SUPERFAMILY 1.75 HMM library and genome assignments server

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Interleukin 8-like chemokines family

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a+b) [ 53931] (376)
Fold:   IL8-like [ 54116] (2)
Superfamily:   Interleukin 8-like chemokines [ 54117]
Family:   Interleukin 8-like chemokines [ 54118] (24)

Family statistics
Genomes (50) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 810 1,735 51
Proteins 809 1,731 51

Disease Ontology (DO)

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DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)organ system cancer0.02529Least InformativeInherited
Disease Ontology (DO)nervous system disease1Least InformativeInherited
Disease Ontology (DO)disease by infectious agent0.0000000001093Moderately InformativeDirect
Disease Ontology (DO)integumentary system disease0.0000002529Moderately InformativeDirect
Disease Ontology (DO)lower respiratory tract disease0.0000005399Moderately InformativeDirect
Disease Ontology (DO)hypersensitivity reaction type II disease0.000008414Moderately InformativeDirect
Disease Ontology (DO)gastrointestinal system disease0.00155Moderately InformativeInherited
Disease Ontology (DO)hematologic cancer0.02564Moderately InformativeInherited
Disease Ontology (DO)hematopoietic system disease0.1409Moderately InformativeInherited
Disease Ontology (DO)connective tissue disease0.2765Moderately InformativeInherited
Disease Ontology (DO)neurodegenerative disease0.3268Moderately InformativeInherited
Disease Ontology (DO)arthritis0.000000006481InformativeDirect
Disease Ontology (DO)inflammatory bowel disease0.000003225InformativeDirect
Disease Ontology (DO)asthma0.0001213InformativeDirect
Disease Ontology (DO)scleroderma0.0006249InformativeDirect
Disease Ontology (DO)multiple sclerosis0.0007134InformativeDirect
Disease Ontology (DO)periodontal disease0.001587InformativeInherited
Disease Ontology (DO)lymphoma0.01676InformativeInherited
Disease Ontology (DO)mature T-cell and NK-cell lymphoma0.0003748Highly InformativeDirect
Disease Ontology (DO)leukocyte disease0.03154Highly InformativeInherited

Document: DO annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)hematopoietic system phenotype0.00004039Least InformativeDirect
Mammalian Phenotype (MP)immune system phenotype0.000279Least InformativeDirect
Mammalian Phenotype (MP)cardiovascular system phenotype0.7782Least InformativeInherited
Mammalian Phenotype (MP)abnormal leukocyte physiology0.00009152Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal blood vessel morphology0.2874Moderately InformativeInherited
Mammalian Phenotype (MP)altered susceptibility to atherosclerosis0.00007518Highly InformativeDirect

Document: MP annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details) Document: ZA annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Disease Ontology (DO) · Mouse Phenotype (MP) · Zebrafish Anatomy (ZA) ]

Internal database links

Superfamily level     Family level

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.

Superfamily level     Family level

Alignments of sequences to 44 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.

Superfamily level

Browse and view proteins in genomes which have different domain combinations including a Interleukin 8-like chemokines domain.

Superfamily level     Family level

Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.

Jump to [ Top of page · SCOP classification · Disease Ontology (DO) · Mouse Phenotype (MP) · Zebrafish Anatomy (ZA) · Internal database links ]