4Fe-4S ferredoxins superfamily

SCOP classification

• Root: SCOP hierarchy in SUPERFAMILY [ 0] (11)
• Class: Alpha and beta proteins (a+b) [ 53931] (376)
• Fold: Ferredoxin-like [ 54861] (59)
• Superfamily: 4Fe-4S ferredoxins [ 54862] (6)
• Families:
  • Short-chain ferredoxins [ 54863]
  • 7-Fe ferredoxin [ 54870] (2)
  • Archaeal ferredoxins [ 54874]
  • Single 4Fe-4S cluster ferredoxin [ 54877] (4)
  • Ferredoxin domains from multidomain proteins [ 54884] (13)
  • ETF-QO domain-like [ 143256]

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Superfamily statistics

	Genomes (2,975)	Uniprot 2018_03 genome	PDB chains (SCOP 1.75)
Domains	36,217	281,174	61
Proteins	35,474	275,863	61

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Functional annotation

• General category: Metabolism
• Detailed category: Redox

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Enzyme Commission (EC)

Highlighted in gray are those with FDR_all>0.001

	EC term	FDR (all)	IC level	SDEO level	Annotation (direct or inherited)
Enzyme Commission (EC)	CoB--CoM heterodisulfide reductase	0	2.083	--	DIRECT
Enzyme Commission (EC)	With other acceptors	0.000003586	2.083	--	DIRECT
Enzyme Commission (EC)	With NAD(+) or NADP(+) as acceptor	0.0002449	1.198	--	DIRECT
Enzyme Commission (EC)	Acting on other nitrogenous compounds as donors	1	1.329	--	INHERITED FROM: Nitrate reductase || With other acceptors
Enzyme Commission (EC)	With a quinone or similar compound as acceptor	0.3894	1.384	--	INHERITED FROM: NADH:ubiquinone reductase (H(+)-translocating)
Enzyme Commission (EC)	Oxidoreductases	0	0.2975	Least Informative	DIRECT
Enzyme Commission (EC)	Acting on NADH or NADPH	0	1.145	Moderately Informative	DIRECT
Enzyme Commission (EC)	Acting on a sulfur group of donors	1	1.198	Moderately Informative	INHERITED FROM: With other, known, acceptors || CoB--CoM heterodisulfide reductase || With other acceptors
Enzyme Commission (EC)	Acting on the CH-NH group of donors	1	1.198	Moderately Informative	INHERITED FROM: With a quinone or similar compound as acceptor
Enzyme Commission (EC)	Acting on the CH-CH group of donors	1	1.055	Moderately Informative	INHERITED FROM: With NAD(+) or NADP(+) as acceptor || Dihydropyrimidine dehydrogenase (NADP(+))
Enzyme Commission (EC)	Acting on the aldehyde or oxo group of donors	1	1.145	Moderately Informative	INHERITED FROM: Formate dehydrogenase || With an iron-sulfur protein as acceptor
Enzyme Commission (EC)	NADH:ubiquinone reductase (H(+)-translocating)	0	1.56	Informative	DIRECT
Enzyme Commission (EC)	With other acceptors	0	1.384	Informative	DIRECT
Enzyme Commission (EC)	With NAD(+) or NADP(+) as acceptor	1	1.446	Informative	INHERITED FROM: Formate dehydrogenase
Enzyme Commission (EC)	Dihydropyrimidine dehydrogenase (NADP(+))	0	1.958	Highly Informative	DIRECT
Enzyme Commission (EC)	With a quinone or similar compound as acceptor	0	2.083	Highly Informative	DIRECT
Enzyme Commission (EC)	Other oxidoreductases	0	1.958	Highly Informative	DIRECT
Enzyme Commission (EC)	Formate dehydrogenase	0.000000000000001404	1.861	Highly Informative	DIRECT
Enzyme Commission (EC)	With an iron-sulfur protein as acceptor	0.0000000000000543	1.782	Highly Informative	DIRECT
Enzyme Commission (EC)	With other acceptors	0.000000000007567	2.083	Highly Informative	DIRECT
Enzyme Commission (EC)	With other, known, acceptors	0.000000000009104	1.958	Highly Informative	DIRECT
Enzyme Commission (EC)	Nitrate reductase	0.000002992	2.083	Highly Informative	DIRECT

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Disease Ontology (DO)

Highlighted in gray are those with FDR_all>0.001

	DO term	FDR (all)	IC level	SDDO level	Annotation (direct or inherited)
Disease Ontology (DO)	disease of anatomical entity	0	0.2157	--	DIRECT

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Human Phenotype (HP)

Highlighted in gray are those with FDR_all>0.001

	HP term	FDR (all)	IC level	SDHP level	Annotation (direct or inherited)
Mode of Inheritance (MI)	Autosomal recessive inheritance	0	0.1924	--	DIRECT
Phenotypic Abnormality (PA)	Abnormality of head or neck	0	0.472	--	DIRECT
Phenotypic Abnormality (PA)	Abnormality of skull size	0	1.26	--	DIRECT
Phenotypic Abnormality (PA)	Abnormality of the nervous system	0	0.2543	--	DIRECT
Phenotypic Abnormality (PA)	Abnormality of the skeletal system	0	0.4621	--	DIRECT
Phenotypic Abnormality (PA)	Muscular hypotonia	0	1.23	--	DIRECT
Phenotypic Abnormality (PA)	Morphological abnormality of the central nervous system	0	0.6284	--	DIRECT
Phenotypic Abnormality (PA)	Abnormality of the cerebrum	0	1.009	--	DIRECT
Phenotypic Abnormality (PA)	Abnormal axial skeleton morphology	0	0.7344	--	DIRECT
Phenotypic Abnormality (PA)	Abnormal muscle physiology	0	0.7631	--	DIRECT
Phenotypic Abnormality (PA)	Abnormal eye morphology	0	0.8155	--	DIRECT
Phenotypic Abnormality (PA)	Abnormality of brain morphology	0	0.7731	--	DIRECT
Phenotypic Abnormality (PA)	Abnormal ear morphology	0	1.23	--	DIRECT
Phenotypic Abnormality (PA)	Proximal tubulopathy	0.00000005929	2.407	--	DIRECT
Phenotypic Abnormality (PA)	Renal tubular dysfunction	0.000002687	2.407	--	DIRECT
Phenotypic Abnormality (PA)	Abnormality of mitochondrial metabolism	0.00001544	1.708	--	DIRECT
Phenotypic Abnormality (PA)	Abnormal social behavior	0.00002565	2.407	--	DIRECT
Phenotypic Abnormality (PA)	Abnormality of the mitochondrion	0.00003158	1.708	--	DIRECT
Phenotypic Abnormality (PA)	Abnormal blood glucose concentration	0.0001921	1.561	--	DIRECT
Phenotypic Abnormality (PA)	Abnormal cellular phenotype	0.001986	1.407	--	INHERITED FROM: Abnormality of the mitochondrion || Abnormality of mitochondrial metabolism
Phenotypic Abnormality (PA)	Abnormal glucose homeostasis	0.003552	1.365	--	INHERITED FROM: Hypoglycemia || Abnormal blood glucose concentration
Phenotypic Abnormality (PA)	Abnormality of the kidney	0.02606	1.176	--	INHERITED FROM: Renal tubular dysfunction || Proximal tubulopathy
Phenotypic Abnormality (PA)	Abdominal symptom	0.05373	1.176	--	INHERITED FROM: Vomiting
Phenotypic Abnormality (PA)	Abnormality of the urinary system	0.07828	0.8268	--	INHERITED FROM: Proximal tubulopathy || Renal tubular dysfunction
Phenotypic Abnormality (PA)	Abnormal homeostasis	0.2953	0.7631	--	INHERITED FROM: Abnormal blood glucose concentration || Acidosis || Abnormality of acid-base homeostasis || Hypoglycemia
Phenotypic Abnormality (PA)	Abnormality of the head	0	0.4771	Least Informative	DIRECT
Phenotypic Abnormality (PA)	Abnormality of the eye	0	0.6004	Least Informative	DIRECT
Phenotypic Abnormality (PA)	Abnormality of metabolism/homeostasis	0	0.5315	Least Informative	DIRECT
Phenotypic Abnormality (PA)	Abnormality of the musculature	0	0.6004	Least Informative	DIRECT
Phenotypic Abnormality (PA)	Abnormality of skeletal morphology	0	0.472	Least Informative	DIRECT
Phenotypic Abnormality (PA)	Abnormality of nervous system physiology	0	0.4022	Least Informative	DIRECT
Phenotypic Abnormality (PA)	Abnormality of nervous system morphology	0	0.5677	Least Informative	DIRECT
Phenotypic Abnormality (PA)	Abnormality of the genitourinary system	0.1634	0.5432	Least Informative	INHERITED FROM: Proximal tubulopathy || Renal tubular dysfunction
Phenotypic Abnormality (PA)	Abnormality of the digestive system	0.2093	0.5805	Least Informative	INHERITED FROM: Vomiting
Phenotypic Abnormality (PA)	Abnormality of the ear	0	1.176	Moderately Informative	DIRECT
Phenotypic Abnormality (PA)	Abnormal skull morphology	0	1.009	Moderately Informative	DIRECT
Phenotypic Abnormality (PA)	Abnormal muscle tone	0	1.045	Moderately Informative	DIRECT
Phenotypic Abnormality (PA)	Abnormality of higher mental function	0	0.8268	Moderately Informative	DIRECT
Phenotypic Abnormality (PA)	Abnormality of forebrain morphology	0	0.9916	Moderately Informative	DIRECT
Phenotypic Abnormality (PA)	Abnormality of acid-base homeostasis	0.000729	1.128	Moderately Informative	DIRECT
Phenotypic Abnormality (PA)	Abnormality of the urinary system physiology	0.01607	1.045	Moderately Informative	INHERITED FROM: Proximal tubulopathy || Renal tubular dysfunction
Phenotypic Abnormality (PA)	Abnormality of the upper urinary tract	0.02802	1.084	Moderately Informative	INHERITED FROM: Renal tubular dysfunction || Proximal tubulopathy
Phenotypic Abnormality (PA)	Abnormality of digestive system physiology	0.09252	0.9441	Moderately Informative	INHERITED FROM: Vomiting
Phenotypic Abnormality (PA)	Behavioral abnormality	0.15	1.176	Moderately Informative	INHERITED FROM: Abnormal social behavior
Phenotypic Abnormality (PA)	Reduced consciousness/confusion	0	1.365	Informative	DIRECT
Phenotypic Abnormality (PA)	Hypoglycemia	0.0001321	1.561	Informative	DIRECT
Phenotypic Abnormality (PA)	Acidosis	0.0005333	1.293	Informative	DIRECT
Phenotypic Abnormality (PA)	Nausea and vomiting	0.001286	1.708	Informative	INHERITED FROM: Vomiting
Phenotypic Abnormality (PA)	Abnormal renal physiology	0.004135	1.452	Informative	INHERITED FROM: Proximal tubulopathy || Renal tubular dysfunction
Phenotypic Abnormality (PA)	Abnormal cellular physiology	0.01695	1.407	Informative	INHERITED FROM: Abnormality of the mitochondrion || Abnormality of mitochondrial metabolism
Phenotypic Abnormality (PA)	Vomiting	0.0001321	1.804	Highly Informative	DIRECT

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Worm Phenotype (WP)

Highlighted in gray are those with FDR_all>0.001

	WP term	FDR (all)	IC level	SDWP level	Annotation (direct or inherited)
Worm Phenotype (WP)	embryonic lethal	0	0.07108	--	DIRECT
Worm Phenotype (WP)	lethal	0	0.01121	--	DIRECT
Worm Phenotype (WP)	fertility variant	0	0.08329	--	DIRECT
Worm Phenotype (WP)	development variant	0	0.001706	--	DIRECT
Worm Phenotype (WP)	morphology variant	0	0.06117	--	DIRECT
Worm Phenotype (WP)	organism development variant	0	0.004279	--	DIRECT
Worm Phenotype (WP)	organ system physiology variant	0	0.05921	--	DIRECT
Worm Phenotype (WP)	reproductive system physiology variant	0	0.07209	--	DIRECT
Worm Phenotype (WP)	embryonic development variant	0	0.06709	--	DIRECT
Worm Phenotype (WP)	hermaphrodite fertility variant	0	0.1278	--	DIRECT
Worm Phenotype (WP)	fertility reduced	0	0.09267	--	DIRECT
Worm Phenotype (WP)	transgene expression variant	0.003872	0.7938	--	INHERITED FROM: transgene expression increased
Worm Phenotype (WP)	gene expression variant	0.007446	0.6038	--	INHERITED FROM: transgene expression increased
Worm Phenotype (WP)	organism homeostasis metabolism variant	0.6771	0.1501	--	INHERITED FROM: transgene expression increased
Worm Phenotype (WP)	organism physiology variant	0.6899	0.1405	--	INHERITED FROM: transgene expression increased || life span variant
Worm Phenotype (WP)	physiology variant	1	0	--	INHERITED FROM: hermaphrodite fertility variant || reproductive system physiology variant || lethal || life span variant || development variant || embryonic development variant || embryonic lethal || fertility variant || organ system physiology variant || organism development variant || fertility reduced || transgene expression increased
Worm Phenotype (WP)	organism metabolism processing variant	0.01451	0.4572	Least Informative	INHERITED FROM: transgene expression increased
Worm Phenotype (WP)	level of transgene expression variant	0.1542	1.151	Moderately Informative	INHERITED FROM: transgene expression increased
Worm Phenotype (WP)	life span variant	0.0002767	1.276	Informative	DIRECT
Worm Phenotype (WP)	transgene expression increased	0.0007558	1.531	Informative	DIRECT

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Fly Phenotype (FP)

Highlighted in gray are those with FDR_all>0.001

	FP term	FDR (all)	IC level	SDFP level	Annotation (direct or inherited)
Fly Phenotype (FP)	phenotype	0	0.05522	--	DIRECT

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Fly Anatomy (FA)

Highlighted in gray are those with FDR_all>0.001

	FA term	FDR (all)	IC level	SDFA level	Annotation (direct or inherited)
Fly Anatomy (FA)	organism	0	0.07918	--	DIRECT
Fly Anatomy (FA)	tagma	0	0.6478	--	DIRECT
Fly Anatomy (FA)	organ system	0	0.2279	--	DIRECT
Fly Anatomy (FA)	portion of tissue	0	0.7782	--	DIRECT
Fly Anatomy (FA)	multicellular structure	0	0.009143	--	DIRECT
Fly Anatomy (FA)	anatomical structure	1	0	--	INHERITED FROM: organism || larva || portion of tissue || multi-tissue structure || tagma || organ system || organism subdivision || multicellular structure
Fly Anatomy (FA)	material anatomical entity	1	0	--	INHERITED FROM: organ system || organism subdivision || multicellular structure || tagma || multi-tissue structure || portion of tissue || larva || organism
Fly Anatomy (FA)	anterior-posterior subdivision of organism	1	0.632	--	INHERITED FROM: tagma
Fly Anatomy (FA)	larva	0	0.4611	Least Informative	DIRECT
Fly Anatomy (FA)	organism subdivision	0	0.6243	Least Informative	DIRECT
Fly Anatomy (FA)	multi-tissue structure	0	0.7081	Least Informative	DIRECT

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Xenopus Anatomy (XA)

Highlighted in gray are those with FDR_all>0.001

	XA term	FDR (all)	IC level	SDXA level	Annotation (direct or inherited)
Xenopus ANatomical entity (XAN)	head region	0	0.5108	--	DIRECT
Xenopus ANatomical entity (XAN)	trunk region	0	0.4287	--	DIRECT
Xenopus ANatomical entity (XAN)	genital system	0	0.5909	--	DIRECT
Xenopus ANatomical entity (XAN)	male genitalia	0	0.8318	--	DIRECT
Xenopus ANatomical entity (XAN)	central nervous system	0	0.6506	--	DIRECT
Xenopus ANatomical entity (XAN)	anatomical structure	0	0	--	DIRECT
Xenopus ANatomical entity (XAN)	anatomical group	0	0.1442	--	DIRECT
Xenopus ANatomical entity (XAN)	male organism	0	0.8318	--	DIRECT
Xenopus ANatomical entity (XAN)	organism subdivision	0	0.1871	--	DIRECT
Xenopus ANatomical entity (XAN)	compound organ	0	0.24	--	DIRECT
Xenopus ANatomical entity (XAN)	gonad	0	0.8318	--	DIRECT
Xenopus ANatomical entity (XAN)	anatomical cluster	0	0.7974	--	DIRECT
Xenopus ANatomical entity (XAN)	anatomical region	0	0.193	--	DIRECT
Xenopus ANatomical entity (XAN)	multicellular anatomical structure	0	0.1217	--	DIRECT
Xenopus ANatomical entity (XAN)	anatomical system	1	0.3094	--	INHERITED FROM: testis || alimentary system || urogenital system || intestine || nervous system || brain || genital system || musculoskeletal system || male genitalia || central nervous system
Xenopus ANatomical entity (XAN)	whole organism	1	0.09747	--	INHERITED FROM: urogenital system || head region || genital system || brain || intestine || nervous system || alimentary system || anatomical group || testis || cavitated compound organ || multicellular anatomical structure || gonad || compound organ || trunk || tissue || anatomical region || central nervous system || male genitalia || trunk region || anatomical cluster || viscus || male organism || musculoskeletal system || organism subdivision || head
Xenopus ANatomical entity (XAN)	embryo	0	0.6341	Least Informative	DIRECT
Xenopus ANatomical entity (XAN)	urogenital system	0	0.5011	Least Informative	DIRECT
Xenopus ANatomical entity (XAN)	nervous system	0	0.6341	Least Informative	DIRECT
Xenopus ANatomical entity (XAN)	head	0	0.5108	Least Informative	DIRECT
Xenopus ANatomical entity (XAN)	trunk	0	0.4308	Least Informative	DIRECT
Xenopus ANatomical entity (XAN)	tissue	0	0.5011	Least Informative	DIRECT
Xenopus ANatomical entity (XAN)	cavitated compound organ	0	0.3033	Least Informative	DIRECT
Xenopus ANatomical entity (XAN)	brain	0	0.8635	Moderately Informative	DIRECT
Xenopus ANatomical entity (XAN)	alimentary system	0	0.955	Moderately Informative	DIRECT
Xenopus ANatomical entity (XAN)	testis	0	0.8318	Moderately Informative	DIRECT
Xenopus ANatomical entity (XAN)	musculoskeletal system	0	1.118	Moderately Informative	DIRECT
Xenopus ANatomical entity (XAN)	viscus	0	0.9618	Moderately Informative	DIRECT
Xenopus ANatomical entity (XAN)	intestine	0	1.363	Informative	DIRECT
Xenopus ANatomical entity (XAN)	anatomical entity in vitro	0	1.314	Informative	DIRECT
Xenopus DEvelopment stage (XDE)	tadpole stage	0	0.5946	--	DIRECT
Xenopus DEvelopment stage (XDE)	metamorphosing tadpole stage	0	0.6715	--	DIRECT
Xenopus DEvelopment stage (XDE)	NF stage	0	0.02327	--	DIRECT
Xenopus DEvelopment stage (XDE)	post-embryonic stage	0	0.5693	Least Informative	DIRECT
Xenopus DEvelopment stage (XDE)	unspecified stage	0	1.131	Moderately Informative	DIRECT
Xenopus DEvelopment stage (XDE)	climax stage	0	0.7597	Moderately Informative	DIRECT

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Arabidopsis Plant Ontology (AP)

Highlighted in gray are those with FDR_all>0.001

	AP term	FDR (all)	IC level	SDAP level	Annotation (direct or inherited)
Plant ANatomical entity (PAN)	stomatal complex	0	0.2774	--	DIRECT
Plant ANatomical entity (PAN)	epidermal cell	0	0.2569	--	DIRECT
Plant ANatomical entity (PAN)	epidermis	0	0.2464	--	DIRECT
Plant ANatomical entity (PAN)	shoot epidermis	0	0.2691	--	DIRECT
Plant ANatomical entity (PAN)	plant cell	0	0.1489	--	DIRECT
Plant ANatomical entity (PAN)	shoot system	0	0.05747	--	DIRECT
Plant ANatomical entity (PAN)	portion of plant tissue	0	0.1892	--	DIRECT
Plant ANatomical entity (PAN)	shoot epidermal cell	0	0.276	--	DIRECT
Plant ANatomical entity (PAN)	collective plant structure	0	0.01577	--	DIRECT
Plant ANatomical entity (PAN)	plant structure	1	0	--	INHERITED FROM: collective plant structure || guard cell || shoot system || portion of plant tissue || stomatal complex || epidermis || epidermal cell || shoot epidermal cell || plant cell || shoot epidermis
Plant ANatomical entity (PAN)	collective plant organ structure	1	0.04502	--	INHERITED FROM: guard cell || shoot epidermal cell || stomatal complex || shoot system || shoot epidermis
Plant ANatomical entity (PAN)	guard cell	0	0.2774	Least Informative	DIRECT
Plant structure DEvelopment stage (PDE)	floral organ differentiation stage	0	0.0937	--	DIRECT
Plant structure DEvelopment stage (PDE)	collective plant organ structure development stage	0	0.03771	--	DIRECT
Plant structure DEvelopment stage (PDE)	plant organ development stage	0	0.08108	--	DIRECT
Plant structure DEvelopment stage (PDE)	reproductive shoot system development stage	0	0.05008	--	DIRECT
Plant structure DEvelopment stage (PDE)	collective phyllome structure development stage	0	0.0937	--	DIRECT
Plant structure DEvelopment stage (PDE)	floral organ formation stage	0	0.0937	--	DIRECT
Plant structure DEvelopment stage (PDE)	flower development stage	1	0.07083	--	INHERITED FROM: floral organ differentiation stage || floral organ formation stage
Plant structure DEvelopment stage (PDE)	shoot system development stage	1	0.04053	--	INHERITED FROM: reproductive shoot system development stage || floral organ formation stage || floral organ differentiation stage || plant organ development stage

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Enzyme Commission (EC)

Highlighted in gray are those with FDR_all>0.001

	EC term	FDR (all)	IC level	SDEC level	Annotation (direct or inherited)
Enzyme Commission (EC)	Formate dehydrogenase	0	2.174	--	DIRECT
Enzyme Commission (EC)	With other acceptors	0	2.253	--	DIRECT
Enzyme Commission (EC)	Epoxyqueuosine reductase	0	2.475	--	DIRECT
Enzyme Commission (EC)	Dihydropyrimidine dehydrogenase (NADP(+))	0	2.35	--	DIRECT
Enzyme Commission (EC)	Electron-transferring-flavoprotein dehydrogenase	0	2.475	--	DIRECT
Enzyme Commission (EC)	With other acceptors	0	1.838	--	DIRECT
Enzyme Commission (EC)	Other oxidoreductases	0	2.35	--	DIRECT
Enzyme Commission (EC)	Translocases	0	1.339	--	DIRECT
Enzyme Commission (EC)	Hydron translocation or charge separation linked to oxidoreductase reactions	0	1.651	--	DIRECT
Enzyme Commission (EC)	Dissimilatory sulfite reductase	5.111e-16	2.475	--	DIRECT
Enzyme Commission (EC)	With a quinone or similar compound as acceptor	0.000000000000001017	2.35	--	DIRECT
Enzyme Commission (EC)	Glutamate synthase (NADPH)	0.0000000000002473	2.174	--	DIRECT
Enzyme Commission (EC)	With other acceptors	0.00000000008761	2.475	--	DIRECT
Enzyme Commission (EC)	Ferredoxin:CoB-CoM heterodisulfide reductase	0.0000000002474	2.475	--	DIRECT
Enzyme Commission (EC)	With other, known, acceptors	0.0000001177	2.35	--	DIRECT
Enzyme Commission (EC)	Dihydrouracil dehydrogenase (NAD(+))	0.000003808	2.475	--	DIRECT
Enzyme Commission (EC)	Indolepyruvate ferredoxin oxidoreductase	0.000274	2.952	--	DIRECT
Enzyme Commission (EC)	Acting on the CH-CH group of donors	1	1.35	--	INHERITED FROM: Dihydrouracil dehydrogenase (NAD(+)) || With NAD(+) or NADP(+) as acceptor || Dihydropyrimidine dehydrogenase (NADP(+))
Enzyme Commission (EC)	Oxidoreductases	0	0.6234	Least Informative	DIRECT
Enzyme Commission (EC)	Acting on NADH or NADPH	0.00000000000004266	1.59	Informative	DIRECT
Enzyme Commission (EC)	Catalysing the translocation of hydrons	0.0000000001246	1.505	Informative	DIRECT
Enzyme Commission (EC)	With NAD(+) or NADP(+) as acceptor	0.000008291	1.505	Informative	DIRECT
Enzyme Commission (EC)	Acting on CH or CH(2) groups	0.0003167	1.475	Informative	DIRECT
Enzyme Commission (EC)	Acting on the CH-NH group of donors	0.05825	1.505	Informative	INHERITED FROM: With a quinone or similar compound as acceptor || Electron-transferring-flavoprotein dehydrogenase
Enzyme Commission (EC)	Acting on a sulfur group of donors	0.3341	1.489	Informative	INHERITED FROM: Dissimilatory sulfite reductase || With other, known, acceptors || With an iron-sulfur protein as acceptor || Ferredoxin:CoB-CoM heterodisulfide reductase || With other acceptors
Enzyme Commission (EC)	Acting on other nitrogenous compounds as donors	0.9953	1.609	Informative	INHERITED FROM: With a quinone or similar compound as acceptor
Enzyme Commission (EC)	Acting on the aldehyde or oxo group of donors	1	1.42	Informative	INHERITED FROM: Indolepyruvate ferredoxin oxidoreductase || With an iron-sulfur protein as acceptor
Enzyme Commission (EC)	Acting on the CH-NH(2) group of donors	1	1.59	Informative	INHERITED FROM: Glutamate synthase (NADPH) || With NAD(+) or NADP(+) as acceptor
Enzyme Commission (EC)	With an iron-sulfur protein as acceptor	0	1.91	Highly Informative	DIRECT
Enzyme Commission (EC)	With a quinone or similar compound as acceptor	0	2.107	Highly Informative	DIRECT
Enzyme Commission (EC)	NADH dehydrogenase	0	1.873	Highly Informative	DIRECT
Enzyme Commission (EC)	NADH:ubiquinone reductase (H(+)-translocating)	0	1.952	Highly Informative	DIRECT
Enzyme Commission (EC)	Acting on hydrogen as donors	0.0000004484	2.049	Highly Informative	DIRECT
Enzyme Commission (EC)	With NAD(+) or NADP(+) as acceptor	0.0000005933	1.91	Highly Informative	DIRECT
Enzyme Commission (EC)	With an iron-sulfur protein as acceptor	0.0001937	2.174	Highly Informative	DIRECT
Enzyme Commission (EC)	With NAD(+) or NADP(+) as acceptor	0.9625	1.838	Highly Informative	INHERITED FROM: Formate dehydrogenase

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