FAD-linked oxidases, C-terminal domain superfamily

SCOP classification

• Root: SCOP hierarchy in SUPERFAMILY [ 0] (11)
• Class: Alpha and beta proteins (a+b) [ 53931] (376)
• Fold: Ferredoxin-like [ 54861] (59)
• Superfamily: FAD-linked oxidases, C-terminal domain [ 55103] (4)
• Families:
  • Vanillyl-alcohol oxidase-like [ 55104] (2)
  • D-lactate dehydrogenase [ 55109]
  • Cholesterol oxidase [ 64284]
  • Cytokinin dehydrogenase 1 [ 110990]

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Superfamily statistics

	Genomes (2,318)	Uniprot 2018_03 genome	PDB chains (SCOP 1.75)
Domains	8,638	65,512	15
Proteins	8,545	64,933	15

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Functional annotation

• General category: Metabolism
• Detailed category: Redox

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Enzyme Commission (EC)

Highlighted in gray are those with FDR_all>0.001

	EC term	FDR (all)	IC level	SDEO level	Annotation (direct or inherited)
Enzyme Commission (EC)	Alkylglycerone-phosphate synthase	0	2.259	--	DIRECT
Enzyme Commission (EC)	D-lactate dehydrogenase (cytochrome)	0	2.259	--	DIRECT
Enzyme Commission (EC)	Cytokinin dehydrogenase	0	2.259	--	DIRECT
Enzyme Commission (EC)	Transferring alkyl or aryl groups, other than meth	0.000005662	1.041	--	DIRECT
Enzyme Commission (EC)	Transferases	1	0	--	INHERITED FROM: Alkylglycerone-phosphate synthase || Transferring alkyl or aryl groups, other than meth
Enzyme Commission (EC)	Acting on the CH-OH group of donors	0.2332	0.8787	--	INHERITED FROM: D-lactate dehydrogenase (cytochrome) || With a cytochrome as acceptor
Enzyme Commission (EC)	Oxidoreductases	0	0.2975	Least Informative	DIRECT
Enzyme Commission (EC)	Acting on the CH-NH group of donors	0	1.198	Moderately Informative	DIRECT
Enzyme Commission (EC)	Transferring alkyl or aryl groups, other than meth	1	1.041	Moderately Informative	INHERITED FROM: Alkylglycerone-phosphate synthase
Enzyme Commission (EC)	With other acceptors	0	1.715	Informative	DIRECT
Enzyme Commission (EC)	With a cytochrome as acceptor	0.000000000000002328	1.958	Highly Informative	DIRECT

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Human Phenotype (HP)

Highlighted in gray are those with FDR_all>0.001

	HP term	FDR (all)	IC level	SDHP level	Annotation (direct or inherited)
Mode of Inheritance (MI)	Autosomal recessive inheritance	0	0.1924	--	DIRECT
Phenotypic Abnormality (PA)	Abnormality of the skeletal system	0	0.4621	--	DIRECT
Phenotypic Abnormality (PA)	Abnormality of skeletal morphology	0	0.472	Least Informative	DIRECT

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Worm Phenotype (WP)

Highlighted in gray are those with FDR_all>0.001

	WP term	FDR (all)	IC level	SDWP level	Annotation (direct or inherited)
Worm Phenotype (WP)	growth variant	0	0.4022	--	DIRECT
Worm Phenotype (WP)	slow growth	0	0.5903	--	DIRECT
Worm Phenotype (WP)	developmental timing variant	0	0.5373	--	DIRECT
Worm Phenotype (WP)	postembryonic development variant	0	0.3347	--	DIRECT
Worm Phenotype (WP)	embryonic lethal	0	0.07108	--	DIRECT
Worm Phenotype (WP)	larval arrest	0	0.5677	--	DIRECT
Worm Phenotype (WP)	lethal	0	0.01121	--	DIRECT
Worm Phenotype (WP)	progeny variant	0	0.7582	--	DIRECT
Worm Phenotype (WP)	fertility variant	0	0.08329	--	DIRECT
Worm Phenotype (WP)	development variant	0	0.001706	--	DIRECT
Worm Phenotype (WP)	morphology variant	0	0.06117	--	DIRECT
Worm Phenotype (WP)	organism development variant	0	0.004279	--	DIRECT
Worm Phenotype (WP)	organism morphology variant	0	0.2011	--	DIRECT
Worm Phenotype (WP)	organ system physiology variant	0	0.05921	--	DIRECT
Worm Phenotype (WP)	organism physiology variant	0	0.1405	--	DIRECT
Worm Phenotype (WP)	organism homeostasis metabolism variant	0	0.1501	--	DIRECT
Worm Phenotype (WP)	reproductive system physiology variant	0	0.07209	--	DIRECT
Worm Phenotype (WP)	maternal sterile	0	0.171	--	DIRECT
Worm Phenotype (WP)	hermaphrodite sterile	0	0.1685	--	DIRECT
Worm Phenotype (WP)	embryonic development variant	0	0.06709	--	DIRECT
Worm Phenotype (WP)	hermaphrodite fertility variant	0	0.1278	--	DIRECT
Worm Phenotype (WP)	developmental growth variant	0	0.5677	--	DIRECT
Worm Phenotype (WP)	hermaphrodite fertility reduced	0	0.1672	--	DIRECT
Worm Phenotype (WP)	fertility reduced	0	0.09267	--	DIRECT
Worm Phenotype (WP)	physiology variant	1	0	--	INHERITED FROM: hermaphrodite fertility variant || developmental growth variant || retarded heterochronic variations || larval lethal || reproductive system physiology variant || organism homeostasis metabolism variant || lethal || larval development variant || sterile progeny || organism physiology variant || progeny variant || slow growth || development variant || developmental timing variant || hermaphrodite sterile || growth variant || hermaphrodite fertility reduced || embryonic development variant || embryonic lethal || larval growth variant || general pace of development variant || fertility variant || postembryonic development variant || larval arrest || organ system physiology variant || maternal sterile || organism development variant || fertility reduced
Worm Phenotype (WP)	sterile	1	0.161	--	INHERITED FROM: hermaphrodite sterile || maternal sterile || sterile progeny
Worm Phenotype (WP)	general pace of development variant	0	0.5708	Least Informative	DIRECT
Worm Phenotype (WP)	larval lethal	0	0.6947	Least Informative	DIRECT
Worm Phenotype (WP)	retarded heterochronic variations	0	0.5373	Least Informative	DIRECT
Worm Phenotype (WP)	larval development variant	0	0.5007	Least Informative	DIRECT
Worm Phenotype (WP)	larval growth variant	0	0.5677	Least Informative	DIRECT
Worm Phenotype (WP)	sterile progeny	0	0.7582	Moderately Informative	DIRECT

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Yeast Phenotype (YP)

Highlighted in gray are those with FDR_all>0.001

	YP term	FDR (all)	IC level	SDYP level	Annotation (direct or inherited)
Yeast Phenotype (YP)	competitive fitness	0	0.1389	--	DIRECT
Yeast Phenotype (YP)	fitness	0	0.1328	--	DIRECT
Yeast Phenotype (YP)	metabolism and growth	0	0.5905	Least Informative	DIRECT
Yeast Phenotype (YP)	chemical compound accumulation	0	1.295	Informative	DIRECT

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Arabidopsis Plant Ontology (AP)

Highlighted in gray are those with FDR_all>0.001

	AP term	FDR (all)	IC level	SDAP level	Annotation (direct or inherited)
Plant ANatomical entity (PAN)	collective plant structure	0	0.01577	--	DIRECT
Plant ANatomical entity (PAN)	shoot system	0	0.05747	--	DIRECT
Plant ANatomical entity (PAN)	plant structure	1	0	--	INHERITED FROM: collective plant structure || shoot system
Plant ANatomical entity (PAN)	collective plant organ structure	1	0.04502	--	INHERITED FROM: shoot system
Plant structure DEvelopment stage (PDE)	collective phyllome structure development stage	0	0.0937	--	DIRECT
Plant structure DEvelopment stage (PDE)	reproductive shoot system development stage	0	0.05008	--	DIRECT
Plant structure DEvelopment stage (PDE)	floral organ differentiation stage	0	0.0937	--	DIRECT
Plant structure DEvelopment stage (PDE)	collective plant organ structure development stage	0	0.03771	--	DIRECT
Plant structure DEvelopment stage (PDE)	floral organ formation stage	0	0.0937	--	DIRECT
Plant structure DEvelopment stage (PDE)	corolla development stage	0	0.1981	--	DIRECT
Plant structure DEvelopment stage (PDE)	flowering stage	0	0.2162	--	DIRECT
Plant structure DEvelopment stage (PDE)	plant organ development stage	0	0.08108	--	DIRECT
Plant structure DEvelopment stage (PDE)	shoot system development stage	1	0.04053	--	INHERITED FROM: reproductive shoot system development stage || floral organ formation stage || floral organ differentiation stage || flowering stage || corolla development stage || plant organ development stage
Plant structure DEvelopment stage (PDE)	flower development stage	1	0.07083	--	INHERITED FROM: corolla development stage || flowering stage || floral organ differentiation stage || floral organ formation stage

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Enzyme Commission (EC)

Highlighted in gray are those with FDR_all>0.001

	EC term	FDR (all)	IC level	SDEC level	Annotation (direct or inherited)
Enzyme Commission (EC)	With a cytochrome as acceptor	0	2.253	--	DIRECT
Enzyme Commission (EC)	D-lactate dehydrogenase (cytochrome)	0	2.651	--	DIRECT
Enzyme Commission (EC)	With other acceptors	0	2.651	--	DIRECT
Enzyme Commission (EC)	Cytokinin dehydrogenase	0	2.952	--	DIRECT
Enzyme Commission (EC)	Alkylglycerone-phosphate synthase	0	2.651	--	DIRECT
Enzyme Commission (EC)	D-lactate dehydrogenase (quinone)	0.00000000000003486	2.651	--	DIRECT
Enzyme Commission (EC)	With other acceptors	0.0000002273	2.253	--	DIRECT
Enzyme Commission (EC)	D-2-hydroxyglutarate dehydrogenase	0.000004963	2.651	--	DIRECT
Enzyme Commission (EC)	Transferring alkyl or aryl groups, other than methyl groups	0.00001727	1.318	--	DIRECT
Enzyme Commission (EC)	Transferases	1	0.3035	--	INHERITED FROM: Transferring alkyl or aryl groups, other than methyl groups || Alkylglycerone-phosphate synthase
Enzyme Commission (EC)	Oxidoreductases	0	0.6234	Least Informative	DIRECT
Enzyme Commission (EC)	Acting on the CH-OH group of donors	0.001324	1.228	Moderately Informative	INHERITED FROM: D-lactate dehydrogenase (quinone) || With other acceptors || D-2-hydroxyglutarate dehydrogenase || D-lactate dehydrogenase (cytochrome) || With a cytochrome as acceptor
Enzyme Commission (EC)	Acting on the CH-NH group of donors	0	1.505	Informative	DIRECT
Enzyme Commission (EC)	Transferring alkyl or aryl groups, other than methyl groups	1	1.329	Informative	INHERITED FROM: Alkylglycerone-phosphate synthase
Enzyme Commission (EC)	With a quinone or similar compound as acceptor	0.00889	2.107	Highly Informative	INHERITED FROM: D-lactate dehydrogenase (quinone)

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