Canonical RBD family

SCOP classification

• Root: SCOP hierarchy in SUPERFAMILY [ 0] (11)
• Class: Alpha and beta proteins (a+b) [ 53931] (376)
• Fold: Ferredoxin-like [ 54861] (59)
• Superfamily: RNA-binding domain, RBD [ 54928] (5)
• Family: Canonical RBD [ 54929] (67)

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Family statistics

	Genomes (488)	Uniprot 2018_03 genome	PDB chains (SCOP 1.75)
Domains	15,913	44,917	131
Proteins	12,849	36,059	123

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Enzyme Commission (EC)

Highlighted in gray are those with FDR_all>0.001

	EC term	FDR (all)	IC level	SDEO level	Annotation (direct or inherited)
Enzyme Commission (EC)	Phosphoinositide 5-phosphatase	0	2.44	--	DIRECT
Enzyme Commission (EC)	Cis-trans-isomerases	0	1.662	--	DIRECT
Enzyme Commission (EC)	RNA uridylyltransferase	0	2.741	--	DIRECT
Enzyme Commission (EC)	Peptidylprolyl isomerase	0	1.741	--	DIRECT
Enzyme Commission (EC)	tRNA (carboxymethyluridine(34)-5-O)-methyltransfer	5.205e-16	2.44	--	DIRECT
Enzyme Commission (EC)	Hydrolases	0.0819	0.01852	--	INHERITED FROM: Exoribonucleases producing 5'-phosphomonoesters || Acting on ester bonds || Phosphoinositide 5-phosphatase || Poly(A)-specific ribonuclease
Enzyme Commission (EC)	Transferring phosphorous-containing groups	0.5032	0.2728	--	INHERITED FROM: Polynucleotide adenylyltransferase || RNA uridylyltransferase
Enzyme Commission (EC)	Transferases	0.191	0	--	INHERITED FROM: Polynucleotide adenylyltransferase || tRNA (carboxymethyluridine(34)-5-O)-methyltransfer || RNA uridylyltransferase || Transferring one-carbon groups || Methyltransferases || Histone-lysine N-methyltransferase
Enzyme Commission (EC)	Isomerases	0.00000001195	0.6881	Least Informative	DIRECT
Enzyme Commission (EC)	Acting on ester bonds	0.000006192	0.5107	Least Informative	DIRECT
Enzyme Commission (EC)	Transferring one-carbon groups	0.000022	0.72	Least Informative	DIRECT
Enzyme Commission (EC)	Nucleotidyltransferases	0.01789	0.6958	Least Informative	INHERITED FROM: RNA uridylyltransferase || Polynucleotide adenylyltransferase
Enzyme Commission (EC)	Methyltransferases	0.0000001778	0.8169	Moderately Informative	DIRECT
Enzyme Commission (EC)	Phosphoric monoester hydrolases	0.0196	0.9703	Moderately Informative	INHERITED FROM: Phosphoinositide 5-phosphatase
Enzyme Commission (EC)	Histone-lysine N-methyltransferase	0.00000000002592	1.595	Informative	DIRECT
Enzyme Commission (EC)	Exoribonucleases producing 5'-phosphomonoesters	0.00000002223	1.486	Informative	DIRECT
Enzyme Commission (EC)	Cis-trans Isomerases	1	1.662	Informative	INHERITED FROM: Peptidylprolyl isomerase
Enzyme Commission (EC)	Polynucleotide adenylyltransferase	0	1.963	Highly Informative	DIRECT
Enzyme Commission (EC)	Poly(A)-specific ribonuclease	1.746e-16	2.139	Highly Informative	DIRECT

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Disease Ontology (DO)

Highlighted in gray are those with FDR_all>0.001

	DO term	FDR (all)	IC level	SDDO level	Annotation (direct or inherited)
Disease Ontology (DO)	transient cerebral ischemia	0.0002989	2.513	--	DIRECT
Disease Ontology (DO)	myopathy of extraocular muscle	0.0003124	2.513	--	DIRECT
Disease Ontology (DO)	brain ischemia	0.002052	2.513	--	INHERITED FROM: transient cerebral ischemia
Disease Ontology (DO)	muscle tissue disease	0.0094	1.434	--	INHERITED FROM: myopathy of extraocular muscle
Disease Ontology (DO)	muscular disease	0.01225	1.399	--	INHERITED FROM: myopathy of extraocular muscle
Disease Ontology (DO)	musculoskeletal system disease	0.6733	0.89	--	INHERITED FROM: myopathy of extraocular muscle
Disease Ontology (DO)	cardiovascular system disease	1	0.7889	--	INHERITED FROM: transient cerebral ischemia
Disease Ontology (DO)	vascular disease	1	0.832	--	INHERITED FROM: transient cerebral ischemia
Disease Ontology (DO)	disease of anatomical entity	1	0.2414	--	INHERITED FROM: transient cerebral ischemia || myopathy of extraocular muscle
Disease Ontology (DO)	myopathy	1	1.559	Informative	INHERITED FROM: myopathy of extraocular muscle
Disease Ontology (DO)	ischemia	0.2244	1.814	Highly Informative	INHERITED FROM: transient cerebral ischemia

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Human Phenotype (HP)

Highlighted in gray are those with FDR_all>0.001

	HP term	FDR (all)	IC level	SDHP level	Annotation (direct or inherited)
Mode of Inheritance (MI)	Gonosomal inheritance	0.0003445	2.021	--	DIRECT
Mode of Inheritance (MI)	Y-linked inheritance	0.0002807	2.021	Highly Informative	DIRECT
Phenotypic Abnormality (PA)	Abnormal motor neuron morphology	0.00000003953	2.161	--	DIRECT
Phenotypic Abnormality (PA)	Abnormal neuron morphology	0.0000000474	2.161	--	DIRECT
Phenotypic Abnormality (PA)	Rimmed vacuoles	0.0000001498	2.462	--	DIRECT
Phenotypic Abnormality (PA)	Oligospermia	0.0000007865	2.462	--	DIRECT
Phenotypic Abnormality (PA)	Laryngospasm	0.000001323	2.161	--	DIRECT
Phenotypic Abnormality (PA)	Xerostomia	0.000005589	2.161	--	DIRECT
Phenotypic Abnormality (PA)	Fatigable weakness of bulbar muscles	0.000005589	2.161	--	DIRECT
Phenotypic Abnormality (PA)	Non-obstructive azoospermia	0.00001558	2.462	--	DIRECT
Phenotypic Abnormality (PA)	Male infertility	0.00001871	2.462	--	DIRECT
Phenotypic Abnormality (PA)	Dyscalculia	0.000052	2.462	--	DIRECT
Phenotypic Abnormality (PA)	Mutism	0.00009387	2.462	--	DIRECT
Phenotypic Abnormality (PA)	Perseveration	0.00009544	2.462	--	DIRECT
Phenotypic Abnormality (PA)	Abnormal lower motor neuron morphology	0.0002089	2.462	--	DIRECT
Phenotypic Abnormality (PA)	Abnormal synaptic transmission	0.000393	1.684	--	DIRECT
Phenotypic Abnormality (PA)	Restlessness	0.000504	2.161	--	DIRECT
Phenotypic Abnormality (PA)	Elevated serum creatine kinase	0.0008646	1.617	--	DIRECT
Phenotypic Abnormality (PA)	Abnormal circulating creatine kinase concentration	0.0009721	1.617	--	DIRECT
Phenotypic Abnormality (PA)	Abnormality of circulating enzyme level	0.001176	1.617	--	INHERITED FROM: Abnormal circulating creatine kinase concentration || Elevated serum creatine kinase
Phenotypic Abnormality (PA)	Abnormality of salivation	0.001568	2.161	--	INHERITED FROM: Xerostomia
Phenotypic Abnormality (PA)	Abnormal spermatogenesis	0.001915	1.985	--	INHERITED FROM: Oligospermia || Non-obstructive azoospermia
Phenotypic Abnormality (PA)	Fatigable weakness	0.003364	1.684	--	INHERITED FROM: Fatigable weakness of swallowing muscles || Fatigable weakness of respiratory muscles || Fatigable weakness of bulbar muscles
Phenotypic Abnormality (PA)	Abnormality of the larynx	0.004438	1.86	--	INHERITED FROM: Laryngospasm
Phenotypic Abnormality (PA)	Infertility	0.005537	2.462	--	INHERITED FROM: Male infertility
Phenotypic Abnormality (PA)	Abnormal muscle fiber morphology	0.005594	1.763	--	INHERITED FROM: Rimmed vacuoles
Phenotypic Abnormality (PA)	Functional abnormality of male internal genitalia	0.008606	1.985	--	INHERITED FROM: Oligospermia || Non-obstructive azoospermia
Phenotypic Abnormality (PA)	Atrophy/Degeneration affecting the central nervous system	0.01351	1.763	--	INHERITED FROM: Motor neuron atrophy
Phenotypic Abnormality (PA)	Abnormal fear/anxiety-related behavior	0.01714	1.763	--	INHERITED FROM: Anxiety
Phenotypic Abnormality (PA)	Abnormal male reproductive system physiology	0.01727	1.985	--	INHERITED FROM: Oligospermia || Non-obstructive azoospermia
Phenotypic Abnormality (PA)	Decreased fertility	0.02148	2.161	--	INHERITED FROM: Decreased fertility in males || Male infertility
Phenotypic Abnormality (PA)	Abnormality of the genital system	0.1481	0.9309	--	INHERITED FROM: Male infertility || Decreased fertility in males || Oligospermia || Non-obstructive azoospermia
Phenotypic Abnormality (PA)	Abnormality of the mouth	0.1617	0.7065	--	INHERITED FROM: Xerostomia
Phenotypic Abnormality (PA)	Abnormality of the respiratory system	0.3116	0.9183	--	INHERITED FROM: Laryngospasm
Phenotypic Abnormality (PA)	Morphological abnormality of the central nervous system	0.3664	0.533	--	INHERITED FROM: Motor neuron atrophy
Phenotypic Abnormality (PA)	Abnormal muscle physiology	0.4091	0.6915	--	INHERITED FROM: Fatigable weakness of bulbar muscles || Fatigable weakness of swallowing muscles || Fatigable weakness of respiratory muscles
Phenotypic Abnormality (PA)	Abnormality of the head	0.5132	0.4538	--	INHERITED FROM: Xerostomia
Phenotypic Abnormality (PA)	Abnormality of head or neck	0.534	0.4454	--	INHERITED FROM: Xerostomia
Phenotypic Abnormality (PA)	Abnormality of the nervous system	0.6191	0.2371	--	INHERITED FROM: Abnormal neuron morphology || Abnormal lower motor neuron morphology || Abnormal motor neuron morphology || Fatigable weakness of swallowing muscles || Mutism || Restlessness || Dyscalculia || Fatigable weakness of respiratory muscles || Motor neuron atrophy || Abnormal synaptic transmission || Perseveration || Anxiety || Paralysis || Agitation || Fatigable weakness of bulbar muscles
Phenotypic Abnormality (PA)	Neurodevelopmental abnormality	0.681	0.7381	--	INHERITED FROM: Dyscalculia
Phenotypic Abnormality (PA)	Abnormal peripheral nervous system synaptic transmission	1	1.684	--	INHERITED FROM: Fatigable weakness of swallowing muscles || Fatigable weakness of bulbar muscles || Fatigable weakness of respiratory muscles
Phenotypic Abnormality (PA)	Abnormality of the genitourinary system	0.4067	0.6051	Least Informative	INHERITED FROM: Decreased fertility in males || Non-obstructive azoospermia || Male infertility || Oligospermia
Phenotypic Abnormality (PA)	Abnormality of the face	0.4263	0.533	Least Informative	INHERITED FROM: Xerostomia
Phenotypic Abnormality (PA)	Abnormality of nervous system morphology	0.4591	0.4756	Least Informative	INHERITED FROM: Abnormal neuron morphology || Abnormal lower motor neuron morphology || Motor neuron atrophy || Abnormal motor neuron morphology
Phenotypic Abnormality (PA)	Abnormality of the musculature	0.4622	0.5433	Least Informative	INHERITED FROM: Fatigable weakness of bulbar muscles || Fatigable weakness of swallowing muscles || Rimmed vacuoles || Fatigable weakness of respiratory muscles
Phenotypic Abnormality (PA)	Abnormality of nervous system physiology	0.6385	0.3869	Least Informative	INHERITED FROM: Fatigable weakness of swallowing muscles || Perseveration || Anxiety || Agitation || Mutism || Paralysis || Fatigable weakness of bulbar muscles || Dyscalculia || Restlessness || Fatigable weakness of respiratory muscles || Abnormal synaptic transmission
Phenotypic Abnormality (PA)	Abnormality of metabolism/homeostasis	0.9123	0.5486	Least Informative	INHERITED FROM: Elevated serum creatine kinase || Abnormal circulating creatine kinase concentration
Phenotypic Abnormality (PA)	Abnormal respiratory system morphology	0.1944	1.064	Moderately Informative	INHERITED FROM: Laryngospasm
Phenotypic Abnormality (PA)	Behavioral abnormality	0.2234	1.082	Moderately Informative	INHERITED FROM: Perseveration || Restlessness || Mutism || Agitation || Anxiety
Phenotypic Abnormality (PA)	Abnormal skeletal muscle morphology	0.2608	0.9061	Moderately Informative	INHERITED FROM: Rimmed vacuoles
Phenotypic Abnormality (PA)	Abnormality of central motor function	0.3158	1.047	Moderately Informative	INHERITED FROM: Paralysis
Phenotypic Abnormality (PA)	Abnormal circulating metabolite concentration	0.5372	0.971	Moderately Informative	INHERITED FROM: Abnormal circulating creatine kinase concentration || Elevated serum creatine kinase
Phenotypic Abnormality (PA)	Abnormality of higher mental function	0.5426	0.8092	Moderately Informative	INHERITED FROM: Mutism
Phenotypic Abnormality (PA)	Abnormal peripheral nervous system morphology	0.6276	1.232	Moderately Informative	INHERITED FROM: Abnormal lower motor neuron morphology
Phenotypic Abnormality (PA)	Abnormality of the upper respiratory tract	0.003163	1.508	Informative	INHERITED FROM: Laryngospasm
Phenotypic Abnormality (PA)	Impairment in personality functioning	0.008933	1.508	Informative	INHERITED FROM: Anxiety
Phenotypic Abnormality (PA)	Abnormal circulating protein level	0.02586	1.508	Informative	INHERITED FROM: Abnormal circulating creatine kinase concentration || Elevated serum creatine kinase
Phenotypic Abnormality (PA)	Muscle weakness	0.03576	1.316	Informative	INHERITED FROM: Fatigable weakness of swallowing muscles || Fatigable weakness of bulbar muscles || Fatigable weakness of respiratory muscles
Phenotypic Abnormality (PA)	Neurological speech impairment	0.205	1.508	Informative	INHERITED FROM: Mutism
Phenotypic Abnormality (PA)	Abnormality of reproductive system physiology	0.427	1.508	Informative	INHERITED FROM: Decreased fertility in males || Oligospermia || Male infertility || Non-obstructive azoospermia
Phenotypic Abnormality (PA)	Abnormal synaptic transmission at the neuromuscular junction	1	1.684	Informative	INHERITED FROM: Fatigable weakness of respiratory muscles || Fatigable weakness of bulbar muscles || Fatigable weakness of swallowing muscles
Phenotypic Abnormality (PA)	Motor neuron atrophy	0.000000246	2.161	Highly Informative	DIRECT
Phenotypic Abnormality (PA)	Fatigable weakness of swallowing muscles	0.0000004367	2.161	Highly Informative	DIRECT
Phenotypic Abnormality (PA)	Fatigable weakness of respiratory muscles	0.00001192	1.86	Highly Informative	DIRECT
Phenotypic Abnormality (PA)	Paralysis	0.0001181	1.985	Highly Informative	DIRECT
Phenotypic Abnormality (PA)	Agitation	0.0001462	2.161	Highly Informative	DIRECT
Phenotypic Abnormality (PA)	Decreased fertility in males	0.000176	2.161	Highly Informative	DIRECT
Phenotypic Abnormality (PA)	Anxiety	0.0005479	1.86	Highly Informative	DIRECT
Phenotypic Abnormality (PA)	Azoospermia	0.001239	1.985	Highly Informative	INHERITED FROM: Non-obstructive azoospermia
Phenotypic Abnormality (PA)	Specific learning disability	0.01433	1.985	Highly Informative	INHERITED FROM: Dyscalculia
Phenotypic Abnormality (PA)	Abnormal larynx physiology	0.01711	1.985	Highly Informative	INHERITED FROM: Laryngospasm
Phenotypic Abnormality (PA)	Abnormal oral physiology	0.01889	1.985	Highly Informative	INHERITED FROM: Xerostomia

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Mouse Phenotype (MP)

Highlighted in gray are those with FDR_all>0.001

	MP term	FDR (all)	IC level	SDMP level	Annotation (direct or inherited)
Mammalian Phenotype (MP)	premature neuronal precursor differentiation	0.000274	2.302	--	DIRECT
Mammalian Phenotype (MP)	abnormal cell differentiation	0.5874	1.373	--	INHERITED FROM: premature neuronal precursor differentiation
Mammalian Phenotype (MP)	abnormal cell physiology	0.9519	0.6209	--	INHERITED FROM: premature neuronal precursor differentiation
Mammalian Phenotype (MP)	abnormal nervous system morphology	0.9756	0.5861	--	INHERITED FROM: premature neuronal precursor differentiation
Mammalian Phenotype (MP)	cellular phenotype	0.3082	0.5387	Least Informative	INHERITED FROM: premature neuronal precursor differentiation
Mammalian Phenotype (MP)	nervous system phenotype	0.9695	0.4959	Least Informative	INHERITED FROM: premature neuronal precursor differentiation
Mammalian Phenotype (MP)	abnormal neuron morphology	0.5561	0.8323	Moderately Informative	INHERITED FROM: premature neuronal precursor differentiation
Mammalian Phenotype (MP)	abnormal nervous system development	0.8572	1.112	Moderately Informative	INHERITED FROM: premature neuronal precursor differentiation
Mammalian Phenotype (MP)	abnormal neuron differentiation	0.2625	1.562	Informative	INHERITED FROM: premature neuronal precursor differentiation

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Worm Phenotype (WP)

Highlighted in gray are those with FDR_all>0.001

	WP term	FDR (all)	IC level	SDWP level	Annotation (direct or inherited)
Worm Phenotype (WP)	lethal	0	0.00521	--	DIRECT
Worm Phenotype (WP)	development variant	0	0.001482	--	DIRECT
Worm Phenotype (WP)	organism development variant	0	0.00297	--	DIRECT
Worm Phenotype (WP)	RNA metabolism variant	6.263e-16	2.468	--	DIRECT
Worm Phenotype (WP)	cell number variant	0.000000000000007503	1.371	--	DIRECT
Worm Phenotype (WP)	cell proliferation variant	0.0000000008202	1.99	--	DIRECT
Worm Phenotype (WP)	oocytes disorganized	0.00000001493	2.769	--	DIRECT
Worm Phenotype (WP)	unfertilized oocytes laid	0.00000002337	2.769	--	DIRECT
Worm Phenotype (WP)	masculinized	0.00000006017	2.468	--	DIRECT
Worm Phenotype (WP)	sex determination variant	0.0000001455	2.468	--	DIRECT
Worm Phenotype (WP)	starvation induced apoptosis variant	0.0000002936	2.769	--	DIRECT
Worm Phenotype (WP)	embryonic morphology variant	0.0000004583	2.468	--	DIRECT
Worm Phenotype (WP)	RNA processing variant	0.0000004718	2.468	--	DIRECT
Worm Phenotype (WP)	sterile F1	0.0000007545	2.769	--	DIRECT
Worm Phenotype (WP)	mRNA export variant	0.0000009181	2.769	--	DIRECT
Worm Phenotype (WP)	excess intestinal cells	0.000001191	2.292	--	DIRECT
Worm Phenotype (WP)	dendrite development variant	0.000001941	2.167	--	DIRECT
Worm Phenotype (WP)	embryonic lethal late emb	0.000001943	2.292	--	DIRECT
Worm Phenotype (WP)	nucleocytoplasmic transport defective	0.000005037	2.769	--	DIRECT
Worm Phenotype (WP)	egg morphology variant	0.00001033	2.292	--	DIRECT
Worm Phenotype (WP)	pathogen induced antimicrobial gene expression variant	0.00006144	1.814	--	DIRECT
Worm Phenotype (WP)	innate immune response variant	0.00007716	1.814	--	DIRECT
Worm Phenotype (WP)	organelle metabolism variant	0.00008026	2.468	--	DIRECT
Worm Phenotype (WP)	locomotion variant	0.000102	1.053	--	DIRECT
Worm Phenotype (WP)	masculinization of germline	0.0001067	2.468	--	DIRECT
Worm Phenotype (WP)	alimentary system development variant	0.0001813	1.814	--	DIRECT
Worm Phenotype (WP)	late larval arrest	0.0006048	2.468	--	DIRECT
Worm Phenotype (WP)	two fold arrest	0.0007993	2.769	--	DIRECT
Worm Phenotype (WP)	P granule localization defective	0.0008385	2.468	--	DIRECT
Worm Phenotype (WP)	tumorous germline	0.0008652	2.769	--	DIRECT
Worm Phenotype (WP)	behavior variant	0.001934	0.6859	--	INHERITED FROM: locomotion variant || unfertilized oocytes laid
Worm Phenotype (WP)	neuron development variant	0.002454	1.321	--	INHERITED FROM: dendrite development variant || neurite development variant
Worm Phenotype (WP)	gene expression variant	0.004154	0.6256	--	INHERITED FROM: RNA processing variant || mRNA export variant || no induction of antimicrobial peptide expression after infection || pathogen induced antimicrobial gene expression variant || RNA expression variant
Worm Phenotype (WP)	cell morphology variant	0.004229	0.7558	--	INHERITED FROM: oocytes disorganized || P granule localization defective
Worm Phenotype (WP)	antimicrobial gene expression variant	0.005041	1.814	--	INHERITED FROM: no induction of antimicrobial peptide expression after infection || pathogen induced antimicrobial gene expression variant
Worm Phenotype (WP)	pathogen induced gene expression variant	0.005409	1.814	--	INHERITED FROM: pathogen induced antimicrobial gene expression variant || no induction of antimicrobial peptide expression after infection
Worm Phenotype (WP)	metabolic pathway variant	0.005529	1.263	--	INHERITED FROM: RNA processing variant || RNA metabolism variant
Worm Phenotype (WP)	hermaphrodite reproductive system morphology variant	0.008103	1.426	--	INHERITED FROM: vulva morphology variant
Worm Phenotype (WP)	germ cell morphology variant	0.01092	1.156	--	INHERITED FROM: P granule localization defective || oocytes disorganized
Worm Phenotype (WP)	organ system morphology variant	0.02036	0.7516	--	INHERITED FROM: vulva morphology variant || reproductive system morphology variant
Worm Phenotype (WP)	organism starvation response variant	0.04263	2.468	--	INHERITED FROM: starvation induced apoptosis variant
Worm Phenotype (WP)	hermaphrodite sexual development variant	0.05715	2.468	--	INHERITED FROM: masculinization of germline || masculinized
Worm Phenotype (WP)	P granule abnormal	0.06154	2.292	--	INHERITED FROM: P granule localization defective
Worm Phenotype (WP)	germ cell cytoplasmic morphology variant	0.06652	1.866	--	INHERITED FROM: P granule localization defective
Worm Phenotype (WP)	organism homeostasis metabolism variant	0.07909	0.1444	--	INHERITED FROM: starvation induced apoptosis variant || pathogen induced antimicrobial gene expression variant || no induction of antimicrobial peptide expression after infection || mRNA export variant || innate immune response variant || sick || RNA metabolism variant || RNA processing variant || RNA expression variant || late larval arrest || organism metabolism processing variant
Worm Phenotype (WP)	organism physiology variant	0.1018	0.1342	--	INHERITED FROM: innate immune response variant || pathogen induced antimicrobial gene expression variant || mRNA export variant || no induction of antimicrobial peptide expression after infection || starvation induced apoptosis variant || RNA metabolism variant || RNA processing variant || sick || RNA expression variant || organism metabolism processing variant || late larval arrest
Worm Phenotype (WP)	hermaphrodite fertility variant	0.1046	0.0947	--	INHERITED FROM: brood size variant
Worm Phenotype (WP)	morphology variant	0.127	0.046	--	INHERITED FROM: P granule localization defective || egg morphology variant || oocytes disorganized || reproductive system morphology variant || developmental morphology variant || embryonic morphology variant || vulva morphology variant
Worm Phenotype (WP)	organism morphology variant	0.1787	0.1372	--	INHERITED FROM: egg morphology variant || developmental morphology variant || embryonic morphology variant
Worm Phenotype (WP)	postembryonic development variant	0.1998	0.269	--	INHERITED FROM: late larval arrest
Worm Phenotype (WP)	fertility reduced	0.204	0.06449	--	INHERITED FROM: sterile F1
Worm Phenotype (WP)	developmental growth variant	0.2228	0.4991	--	INHERITED FROM: late larval arrest
Worm Phenotype (WP)	fertility variant	0.2255	0.05937	--	INHERITED FROM: sterile F1 || brood size variant
Worm Phenotype (WP)	gametogenesis variant	0.2275	1.013	--	INHERITED FROM: tumorous germline || masculinization of germline || germline proliferation variant
Worm Phenotype (WP)	nuclear export defective	0.2351	2.769	--	INHERITED FROM: mRNA export variant
Worm Phenotype (WP)	reproductive system physiology variant	0.2459	0.05515	--	INHERITED FROM: brood size variant || sterile F1
Worm Phenotype (WP)	organ system physiology variant	0.252	0.04518	--	INHERITED FROM: brood size variant || sterile F1
Worm Phenotype (WP)	embryonic development variant	0.3108	0.04518	--	INHERITED FROM: embryonic lethal late emb || two fold arrest
Worm Phenotype (WP)	embryonic lethal	0.3339	0.046	--	INHERITED FROM: embryonic lethal late emb
Worm Phenotype (WP)	apoptosis variant	0.4177	1.125	--	INHERITED FROM: starvation induced apoptosis variant
Worm Phenotype (WP)	late embryonic arrest	0.4777	2.292	--	INHERITED FROM: two fold arrest
Worm Phenotype (WP)	programmed cell death variant	0.4968	1.087	--	INHERITED FROM: starvation induced apoptosis variant
Worm Phenotype (WP)	growth variant	0.6076	0.3438	--	INHERITED FROM: late larval arrest || sick
Worm Phenotype (WP)	larval development variant	0.7155	0.4322	--	INHERITED FROM: late larval arrest
Worm Phenotype (WP)	sterile progeny	0.8804	0.6547	--	INHERITED FROM: sterile F1
Worm Phenotype (WP)	mRNA expression variant	0.9933	1.814	--	INHERITED FROM: mRNA export variant
Worm Phenotype (WP)	physiology variant	1	0	--	INHERITED FROM: neurite development variant || organism metabolism processing variant || germline proliferation variant || organ system development variant || RNA expression variant || lethal || unfertilized oocytes laid || sex determination variant || innate immune response variant || masculinized || sterile F1 || dendrite development variant || intestinal development variant || cell proliferation increased || development variant || alimentary system development variant || late larval arrest || organelle metabolism variant || cell physiology variant || no induction of antimicrobial peptide expression after infection || mRNA export variant || sick || brood size variant || cell number variant || cell proliferation variant || excess intestinal cells || tumorous germline || starvation induced apoptosis variant || sexually dimorphic development variant || pathogen induced antimicrobial gene expression variant || organism development variant || locomotion variant || embryonic lethal late emb || nucleocytoplasmic transport defective || masculinization of germline || RNA processing variant || RNA metabolism variant || two fold arrest || cell development variant
Worm Phenotype (WP)	sterile	1	0.1135	--	INHERITED FROM: sterile F1
Worm Phenotype (WP)	larval growth variant	1	0.4991	--	INHERITED FROM: late larval arrest
Worm Phenotype (WP)	cell component morphology variant	1	0.8392	--	INHERITED FROM: P granule localization defective
Worm Phenotype (WP)	cell development variant	0.000000000003364	0.6752	Least Informative	DIRECT
Worm Phenotype (WP)	cell physiology variant	0.000007147	0.5955	Least Informative	DIRECT
Worm Phenotype (WP)	organism metabolism processing variant	0.0001279	0.4899	Least Informative	DIRECT
Worm Phenotype (WP)	organism behavior variant	0.001762	0.6859	Least Informative	INHERITED FROM: locomotion variant || unfertilized oocytes laid
Worm Phenotype (WP)	larval arrest	0.305	0.4991	Least Informative	INHERITED FROM: late larval arrest
Worm Phenotype (WP)	progeny variant	0.8303	0.6514	Least Informative	INHERITED FROM: sterile F1
Worm Phenotype (WP)	organism environmental stimulus response variant	0.9329	0.6614	Least Informative	INHERITED FROM: innate immune response variant || starvation induced apoptosis variant || no induction of antimicrobial peptide expression after infection || pathogen induced antimicrobial gene expression variant
Worm Phenotype (WP)	organ system development variant	0.000000002527	0.9113	Moderately Informative	DIRECT
Worm Phenotype (WP)	reproductive system morphology variant	0.0001203	1.078	Moderately Informative	DIRECT
Worm Phenotype (WP)	cell type morphology variant	0.01465	0.8878	Moderately Informative	INHERITED FROM: P granule localization defective || oocytes disorganized
Worm Phenotype (WP)	movement variant	0.02219	1.02	Moderately Informative	INHERITED FROM: locomotion variant
Worm Phenotype (WP)	cell homeostasis metabolism variant	0.2751	1.036	Moderately Informative	INHERITED FROM: organelle metabolism variant || nucleocytoplasmic transport defective || RNA processing variant || RNA metabolism variant || mRNA export variant
Worm Phenotype (WP)	organism stress response variant	0.2778	0.9693	Moderately Informative	INHERITED FROM: innate immune response variant || starvation induced apoptosis variant || no induction of antimicrobial peptide expression after infection || pathogen induced antimicrobial gene expression variant
Worm Phenotype (WP)	germ cell development variant	0.992	1.013	Moderately Informative	INHERITED FROM: germline proliferation variant || masculinization of germline || tumorous germline
Worm Phenotype (WP)	cell death variant	1	1.061	Moderately Informative	INHERITED FROM: starvation induced apoptosis variant
Worm Phenotype (WP)	RNA expression variant	0.000000004601	1.565	Informative	DIRECT
Worm Phenotype (WP)	vulva morphology variant	0.000001949	1.426	Informative	DIRECT
Worm Phenotype (WP)	sick	0.000002671	1.727	Informative	DIRECT
Worm Phenotype (WP)	brood size variant	0.00003129	1.538	Informative	DIRECT
Worm Phenotype (WP)	cell number increased	0.001242	1.446	Informative	INHERITED FROM: excess intestinal cells || tumorous germline
Worm Phenotype (WP)	egg laying variant	0.06377	1.513	Informative	INHERITED FROM: unfertilized oocytes laid
Worm Phenotype (WP)	organism pathogen response variant	0.07764	1.468	Informative	INHERITED FROM: no induction of antimicrobial peptide expression after infection || innate immune response variant || pathogen induced antimicrobial gene expression variant
Worm Phenotype (WP)	oocyte morphology variant	0.2169	1.292	Informative	INHERITED FROM: oocytes disorganized
Worm Phenotype (WP)	cell proliferation increased	0	1.99	Highly Informative	DIRECT
Worm Phenotype (WP)	intestinal development variant	0.0000000000015	1.866	Highly Informative	DIRECT
Worm Phenotype (WP)	neurite development variant	0.000003179	1.866	Highly Informative	DIRECT
Worm Phenotype (WP)	no induction of antimicrobial peptide expression after infection	0.00001947	1.99	Highly Informative	DIRECT
Worm Phenotype (WP)	sexually dimorphic development variant	0.00002557	2.07	Highly Informative	DIRECT
Worm Phenotype (WP)	developmental morphology variant	0.00009629	2.07	Highly Informative	DIRECT
Worm Phenotype (WP)	germline proliferation variant	0.0004664	2.07	Highly Informative	DIRECT
Worm Phenotype (WP)	embryonic arrest	0.01323	1.924	Highly Informative	INHERITED FROM: two fold arrest

---

Fly Phenotype (FP)

Highlighted in gray are those with FDR_all>0.001

	FP term	FDR (all)	IC level	SDFP level	Annotation (direct or inherited)
Fly Phenotype (FP)	lethal	0.00004752	0.678	--	DIRECT
Fly Phenotype (FP)	increased mortality during development	0.06566	0.6148	--	INHERITED FROM: lethal
Fly Phenotype (FP)	phenotype	0.5286	0.06546	--	INHERITED FROM: lethal
Fly Phenotype (FP)	increased mortality	0.002976	0.5343	Least Informative	INHERITED FROM: lethal

---

Fly Anatomy (FA)

Highlighted in gray are those with FDR_all>0.001

	FA term	FDR (all)	IC level	SDFA level	Annotation (direct or inherited)
Fly Anatomy (FA)	multicellular structure	0	0.008955	--	DIRECT
Fly Anatomy (FA)	anatomical structure	1	0	--	INHERITED FROM: multicellular structure
Fly Anatomy (FA)	material anatomical entity	1	0	--	INHERITED FROM: multicellular structure

---

Zebrafish Anatomy (ZA)

Highlighted in gray are those with FDR_all>0.001

	ZA term	FDR (all)	IC level	SDZA level	Annotation (direct or inherited)
Zebrafish Anatomy (ZA)	whole organism	0	0.00147	--	DIRECT
Zebrafish Anatomy (ZA)	anatomical structure	1	0	--	INHERITED FROM: whole organism

---

Xenopus Anatomy (XA)

Highlighted in gray are those with FDR_all>0.001

	XA term	FDR (all)	IC level	SDXA level	Annotation (direct or inherited)
Xenopus ANatomical entity (XAN)	anatomical structure	0	0	--	DIRECT
Xenopus ANatomical entity (XAN)	egg	0.0000000000000278	1.202	--	DIRECT
Xenopus ANatomical entity (XAN)	immune system	0.000000000000296	1.786	--	DIRECT
Xenopus ANatomical entity (XAN)	cell	0.000000000003536	0.8608	--	DIRECT
Xenopus ANatomical entity (XAN)	animal cap	0.00000001033	2.865	--	DIRECT
Xenopus ANatomical entity (XAN)	gamete	0.00000001318	1.202	--	DIRECT
Xenopus ANatomical entity (XAN)	male organism	0.0000001376	0.7647	--	DIRECT
Xenopus ANatomical entity (XAN)	intestine	0.0000002192	1.242	--	DIRECT
Xenopus ANatomical entity (XAN)	muscular system	0.0000004608	1.263	--	DIRECT
Xenopus ANatomical entity (XAN)	genital system	0.000001021	0.5751	--	DIRECT
Xenopus ANatomical entity (XAN)	pharyngeal arch	0.000002875	1.689	--	DIRECT
Xenopus ANatomical entity (XAN)	upper blastopore lip	0.00000418	2.388	--	DIRECT
Xenopus ANatomical entity (XAN)	central nervous system	0.000009734	0.5841	--	DIRECT
Xenopus ANatomical entity (XAN)	gonad	0.00001101	0.7579	--	DIRECT
Xenopus ANatomical entity (XAN)	vegetal yolk mass	0.00001308	2.166	--	DIRECT
Xenopus ANatomical entity (XAN)	blastopore	0.00002203	2.166	--	DIRECT
Xenopus ANatomical entity (XAN)	primary germ layer	0.00003185	0.6748	--	DIRECT
Xenopus ANatomical entity (XAN)	vegetal pole	0.0001599	2.865	--	DIRECT
Xenopus ANatomical entity (XAN)	marginal zone	0.000206	1.786	--	DIRECT
Xenopus ANatomical entity (XAN)	neural crest	0.0009152	1.689	--	DIRECT
Xenopus ANatomical entity (XAN)	compound organ	0.001306	0.2177	--	INHERITED FROM: gonad || thymus || spinal cord || eye || intestine || solid compound organ || hindbrain || testis
Xenopus ANatomical entity (XAN)	trunk region	0.0025	0.388	--	INHERITED FROM: gonad || intestine || testis
Xenopus ANatomical entity (XAN)	anatomical region	0.004573	0.1803	--	INHERITED FROM: intestine || eye || tail region || vegetal pole || pharyngeal region || tail || gonad || pharyngeal arch || hindbrain || testis
Xenopus ANatomical entity (XAN)	organism subdivision	0.01325	0.1679	--	INHERITED FROM: eye || intestine || pharyngeal region || limb || tail || gonad || pharyngeal arch || hindbrain || testis
Xenopus ANatomical entity (XAN)	head region	0.02372	0.4759	--	INHERITED FROM: eye || hindbrain || pharyngeal arch || pharyngeal region
Xenopus ANatomical entity (XAN)	anatomical group	0.03156	0.1408	--	INHERITED FROM: testis || muscular system || hindbrain || alimentary system || liver and biliary system || thymus || spinal cord || immune system || urogenital system || nervous system || intestine || endocrine system || genital system || egg || musculoskeletal system || sensory system || central nervous system || eye || anatomical cluster || gamete
Xenopus ANatomical entity (XAN)	male genitalia	0.07326	0.7647	--	INHERITED FROM: testis
Xenopus ANatomical entity (XAN)	visual system	0.08832	1.321	--	INHERITED FROM: eye
Xenopus ANatomical entity (XAN)	multicellular anatomical structure	0.1666	0.1131	--	INHERITED FROM: hindbrain || testis || gonad || thymus || spinal cord || tail || ectoderm || tissue || solid compound organ || intestine || multi-tissue structure || pharyngeal arch || neural crest || primary germ layer || limb || pharyngeal region || animal cap || eye || endomesoderm
Xenopus ANatomical entity (XAN)	anatomical system	1	0.283	--	INHERITED FROM: muscular system || testis || alimentary system || hindbrain || liver and biliary system || spinal cord || thymus || immune system || urogenital system || intestine || endocrine system || nervous system || egg || genital system || musculoskeletal system || sensory system || central nervous system || eye || gamete
Xenopus ANatomical entity (XAN)	whole organism	1	0.0884	--	INHERITED FROM: urogenital system || tail region || immune system || blastopore || genital system || egg || intestine || endocrine system || nervous system || alimentary system || hindbrain || testis || muscular system || thymus || gonad || ectoderm || spinal cord || tail || tissue || liver and biliary system || vegetal yolk mass || solid compound organ || vegetal pole || marginal zone || limb || central nervous system || blastopore lip || pharyngeal region || animal cap || gamete || eye || anatomical cluster || male organism || endomesoderm || sensory system || pharyngeal arch || multi-tissue structure || musculoskeletal system || embryonic structure || cell || neural crest || upper blastopore lip || primary germ layer
Xenopus ANatomical entity (XAN)	embryo	0.0000000000001556	0.5979	Least Informative	DIRECT
Xenopus ANatomical entity (XAN)	tissue	0.000000305	0.4672	Least Informative	DIRECT
Xenopus ANatomical entity (XAN)	urogenital system	0.00000707	0.4777	Least Informative	DIRECT
Xenopus ANatomical entity (XAN)	nervous system	0.0001625	0.5619	Least Informative	DIRECT
Xenopus ANatomical entity (XAN)	anatomical cluster	0.0001729	0.7159	Least Informative	DIRECT
Xenopus ANatomical entity (XAN)	trunk	0.001048	0.3894	Least Informative	INHERITED FROM: gonad || testis || intestine
Xenopus ANatomical entity (XAN)	head	0.01151	0.4777	Least Informative	INHERITED FROM: hindbrain || pharyngeal arch || pharyngeal region || eye
Xenopus ANatomical entity (XAN)	cavitated compound organ	0.1475	0.2685	Least Informative	INHERITED FROM: gonad || spinal cord || eye || intestine || hindbrain || testis
Xenopus ANatomical entity (XAN)	embryonic structure	0.0000000000009336	1.149	Moderately Informative	DIRECT
Xenopus ANatomical entity (XAN)	testis	0.000000131	0.7647	Moderately Informative	DIRECT
Xenopus ANatomical entity (XAN)	ectoderm	0.000007931	0.9357	Moderately Informative	DIRECT
Xenopus ANatomical entity (XAN)	musculoskeletal system	0.00001159	1.087	Moderately Informative	DIRECT
Xenopus ANatomical entity (XAN)	multi-tissue structure	0.00003505	1.066	Moderately Informative	DIRECT
Xenopus ANatomical entity (XAN)	alimentary system	0.0000372	0.8739	Moderately Informative	DIRECT
Xenopus ANatomical entity (XAN)	tail region	0.0002146	1.242	Moderately Informative	DIRECT
Xenopus ANatomical entity (XAN)	sensory system	0.000325	1.158	Moderately Informative	DIRECT
Xenopus ANatomical entity (XAN)	viscus	0.002096	0.8828	Moderately Informative	INHERITED FROM: intestine
Xenopus ANatomical entity (XAN)	brain	0.00353	0.7859	Moderately Informative	INHERITED FROM: hindbrain
Xenopus ANatomical entity (XAN)	germ cell	0.03823	1.08	Moderately Informative	INHERITED FROM: gamete || egg
Xenopus ANatomical entity (XAN)	anatomical entity in vitro	0	1.347	Informative	DIRECT
Xenopus ANatomical entity (XAN)	endocrine system	0.000000000001651	1.719	Informative	DIRECT
Xenopus ANatomical entity (XAN)	endomesoderm	0.00000003273	1.263	Informative	DIRECT
Xenopus ANatomical entity (XAN)	pharyngeal region	0.000005612	1.467	Informative	DIRECT
Xenopus ANatomical entity (XAN)	liver and biliary system	0.0000169	1.689	Informative	DIRECT
Xenopus ANatomical entity (XAN)	limb	0.0001626	1.635	Informative	DIRECT
Xenopus ANatomical entity (XAN)	spinal cord	0.0002983	1.45	Informative	DIRECT
Xenopus ANatomical entity (XAN)	tail	0.0003253	1.334	Informative	DIRECT
Xenopus ANatomical entity (XAN)	solid compound organ	0.0004546	1.334	Informative	DIRECT
Xenopus ANatomical entity (XAN)	eye	0.0005517	1.403	Informative	DIRECT
Xenopus ANatomical entity (XAN)	neuroectoderm	0.04522	1.374	Informative	INHERITED FROM: neural crest
Xenopus ANatomical entity (XAN)	thymus	0.000000000001174	1.824	Highly Informative	DIRECT
Xenopus ANatomical entity (XAN)	blastopore lip	0.00001029	2.166	Highly Informative	DIRECT
Xenopus ANatomical entity (XAN)	hindbrain	0.0003416	1.824	Highly Informative	DIRECT
Xenopus ANatomical entity (XAN)	vegetal hemisphere	0.003453	2.087	Highly Informative	INHERITED FROM: vegetal pole
Xenopus DEvelopment stage (XDE)	NF stage	0	0.01895	--	DIRECT
Xenopus DEvelopment stage (XDE)	tadpole stage	0.00001718	0.5805	--	DIRECT
Xenopus DEvelopment stage (XDE)	climax stage	0.01614	0.7127	--	INHERITED FROM: NF stage 66
Xenopus DEvelopment stage (XDE)	metamorphosing tadpole stage	0.2867	0.6447	--	INHERITED FROM: NF stage 66
Xenopus DEvelopment stage (XDE)	post-embryonic stage	0.00004018	0.5593	Least Informative	DIRECT
Xenopus DEvelopment stage (XDE)	unspecified stage	0.00008088	1.131	Moderately Informative	DIRECT
Xenopus DEvelopment stage (XDE)	NF stage 66	0.00003466	1.353	Informative	DIRECT

---

Arabidopsis Plant Ontology (AP)

Highlighted in gray are those with FDR_all>0.001

	AP term	FDR (all)	IC level	SDAP level	Annotation (direct or inherited)
Plant ANatomical entity (PAN)	collective plant structure	0	0.01555	--	DIRECT
Plant ANatomical entity (PAN)	vegetative bud	0.000000007019	2.901	--	DIRECT
Plant ANatomical entity (PAN)	axillary vegetative bud	0.000000007019	2.901	--	DIRECT
Plant ANatomical entity (PAN)	axillary bud	0.000000141	2.901	--	DIRECT
Plant ANatomical entity (PAN)	guard cell	0.000001445	0.2279	--	DIRECT
Plant ANatomical entity (PAN)	stomatal complex	0.000001467	0.2279	--	DIRECT
Plant ANatomical entity (PAN)	petiole	0.000001682	0.6385	--	DIRECT
Plant ANatomical entity (PAN)	shoot epidermal cell	0.000001716	0.227	--	DIRECT
Plant ANatomical entity (PAN)	pedicel	0.000004091	0.5373	--	DIRECT
Plant ANatomical entity (PAN)	inflorescence branch	0.000004142	0.5373	--	DIRECT
Plant ANatomical entity (PAN)	inflorescence axis	0.00000458	0.5373	--	DIRECT
Plant ANatomical entity (PAN)	portion of plant tissue	0.00001135	0.1621	--	DIRECT
Plant ANatomical entity (PAN)	plant embryo axis	0.00002449	2.6	--	DIRECT
Plant ANatomical entity (PAN)	carpel	0.00003553	0.5117	--	DIRECT
Plant ANatomical entity (PAN)	gamete	0.00003636	1.333	--	DIRECT
Plant ANatomical entity (PAN)	cultured plant cell	0.00004072	2.424	--	DIRECT
Plant ANatomical entity (PAN)	plant cell	0.00005036	0.1228	--	DIRECT
Plant ANatomical entity (PAN)	in vitro plant structure	0.00005065	2.424	--	DIRECT
Plant ANatomical entity (PAN)	shoot epidermis	0.00009039	0.2224	--	DIRECT
Plant ANatomical entity (PAN)	corolla	0.0002254	0.4893	--	DIRECT
Plant ANatomical entity (PAN)	cardinal organ part	0.0003395	0.4385	--	DIRECT
Plant ANatomical entity (PAN)	cardinal part of multi-tissue plant structure	0.0003468	0.437	--	DIRECT
Plant ANatomical entity (PAN)	leaf	0.0007128	0.4282	--	DIRECT
Plant ANatomical entity (PAN)	calyx	0.0008994	0.4728	--	DIRECT
Plant ANatomical entity (PAN)	root system	0.001974	0.4584	--	INHERITED FROM: root
Plant ANatomical entity (PAN)	lamina	0.002276	0.6199	--	INHERITED FROM: leaf lamina
Plant ANatomical entity (PAN)	whole plant	0.007784	0.3507	--	INHERITED FROM: plant embryo || plant embryo axis
Plant ANatomical entity (PAN)	perianth	0.009118	0.4476	--	INHERITED FROM: corolla || sepal || calyx || petal
Plant ANatomical entity (PAN)	epidermal cell	0.0127	0.2152	--	INHERITED FROM: guard cell || shoot epidermal cell
Plant ANatomical entity (PAN)	sporophyll	0.01756	0.3985	--	INHERITED FROM: megasporophyll || carpel
Plant ANatomical entity (PAN)	shoot system	0.02968	0.05272	--	INHERITED FROM: gynoecium || petiole || axillary bud || sepal || axillary vegetative bud || leaf || vegetative bud || inflorescence axis || calyx || shoot epidermis || branch || inflorescence branch || phyllome apex || stomatal complex || pedicel || androecium || shoot epidermal cell || corolla || leaf lamina || guard cell || megasporophyll || shoot apex || carpel || petal
Plant ANatomical entity (PAN)	flower	0.05589	0.3446	--	INHERITED FROM: petal || calyx || androecium || carpel || gynoecium || corolla || sepal
Plant ANatomical entity (PAN)	collective phyllome structure	0.1226	0.3837	--	INHERITED FROM: sepal || gynoecium || corolla || petal || calyx || androecium || carpel
Plant ANatomical entity (PAN)	shoot axis	0.1453	0.3985	--	INHERITED FROM: branch || shoot apex || pedicel || inflorescence axis || inflorescence branch
Plant ANatomical entity (PAN)	epidermis	0.1667	0.2046	--	INHERITED FROM: shoot epidermal cell || shoot epidermis || stomatal complex || guard cell
Plant ANatomical entity (PAN)	plant axis	0.3055	0.3257	--	INHERITED FROM: branch || plant embryo axis || inflorescence branch || pedicel || root || shoot apex || inflorescence axis
Plant ANatomical entity (PAN)	reproductive shoot system	0.3776	0.3304	--	INHERITED FROM: sepal || gynoecium || androecium || pedicel || inflorescence branch || corolla || carpel || petal || calyx || inflorescence axis
Plant ANatomical entity (PAN)	phyllome	0.451	0.3234	--	INHERITED FROM: leaf || phyllome apex || petiole || sepal || megasporophyll || petal || carpel || leaf lamina
Plant ANatomical entity (PAN)	plant organ	0.7746	0.2391	--	INHERITED FROM: root || inflorescence axis || petiole || stalk || sepal || leaf || cardinal organ part || leaf lamina || megasporophyll || carpel || shoot apex || petal || branch || plant embryo axis || inflorescence branch || phyllome apex || pedicel
Plant ANatomical entity (PAN)	multi-tissue plant structure	0.8438	0.2335	--	INHERITED FROM: root || inflorescence axis || cardinal part of multi-tissue plant structure || sepal || stalk || petiole || leaf || leaf lamina || cardinal organ part || petal || shoot apex || carpel || megasporophyll || plant embryo axis || branch || seed || pedicel || phyllome apex || inflorescence branch
Plant ANatomical entity (PAN)	plant structure	1	0	--	INHERITED FROM: in vitro plant structure || root || calyx || inflorescence axis || collective plant structure || plant embryo || leaf || axillary vegetative bud || cardinal organ part || guard cell || megasporophyll || shoot apex || plant embryo axis || branch || inflorescence branch || portion of plant tissue || stomatal complex || vegetative bud || cardinal part of multi-tissue plant structure || petiole || stalk || gynoecium || axillary bud || sepal || leaf lamina || shoot epidermal cell || corolla || petal || plant cell || gamete || carpel || seed || shoot epidermis || cultured plant cell || phyllome apex || pedicel || androecium
Plant ANatomical entity (PAN)	collective plant organ structure	1	0.03998	--	INHERITED FROM: inflorescence axis || calyx || root || vegetative bud || leaf || axillary vegetative bud || sepal || axillary bud || gynoecium || petiole || petal || shoot apex || carpel || guard cell || megasporophyll || leaf lamina || shoot epidermal cell || corolla || pedicel || androecium || stomatal complex || phyllome apex || inflorescence branch || branch || shoot epidermis
Plant ANatomical entity (PAN)	phyllome lamina	1	0.6199	--	INHERITED FROM: leaf lamina
Plant ANatomical entity (PAN)	organ lamina	1	0.6199	--	INHERITED FROM: leaf lamina
Plant ANatomical entity (PAN)	seed	0.0000004931	0.5189	Least Informative	DIRECT
Plant ANatomical entity (PAN)	shoot apex	0.000001725	0.481	Least Informative	DIRECT
Plant ANatomical entity (PAN)	branch	0.000004142	0.5373	Least Informative	DIRECT
Plant ANatomical entity (PAN)	phyllome apex	0.00003465	0.5956	Least Informative	DIRECT
Plant ANatomical entity (PAN)	stalk	0.00004228	0.6176	Least Informative	DIRECT
Plant ANatomical entity (PAN)	gynoecium	0.00005758	0.5082	Least Informative	DIRECT
Plant ANatomical entity (PAN)	plant embryo	0.00007026	0.4978	Least Informative	DIRECT
Plant ANatomical entity (PAN)	megasporophyll	0.00008464	0.5117	Least Informative	DIRECT
Plant ANatomical entity (PAN)	petal	0.0002254	0.4893	Least Informative	DIRECT
Plant ANatomical entity (PAN)	androecium	0.0002946	0.5153	Least Informative	DIRECT
Plant ANatomical entity (PAN)	root	0.0006504	0.4679	Least Informative	DIRECT
Plant ANatomical entity (PAN)	leaf lamina	0.0008448	0.6199	Least Informative	DIRECT
Plant ANatomical entity (PAN)	sepal	0.0008994	0.4728	Least Informative	DIRECT
Plant ANatomical entity (PAN)	inflorescence	0.01814	0.4859	Least Informative	INHERITED FROM: pedicel || inflorescence axis || inflorescence branch
Plant ANatomical entity (PAN)	vascular leaf	0.7638	0.437	Least Informative	INHERITED FROM: petiole
Plant ANatomical entity (PAN)	bud	0.01703	2.202	Highly Informative	INHERITED FROM: vegetative bud || axillary bud || axillary vegetative bud
Plant structure DEvelopment stage (PDE)	sepals enclosing flower bud stage	0.00001748	2.835	--	DIRECT
Plant structure DEvelopment stage (PDE)	calyx development stage	0.00003773	2.835	--	DIRECT
Plant structure DEvelopment stage (PDE)	sporophyte vegetative stage	0.0008651	0.1593	--	DIRECT
Plant structure DEvelopment stage (PDE)	whole plant development stage	0.0009481	0.1547	--	DIRECT
Plant structure DEvelopment stage (PDE)	floral organ differentiation stage	0.001087	0.07163	--	INHERITED FROM: calyx development stage || sepals enclosing flower bud stage
Plant structure DEvelopment stage (PDE)	collective phyllome structure development stage	0.001087	0.07163	--	INHERITED FROM: calyx development stage || sepals enclosing flower bud stage
Plant structure DEvelopment stage (PDE)	floral organ formation stage	0.001087	0.07163	--	INHERITED FROM: sepals enclosing flower bud stage || calyx development stage
Plant structure DEvelopment stage (PDE)	plant embryo stage	0.001646	0.2319	--	INHERITED FROM: D bilateral stage || F mature embryo stage || E expanded cotyledon stage
Plant structure DEvelopment stage (PDE)	phyllome development stage	0.002083	0.3879	--	INHERITED FROM: 4 leaf senescence stage
Plant structure DEvelopment stage (PDE)	plant organ development stage	0.002562	0.06127	--	INHERITED FROM: calyx development stage || sepals enclosing flower bud stage || 4 leaf senescence stage
Plant structure DEvelopment stage (PDE)	reproductive shoot system development stage	0.0934	0.0371	--	INHERITED FROM: calyx development stage || sepals enclosing flower bud stage
Plant structure DEvelopment stage (PDE)	collective plant organ structure development stage	0.1388	0.0282	--	INHERITED FROM: calyx development stage || 4 leaf senescence stage || sepals enclosing flower bud stage
Plant structure DEvelopment stage (PDE)	sepal differentiation and expansion stage	1	2.835	--	INHERITED FROM: sepals enclosing flower bud stage
Plant structure DEvelopment stage (PDE)	leaf development stage	1	0.3879	--	INHERITED FROM: 4 leaf senescence stage
Plant structure DEvelopment stage (PDE)	flower development stage	1	0.05402	--	INHERITED FROM: calyx development stage || sepals enclosing flower bud stage
Plant structure DEvelopment stage (PDE)	life of whole plant stage	1	0.1584	--	INHERITED FROM: sporophyte vegetative stage || E expanded cotyledon stage || F mature embryo stage || D bilateral stage
Plant structure DEvelopment stage (PDE)	shoot system development stage	1	0.02956	--	INHERITED FROM: calyx development stage || 4 leaf senescence stage || sepals enclosing flower bud stage
Plant structure DEvelopment stage (PDE)	sporophyte development stage	1	0.1584	--	INHERITED FROM: E expanded cotyledon stage || sporophyte vegetative stage || D bilateral stage || F mature embryo stage
Plant structure DEvelopment stage (PDE)	E expanded cotyledon stage	0.000002108	0.2861	Least Informative	DIRECT
Plant structure DEvelopment stage (PDE)	F mature embryo stage	0.000004237	0.3205	Least Informative	DIRECT
Plant structure DEvelopment stage (PDE)	D bilateral stage	0.00001015	0.301	Least Informative	DIRECT
Plant structure DEvelopment stage (PDE)	4 leaf senescence stage	0.0001038	0.3895	Least Informative	DIRECT

---

Enzyme Commission (EC)

Highlighted in gray are those with FDR_all>0.001

	EC term	FDR (all)	IC level	SDEC level	Annotation (direct or inherited)
Enzyme Commission (EC)	[Histone H3]-lysine(4) N-trimethyltransferase	0	2.628	--	DIRECT
Enzyme Commission (EC)	Polynucleotide adenylyltransferase	0	2.385	--	DIRECT
Enzyme Commission (EC)	RNA uridylyltransferase	0	2.753	--	DIRECT
Enzyme Commission (EC)	Phosphoinositide 5-phosphatase	0	2.628	--	DIRECT
Enzyme Commission (EC)	Cis-trans-isomerases	0	2.151	--	DIRECT
Enzyme Commission (EC)	Peptidylprolyl isomerase	0	2.23	--	DIRECT
Enzyme Commission (EC)	tRNA (carboxymethyluridine(34)-5-O)-methyltransferase	3.693e-16	2.929	--	DIRECT
Enzyme Commission (EC)	Poly(A)-specific ribonuclease	7.357e-16	2.531	--	DIRECT
Enzyme Commission (EC)	RNA helicase	0.0002457	1.711	--	DIRECT
Enzyme Commission (EC)	Transferring phosphorus-containing groups	0.5495	0.7021	--	INHERITED FROM: Polynucleotide adenylyltransferase || RNA uridylyltransferase
Enzyme Commission (EC)	Hydrolases	0.08217	0.4043	Least Informative	INHERITED FROM: Acting on ester bonds || Poly(A)-specific ribonuclease || Phosphoinositide 5-phosphatase || RNA helicase || Exoribonucleases producing 5'-phosphomonoesters
Enzyme Commission (EC)	Transferases	0.2117	0.3972	Least Informative	INHERITED FROM: Transferring one-carbon groups || [Histone H3]-lysine(4) N-trimethyltransferase || Polynucleotide adenylyltransferase || RNA uridylyltransferase || Methyltransferases || tRNA (carboxymethyluridine(34)-5-O)-methyltransferase
Enzyme Commission (EC)	Isomerases	0.0000000001247	1.026	Moderately Informative	DIRECT
Enzyme Commission (EC)	Acting on ester bonds	0.00001779	0.8756	Moderately Informative	DIRECT
Enzyme Commission (EC)	Transferring one-carbon groups	0.00008862	1.161	Moderately Informative	DIRECT
Enzyme Commission (EC)	Nucleotidyltransferases	0.02409	1.126	Moderately Informative	INHERITED FROM: Polynucleotide adenylyltransferase || RNA uridylyltransferase
Enzyme Commission (EC)	Acting on acid anhydrides	0.2346	1.133	Moderately Informative	INHERITED FROM: RNA helicase
Enzyme Commission (EC)	Methyltransferases	0.000000498	1.257	Informative	DIRECT
Enzyme Commission (EC)	Acting on ATP; involved in cellular and subcellular movement	0.01106	1.385	Informative	INHERITED FROM: RNA helicase
Enzyme Commission (EC)	Phosphoric monoester hydrolases	0.01701	1.338	Informative	INHERITED FROM: Phosphoinositide 5-phosphatase
Enzyme Commission (EC)	Exoribonucleases producing 5'-phosphomonoesters	0.00000001657	1.951	Highly Informative	DIRECT
Enzyme Commission (EC)	Cis-trans isomerases	1	2.151	Highly Informative	INHERITED FROM: Peptidylprolyl isomerase

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UniProtKB KeyWords (KW)

Highlighted in gray are those with FDR_all>0.001

	KW term	FDR (all)	IC level	SDKW level	Annotation (direct or inherited)
Post-translational modification	RNA-binding	0	1.431	Informative	DIRECT

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