Ras-binding domain, RBD family

SCOP classification

• Root: SCOP hierarchy in SUPERFAMILY [ 0] (11)
• Class: Alpha and beta proteins (a+b) [ 53931] (376)
• Fold: beta-Grasp (ubiquitin-like) [ 54235] (14)
• Superfamily: Ubiquitin-like [ 54236] (8)
• Family: Ras-binding domain, RBD [ 54263] (13)

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Family statistics

	Genomes (114)	Uniprot 2018_03 genome	PDB chains (SCOP 1.75)
Domains	1,145	3,111	26
Proteins	1,084	2,954	26

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Enzyme Commission (EC)

Highlighted in gray are those with FDR_all>0.001

	EC term	FDR (all)	IC level	SDEO level	Annotation (direct or inherited)
Enzyme Commission (EC)	Transferring phosphorous-containing groups	0	0.2728	--	DIRECT
Enzyme Commission (EC)	Transferases	0.000000000004648	0	--	DIRECT
Enzyme Commission (EC)	Protein-serine/threonine kinases	0.000000000000001037	1.042	Moderately Informative	DIRECT
Enzyme Commission (EC)	Phosphotransferases with an alcohol group as accep	0.001842	0.8381	Moderately Informative	INHERITED FROM: Phosphatidylinositol-4,5-bisphosphate 3-kinase
Enzyme Commission (EC)	Non-specific serine/threonine protein kinase	0.0004238	1.279	Informative	DIRECT
Enzyme Commission (EC)	Phosphatidylinositol-4,5-bisphosphate 3-kinase	0	2.139	Highly Informative	DIRECT

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Disease Ontology (DO)

Highlighted in gray are those with FDR_all>0.001

	DO term	FDR (all)	IC level	SDDO level	Annotation (direct or inherited)
Disease Ontology (DO)	disease of cellular proliferation	0	0.2322	--	DIRECT
Disease Ontology (DO)	cancer	0	0.2555	--	DIRECT
Disease Ontology (DO)	LEOPARD syndrome	0.0000001058	2.513	--	DIRECT
Disease Ontology (DO)	pilocytic astrocytoma	0.00001706	2.513	--	DIRECT
Disease Ontology (DO)	head and neck squamous cell carcinoma	0.00007231	1.668	--	DIRECT
Disease Ontology (DO)	head and neck cancer	0.001152	1.513	--	INHERITED FROM: head and neck squamous cell carcinoma || head and neck carcinoma
Disease Ontology (DO)	astrocytoma	0.01591	1.735	--	INHERITED FROM: pilocytic astrocytoma
Disease Ontology (DO)	autosomal dominant disease	0.03644	1.399	--	INHERITED FROM: LEOPARD syndrome
Disease Ontology (DO)	autosomal genetic disease	0.1538	1.133	--	INHERITED FROM: LEOPARD syndrome
Disease Ontology (DO)	monogenic disease	0.7038	1.115	--	INHERITED FROM: LEOPARD syndrome
Disease Ontology (DO)	organ system cancer	0.6627	0.4879	Least Informative	INHERITED FROM: head and neck squamous cell carcinoma || head and neck carcinoma
Disease Ontology (DO)	genetic disease	0.09568	1.066	Moderately Informative	INHERITED FROM: LEOPARD syndrome
Disease Ontology (DO)	cell type cancer	0.2432	0.9112	Moderately Informative	INHERITED FROM: pilocytic astrocytoma
Disease Ontology (DO)	head and neck carcinoma	0.0003105	1.513	Informative	DIRECT
Disease Ontology (DO)	malignant glioma	0.1077	1.61	Informative	INHERITED FROM: pilocytic astrocytoma

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Human Phenotype (HP)

Highlighted in gray are those with FDR_all>0.001

	HP term	FDR (all)	IC level	SDHP level	Annotation (direct or inherited)
Phenotypic Abnormality (PA)	Neuroblastic tumor	0.000003514	1.985	--	DIRECT
Phenotypic Abnormality (PA)	Peripheral primitive neuroectodermal neoplasm	0.00000396	1.985	--	DIRECT
Phenotypic Abnormality (PA)	Primitive neuroectodermal tumor	0.000004943	1.985	--	DIRECT
Phenotypic Abnormality (PA)	Melanocytic nevus	0.00001526	2.462	--	DIRECT
Phenotypic Abnormality (PA)	Melanoma	0.00001526	2.462	--	DIRECT
Phenotypic Abnormality (PA)	Hypermelanotic macule	0.00002069	2.462	--	DIRECT
Phenotypic Abnormality (PA)	Neuroepithelial neoplasm	0.00002376	1.684	--	DIRECT
Phenotypic Abnormality (PA)	Nervous tissue neoplasm	0.0000255	1.684	--	DIRECT
Phenotypic Abnormality (PA)	Macule	0.00008975	2.462	--	DIRECT
Phenotypic Abnormality (PA)	Skin nodule	0.000134	1.985	--	DIRECT
Phenotypic Abnormality (PA)	Irregular hyperpigmentation	0.0001843	2.462	--	DIRECT
Phenotypic Abnormality (PA)	Neoplasm of the central nervous system	0.0002292	1.684	--	DIRECT
Phenotypic Abnormality (PA)	Spinal dysraphism	0.0003099	1.763	--	DIRECT
Phenotypic Abnormality (PA)	Abnormal neural tube morphology	0.0003201	1.763	--	DIRECT
Phenotypic Abnormality (PA)	Neoplasm of the nervous system	0.0004726	1.684	--	DIRECT
Phenotypic Abnormality (PA)	Joint hyperflexibility	0.0006392	1.617	--	DIRECT
Phenotypic Abnormality (PA)	Abnormal lung morphology	0.0006743	1.207	--	DIRECT
Phenotypic Abnormality (PA)	Polyhydramnios	0.0007044	2.462	--	DIRECT
Phenotypic Abnormality (PA)	Abnormality of the spleen	0.0009928	1.316	--	DIRECT
Phenotypic Abnormality (PA)	Abnormality of fluid regulation	0.001339	1.508	--	INHERITED FROM: Edema
Phenotypic Abnormality (PA)	Hyperkeratosis	0.001354	1.763	--	INHERITED FROM: Palmoplantar keratoderma
Phenotypic Abnormality (PA)	Abnormality of the spinal cord	0.002169	1.763	--	INHERITED FROM: Spinal dysraphism
Phenotypic Abnormality (PA)	Abnormality of the respiratory system	0.0116	0.9183	--	INHERITED FROM: Abnormal lung morphology
Phenotypic Abnormality (PA)	Abnormality of joint mobility	0.01634	1.14	--	INHERITED FROM: Joint hyperflexibility
Phenotypic Abnormality (PA)	Thickened skin	0.018	1.684	--	INHERITED FROM: Palmoplantar keratoderma
Phenotypic Abnormality (PA)	Neoplasm by anatomical site	0.05219	1.184	--	INHERITED FROM: Malignant neoplasm of the central nervous system || Neuroblastoma || Neoplasm of the nervous system || Neuroblastic tumor || Neoplasm of the central nervous system
Phenotypic Abnormality (PA)	Abnormality of the vasculature	0.06858	0.7142	--	INHERITED FROM: Abnormality of the spleen
Phenotypic Abnormality (PA)	Abnormality of skin morphology	0.1003	0.7722	--	INHERITED FROM: Melanocytic nevus || Palmoplantar keratoderma || Cafe-au-lait spot || Nevus || Macule || Hyperpigmentation of the skin || Hypermelanotic macule || Skin nodule || Subcutaneous nodule || Irregular hyperpigmentation
Phenotypic Abnormality (PA)	Abnormality of the skin	0.1279	0.722	--	INHERITED FROM: Hypermelanotic macule || Macule || Hyperpigmentation of the skin || Subcutaneous nodule || Irregular hyperpigmentation || Skin nodule || Palmoplantar keratoderma || Cafe-au-lait spot || Melanocytic nevus || Nevus
Phenotypic Abnormality (PA)	Abnormal axial skeleton morphology	0.1873	0.6771	--	INHERITED FROM: Abnormality of the sternum
Phenotypic Abnormality (PA)	Abnormality of the skeletal system	0.3583	0.4712	--	INHERITED FROM: Abnormality of the sternum || Joint hyperflexibility
Phenotypic Abnormality (PA)	Abnormality of the nervous system	0.6409	0.2371	--	INHERITED FROM: Neuroblastic tumor || Abnormal neural tube morphology || Malignant neoplasm of the central nervous system || Neoplasm of the nervous system || Neoplasm of the central nervous system || Spinal dysraphism || Neuroblastoma
Phenotypic Abnormality (PA)	Morphological abnormality of the central nervous system	0.765	0.533	--	INHERITED FROM: Neoplasm of the central nervous system || Spinal dysraphism || Neuroblastoma || Malignant neoplasm of the central nervous system || Abnormal neural tube morphology || Neuroblastic tumor
Phenotypic Abnormality (PA)	Neuroectodermal neoplasm	1	1.684	--	INHERITED FROM: Peripheral primitive neuroectodermal neoplasm || Neuroblastoma || Primitive neuroectodermal tumor || Neuroepithelial neoplasm
Phenotypic Abnormality (PA)	Neural tube defect	1	1.763	--	INHERITED FROM: Spinal dysraphism
Phenotypic Abnormality (PA)	Abnormality of the immune system	0.01472	0.7464	Least Informative	INHERITED FROM: Abnormality of the spleen
Phenotypic Abnormality (PA)	Abnormality of metabolism/homeostasis	0.0498	0.5486	Least Informative	INHERITED FROM: Edema
Phenotypic Abnormality (PA)	Abnormality of the digestive system	0.07845	0.5759	Least Informative	INHERITED FROM: Abnormality of the spleen
Phenotypic Abnormality (PA)	Abnormality of the integument	0.2184	0.6235	Least Informative	INHERITED FROM: Nevus || Melanocytic nevus || Palmoplantar keratoderma || Cafe-au-lait spot || Skin nodule || Subcutaneous nodule || Irregular hyperpigmentation || Hyperpigmentation of the skin || Macule || Hypermelanotic macule
Phenotypic Abnormality (PA)	Abnormality of the cardiovascular system	0.225	0.5179	Least Informative	INHERITED FROM: Abnormality of the spleen
Phenotypic Abnormality (PA)	Abnormality of nervous system morphology	0.3038	0.4756	Least Informative	INHERITED FROM: Neoplasm of the central nervous system || Spinal dysraphism || Neuroblastic tumor || Abnormal neural tube morphology || Malignant neoplasm of the central nervous system || Neoplasm of the nervous system || Neuroblastoma
Phenotypic Abnormality (PA)	Abnormality of skeletal morphology	0.321	0.513	Least Informative	INHERITED FROM: Abnormality of the sternum
Phenotypic Abnormality (PA)	Abnormal respiratory system morphology	0.001527	1.064	Moderately Informative	INHERITED FROM: Abnormal lung morphology
Phenotypic Abnormality (PA)	Abnormality of the thorax	0.005989	1.207	Moderately Informative	INHERITED FROM: Abnormality of the sternum
Phenotypic Abnormality (PA)	Abnormality of the lymphatic system	0.01193	1.184	Moderately Informative	INHERITED FROM: Abnormality of the spleen
Phenotypic Abnormality (PA)	Abnormality of skeletal physiology	0.03809	1.101	Moderately Informative	INHERITED FROM: Joint hyperflexibility
Phenotypic Abnormality (PA)	Neoplasm	0.05974	1.14	Moderately Informative	INHERITED FROM: Neuroepithelial neoplasm || Peripheral primitive neuroectodermal neoplasm || Neoplasm of the central nervous system || Melanoma || Malignant neoplasm of the central nervous system || Primitive neuroectodermal tumor || Nervous tissue neoplasm || Neoplasm of the nervous system || Neuroblastoma || Neuroblastic tumor
Phenotypic Abnormality (PA)	Abnormality of the abdominal organs	0.06799	1.031	Moderately Informative	INHERITED FROM: Abnormality of the spleen
Phenotypic Abnormality (PA)	Localized skin lesion	0.1255	1.161	Moderately Informative	INHERITED FROM: Macule || Melanocytic nevus || Skin nodule || Hypermelanotic macule || Cafe-au-lait spot || Subcutaneous nodule || Nevus
Phenotypic Abnormality (PA)	Abnormal homeostasis	0.1918	0.7903	Moderately Informative	INHERITED FROM: Edema
Phenotypic Abnormality (PA)	Malignant neoplasm of the central nervous system	0.00002731	1.684	Informative	DIRECT
Phenotypic Abnormality (PA)	Edema	0.000689	1.508	Informative	DIRECT
Phenotypic Abnormality (PA)	Neoplasm by histology	0.002975	1.617	Informative	INHERITED FROM: Neuroepithelial neoplasm || Melanoma || Peripheral primitive neuroectodermal neoplasm || Primitive neuroectodermal tumor || Nervous tissue neoplasm || Neuroblastoma
Phenotypic Abnormality (PA)	Epidermal thickening	0.004464	1.684	Informative	INHERITED FROM: Palmoplantar keratoderma
Phenotypic Abnormality (PA)	Abnormality of skin pigmentation	0.01703	1.559	Informative	INHERITED FROM: Hypermelanotic macule || Hyperpigmentation of the skin || Melanocytic nevus || Irregular hyperpigmentation
Phenotypic Abnormality (PA)	Joint hypermobility	0.02769	1.508	Informative	INHERITED FROM: Joint hyperflexibility
Phenotypic Abnormality (PA)	Abnormality of prenatal development or birth	0.03424	1.286	Informative	INHERITED FROM: Polyhydramnios
Phenotypic Abnormality (PA)	Neuroblastoma	0.000003514	1.985	Highly Informative	DIRECT
Phenotypic Abnormality (PA)	Subcutaneous nodule	0.00006996	1.985	Highly Informative	DIRECT
Phenotypic Abnormality (PA)	Cafe-au-lait spot	0.00007364	1.985	Highly Informative	DIRECT
Phenotypic Abnormality (PA)	Nevus	0.0001843	2.161	Highly Informative	DIRECT
Phenotypic Abnormality (PA)	Palmoplantar keratoderma	0.0002722	2.161	Highly Informative	DIRECT
Phenotypic Abnormality (PA)	Abnormality of the sternum	0.0003553	2.161	Highly Informative	DIRECT
Phenotypic Abnormality (PA)	Hyperpigmentation of the skin	0.0009491	2.161	Highly Informative	DIRECT
Phenotypic Abnormality (PA)	Abnormality of the amniotic fluid	0.002169	2.161	Highly Informative	INHERITED FROM: Polyhydramnios

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Mouse Phenotype (MP)

Highlighted in gray are those with FDR_all>0.001

	MP term	FDR (all)	IC level	SDMP level	Annotation (direct or inherited)
Mammalian Phenotype (MP)	small placenta	0.0004024	2.603	--	DIRECT
Mammalian Phenotype (MP)	abnormal placenta size	0.0008894	2.603	--	DIRECT
Mammalian Phenotype (MP)	abnormal endocrine pancreas secretion	0.0009448	1.7	--	DIRECT
Mammalian Phenotype (MP)	abnormal pancreas secretion	0.001211	1.603	--	INHERITED FROM: abnormal endocrine pancreas secretion
Mammalian Phenotype (MP)	abnormal extraembryonic tissue morphology	0.03352	1.348	--	INHERITED FROM: small placenta || abnormal placenta size
Mammalian Phenotype (MP)	embryo phenotype	0.07201	0.8708	--	INHERITED FROM: abnormal placenta size || small placenta
Mammalian Phenotype (MP)	abnormal gland physiology	0.09338	1.324	--	INHERITED FROM: abnormal endocrine pancreas secretion
Mammalian Phenotype (MP)	abnormal cardiovascular system morphology	0.3567	0.7902	--	INHERITED FROM: thick ventricular wall
Mammalian Phenotype (MP)	abnormal heart ventricle morphology	0.5365	1.261	--	INHERITED FROM: thick ventricular wall
Mammalian Phenotype (MP)	cardiovascular system phenotype	0.02119	0.6737	Least Informative	INHERITED FROM: thick ventricular wall
Mammalian Phenotype (MP)	endocrine/exocrine gland phenotype	0.02317	0.6947	Least Informative	INHERITED FROM: abnormal endocrine pancreas secretion
Mammalian Phenotype (MP)	abnormal heart morphology	0.002907	0.9597	Moderately Informative	INHERITED FROM: thick ventricular wall
Mammalian Phenotype (MP)	abnormal heart ventricle wall thickness	0.07132	1.7	Informative	INHERITED FROM: thick ventricular wall
Mammalian Phenotype (MP)	abnormal pancreas physiology	0.1535	1.524	Informative	INHERITED FROM: abnormal endocrine pancreas secretion
Mammalian Phenotype (MP)	abnormal placenta morphology	0.5459	1.649	Informative	INHERITED FROM: small placenta || abnormal placenta size
Mammalian Phenotype (MP)	thick ventricular wall	0.0003107	1.904	Highly Informative	DIRECT

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Worm Phenotype (WP)

Highlighted in gray are those with FDR_all>0.001

	WP term	FDR (all)	IC level	SDWP level	Annotation (direct or inherited)
Worm Phenotype (WP)	growth variant	0	0.3438	--	DIRECT
Worm Phenotype (WP)	developmental timing variant	0	0.4548	--	DIRECT
Worm Phenotype (WP)	general pace of development variant	0	0.4786	--	DIRECT
Worm Phenotype (WP)	postembryonic development variant	0	0.269	--	DIRECT
Worm Phenotype (WP)	embryonic lethal	0	0.046	--	DIRECT
Worm Phenotype (WP)	lethal	0	0.00521	--	DIRECT
Worm Phenotype (WP)	fertility variant	0	0.05937	--	DIRECT
Worm Phenotype (WP)	retarded heterochronic variations	0	0.4548	--	DIRECT
Worm Phenotype (WP)	development variant	0	0.001482	--	DIRECT
Worm Phenotype (WP)	morphology variant	0	0.046	--	DIRECT
Worm Phenotype (WP)	organism development variant	0	0.00297	--	DIRECT
Worm Phenotype (WP)	organism morphology variant	0	0.1372	--	DIRECT
Worm Phenotype (WP)	organ system physiology variant	0	0.04518	--	DIRECT
Worm Phenotype (WP)	organism physiology variant	0	0.1342	--	DIRECT
Worm Phenotype (WP)	organism homeostasis metabolism variant	0	0.1444	--	DIRECT
Worm Phenotype (WP)	reproductive system physiology variant	0	0.05515	--	DIRECT
Worm Phenotype (WP)	maternal sterile	0	0.1213	--	DIRECT
Worm Phenotype (WP)	hermaphrodite sterile	0	0.1203	--	DIRECT
Worm Phenotype (WP)	embryonic development variant	0	0.04518	--	DIRECT
Worm Phenotype (WP)	larval development variant	0	0.4322	--	DIRECT
Worm Phenotype (WP)	hermaphrodite fertility variant	0	0.0947	--	DIRECT
Worm Phenotype (WP)	developmental growth variant	0	0.4991	--	DIRECT
Worm Phenotype (WP)	larval growth variant	0	0.4991	--	DIRECT
Worm Phenotype (WP)	sterile progeny	0	0.6547	--	DIRECT
Worm Phenotype (WP)	hermaphrodite fertility reduced	0	0.1193	--	DIRECT
Worm Phenotype (WP)	fertility reduced	0	0.06449	--	DIRECT
Worm Phenotype (WP)	physiology variant	1	0	--	INHERITED FROM: hermaphrodite fertility variant || developmental growth variant || retarded heterochronic variations || larval lethal || reproductive system physiology variant || organism homeostasis metabolism variant || lethal || larval development variant || sterile progeny || organism physiology variant || progeny variant || slow growth || development variant || developmental timing variant || hermaphrodite sterile || growth variant || hermaphrodite fertility reduced || embryonic development variant || embryonic lethal || larval growth variant || general pace of development variant || fertility variant || postembryonic development variant || larval arrest || organ system physiology variant || maternal sterile || organism development variant || fertility reduced
Worm Phenotype (WP)	sterile	1	0.1135	--	INHERITED FROM: hermaphrodite sterile || maternal sterile || sterile progeny
Worm Phenotype (WP)	slow growth	0	0.4945	Least Informative	DIRECT
Worm Phenotype (WP)	larval lethal	0	0.5727	Least Informative	DIRECT
Worm Phenotype (WP)	larval arrest	0	0.4991	Least Informative	DIRECT
Worm Phenotype (WP)	progeny variant	0	0.6514	Least Informative	DIRECT

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Fly Anatomy (FA)

Highlighted in gray are those with FDR_all>0.001

	FA term	FDR (all)	IC level	SDFA level	Annotation (direct or inherited)
Fly Anatomy (FA)	organism	0	0.06695	--	DIRECT
Fly Anatomy (FA)	multicellular structure	0	0.008955	--	DIRECT
Fly Anatomy (FA)	anatomical structure	1	0	--	INHERITED FROM: organism || multicellular structure
Fly Anatomy (FA)	material anatomical entity	1	0	--	INHERITED FROM: anatomical group || multicellular structure || organism
Fly Anatomy (FA)	anatomical group	0	0.6816	Least Informative	DIRECT

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Zebrafish Anatomy (ZA)

Highlighted in gray are those with FDR_all>0.001

	ZA term	FDR (all)	IC level	SDZA level	Annotation (direct or inherited)
Zebrafish Anatomy (ZA)	whole organism	0	0.00147	--	DIRECT
Zebrafish Anatomy (ZA)	anatomical structure	1	0	--	INHERITED FROM: cell || whole organism
Zebrafish Anatomy (ZA)	cell	0	0.6388	Least Informative	DIRECT

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Xenopus Anatomy (XA)

Highlighted in gray are those with FDR_all>0.001

	XA term	FDR (all)	IC level	SDXA level	Annotation (direct or inherited)
Xenopus ANatomical entity (XAN)	anatomical structure	0	0	--	DIRECT
Xenopus DEvelopment stage (XDE)	NF stage	0	0.01895	--	DIRECT

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Enzyme Commission (EC)

Highlighted in gray are those with FDR_all>0.001

	EC term	FDR (all)	IC level	SDEC level	Annotation (direct or inherited)
Enzyme Commission (EC)	Transferring phosphorus-containing groups	0	0.7021	--	DIRECT
Enzyme Commission (EC)	Phosphatidylinositol-4,5-bisphosphate 3-kinase	0	2.531	--	DIRECT
Enzyme Commission (EC)	Phosphoinositide phospholipase C	0.00000000000555	2.275	--	DIRECT
Enzyme Commission (EC)	Non-specific serine/threonine protein kinase	0.0005776	1.639	--	DIRECT
Enzyme Commission (EC)	Transferases	0.00000000002181	0.3972	Least Informative	DIRECT
Enzyme Commission (EC)	Hydrolases	0.9195	0.4043	Least Informative	INHERITED FROM: Phosphoric diester hydrolases || Phosphoinositide phospholipase C
Enzyme Commission (EC)	Phosphotransferases with an alcohol group as acceptor	0.0009164	1.238	Moderately Informative	DIRECT
Enzyme Commission (EC)	Acting on ester bonds	0.05416	0.8756	Moderately Informative	INHERITED FROM: Phosphoinositide phospholipase C || Phosphoric diester hydrolases
Enzyme Commission (EC)	Protein-serine/threonine kinases	5.532e-16	1.437	Informative	DIRECT
Enzyme Commission (EC)	Phosphoric diester hydrolases	0.00000001255	1.753	Highly Informative	DIRECT

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