FKBP-like superfamily

SCOP classification

• Root: SCOP hierarchy in SUPERFAMILY [ 0] (11)
• Class: Alpha and beta proteins (a+b) [ 53931] (376)
• Fold: FKBP-like [ 54533] (3)
• Superfamily: FKBP-like [ 54534] (3)
• Families:
  • FKBP immunophilin/proline isomerase [ 54535] (16)
  • GreA transcript cleavage factor, C-terminal domain [ 54549]
  • 3-mercaptopyruvate sulfurtransferase, C-terminal domain [ 102868]

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Superfamily statistics

	Genomes (3,247)	Uniprot 2018_03 genome	PDB chains (SCOP 1.75)
Domains	26,761	179,594	48
Proteins	24,031	164,911	44

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Functional annotation

• General category: Processes_IC
• Detailed category: Protein modification

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Enzyme Commission (EC)

Highlighted in gray are those with FDR_all>0.001

	EC term	FDR (all)	IC level	SDEO level	Annotation (direct or inherited)
Enzyme Commission (EC)	Cis-trans-isomerases	0	1.414	--	DIRECT
Enzyme Commission (EC)	Cis-trans Isomerases	1	1.414	--	INHERITED FROM: Peptidylprolyl isomerase
Enzyme Commission (EC)	Isomerases	0	0.5914	Least Informative	DIRECT
Enzyme Commission (EC)	Peptidylprolyl isomerase	0	1.519	Informative	DIRECT

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Human Phenotype (HP)

Highlighted in gray are those with FDR_all>0.001

	HP term	FDR (all)	IC level	SDHP level	Annotation (direct or inherited)
Mode of Inheritance (MI)	Autosomal recessive inheritance	0	0.1924	--	DIRECT
Phenotypic Abnormality (PA)	Abnormality of head or neck	0	0.472	--	DIRECT
Phenotypic Abnormality (PA)	Abnormality of the nervous system	0	0.2543	--	DIRECT
Phenotypic Abnormality (PA)	Abnormality of the skeletal system	0	0.4621	--	DIRECT
Phenotypic Abnormality (PA)	Abnormal axial skeleton morphology	0	0.7344	--	DIRECT
Phenotypic Abnormality (PA)	Osteopenia	0.0001321	2.407	--	DIRECT
Phenotypic Abnormality (PA)	Abnormality of bone mineral density	0.002144	2.106	--	INHERITED FROM: Osteopenia
Phenotypic Abnormality (PA)	Abnormal bone ossification	0.003523	1.804	--	INHERITED FROM: Osteopenia
Phenotypic Abnormality (PA)	Abnormality of the curvature of the vertebral column	0.01762	1.293	--	INHERITED FROM: Kyphosis
Phenotypic Abnormality (PA)	Abnormal bone structure	0.02531	1.804	--	INHERITED FROM: Osteopenia
Phenotypic Abnormality (PA)	Abnormality of the head	0	0.4771	Least Informative	DIRECT
Phenotypic Abnormality (PA)	Abnormality of the eye	0	0.6004	Least Informative	DIRECT
Phenotypic Abnormality (PA)	Abnormality of the musculature	0	0.6004	Least Informative	DIRECT
Phenotypic Abnormality (PA)	Abnormality of skeletal morphology	0	0.472	Least Informative	DIRECT
Phenotypic Abnormality (PA)	Abnormality of nervous system physiology	0	0.4022	Least Informative	DIRECT
Phenotypic Abnormality (PA)	Abnormality of the vertebral column	0.2245	1.064	Moderately Informative	INHERITED FROM: Kyphosis
Phenotypic Abnormality (PA)	Kyphosis	0.0009771	1.929	Highly Informative	DIRECT
Phenotypic Abnormality (PA)	Reduced bone mineral density	0.001504	2.106	Highly Informative	INHERITED FROM: Osteopenia

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Worm Phenotype (WP)

Highlighted in gray are those with FDR_all>0.001

	WP term	FDR (all)	IC level	SDWP level	Annotation (direct or inherited)
Worm Phenotype (WP)	lethal	0	0.01121	--	DIRECT
Worm Phenotype (WP)	development variant	0	0.001706	--	DIRECT
Worm Phenotype (WP)	organism development variant	0	0.004279	--	DIRECT
Worm Phenotype (WP)	dauer behavior variant	0.000000003214	2.407	--	DIRECT
Worm Phenotype (WP)	postembryonic behavior variant	0.000000005457	2.407	--	DIRECT
Worm Phenotype (WP)	developmental behavior variant	0.00000003533	2.407	--	DIRECT
Worm Phenotype (WP)	protein aggregation variant	0.0000007525	1.074	--	DIRECT
Worm Phenotype (WP)	protein protein interaction variant	0.0000008948	1.064	--	DIRECT
Worm Phenotype (WP)	developmental delay	0.00001109	2.407	--	DIRECT
Worm Phenotype (WP)	transgene subcellular localization variant	0.00004976	1.23	--	DIRECT
Worm Phenotype (WP)	transgene expression variant	0.002089	0.7938	--	INHERITED FROM: pattern of transgene expression variant || transgene subcellular localization variant
Worm Phenotype (WP)	gene expression variant	0.005477	0.6038	--	INHERITED FROM: transgene subcellular localization variant || pattern of transgene expression variant
Worm Phenotype (WP)	behavior variant	0.05182	0.632	--	INHERITED FROM: postembryonic behavior variant || developmental behavior variant || dauer behavior variant
Worm Phenotype (WP)	organism homeostasis metabolism variant	0.4076	0.1501	--	INHERITED FROM: transgene subcellular localization variant || protein interaction variant || pattern of transgene expression variant || protein protein interaction variant || protein aggregation variant
Worm Phenotype (WP)	organism physiology variant	0.4236	0.1405	--	INHERITED FROM: transgene subcellular localization variant || protein protein interaction variant || protein aggregation variant || pattern of transgene expression variant || protein interaction variant
Worm Phenotype (WP)	developmental timing variant	0.8617	0.5373	--	INHERITED FROM: developmental delay
Worm Phenotype (WP)	physiology variant	1	0	--	INHERITED FROM: protein protein interaction variant || postembryonic behavior variant || dauer behavior variant || lethal || protein interaction variant || transgene subcellular localization variant || developmental delay || development variant || pattern of transgene expression variant || protein aggregation variant || developmental behavior variant || organism development variant
Worm Phenotype (WP)	organism metabolism processing variant	0.01428	0.4572	Least Informative	INHERITED FROM: protein interaction variant || transgene subcellular localization variant || pattern of transgene expression variant || protein aggregation variant || protein protein interaction variant
Worm Phenotype (WP)	organism behavior variant	0.05019	0.632	Least Informative	INHERITED FROM: postembryonic behavior variant || dauer behavior variant || developmental behavior variant
Worm Phenotype (WP)	retarded heterochronic variations	0.8559	0.5373	Least Informative	INHERITED FROM: developmental delay
Worm Phenotype (WP)	protein interaction variant	0.000001019	1.035	Moderately Informative	DIRECT
Worm Phenotype (WP)	pattern of transgene expression variant	0.0002116	1.017	Moderately Informative	DIRECT

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Yeast Phenotype (YP)

Highlighted in gray are those with FDR_all>0.001

	YP term	FDR (all)	IC level	SDYP level	Annotation (direct or inherited)
Yeast Phenotype (YP)	competitive fitness	0	0.1389	--	DIRECT
Yeast Phenotype (YP)	fitness	0	0.1328	--	DIRECT

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Fly Anatomy (FA)

Highlighted in gray are those with FDR_all>0.001

	FA term	FDR (all)	IC level	SDFA level	Annotation (direct or inherited)
Fly Anatomy (FA)	organism	0	0.07918	--	DIRECT
Fly Anatomy (FA)	organ system	0	0.2279	--	DIRECT
Fly Anatomy (FA)	portion of tissue	0	0.7782	--	DIRECT
Fly Anatomy (FA)	multicellular structure	0	0.009143	--	DIRECT
Fly Anatomy (FA)	anatomical structure	1	0	--	INHERITED FROM: organism || portion of tissue || organ system || multicellular structure
Fly Anatomy (FA)	material anatomical entity	1	0	--	INHERITED FROM: organ system || multicellular structure || portion of tissue || organism

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Xenopus Anatomy (XA)

Highlighted in gray are those with FDR_all>0.001

	XA term	FDR (all)	IC level	SDXA level	Annotation (direct or inherited)
Xenopus ANatomical entity (XAN)	anatomical structure	0	0	--	DIRECT
Xenopus DEvelopment stage (XDE)	NF stage	0	0.02327	--	DIRECT

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Arabidopsis Plant Ontology (AP)

Highlighted in gray are those with FDR_all>0.001

	AP term	FDR (all)	IC level	SDAP level	Annotation (direct or inherited)
Plant ANatomical entity (PAN)	cauline leaf	0	0.7019	--	DIRECT
Plant ANatomical entity (PAN)	shoot apex	0	0.5633	--	DIRECT
Plant ANatomical entity (PAN)	stomatal complex	0	0.2774	--	DIRECT
Plant ANatomical entity (PAN)	epidermal cell	0	0.2569	--	DIRECT
Plant ANatomical entity (PAN)	shoot internode	0	0.6463	--	DIRECT
Plant ANatomical entity (PAN)	epidermis	0	0.2464	--	DIRECT
Plant ANatomical entity (PAN)	phyllome	0	0.3809	--	DIRECT
Plant ANatomical entity (PAN)	shoot epidermis	0	0.2691	--	DIRECT
Plant ANatomical entity (PAN)	leaf lamina base	0	0.7094	--	DIRECT
Plant ANatomical entity (PAN)	plant cell	0	0.1489	--	DIRECT
Plant ANatomical entity (PAN)	shoot system	0	0.05747	--	DIRECT
Plant ANatomical entity (PAN)	portion of plant tissue	0	0.1892	--	DIRECT
Plant ANatomical entity (PAN)	plant organ	0	0.2816	--	DIRECT
Plant ANatomical entity (PAN)	plant embryo	0	0.5969	--	DIRECT
Plant ANatomical entity (PAN)	vascular leaf	0	0.5246	--	DIRECT
Plant ANatomical entity (PAN)	sporophyll	0	0.4713	--	DIRECT
Plant ANatomical entity (PAN)	stamen	0	0.6028	--	DIRECT
Plant ANatomical entity (PAN)	carpel	0	0.6087	--	DIRECT
Plant ANatomical entity (PAN)	sepal	0	0.5715	--	DIRECT
Plant ANatomical entity (PAN)	petal	0	0.594	--	DIRECT
Plant ANatomical entity (PAN)	stem	0	0.577	--	DIRECT
Plant ANatomical entity (PAN)	pedicel	0	0.6366	--	DIRECT
Plant ANatomical entity (PAN)	perianth	0	0.5448	--	DIRECT
Plant ANatomical entity (PAN)	corolla	0	0.594	--	DIRECT
Plant ANatomical entity (PAN)	calyx	0	0.5715	--	DIRECT
Plant ANatomical entity (PAN)	androecium	0	0.594	--	DIRECT
Plant ANatomical entity (PAN)	gynoecium	0	0.6058	--	DIRECT
Plant ANatomical entity (PAN)	inflorescence branch	0	0.6366	--	DIRECT
Plant ANatomical entity (PAN)	petiole	0	0.7287	--	DIRECT
Plant ANatomical entity (PAN)	leaf lamina	0	0.7057	--	DIRECT
Plant ANatomical entity (PAN)	inflorescence axis	0	0.6366	--	DIRECT
Plant ANatomical entity (PAN)	leaf apex	0	0.7094	--	DIRECT
Plant ANatomical entity (PAN)	stem internode	0	0.6495	--	DIRECT
Plant ANatomical entity (PAN)	cardinal organ part	0	0.51	--	DIRECT
Plant ANatomical entity (PAN)	plant axis	0	0.3881	--	DIRECT
Plant ANatomical entity (PAN)	collective leaf structure	0	0.55	--	DIRECT
Plant ANatomical entity (PAN)	lamina	0	0.7057	--	DIRECT
Plant ANatomical entity (PAN)	stalk	0	0.7019	--	DIRECT
Plant ANatomical entity (PAN)	branch	0	0.6366	--	DIRECT
Plant ANatomical entity (PAN)	reproductive shoot system	0	0.4141	--	DIRECT
Plant ANatomical entity (PAN)	phyllome apex	0	0.7019	--	DIRECT
Plant ANatomical entity (PAN)	shoot epidermal cell	0	0.276	--	DIRECT
Plant ANatomical entity (PAN)	multi-tissue plant structure	0	0.2691	--	DIRECT
Plant ANatomical entity (PAN)	collective plant structure	0	0.01577	--	DIRECT
Plant ANatomical entity (PAN)	plant structure	1	0	--	INHERITED FROM: perianth || sporophyll || calyx || inflorescence axis || flower || lamina || collective plant structure || plant embryo || leaf || shoot internode || phyllome || cardinal organ part || multi-tissue plant structure || microsporophyll || guard cell || megasporophyll || cauline leaf || reproductive shoot system || shoot apex || leaf apex || leaf lamina base || branch || collective leaf structure || stem internode || inflorescence branch || shoot system || portion of plant tissue || stomatal complex || plant organ || portion of meristem tissue || stem || whole plant || epidermis || inflorescence || cardinal part of multi-tissue plant structure || petiole || stalk || gynoecium || vascular leaf || sepal || epidermal cell || leaf lamina || shoot epidermal cell || corolla || plant axis || collective phyllome structure || petal || plant cell || carpel || seed || shoot epidermis || phyllome apex || stamen || shoot axis || pedicel || androecium
Plant ANatomical entity (PAN)	collective plant organ structure	1	0.04502	--	INHERITED FROM: inflorescence axis || calyx || flower || sporophyll || inflorescence || perianth || stem || leaf || phyllome || shoot internode || sepal || vascular leaf || gynoecium || petiole || petal || reproductive shoot system || shoot apex || leaf apex || carpel || collective phyllome structure || guard cell || megasporophyll || cauline leaf || microsporophyll || leaf lamina || shoot epidermal cell || corolla || pedicel || androecium || stomatal complex || phyllome apex || stamen || stem internode || inflorescence branch || shoot axis || shoot system || leaf lamina base || collective leaf structure || branch || shoot epidermis
Plant ANatomical entity (PAN)	phyllome lamina	1	0.7057	--	INHERITED FROM: leaf lamina base || leaf lamina
Plant ANatomical entity (PAN)	organ lamina	1	0.7057	--	INHERITED FROM: leaf lamina base || leaf lamina
Plant ANatomical entity (PAN)	whole plant	0	0.4218	Least Informative	DIRECT
Plant ANatomical entity (PAN)	guard cell	0	0.2774	Least Informative	DIRECT
Plant ANatomical entity (PAN)	seed	0	0.6087	Least Informative	DIRECT
Plant ANatomical entity (PAN)	megasporophyll	0	0.6087	Least Informative	DIRECT
Plant ANatomical entity (PAN)	microsporophyll	0	0.5029	Least Informative	DIRECT
Plant ANatomical entity (PAN)	flower	0	0.4337	Least Informative	DIRECT
Plant ANatomical entity (PAN)	inflorescence	0	0.5969	Least Informative	DIRECT
Plant ANatomical entity (PAN)	collective phyllome structure	0	0.4648	Least Informative	DIRECT
Plant ANatomical entity (PAN)	shoot axis	0	0.4735	Least Informative	DIRECT
Plant ANatomical entity (PAN)	leaf	0	0.5053	Least Informative	DIRECT
Plant ANatomical entity (PAN)	cardinal part of multi-tissue plant structure	0	0.5029	Least Informative	DIRECT
Plant ANatomical entity (PAN)	portion of meristem tissue	0.0005162	0.6838	Least Informative	DIRECT
Plant structure DEvelopment stage (PDE)	whole plant development stage	0	0.1968	--	DIRECT
Plant structure DEvelopment stage (PDE)	1 main shoot growth stage	0	0.3937	--	DIRECT
Plant structure DEvelopment stage (PDE)	leaf production stage	0	0.3937	--	DIRECT
Plant structure DEvelopment stage (PDE)	sporophyte vegetative stage	0	0.2036	--	DIRECT
Plant structure DEvelopment stage (PDE)	floral organ differentiation stage	0	0.0937	--	DIRECT
Plant structure DEvelopment stage (PDE)	corolla development stage	0	0.1981	--	DIRECT
Plant structure DEvelopment stage (PDE)	flowering stage	0	0.2162	--	DIRECT
Plant structure DEvelopment stage (PDE)	plant embryo stage	0	0.2833	--	DIRECT
Plant structure DEvelopment stage (PDE)	collective plant organ structure development stage	0	0.03771	--	DIRECT
Plant structure DEvelopment stage (PDE)	plant organ development stage	0	0.08108	--	DIRECT
Plant structure DEvelopment stage (PDE)	reproductive shoot system development stage	0	0.05008	--	DIRECT
Plant structure DEvelopment stage (PDE)	collective phyllome structure development stage	0	0.0937	--	DIRECT
Plant structure DEvelopment stage (PDE)	phyllome development stage	0	0.4754	--	DIRECT
Plant structure DEvelopment stage (PDE)	floral organ formation stage	0	0.0937	--	DIRECT
Plant structure DEvelopment stage (PDE)	leaf development stage	1	0.4754	--	INHERITED FROM: 4 leaf senescence stage
Plant structure DEvelopment stage (PDE)	flower development stage	1	0.07083	--	INHERITED FROM: corolla development stage || flowering stage || floral organ differentiation stage || floral organ formation stage
Plant structure DEvelopment stage (PDE)	life of whole plant stage	1	0.2022	--	INHERITED FROM: sporophyte vegetative stage || C globular stage || LP.10 ten leaves visible stage || E expanded cotyledon stage || F mature embryo stage || LP.04 four leaves visible stage || D bilateral stage || LP.06 six leaves visible stage || LP.02 two leaves visible stage || plant embryo stage || leaf production stage || 1 main shoot growth stage
Plant structure DEvelopment stage (PDE)	shoot system development stage	1	0.04053	--	INHERITED FROM: phyllome development stage || reproductive shoot system development stage || floral organ formation stage || floral organ differentiation stage || flowering stage || corolla development stage || plant organ development stage || 4 leaf senescence stage
Plant structure DEvelopment stage (PDE)	sporophyte development stage	1	0.2022	--	INHERITED FROM: E expanded cotyledon stage || LP.10 ten leaves visible stage || LP.06 six leaves visible stage || sporophyte vegetative stage || C globular stage || leaf production stage || 1 main shoot growth stage || D bilateral stage || F mature embryo stage || LP.04 four leaves visible stage || plant embryo stage || LP.02 two leaves visible stage
Plant structure DEvelopment stage (PDE)	4 leaf senescence stage	0	0.478	Least Informative	DIRECT
Plant structure DEvelopment stage (PDE)	E expanded cotyledon stage	0	0.353	Least Informative	DIRECT
Plant structure DEvelopment stage (PDE)	F mature embryo stage	0	0.4088	Least Informative	DIRECT
Plant structure DEvelopment stage (PDE)	C globular stage	0	0.3937	Least Informative	DIRECT
Plant structure DEvelopment stage (PDE)	D bilateral stage	0	0.3729	Least Informative	DIRECT
Plant structure DEvelopment stage (PDE)	LP.02 two leaves visible stage	0	0.5603	Least Informative	DIRECT
Plant structure DEvelopment stage (PDE)	LP.10 ten leaves visible stage	0	0.513	Least Informative	DIRECT
Plant structure DEvelopment stage (PDE)	LP.04 four leaves visible stage	0	0.4338	Least Informative	DIRECT
Plant structure DEvelopment stage (PDE)	LP.06 six leaves visible stage	0	0.5243	Least Informative	DIRECT

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Enzyme Commission (EC)

Highlighted in gray are those with FDR_all>0.001

	EC term	FDR (all)	IC level	SDEC level	Annotation (direct or inherited)
Enzyme Commission (EC)	Cis-trans-isomerases	0	1.806	--	DIRECT
Enzyme Commission (EC)	Cis-trans isomerases	1	1.806	--	INHERITED FROM: Peptidylprolyl isomerase
Enzyme Commission (EC)	Isomerases	0	0.8446	Moderately Informative	DIRECT
Enzyme Commission (EC)	Peptidylprolyl isomerase	0	1.91	Highly Informative	DIRECT

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