GHMP Kinase, N-terminal domain family

SCOP classification

• Root: SCOP hierarchy in SUPERFAMILY [ 0] (11)
• Class: Alpha and beta proteins (a+b) [ 53931] (376)
• Fold: Ribosomal protein S5 domain 2-like [ 54210]
• Superfamily: Ribosomal protein S5 domain 2-like [ 54211] (12)
• Family: GHMP Kinase, N-terminal domain [ 54232] (6)

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Family statistics

	Genomes (2,525)	Uniprot 2018_03 genome	PDB chains (SCOP 1.75)
Domains	4,347	28,282	11
Proteins	4,347	28,278	11

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Enzyme Commission (EC)

Highlighted in gray are those with FDR_all>0.001

	EC term	FDR (all)	IC level	SDEO level	Annotation (direct or inherited)
Enzyme Commission (EC)	Homoserine kinase	0	2.264	--	DIRECT
Enzyme Commission (EC)	Diphosphomevalonate decarboxylase	0	2.44	--	DIRECT
Enzyme Commission (EC)	Transferases	0	0	--	DIRECT
Enzyme Commission (EC)	4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol	0	2.44	--	DIRECT
Enzyme Commission (EC)	Galactokinase	0	2.44	--	DIRECT
Enzyme Commission (EC)	Transferring phosphorous-containing groups	0	0.2728	--	DIRECT
Enzyme Commission (EC)	Mevalonate kinase	0.0000000008824	2.44	--	DIRECT
Enzyme Commission (EC)	Carbon-carbon lyases	1	0.9151	--	INHERITED FROM: Diphosphomevalonate decarboxylase
Enzyme Commission (EC)	Lyases	1	0.4956	Least Informative	INHERITED FROM: Diphosphomevalonate decarboxylase
Enzyme Commission (EC)	Phosphotransferases with an alcohol group as accep	0	0.8381	Moderately Informative	DIRECT
Enzyme Commission (EC)	Carboxy-lyases	1	1.06	Moderately Informative	INHERITED FROM: Diphosphomevalonate decarboxylase

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Worm Phenotype (WP)

Highlighted in gray are those with FDR_all>0.001

	WP term	FDR (all)	IC level	SDWP level	Annotation (direct or inherited)
Worm Phenotype (WP)	embryonic lethal	0	0.046	--	DIRECT
Worm Phenotype (WP)	lethal	0	0.00521	--	DIRECT
Worm Phenotype (WP)	fertility variant	0	0.05937	--	DIRECT
Worm Phenotype (WP)	development variant	0	0.001482	--	DIRECT
Worm Phenotype (WP)	morphology variant	0	0.046	--	DIRECT
Worm Phenotype (WP)	organism development variant	0	0.00297	--	DIRECT
Worm Phenotype (WP)	organism morphology variant	0	0.1372	--	DIRECT
Worm Phenotype (WP)	organ system physiology variant	0	0.04518	--	DIRECT
Worm Phenotype (WP)	reproductive system physiology variant	0	0.05515	--	DIRECT
Worm Phenotype (WP)	maternal sterile	0	0.1213	--	DIRECT
Worm Phenotype (WP)	hermaphrodite sterile	0	0.1203	--	DIRECT
Worm Phenotype (WP)	embryonic development variant	0	0.04518	--	DIRECT
Worm Phenotype (WP)	hermaphrodite fertility variant	0	0.0947	--	DIRECT
Worm Phenotype (WP)	hermaphrodite fertility reduced	0	0.1193	--	DIRECT
Worm Phenotype (WP)	fertility reduced	0	0.06449	--	DIRECT
Worm Phenotype (WP)	physiology variant	1	0	--	INHERITED FROM: hermaphrodite fertility variant || reproductive system physiology variant || lethal || development variant || hermaphrodite sterile || hermaphrodite fertility reduced || embryonic development variant || embryonic lethal || fertility variant || organ system physiology variant || maternal sterile || organism development variant || fertility reduced
Worm Phenotype (WP)	sterile	1	0.1135	--	INHERITED FROM: hermaphrodite sterile || maternal sterile

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Yeast Phenotype (YP)

Highlighted in gray are those with FDR_all>0.001

	YP term	FDR (all)	IC level	SDYP level	Annotation (direct or inherited)
Yeast Phenotype (YP)	cellular processes	0	0.09186	--	DIRECT
Yeast Phenotype (YP)	stress resistance	0	0.1452	--	DIRECT
Yeast Phenotype (YP)	competitive fitness	0	0.1116	--	DIRECT
Yeast Phenotype (YP)	fitness	0	0.1096	--	DIRECT
Yeast Phenotype (YP)	mitochondrial morphology	0.0004946	2.444	--	DIRECT
Yeast Phenotype (YP)	cellular morphology	0.0763	1.24	--	INHERITED FROM: mitochondrial morphology
Yeast Phenotype (YP)	resistance to chemicals	0	0.3202	Least Informative	DIRECT
Yeast Phenotype (YP)	morphology	0.1476	1.143	Moderately Informative	INHERITED FROM: mitochondrial morphology
Yeast Phenotype (YP)	subcellular morphology	0.01613	1.541	Informative	INHERITED FROM: mitochondrial morphology

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Xenopus Anatomy (XA)

Highlighted in gray are those with FDR_all>0.001

	XA term	FDR (all)	IC level	SDXA level	Annotation (direct or inherited)
Xenopus ANatomical entity (XAN)	anatomical structure	0	0	--	DIRECT
Xenopus ANatomical entity (XAN)	anatomical group	0	0.1408	--	DIRECT
Xenopus ANatomical entity (XAN)	organism subdivision	0	0.1679	--	DIRECT
Xenopus ANatomical entity (XAN)	compound organ	0	0.2177	--	DIRECT
Xenopus ANatomical entity (XAN)	anatomical region	0	0.1803	--	DIRECT
Xenopus ANatomical entity (XAN)	multicellular anatomical structure	0	0.1131	--	DIRECT
Xenopus ANatomical entity (XAN)	whole organism	1	0.0884	--	INHERITED FROM: anatomical group || cavitated compound organ || multicellular anatomical structure || compound organ || anatomical region || organism subdivision
Xenopus ANatomical entity (XAN)	cavitated compound organ	0	0.2685	Least Informative	DIRECT
Xenopus DEvelopment stage (XDE)	NF stage	0	0.01895	--	DIRECT

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Arabidopsis Plant Ontology (AP)

Highlighted in gray are those with FDR_all>0.001

	AP term	FDR (all)	IC level	SDAP level	Annotation (direct or inherited)
Plant ANatomical entity (PAN)	phyllome	0	0.3234	--	DIRECT
Plant ANatomical entity (PAN)	plant cell	0	0.1228	--	DIRECT
Plant ANatomical entity (PAN)	shoot system	0	0.05272	--	DIRECT
Plant ANatomical entity (PAN)	plant organ	0	0.2391	--	DIRECT
Plant ANatomical entity (PAN)	sporophyll	0	0.3985	--	DIRECT
Plant ANatomical entity (PAN)	carpel	0	0.5117	--	DIRECT
Plant ANatomical entity (PAN)	flower	0	0.3446	--	DIRECT
Plant ANatomical entity (PAN)	collective phyllome structure	0	0.3837	--	DIRECT
Plant ANatomical entity (PAN)	reproductive shoot system	0	0.3304	--	DIRECT
Plant ANatomical entity (PAN)	multi-tissue plant structure	0	0.2335	--	DIRECT
Plant ANatomical entity (PAN)	collective plant structure	0	0.01555	--	DIRECT
Plant ANatomical entity (PAN)	plant structure	1	0	--	INHERITED FROM: sporophyll || flower || collective plant structure || phyllome || multi-tissue plant structure || megasporophyll || reproductive shoot system || shoot system || plant organ || gynoecium || collective phyllome structure || plant cell || carpel
Plant ANatomical entity (PAN)	collective plant organ structure	1	0.03998	--	INHERITED FROM: flower || sporophyll || phyllome || gynoecium || reproductive shoot system || carpel || collective phyllome structure || megasporophyll || shoot system
Plant ANatomical entity (PAN)	megasporophyll	0	0.5117	Least Informative	DIRECT
Plant ANatomical entity (PAN)	gynoecium	0	0.5082	Least Informative	DIRECT
Plant structure DEvelopment stage (PDE)	floral organ differentiation stage	0	0.07163	--	DIRECT
Plant structure DEvelopment stage (PDE)	corolla development stage	0	0.1484	--	DIRECT
Plant structure DEvelopment stage (PDE)	flowering stage	0	0.1648	--	DIRECT
Plant structure DEvelopment stage (PDE)	collective plant organ structure development stage	0	0.0282	--	DIRECT
Plant structure DEvelopment stage (PDE)	plant organ development stage	0	0.06127	--	DIRECT
Plant structure DEvelopment stage (PDE)	reproductive shoot system development stage	0	0.0371	--	DIRECT
Plant structure DEvelopment stage (PDE)	collective phyllome structure development stage	0	0.07163	--	DIRECT
Plant structure DEvelopment stage (PDE)	floral organ formation stage	0	0.07163	--	DIRECT
Plant structure DEvelopment stage (PDE)	flower development stage	1	0.05402	--	INHERITED FROM: corolla development stage || flowering stage || floral organ differentiation stage || floral organ formation stage
Plant structure DEvelopment stage (PDE)	shoot system development stage	1	0.02956	--	INHERITED FROM: reproductive shoot system development stage || floral organ formation stage || floral organ differentiation stage || flowering stage || corolla development stage || plant organ development stage

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Enzyme Commission (EC)

Highlighted in gray are those with FDR_all>0.001

	EC term	FDR (all)	IC level	SDEC level	Annotation (direct or inherited)
Enzyme Commission (EC)	Transferring phosphorus-containing groups	0	0.7021	--	DIRECT
Enzyme Commission (EC)	4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase	0	2.929	--	DIRECT
Enzyme Commission (EC)	Homoserine kinase	0	2.753	--	DIRECT
Enzyme Commission (EC)	Galactokinase	0	2.929	--	DIRECT
Enzyme Commission (EC)	Diphosphomevalonate decarboxylase	0	2.929	--	DIRECT
Enzyme Commission (EC)	Phosphomevalonate kinase	0.00000000007758	3.23	--	DIRECT
Enzyme Commission (EC)	Mevalonate kinase	0.0000000001531	2.929	--	DIRECT
Enzyme Commission (EC)	Beta-ribofuranosylphenol 5'-phosphate synthase	0.000000005166	3.23	--	DIRECT
Enzyme Commission (EC)	Bisphosphomevalonate decarboxylase	0.000000005166	3.23	--	DIRECT
Enzyme Commission (EC)	N-acetylgalactosamine kinase	0.0008613	2.929	--	DIRECT
Enzyme Commission (EC)	Pentosyltransferases	1	1.738	--	INHERITED FROM: Beta-ribofuranosylphenol 5'-phosphate synthase
Enzyme Commission (EC)	Carbon-carbon lyases	1	1.305	--	INHERITED FROM: Bisphosphomevalonate decarboxylase || Diphosphomevalonate decarboxylase
Enzyme Commission (EC)	Transferases	0	0.3972	Least Informative	DIRECT
Enzyme Commission (EC)	Phosphotransferases with an alcohol group as acceptor	0	1.238	Moderately Informative	DIRECT
Enzyme Commission (EC)	Lyases	1	0.8775	Moderately Informative	INHERITED FROM: Bisphosphomevalonate decarboxylase || Diphosphomevalonate decarboxylase
Enzyme Commission (EC)	Carboxy-lyases	0.8656	1.474	Informative	INHERITED FROM: Bisphosphomevalonate decarboxylase || Diphosphomevalonate decarboxylase
Enzyme Commission (EC)	Glycosyltransferases	1	1.378	Informative	INHERITED FROM: Beta-ribofuranosylphenol 5'-phosphate synthase
Enzyme Commission (EC)	Phosphotransferases with a phosphate group as acceptor	1	1.951	Highly Informative	INHERITED FROM: Phosphomevalonate kinase

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