CAD domain family

SCOP classification

• Root: SCOP hierarchy in SUPERFAMILY [ 0] (11)
• Class: Alpha and beta proteins (a+b) [ 53931] (376)
• Fold: beta-Grasp (ubiquitin-like) [ 54235] (14)
• Superfamily: CAD & PB1 domains [ 54277] (2)
• Family: CAD domain [ 54278] (3)

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Family statistics

	Genomes (52)	Uniprot 2018_03 genome	PDB chains (SCOP 1.75)
Domains	150	281	7
Proteins	150	281	7

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Disease Ontology (DO)

Highlighted in gray are those with FDR_all>0.001

	DO term	FDR (all)	IC level	SDDO level	Annotation (direct or inherited)
Disease Ontology (DO)	disease of cellular proliferation	0	0.2322	--	DIRECT
Disease Ontology (DO)	cancer	0	0.2555	--	DIRECT

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Mouse Phenotype (MP)

Highlighted in gray are those with FDR_all>0.001

	MP term	FDR (all)	IC level	SDMP level	Annotation (direct or inherited)
Mammalian Phenotype (MP)	decreased fatty acid level	0.000007705	2.603	--	DIRECT
Mammalian Phenotype (MP)	decreased circulating triglyceride level	0.00003128	2.603	--	DIRECT
Mammalian Phenotype (MP)	abnormal circulating lipid level	0.002941	1.241	--	INHERITED FROM: abnormal circulating triglyceride level || decreased circulating triglyceride level
Mammalian Phenotype (MP)	abnormal adipose tissue morphology	0.003864	1.223	--	INHERITED FROM: abnormal white adipose tissue morphology || abnormal fat cell morphology
Mammalian Phenotype (MP)	abnormal lipid level	0.005943	1.156	--	INHERITED FROM: decreased fatty acid level || decreased circulating triglyceride level || decreased triglyceride level || abnormal triglyceride level || abnormal circulating triglyceride level || abnormal fatty acid level
Mammalian Phenotype (MP)	homeostasis/metabolism phenotype	0.09084	0.3626	--	INHERITED FROM: abnormal circulating triglyceride level || decreased triglyceride level || decreased fatty acid level || abnormal fatty acid level || abnormal triglyceride level || decreased circulating triglyceride level
Mammalian Phenotype (MP)	abnormal blood homeostasis	0.1087	0.6893	--	INHERITED FROM: decreased circulating triglyceride level || abnormal circulating triglyceride level
Mammalian Phenotype (MP)	abnormal homeostasis	0.7076	0.4926	Least Informative	INHERITED FROM: decreased triglyceride level || abnormal circulating triglyceride level || decreased fatty acid level || abnormal fatty acid level || abnormal triglyceride level || decreased circulating triglyceride level
Mammalian Phenotype (MP)	adipose tissue phenotype	0.00413	1.205	Moderately Informative	INHERITED FROM: abnormal white adipose tissue morphology || abnormal fat cell morphology
Mammalian Phenotype (MP)	abnormal lipid homeostasis	0.007216	1.141	Moderately Informative	INHERITED FROM: abnormal circulating triglyceride level || abnormal triglyceride level || abnormal fatty acid level || decreased fatty acid level || decreased circulating triglyceride level || decreased triglyceride level
Mammalian Phenotype (MP)	abnormal white adipose tissue morphology	0.00009349	1.603	Informative	DIRECT
Mammalian Phenotype (MP)	abnormal circulating triglyceride level	0.0001801	1.562	Informative	DIRECT
Mammalian Phenotype (MP)	abnormal triglyceride level	0.0004481	1.457	Informative	DIRECT
Mammalian Phenotype (MP)	abnormal fat cell morphology	0.00002563	2.001	Highly Informative	DIRECT
Mammalian Phenotype (MP)	abnormal fatty acid level	0.00005843	2.126	Highly Informative	DIRECT
Mammalian Phenotype (MP)	decreased triglyceride level	0.00007567	2.001	Highly Informative	DIRECT

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Fly Phenotype (FP)

Highlighted in gray are those with FDR_all>0.001

	FP term	FDR (all)	IC level	SDFP level	Annotation (direct or inherited)
Fly Phenotype (FP)	phenotype	0	0.06546	--	DIRECT

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Fly Anatomy (FA)

Highlighted in gray are those with FDR_all>0.001

	FA term	FDR (all)	IC level	SDFA level	Annotation (direct or inherited)
Fly Anatomy (FA)	organism	0	0.06695	--	DIRECT
Fly Anatomy (FA)	cell	0	0.4069	--	DIRECT
Fly Anatomy (FA)	multicellular structure	0	0.008955	--	DIRECT
Fly Anatomy (FA)	anatomical structure	1	0	--	INHERITED FROM: organism || somatic cell || cell || multicellular structure
Fly Anatomy (FA)	material anatomical entity	1	0	--	INHERITED FROM: multicellular structure || cell || somatic cell || organism
Fly Anatomy (FA)	somatic cell	0	0.4861	Least Informative	DIRECT

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Xenopus Anatomy (XA)

Highlighted in gray are those with FDR_all>0.001

	XA term	FDR (all)	IC level	SDXA level	Annotation (direct or inherited)
Xenopus ANatomical entity (XAN)	trunk region	0	0.388	--	DIRECT
Xenopus ANatomical entity (XAN)	anatomical structure	0	0	--	DIRECT
Xenopus ANatomical entity (XAN)	anatomical group	0	0.1408	--	DIRECT
Xenopus ANatomical entity (XAN)	organism subdivision	0	0.1679	--	DIRECT
Xenopus ANatomical entity (XAN)	compound organ	0	0.2177	--	DIRECT
Xenopus ANatomical entity (XAN)	anatomical region	0	0.1803	--	DIRECT
Xenopus ANatomical entity (XAN)	multicellular anatomical structure	0	0.1131	--	DIRECT
Xenopus ANatomical entity (XAN)	anatomical system	1	0.283	--	INHERITED FROM: urogenital system
Xenopus ANatomical entity (XAN)	whole organism	1	0.0884	--	INHERITED FROM: urogenital system || anatomical group || cavitated compound organ || multicellular anatomical structure || compound organ || trunk || anatomical region || trunk region || organism subdivision
Xenopus ANatomical entity (XAN)	urogenital system	0	0.4777	Least Informative	DIRECT
Xenopus ANatomical entity (XAN)	trunk	0	0.3894	Least Informative	DIRECT
Xenopus ANatomical entity (XAN)	cavitated compound organ	0	0.2685	Least Informative	DIRECT

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