Dimeric alpha+beta barrel superfamily

SCOP classification

• Root: SCOP hierarchy in SUPERFAMILY [ 0] (11)
• Class: Alpha and beta proteins (a+b) [ 53931] (376)
• Fold: Ferredoxin-like [ 54861] (59)
• Superfamily: Dimeric alpha+beta barrel [ 54909] (23)
• Families:
  • Actinorhodin biosynthesis monooxygenase ActVa-Orf6 [ 82666]
  • Plant stress-induced protein [ 89927] (3)
  • PG130-like [ 102959] (5)
  • Hypothetical protein YjcS [ 102962]
  • YciI-like [ 102965]
  • Muconalactone isomerase, MLI [ 54910]
  • Lrp/AsnC-like transcriptional regulator C-terminal domain [ 69733] (4)
  • Polyketide synthesis cyclase [ 110959]
  • DGPF domain (Pfam 04946) [ 110962]
  • Chlorite dismutase-like [ 110965] (2)
  • PA3566-like [ 110970] (5)
  • Hypothetical protein YdhR [ 117940]
  • NIPSNAP [ 117943] (2)
  • Dyp-type peroxidase-like [ 143265] (3)
  • EthD-like [ 143272]
  • Atu0297-like [ 143275]
  • SOR-like [ 143278]
  • YbaA-like [ 160289]
  • MmlI-like [ 160292]
  • Marine metagenome family DABB2 [ 160295]
  • YiiL-like [ 160298]
  • Marine metagenome family DABB1 [ 160301] (2)
  • Marine metagenome family DABB3 [ 160306]

---

Superfamily statistics

	Genomes (2,669)	Uniprot 2018_03 genome	PDB chains (SCOP 1.75)
Domains	29,069	262,135	47
Proteins	27,717	254,037	47

---

Functional annotation

• General category: Metabolism
• Detailed category: Secondary metabolism

---

Enzyme Commission (EC)

Highlighted in gray are those with FDR_all>0.001

	EC term	FDR (all)	IC level	SDEO level	Annotation (direct or inherited)
Enzyme Commission (EC)	L-rhamnose mutarotase	0	2.56	--	DIRECT
Enzyme Commission (EC)	Heme oxygenase	0	2.259	--	DIRECT
Enzyme Commission (EC)	Muconolactone Delta-isomerase	0	2.56	--	DIRECT
Enzyme Commission (EC)	Isomerases	0	0.5914	Least Informative	DIRECT
Enzyme Commission (EC)	Oxidoreductases	0.2323	0.2975	Least Informative	INHERITED FROM: Acting on paired donors, with incorporation or red || Miscellaneous (requires further characterization) || Heme oxygenase
Enzyme Commission (EC)	Racemases and epimerases	0	1.238	Moderately Informative	DIRECT
Enzyme Commission (EC)	Acting on paired donors, with incorporation or red	0.000000000000005545	1.016	Moderately Informative	DIRECT
Enzyme Commission (EC)	Intramolecular oxidoreductases	1	1.069	Moderately Informative	INHERITED FROM: Muconolactone Delta-isomerase || Transposing C==C bonds
Enzyme Commission (EC)	Acting on carbohydrates and derivatives	0	1.519	Informative	DIRECT
Enzyme Commission (EC)	Miscellaneous (requires further characterization)	0	1.715	Informative	DIRECT
Enzyme Commission (EC)	Transposing C==C bonds	0.0000000001622	1.657	Informative	DIRECT

---

Xenopus Anatomy (XA)

Highlighted in gray are those with FDR_all>0.001

	XA term	FDR (all)	IC level	SDXA level	Annotation (direct or inherited)
Xenopus ANatomical entity (XAN)	head region	0	0.5108	--	DIRECT
Xenopus ANatomical entity (XAN)	central nervous system	0	0.6506	--	DIRECT
Xenopus ANatomical entity (XAN)	anatomical structure	0	0	--	DIRECT
Xenopus ANatomical entity (XAN)	anatomical group	0	0.1442	--	DIRECT
Xenopus ANatomical entity (XAN)	organism subdivision	0	0.1871	--	DIRECT
Xenopus ANatomical entity (XAN)	compound organ	0	0.24	--	DIRECT
Xenopus ANatomical entity (XAN)	anatomical region	0	0.193	--	DIRECT
Xenopus ANatomical entity (XAN)	multicellular anatomical structure	0	0.1217	--	DIRECT
Xenopus ANatomical entity (XAN)	anatomical system	1	0.3094	--	INHERITED FROM: nervous system || brain || central nervous system
Xenopus ANatomical entity (XAN)	whole organism	1	0.09747	--	INHERITED FROM: head region || brain || nervous system || anatomical group || cavitated compound organ || multicellular anatomical structure || compound organ || anatomical region || central nervous system || organism subdivision || head
Xenopus ANatomical entity (XAN)	nervous system	0	0.6341	Least Informative	DIRECT
Xenopus ANatomical entity (XAN)	head	0	0.5108	Least Informative	DIRECT
Xenopus ANatomical entity (XAN)	cavitated compound organ	0	0.3033	Least Informative	DIRECT
Xenopus ANatomical entity (XAN)	brain	0	0.8635	Moderately Informative	DIRECT
Xenopus DEvelopment stage (XDE)	tadpole stage	0	0.5946	--	DIRECT
Xenopus DEvelopment stage (XDE)	metamorphosing tadpole stage	0	0.6715	--	DIRECT
Xenopus DEvelopment stage (XDE)	NF stage	0	0.02327	--	DIRECT
Xenopus DEvelopment stage (XDE)	post-embryonic stage	0	0.5693	Least Informative	DIRECT
Xenopus DEvelopment stage (XDE)	climax stage	0	0.7597	Moderately Informative	DIRECT

---

Arabidopsis Plant Ontology (AP)

Highlighted in gray are those with FDR_all>0.001

	AP term	FDR (all)	IC level	SDAP level	Annotation (direct or inherited)
Plant ANatomical entity (PAN)	stamen	0	0.6028	--	DIRECT
Plant ANatomical entity (PAN)	phyllome apex	0	0.7019	--	DIRECT
Plant ANatomical entity (PAN)	stem internode	0	0.6495	--	DIRECT
Plant ANatomical entity (PAN)	inflorescence branch	0	0.6366	--	DIRECT
Plant ANatomical entity (PAN)	epidermal cell	0	0.2569	--	DIRECT
Plant ANatomical entity (PAN)	gynoecium	0	0.6058	--	DIRECT
Plant ANatomical entity (PAN)	leaf lamina	0	0.7057	--	DIRECT
Plant ANatomical entity (PAN)	pollen sac	0	0.7531	--	DIRECT
Plant ANatomical entity (PAN)	plant embryo	0	0.5969	--	DIRECT
Plant ANatomical entity (PAN)	stalk	0	0.7019	--	DIRECT
Plant ANatomical entity (PAN)	petiole	0	0.7287	--	DIRECT
Plant ANatomical entity (PAN)	cauline leaf	0	0.7019	--	DIRECT
Plant ANatomical entity (PAN)	lamina	0	0.7057	--	DIRECT
Plant ANatomical entity (PAN)	microsporangium	0	0.7448	--	DIRECT
Plant ANatomical entity (PAN)	sporophyll	0	0.4713	--	DIRECT
Plant ANatomical entity (PAN)	shoot epidermal cell	0	0.276	--	DIRECT
Plant ANatomical entity (PAN)	microgametophyte	0	0.7531	--	DIRECT
Plant ANatomical entity (PAN)	shoot system	0	0.05747	--	DIRECT
Plant ANatomical entity (PAN)	cardinal organ part	0	0.51	--	DIRECT
Plant ANatomical entity (PAN)	perianth	0	0.5448	--	DIRECT
Plant ANatomical entity (PAN)	stem	0	0.577	--	DIRECT
Plant ANatomical entity (PAN)	shoot epidermis	0	0.2691	--	DIRECT
Plant ANatomical entity (PAN)	corolla	0	0.594	--	DIRECT
Plant ANatomical entity (PAN)	phyllome	0	0.3809	--	DIRECT
Plant ANatomical entity (PAN)	shoot internode	0	0.6463	--	DIRECT
Plant ANatomical entity (PAN)	collective plant structure	0	0.01577	--	DIRECT
Plant ANatomical entity (PAN)	inflorescence axis	0	0.6366	--	DIRECT
Plant ANatomical entity (PAN)	portion of plant tissue	0	0.1892	--	DIRECT
Plant ANatomical entity (PAN)	pedicel	0	0.6366	--	DIRECT
Plant ANatomical entity (PAN)	calyx	0	0.5715	--	DIRECT
Plant ANatomical entity (PAN)	petal	0	0.594	--	DIRECT
Plant ANatomical entity (PAN)	leaf lamina base	0	0.7094	--	DIRECT
Plant ANatomical entity (PAN)	reproductive shoot system	0	0.4141	--	DIRECT
Plant ANatomical entity (PAN)	androecium	0	0.594	--	DIRECT
Plant ANatomical entity (PAN)	epidermis	0	0.2464	--	DIRECT
Plant ANatomical entity (PAN)	plant cell	0	0.1489	--	DIRECT
Plant ANatomical entity (PAN)	collective leaf structure	0	0.55	--	DIRECT
Plant ANatomical entity (PAN)	shoot apex	0	0.5633	--	DIRECT
Plant ANatomical entity (PAN)	stomatal complex	0	0.2774	--	DIRECT
Plant ANatomical entity (PAN)	sepal	0	0.5715	--	DIRECT
Plant ANatomical entity (PAN)	branch	0	0.6366	--	DIRECT
Plant ANatomical entity (PAN)	vascular leaf	0	0.5246	--	DIRECT
Plant ANatomical entity (PAN)	plant organ	0	0.2816	--	DIRECT
Plant ANatomical entity (PAN)	root	0	0.5579	--	DIRECT
Plant ANatomical entity (PAN)	multi-tissue plant structure	0	0.2691	--	DIRECT
Plant ANatomical entity (PAN)	leaf apex	0	0.7094	--	DIRECT
Plant ANatomical entity (PAN)	plant axis	0	0.3881	--	DIRECT
Plant ANatomical entity (PAN)	carpel	0	0.6087	--	DIRECT
Plant ANatomical entity (PAN)	organ lamina	1	0.7057	--	INHERITED FROM: leaf lamina base || leaf lamina
Plant ANatomical entity (PAN)	collective plant organ structure	1	0.04502	--	INHERITED FROM: inflorescence axis || calyx || flower || sporophyll || inflorescence meristem || root system || inflorescence || root || perianth || stem || leaf || phyllome || shoot internode || sepal || vascular leaf || gynoecium || petiole || petal || reproductive shoot system || shoot apex || leaf apex || carpel || collective phyllome structure || guard cell || megasporophyll || cauline leaf || pollen || microsporophyll || pollen sac || leaf lamina || shoot epidermal cell || corolla || pedicel || androecium || stomatal complex || phyllome apex || cotyledon || stamen || stem internode || inflorescence branch || shoot axis || shoot system || leaf lamina base || collective leaf structure || branch || shoot epidermis
Plant ANatomical entity (PAN)	phyllome lamina	1	0.7057	--	INHERITED FROM: leaf lamina base || leaf lamina
Plant ANatomical entity (PAN)	plant structure	1	0	--	INHERITED FROM: perianth || root || sporophyll || calyx || inflorescence axis || flower || lamina || collective plant structure || plant embryo || leaf || shoot internode || phyllome || pollen sac || cardinal organ part || multi-tissue plant structure || microsporophyll || guard cell || megasporophyll || cauline leaf || reproductive shoot system || shoot apex || leaf apex || leaf lamina base || branch || collective leaf structure || stem internode || inflorescence branch || shoot system || sporangium || portion of plant tissue || stomatal complex || plant organ || portion of meristem tissue || stem || whole plant || inflorescence meristem || epidermis || root system || inflorescence || cardinal part of multi-tissue plant structure || petiole || stalk || gynoecium || vascular leaf || sepal || microsporangium || epidermal cell || leaf lamina || shoot epidermal cell || corolla || pollen || plant axis || collective phyllome structure || petal || plant cell || carpel || seed || shoot epidermis || phyllome apex || cotyledon || stamen || shoot axis || microgametophyte || pedicel || androecium
Plant ANatomical entity (PAN)	collective phyllome structure	0	0.4648	Least Informative	DIRECT
Plant ANatomical entity (PAN)	portion of meristem tissue	0	0.6838	Least Informative	DIRECT
Plant ANatomical entity (PAN)	seed	0	0.6087	Least Informative	DIRECT
Plant ANatomical entity (PAN)	guard cell	0	0.2774	Least Informative	DIRECT
Plant ANatomical entity (PAN)	leaf	0	0.5053	Least Informative	DIRECT
Plant ANatomical entity (PAN)	megasporophyll	0	0.6087	Least Informative	DIRECT
Plant ANatomical entity (PAN)	shoot axis	0	0.4735	Least Informative	DIRECT
Plant ANatomical entity (PAN)	whole plant	0	0.4218	Least Informative	DIRECT
Plant ANatomical entity (PAN)	sporangium	0	0.7407	Least Informative	DIRECT
Plant ANatomical entity (PAN)	cardinal part of multi-tissue plant structure	0	0.5029	Least Informative	DIRECT
Plant ANatomical entity (PAN)	root system	0	0.5346	Least Informative	DIRECT
Plant ANatomical entity (PAN)	inflorescence	0	0.5969	Least Informative	DIRECT
Plant ANatomical entity (PAN)	flower	0	0.4337	Least Informative	DIRECT
Plant ANatomical entity (PAN)	microsporophyll	0	0.5029	Least Informative	DIRECT
Plant ANatomical entity (PAN)	cotyledon	0	0.7615	Moderately Informative	DIRECT
Plant ANatomical entity (PAN)	inflorescence meristem	0	0.7789	Moderately Informative	DIRECT
Plant ANatomical entity (PAN)	pollen	0	0.7531	Moderately Informative	DIRECT
Plant structure DEvelopment stage (PDE)	whole plant development stage	0	0.1968	--	DIRECT
Plant structure DEvelopment stage (PDE)	leaf production stage	0	0.3937	--	DIRECT
Plant structure DEvelopment stage (PDE)	1 main shoot growth stage	0	0.3937	--	DIRECT
Plant structure DEvelopment stage (PDE)	plant embryo stage	0	0.2833	--	DIRECT
Plant structure DEvelopment stage (PDE)	plant organ development stage	0	0.08108	--	DIRECT
Plant structure DEvelopment stage (PDE)	flowering stage	0	0.2162	--	DIRECT
Plant structure DEvelopment stage (PDE)	corolla development stage	0	0.1981	--	DIRECT
Plant structure DEvelopment stage (PDE)	floral organ differentiation stage	0	0.0937	--	DIRECT
Plant structure DEvelopment stage (PDE)	floral organ formation stage	0	0.0937	--	DIRECT
Plant structure DEvelopment stage (PDE)	collective plant organ structure development stage	0	0.03771	--	DIRECT
Plant structure DEvelopment stage (PDE)	reproductive shoot system development stage	0	0.05008	--	DIRECT
Plant structure DEvelopment stage (PDE)	sporophyte vegetative stage	0	0.2036	--	DIRECT
Plant structure DEvelopment stage (PDE)	phyllome development stage	0	0.4754	--	DIRECT
Plant structure DEvelopment stage (PDE)	collective phyllome structure development stage	0	0.0937	--	DIRECT
Plant structure DEvelopment stage (PDE)	life of whole plant stage	1	0.2022	--	INHERITED FROM: sporophyte vegetative stage || C globular stage || LP.10 ten leaves visible stage || E expanded cotyledon stage || LP.12 twelve leaves visible stage || F mature embryo stage || LP.04 four leaves visible stage || D bilateral stage || LP.06 six leaves visible stage || LP.08 eight leaves visible stage || LP.02 two leaves visible stage || plant embryo stage || leaf production stage || 1 main shoot growth stage
Plant structure DEvelopment stage (PDE)	flower development stage	1	0.07083	--	INHERITED FROM: corolla development stage || flowering stage || floral organ differentiation stage || floral organ formation stage
Plant structure DEvelopment stage (PDE)	leaf development stage	1	0.4754	--	INHERITED FROM: 4 leaf senescence stage
Plant structure DEvelopment stage (PDE)	shoot system development stage	1	0.04053	--	INHERITED FROM: phyllome development stage || reproductive shoot system development stage || floral organ formation stage || floral organ differentiation stage || flowering stage || corolla development stage || plant organ development stage || 4 leaf senescence stage
Plant structure DEvelopment stage (PDE)	sporophyte development stage	1	0.2022	--	INHERITED FROM: LP.08 eight leaves visible stage || LP.12 twelve leaves visible stage || E expanded cotyledon stage || LP.10 ten leaves visible stage || LP.06 six leaves visible stage || sporophyte vegetative stage || C globular stage || leaf production stage || 1 main shoot growth stage || D bilateral stage || F mature embryo stage || LP.04 four leaves visible stage || plant embryo stage || LP.02 two leaves visible stage
Plant structure DEvelopment stage (PDE)	D bilateral stage	0	0.3729	Least Informative	DIRECT
Plant structure DEvelopment stage (PDE)	4 leaf senescence stage	0	0.478	Least Informative	DIRECT
Plant structure DEvelopment stage (PDE)	F mature embryo stage	0	0.4088	Least Informative	DIRECT
Plant structure DEvelopment stage (PDE)	LP.04 four leaves visible stage	0	0.4338	Least Informative	DIRECT
Plant structure DEvelopment stage (PDE)	LP.02 two leaves visible stage	0	0.5603	Least Informative	DIRECT
Plant structure DEvelopment stage (PDE)	LP.12 twelve leaves visible stage	0	0.5666	Least Informative	DIRECT
Plant structure DEvelopment stage (PDE)	LP.08 eight leaves visible stage	0	0.586	Least Informative	DIRECT
Plant structure DEvelopment stage (PDE)	LP.10 ten leaves visible stage	0	0.513	Least Informative	DIRECT
Plant structure DEvelopment stage (PDE)	E expanded cotyledon stage	0	0.353	Least Informative	DIRECT
Plant structure DEvelopment stage (PDE)	LP.06 six leaves visible stage	0	0.5243	Least Informative	DIRECT
Plant structure DEvelopment stage (PDE)	C globular stage	0	0.3937	Least Informative	DIRECT

---

Enzyme Commission (EC)

Highlighted in gray are those with FDR_all>0.001

	EC term	FDR (all)	IC level	SDEC level	Annotation (direct or inherited)
Enzyme Commission (EC)	Dye decolorizing peroxidase	0	2.952	--	DIRECT
Enzyme Commission (EC)	Heme oxygenase (biliverdin-producing)	0	2.651	--	DIRECT
Enzyme Commission (EC)	L-rhamnose mutarotase	0	2.952	--	DIRECT
Enzyme Commission (EC)	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase	0	2.952	--	DIRECT
Enzyme Commission (EC)	Muconolactone Delta-isomerase	0	2.952	--	DIRECT
Enzyme Commission (EC)	Homocitrate synthase	0.000000000000151	2.952	--	DIRECT
Enzyme Commission (EC)	Heme oxygenase (staphylobilin-producing)	0.00000000001692	2.952	--	DIRECT
Enzyme Commission (EC)	Peroxidases	0.00001074	1.721	--	DIRECT
Enzyme Commission (EC)	Peroxidase	0.00001632	2.253	--	DIRECT
Enzyme Commission (EC)	Acyltransferases	0.6172	0.8446	--	INHERITED FROM: Acyl groups converted into alkyl groups on transfer || Homocitrate synthase
Enzyme Commission (EC)	Transferases	1	0.3035	--	INHERITED FROM: Acyl groups converted into alkyl groups on transfer || Homocitrate synthase
Enzyme Commission (EC)	Oxidoreductases	0.001178	0.6234	Least Informative	INHERITED FROM: Dye decolorizing peroxidase || Acting on a peroxide as acceptor || Miscellaneous || Acting on paired donors, with incorporation or reduction of molecular oxygen. The oxygen incorporate || Peroxidases || Peroxidase || Heme oxygenase (staphylobilin-producing) || Heme oxygenase (biliverdin-producing) || Acting on single donors with incorporation of molecular oxygen (oxygenases). The oxygen incorporated
Enzyme Commission (EC)	Isomerases	0	0.8446	Moderately Informative	DIRECT
Enzyme Commission (EC)	Racemases and epimerases	0	1.447	Informative	DIRECT
Enzyme Commission (EC)	Acting on paired donors, with incorporation or reduction of molecular oxygen. The oxygen incorporate	0.0000000000003717	1.308	Informative	DIRECT
Enzyme Commission (EC)	Acting on single donors with incorporation of molecular oxygen (oxygenases). The oxygen incorporated	0.0001232	1.673	Informative	DIRECT
Enzyme Commission (EC)	Acting on a peroxide as acceptor	0.0002373	1.697	Informative	DIRECT
Enzyme Commission (EC)	Intramolecular oxidoreductases	1	1.35	Informative	INHERITED FROM: (4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase || Muconolactone Delta-isomerase
Enzyme Commission (EC)	Acting on carbohydrates and derivatives	0	1.776	Highly Informative	DIRECT
Enzyme Commission (EC)	Acyl groups converted into alkyl groups on transfer	0.000008744	1.838	Highly Informative	DIRECT
Enzyme Commission (EC)	Miscellaneous	0.0004474	2.049	Highly Informative	DIRECT
Enzyme Commission (EC)	Transposing C=C bonds	0.001141	1.776	Highly Informative	INHERITED FROM: Muconolactone Delta-isomerase
Enzyme Commission (EC)	With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen	0.01478	1.91	Highly Informative	INHERITED FROM: Heme oxygenase (biliverdin-producing)
Enzyme Commission (EC)	Interconverting aldoses and ketoses	1	1.776	Highly Informative	INHERITED FROM: (4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase

---

InterPro annotation

• Cross references: IPR011008 SSF54909 Protein matches
• Abstract:

  Dimeric alpha-beta barrel domains exhibit an alpha+beta sandwich fold with an antiparallel beta sheet that forms a closed barrel. These domains dimerise through the beta-sheet, and in some cases these dimers may assemble into higher oligomers. Domains with this structure are found in proteins from several different families, including bacterial actinorhodin biosynthesis monooxygenase (ActVa-Orf6), which catalyses the oxidation of an aromatic intermediate of the actinorhodin biosynthetic pathway [12514126]; bacterial muconalactone isomerase, a decamer composed of five dimers [2926818]; and the C-terminal domain of archaeal LprA, a member of the Lrp/AqsnC family of transcription regulators [11230123].

InterPro database

---