	INHERITED FROM: multiple sclerosis || demyelinating disease
Disease Ontology (DO)	arthritis	0.000000006481	1.472	Informative	DIRECT
Disease Ontology (DO)	inflammatory bowel disease	0.000003225	1.472	Informative	DIRECT
Disease Ontology (DO)	asthma	0.0001213	1.258	Informative	DIRECT
Disease Ontology (DO)	scleroderma	0.0006249	1.513	Informative	DIRECT
Disease Ontology (DO)	multiple sclerosis	0.0007134	1.399	Informative	DIRECT
Disease Ontology (DO)	periodontal disease	0.001587	1.513	Informative	INHERITED FROM: periodontitis
Disease Ontology (DO)	lymphoma	0.01676	1.668	Informative	INHERITED FROM: mature T-cell and NK-cell lymphoma
Disease Ontology (DO)	mature T-cell and NK-cell lymphoma	0.0003748	1.911	Highly Informative	DIRECT
Disease Ontology (DO)	leukocyte disease	0.03154	2.212	Highly Informative	INHERITED FROM: aggressive systemic mastocytosis

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Mouse Phenotype (MP)

Highlighted in gray are those with FDR_all>0.001

	MP term	FDR (all)	IC level	SDMP level	Annotation (direct or inherited)
Mammalian Phenotype (MP)	decreased susceptibility to atherosclerosis	0.000008683	2.603	--	DIRECT
Mammalian Phenotype (MP)	abnormal immune system cell morphology	0.00002032	0.8038	--	DIRECT
Mammalian Phenotype (MP)	abnormal hematopoietic cell morphology	0.0001338	0.7167	--	DIRECT
Mammalian Phenotype (MP)	abnormal blood cell physiology	0.0002266	0.8789	--	DIRECT
Mammalian Phenotype (MP)	atherosclerotic lesions	0.0003387	2.126	--	DIRECT
Mammalian Phenotype (MP)	arteriosclerosis	0.004916	1.758	--	INHERITED FROM: altered susceptibility to atherosclerosis || atherosclerotic lesions || decreased susceptibility to atherosclerosis
Mammalian Phenotype (MP)	abnormal artery morphology	0.02155	1.302	--	INHERITED FROM: atherosclerotic lesions || decreased susceptibility to atherosclerosis || altered susceptibility to atherosclerosis
Mammalian Phenotype (MP)	abnormal immune cell physiology	0.07711	0.9219	--	INHERITED FROM: abnormal leukocyte physiology
Mammalian Phenotype (MP)	abnormal cell-mediated immunity	0.08217	0.9219	--	INHERITED FROM: abnormal leukocyte physiology
Mammalian Phenotype (MP)	abnormal adaptive immunity	0.09338	0.9219	--	INHERITED FROM: abnormal leukocyte physiology
Mammalian Phenotype (MP)	abnormal immune system physiology	0.1339	0.6789	--	INHERITED FROM: abnormal leukocyte physiology
Mammalian Phenotype (MP)	abnormal immune system morphology	0.1375	0.7223	--	INHERITED FROM: abnormal immune system cell morphology
Mammalian Phenotype (MP)	abnormal hematopoietic system physiology	0.1604	0.8789	--	INHERITED FROM: abnormal leukocyte physiology || abnormal blood cell physiology
Mammalian Phenotype (MP)	abnormal hematopoietic system morphology/development	0.6321	0.6686	--	INHERITED FROM: abnormal hematopoietic cell morphology
Mammalian Phenotype (MP)	abnormal cardiovascular system morphology	0.6901	0.7902	--	INHERITED FROM: decreased susceptibility to atherosclerosis || atherosclerotic lesions || altered susceptibility to atherosclerosis
Mammalian Phenotype (MP)	hematopoietic system phenotype	0.00004039	0.5945	Least Informative	DIRECT
Mammalian Phenotype (MP)	immune system phenotype	0.000279	0.5462	Least Informative	DIRECT
Mammalian Phenotype (MP)	cardiovascular system phenotype	0.7782	0.6737	Least Informative	INHERITED FROM: altered susceptibility to atherosclerosis || atherosclerotic lesions || decreased susceptibility to atherosclerosis
Mammalian Phenotype (MP)	abnormal leukocyte physiology	0.00009152	0.9219	Moderately Informative	DIRECT
Mammalian Phenotype (MP)	abnormal blood vessel morphology	0.2874	1.023	Moderately Informative	INHERITED FROM: decreased susceptibility to atherosclerosis || atherosclerotic lesions || altered susceptibility to atherosclerosis
Mammalian Phenotype (MP)	altered susceptibility to atherosclerosis	0.00007518	2.126	Highly Informative	DIRECT

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Zebrafish Anatomy (ZA)

Highlighted in gray are those with FDR_all>0.001

	ZA term	FDR (all)	IC level	SDZA level	Annotation (direct or inherited)
Zebrafish Anatomy (ZA)	whole organism	0	0.00147	--	DIRECT
Zebrafish Anatomy (ZA)	anatomical structure	1	0	--	INHERITED FROM: whole organism

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