Glutamine synthetase, N-terminal domain family

SCOP classification

• Root: SCOP hierarchy in SUPERFAMILY [ 0] (11)
• Class: Alpha and beta proteins (a+b) [ 53931] (376)
• Fold: beta-Grasp (ubiquitin-like) [ 54235] (14)
• Superfamily: Glutamine synthetase, N-terminal domain [ 54368]
• Family: Glutamine synthetase, N-terminal domain [ 54369]

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Family statistics

	Genomes (1,263)	Uniprot 2018_03 genome	PDB chains (SCOP 1.75)
Domains	1,286	11,051	4
Proteins	1,286	11,051	4

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Enzyme Commission (EC)

Highlighted in gray are those with FDR_all>0.001

	EC term	FDR (all)	IC level	SDEO level	Annotation (direct or inherited)
Enzyme Commission (EC)	Glutamate--ammonia ligase	0	2.44	--	DIRECT
Enzyme Commission (EC)	Glutamate decarboxylase	0	2.264	--	DIRECT
Enzyme Commission (EC)	Carbon-carbon lyases	0.004793	0.9151	--	INHERITED FROM: Glutamate decarboxylase || Carboxy-lyases
Enzyme Commission (EC)	Ligases	0	0.7455	Least Informative	DIRECT
Enzyme Commission (EC)	Lyases	0.9333	0.4956	Least Informative	INHERITED FROM: Carboxy-lyases || Glutamate decarboxylase
Enzyme Commission (EC)	Forming carbon-nitrogen bonds	0	0.993	Moderately Informative	DIRECT
Enzyme Commission (EC)	Carboxy-lyases	0.0002973	1.06	Moderately Informative	DIRECT
Enzyme Commission (EC)	Acid--ammonia (or amide) ligases (amide synthases)	0	1.963	Highly Informative	DIRECT

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Worm Phenotype (WP)

Highlighted in gray are those with FDR_all>0.001

	WP term	FDR (all)	IC level	SDWP level	Annotation (direct or inherited)
Worm Phenotype (WP)	postembryonic development variant	0	0.269	--	DIRECT
Worm Phenotype (WP)	embryonic lethal	0	0.046	--	DIRECT
Worm Phenotype (WP)	lethal	0	0.00521	--	DIRECT
Worm Phenotype (WP)	fertility variant	0	0.05937	--	DIRECT
Worm Phenotype (WP)	development variant	0	0.001482	--	DIRECT
Worm Phenotype (WP)	morphology variant	0	0.046	--	DIRECT
Worm Phenotype (WP)	organism development variant	0	0.00297	--	DIRECT
Worm Phenotype (WP)	organism morphology variant	0	0.1372	--	DIRECT
Worm Phenotype (WP)	organ system physiology variant	0	0.04518	--	DIRECT
Worm Phenotype (WP)	reproductive system physiology variant	0	0.05515	--	DIRECT
Worm Phenotype (WP)	maternal sterile	0	0.1213	--	DIRECT
Worm Phenotype (WP)	hermaphrodite sterile	0	0.1203	--	DIRECT
Worm Phenotype (WP)	embryonic development variant	0	0.04518	--	DIRECT
Worm Phenotype (WP)	hermaphrodite fertility variant	0	0.0947	--	DIRECT
Worm Phenotype (WP)	hermaphrodite fertility reduced	0	0.1193	--	DIRECT
Worm Phenotype (WP)	fertility reduced	0	0.06449	--	DIRECT
Worm Phenotype (WP)	physiology variant	1	0	--	INHERITED FROM: hermaphrodite fertility variant || reproductive system physiology variant || lethal || development variant || hermaphrodite sterile || hermaphrodite fertility reduced || embryonic development variant || embryonic lethal || fertility variant || postembryonic development variant || organ system physiology variant || maternal sterile || organism development variant || fertility reduced
Worm Phenotype (WP)	sterile	1	0.1135	--	INHERITED FROM: hermaphrodite sterile || maternal sterile

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Arabidopsis Plant Ontology (AP)

Highlighted in gray are those with FDR_all>0.001

	AP term	FDR (all)	IC level	SDAP level	Annotation (direct or inherited)
Plant ANatomical entity (PAN)	collective phyllome structure	0	0.3837	--	DIRECT
Plant ANatomical entity (PAN)	stamen	0	0.5171	--	DIRECT
Plant ANatomical entity (PAN)	leaf	0	0.4282	--	DIRECT
Plant ANatomical entity (PAN)	shoot axis	0	0.3985	--	DIRECT
Plant ANatomical entity (PAN)	shoot system	0	0.05272	--	DIRECT
Plant ANatomical entity (PAN)	sporophyll	0	0.3985	--	DIRECT
Plant ANatomical entity (PAN)	corolla	0	0.4893	--	DIRECT
Plant ANatomical entity (PAN)	phyllome	0	0.3234	--	DIRECT
Plant ANatomical entity (PAN)	perianth	0	0.4476	--	DIRECT
Plant ANatomical entity (PAN)	whole plant	0	0.3507	--	DIRECT
Plant ANatomical entity (PAN)	calyx	0	0.4728	--	DIRECT
Plant ANatomical entity (PAN)	collective plant structure	0	0.01555	--	DIRECT
Plant ANatomical entity (PAN)	reproductive shoot system	0	0.3304	--	DIRECT
Plant ANatomical entity (PAN)	multi-tissue plant structure	0	0.2335	--	DIRECT
Plant ANatomical entity (PAN)	plant axis	0	0.3257	--	DIRECT
Plant ANatomical entity (PAN)	carpel	0	0.5117	--	DIRECT
Plant ANatomical entity (PAN)	flower	0	0.3446	--	DIRECT
Plant ANatomical entity (PAN)	plant organ	0	0.2391	--	DIRECT
Plant ANatomical entity (PAN)	collective plant organ structure	1	0.03998	--	INHERITED FROM: calyx || flower || sporophyll || perianth || leaf || phyllome || sepal || vascular leaf || gynoecium || petal || reproductive shoot system || carpel || collective phyllome structure || megasporophyll || microsporophyll || corolla || androecium || stamen || shoot axis || shoot system || collective leaf structure
Plant ANatomical entity (PAN)	plant structure	1	0	--	INHERITED FROM: perianth || sporophyll || calyx || flower || collective plant structure || leaf || phyllome || multi-tissue plant structure || microsporophyll || megasporophyll || reproductive shoot system || collective leaf structure || shoot system || plant organ || whole plant || gynoecium || vascular leaf || sepal || corolla || plant axis || collective phyllome structure || petal || carpel || seed || stamen || shoot axis || androecium
Plant ANatomical entity (PAN)	seed	0	0.5189	Least Informative	DIRECT
Plant ANatomical entity (PAN)	megasporophyll	0	0.5117	Least Informative	DIRECT
Plant ANatomical entity (PAN)	gynoecium	0	0.5082	Least Informative	DIRECT
Plant ANatomical entity (PAN)	petal	0	0.4893	Least Informative	DIRECT
Plant ANatomical entity (PAN)	androecium	0	0.5153	Least Informative	DIRECT
Plant ANatomical entity (PAN)	vascular leaf	0	0.437	Least Informative	DIRECT
Plant ANatomical entity (PAN)	collective leaf structure	0	0.46	Least Informative	DIRECT
Plant ANatomical entity (PAN)	sepal	0	0.4728	Least Informative	DIRECT
Plant ANatomical entity (PAN)	microsporophyll	0	0.4415	Least Informative	DIRECT
Plant structure DEvelopment stage (PDE)	whole plant development stage	0	0.1547	--	DIRECT
Plant structure DEvelopment stage (PDE)	plant embryo stage	0	0.2319	--	DIRECT
Plant structure DEvelopment stage (PDE)	plant organ development stage	0	0.06127	--	DIRECT
Plant structure DEvelopment stage (PDE)	flowering stage	0	0.1648	--	DIRECT
Plant structure DEvelopment stage (PDE)	corolla development stage	0	0.1484	--	DIRECT
Plant structure DEvelopment stage (PDE)	floral organ differentiation stage	0	0.07163	--	DIRECT
Plant structure DEvelopment stage (PDE)	floral organ formation stage	0	0.07163	--	DIRECT
Plant structure DEvelopment stage (PDE)	collective plant organ structure development stage	0	0.0282	--	DIRECT
Plant structure DEvelopment stage (PDE)	reproductive shoot system development stage	0	0.0371	--	DIRECT
Plant structure DEvelopment stage (PDE)	collective phyllome structure development stage	0	0.07163	--	DIRECT
Plant structure DEvelopment stage (PDE)	sporophyte vegetative stage	0	0.1593	--	DIRECT
Plant structure DEvelopment stage (PDE)	life of whole plant stage	1	0.1584	--	INHERITED FROM: sporophyte vegetative stage || E expanded cotyledon stage || plant embryo stage
Plant structure DEvelopment stage (PDE)	flower development stage	1	0.05402	--	INHERITED FROM: corolla development stage || flowering stage || floral organ differentiation stage || floral organ formation stage
Plant structure DEvelopment stage (PDE)	shoot system development stage	1	0.02956	--	INHERITED FROM: reproductive shoot system development stage || floral organ formation stage || floral organ differentiation stage || flowering stage || corolla development stage || plant organ development stage
Plant structure DEvelopment stage (PDE)	sporophyte development stage	1	0.1584	--	INHERITED FROM: E expanded cotyledon stage || sporophyte vegetative stage || plant embryo stage
Plant structure DEvelopment stage (PDE)	E expanded cotyledon stage	0	0.2861	Least Informative	DIRECT

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Enzyme Commission (EC)

Highlighted in gray are those with FDR_all>0.001

	EC term	FDR (all)	IC level	SDEC level	Annotation (direct or inherited)
Enzyme Commission (EC)	Protein S-acyltransferase	0	2.753	--	DIRECT
Enzyme Commission (EC)	Glutamine synthetase	0	2.929	--	DIRECT
Enzyme Commission (EC)	Transferases	1	0.3972	Least Informative	INHERITED FROM: Protein S-acyltransferase
Enzyme Commission (EC)	Ligases	0	1.14	Moderately Informative	DIRECT
Enzyme Commission (EC)	Acyltransferases	0.1678	1.034	Moderately Informative	INHERITED FROM: Protein S-acyltransferase
Enzyme Commission (EC)	Forming carbon-nitrogen bonds	0	1.338	Informative	DIRECT
Enzyme Commission (EC)	Transferring groups other than amino-acyl groups	0.02346	1.321	Informative	INHERITED FROM: Protein S-acyltransferase
Enzyme Commission (EC)	Acid--ammonia (or amine) ligases (amide synthases)	0	2.188	Highly Informative	DIRECT

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