2Fe-2S ferredoxin domains from multidomain proteins family

SCOP classification

• Root: SCOP hierarchy in SUPERFAMILY [ 0] (11)
• Class: Alpha and beta proteins (a+b) [ 53931] (376)
• Fold: beta-Grasp (ubiquitin-like) [ 54235] (14)
• Superfamily: 2Fe-2S ferredoxin-like [ 54292] (2)
• Family: 2Fe-2S ferredoxin domains from multidomain proteins [ 54312] (13)

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Family statistics

	Genomes (950)	Uniprot 2018_03 genome	PDB chains (SCOP 1.75)
Domains	1,443	8,007	19
Proteins	1,442	8,006	19

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Enzyme Commission (EC)

Highlighted in gray are those with FDR_all>0.001

	EC term	FDR (all)	IC level	SDEO level	Annotation (direct or inherited)
Enzyme Commission (EC)	Succinate dehydrogenase (ubiquinone)	0	2.042	--	DIRECT
Enzyme Commission (EC)	With other acceptors	0.000000000002138	1.838	--	DIRECT
Enzyme Commission (EC)	Acting on NADH or NADPH	0.1332	1.31	--	INHERITED FROM: With other acceptors
Enzyme Commission (EC)	Oxidoreductases	0	0.3212	Least Informative	DIRECT
Enzyme Commission (EC)	Acting on the CH-CH group of donors	0	1.185	Moderately Informative	DIRECT
Enzyme Commission (EC)	Acting on the aldehyde or oxo group of donors	0.02409	1.236	Moderately Informative	INHERITED FROM: With oxygen as acceptor
Enzyme Commission (EC)	With other acceptors	0.000000002524	1.627	Informative	DIRECT
Enzyme Commission (EC)	Acting on CH or CH(2) groups	0.00000001958	1.627	Informative	DIRECT
Enzyme Commission (EC)	With oxygen as acceptor	0	1.963	Highly Informative	DIRECT
Enzyme Commission (EC)	With NAD(+) or NADP(+) as acceptor	0	1.963	Highly Informative	DIRECT
Enzyme Commission (EC)	With oxygen as acceptor	0.000000000131	1.963	Highly Informative	DIRECT
Enzyme Commission (EC)	With a quinone or related compound as acceptor	0.000000006721	1.963	Highly Informative	DIRECT
Enzyme Commission (EC)	Succinate dehydrogenase	0.00000007658	2.042	Highly Informative	DIRECT

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Mouse Phenotype (MP)

Highlighted in gray are those with FDR_all>0.001

	MP term	FDR (all)	IC level	SDMP level	Annotation (direct or inherited)
Mammalian Phenotype (MP)	abnormal survival	0	0.6441	--	DIRECT
Mammalian Phenotype (MP)	preweaning lethality	0	0.7055	--	DIRECT
Mammalian Phenotype (MP)	mortality/aging	0	0.5424	Least Informative	DIRECT

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Worm Phenotype (WP)

Highlighted in gray are those with FDR_all>0.001

	WP term	FDR (all)	IC level	SDWP level	Annotation (direct or inherited)
Worm Phenotype (WP)	growth variant	0	0.3438	--	DIRECT
Worm Phenotype (WP)	developmental timing variant	0	0.4548	--	DIRECT
Worm Phenotype (WP)	general pace of development variant	0	0.4786	--	DIRECT
Worm Phenotype (WP)	postembryonic development variant	0	0.269	--	DIRECT
Worm Phenotype (WP)	embryonic lethal	0	0.046	--	DIRECT
Worm Phenotype (WP)	lethal	0	0.00521	--	DIRECT
Worm Phenotype (WP)	fertility variant	0	0.05937	--	DIRECT
Worm Phenotype (WP)	retarded heterochronic variations	0	0.4548	--	DIRECT
Worm Phenotype (WP)	development variant	0	0.001482	--	DIRECT
Worm Phenotype (WP)	morphology variant	0	0.046	--	DIRECT
Worm Phenotype (WP)	organism development variant	0	0.00297	--	DIRECT
Worm Phenotype (WP)	organism morphology variant	0	0.1372	--	DIRECT
Worm Phenotype (WP)	organ system physiology variant	0	0.04518	--	DIRECT
Worm Phenotype (WP)	organism physiology variant	0	0.1342	--	DIRECT
Worm Phenotype (WP)	organism homeostasis metabolism variant	0	0.1444	--	DIRECT
Worm Phenotype (WP)	reproductive system physiology variant	0	0.05515	--	DIRECT
Worm Phenotype (WP)	maternal sterile	0	0.1213	--	DIRECT
Worm Phenotype (WP)	hermaphrodite sterile	0	0.1203	--	DIRECT
Worm Phenotype (WP)	embryonic development variant	0	0.04518	--	DIRECT
Worm Phenotype (WP)	larval development variant	0	0.4322	--	DIRECT
Worm Phenotype (WP)	hermaphrodite fertility variant	0	0.0947	--	DIRECT
Worm Phenotype (WP)	developmental growth variant	0	0.4991	--	DIRECT
Worm Phenotype (WP)	larval growth variant	0	0.4991	--	DIRECT
Worm Phenotype (WP)	hermaphrodite fertility reduced	0	0.1193	--	DIRECT
Worm Phenotype (WP)	fertility reduced	0	0.06449	--	DIRECT
Worm Phenotype (WP)	physiology variant	1	0	--	INHERITED FROM: hermaphrodite fertility variant || developmental growth variant || retarded heterochronic variations || reproductive system physiology variant || organism homeostasis metabolism variant || lethal || larval development variant || organism physiology variant || slow growth || life span variant || development variant || developmental timing variant || hermaphrodite sterile || growth variant || hermaphrodite fertility reduced || embryonic development variant || embryonic lethal || larval growth variant || general pace of development variant || fertility variant || postembryonic development variant || larval arrest || organ system physiology variant || maternal sterile || organism development variant || fertility reduced
Worm Phenotype (WP)	sterile	1	0.1135	--	INHERITED FROM: hermaphrodite sterile || maternal sterile
Worm Phenotype (WP)	slow growth	0	0.4945	Least Informative	DIRECT
Worm Phenotype (WP)	larval arrest	0	0.4991	Least Informative	DIRECT
Worm Phenotype (WP)	life span variant	0.0006855	1.321	Informative	DIRECT

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Fly Phenotype (FP)

Highlighted in gray are those with FDR_all>0.001

	FP term	FDR (all)	IC level	SDFP level	Annotation (direct or inherited)
Fly Phenotype (FP)	locomotor behavior defective	0	1.784	--	DIRECT
Fly Phenotype (FP)	phenotype	0	0.06546	--	DIRECT
Fly Phenotype (FP)	behavior defective	0	1.306	Informative	DIRECT

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Fly Anatomy (FA)

Highlighted in gray are those with FDR_all>0.001

	FA term	FDR (all)	IC level	SDFA level	Annotation (direct or inherited)
Fly Anatomy (FA)	organism	0	0.06695	--	DIRECT
Fly Anatomy (FA)	organ system	0	0.1823	--	DIRECT
Fly Anatomy (FA)	cell	0	0.4069	--	DIRECT
Fly Anatomy (FA)	multicellular structure	0	0.008955	--	DIRECT
Fly Anatomy (FA)	anatomical structure	1	0	--	INHERITED FROM: organism || somatic cell || cell || organ system || multicellular structure
Fly Anatomy (FA)	material anatomical entity	1	0	--	INHERITED FROM: organ system || multicellular structure || cell || somatic cell || organism
Fly Anatomy (FA)	somatic cell	0	0.4861	Least Informative	DIRECT

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Arabidopsis Plant Ontology (AP)

Highlighted in gray are those with FDR_all>0.001

	AP term	FDR (all)	IC level	SDAP level	Annotation (direct or inherited)
Plant structure DEvelopment stage (PDE)	whole plant development stage	0	0.1547	--	DIRECT
Plant structure DEvelopment stage (PDE)	sporophyte vegetative stage	0	0.1593	--	DIRECT
Plant structure DEvelopment stage (PDE)	life of whole plant stage	1	0.1584	--	INHERITED FROM: sporophyte vegetative stage || 0 seed germination stage || seedling development stage
Plant structure DEvelopment stage (PDE)	sporophyte development stage	1	0.1584	--	INHERITED FROM: sporophyte vegetative stage || 0 seed germination stage || seedling development stage
Plant structure DEvelopment stage (PDE)	seedling development stage	0.00000008546	1.721	Informative	DIRECT
Plant structure DEvelopment stage (PDE)	0 seed germination stage	0.0000001981	1.689	Informative	DIRECT

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Enzyme Commission (EC)

Highlighted in gray are those with FDR_all>0.001

	EC term	FDR (all)	IC level	SDEC level	Annotation (direct or inherited)
Enzyme Commission (EC)	Xanthine dehydrogenase	0	2.452	--	DIRECT
Enzyme Commission (EC)	With oxygen as acceptor	0	2.327	--	DIRECT
Enzyme Commission (EC)	With a quinone or related compound as acceptor	0	2.385	--	DIRECT
Enzyme Commission (EC)	Succinate dehydrogenase (quinone)	0	2.531	--	DIRECT
Enzyme Commission (EC)	Ferredoxin--NAD(+) reductase	0.0000000000533	2.753	--	DIRECT
Enzyme Commission (EC)	With oxygen as acceptor	0.00000000006001	2.452	--	DIRECT
Enzyme Commission (EC)	Acting on CH or CH(2) groups	0.000000007576	1.849	--	DIRECT
Enzyme Commission (EC)	With NAD(+) or NADP(+) as acceptor	0.0000002406	2.327	--	DIRECT
Enzyme Commission (EC)	NADH:ubiquinone reductase (H(+)-translocating)	0.000002111	2.23	--	DIRECT
Enzyme Commission (EC)	NADH dehydrogenase	0.000002758	2.151	--	DIRECT
Enzyme Commission (EC)	Carnitine monooxygenase	0.000002879	2.628	--	DIRECT
Enzyme Commission (EC)	With other acceptors	0.000008688	2.531	--	DIRECT
Enzyme Commission (EC)	Catalysing the translocation of hydrons	0.06763	1.832	--	INHERITED FROM: NADH:ubiquinone reductase (H(+)-translocating) || Hydron translocation or charge separation linked to oxidoreductase reactions
Enzyme Commission (EC)	Acting on NADH or NADPH	0.3847	1.783	--	INHERITED FROM: With other acceptors || NADH dehydrogenase
Enzyme Commission (EC)	Oxidoreductases	0	0.7328	Least Informative	DIRECT
Enzyme Commission (EC)	Acting on the CH-CH group of donors	0	1.586	Informative	DIRECT
Enzyme Commission (EC)	Acting on the aldehyde or oxo group of donors	0.00003052	1.65	Informative	DIRECT
Enzyme Commission (EC)	Translocases	0.3988	1.628	Informative	INHERITED FROM: Hydron translocation or charge separation linked to oxidoreductase reactions || NADH:ubiquinone reductase (H(+)-translocating)
Enzyme Commission (EC)	Acting on paired donors, with incorporation or reduction of molecular oxygen. The oxygen incorporate	0.7772	1.514	Informative	INHERITED FROM: With NADH or NADPH as one donor, and incorporation of one atom of oxygen || Carnitine monooxygenase
Enzyme Commission (EC)	With other acceptors	0.000007239	2.116	Highly Informative	DIRECT
Enzyme Commission (EC)	With NAD(+) or NADP(+) as acceptor	0.00001309	2.151	Highly Informative	DIRECT
Enzyme Commission (EC)	With NADH or NADPH as one donor, and incorporation of one atom of oxygen	0.00001804	2.026	Highly Informative	DIRECT
Enzyme Commission (EC)	Hydron translocation or charge separation linked to oxidoreductase reactions	0.00003318	1.974	Highly Informative	DIRECT
Enzyme Commission (EC)	Acting on iron-sulfur proteins as donors	0.04316	2.23	Highly Informative	INHERITED FROM: Ferredoxin--NAD(+) reductase || With NAD(+) or NADP(+) as acceptor

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