Hedgehog (development protein), N-terminal signaling domain family

SCOP classification

• Root: SCOP hierarchy in SUPERFAMILY [ 0] (11)
• Class: Alpha and beta proteins (a+b) [ 53931] (376)
• Fold: Hedgehog/DD-peptidase [ 55165]
• Superfamily: Hedgehog/DD-peptidase [ 55166] (5)
• Family: Hedgehog (development protein), N-terminal signaling domain [ 55170] (2)

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Family statistics

	Genomes (117)	Uniprot 2018_03 genome	PDB chains (SCOP 1.75)
Domains	287	790	3
Proteins	286	785	3

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Human Phenotype (HP)

Highlighted in gray are those with FDR_all>0.001

	HP term	FDR (all)	IC level	SDHP level	Annotation (direct or inherited)
Phenotypic Abnormality (PA)	Abnormality of the foot	0	1.082	--	DIRECT
Phenotypic Abnormality (PA)	Abnormality of limbs	0	0.6429	Least Informative	DIRECT
Phenotypic Abnormality (PA)	Abnormality of the lower limb	0	0.9309	Moderately Informative	DIRECT

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Mouse Phenotype (MP)

Highlighted in gray are those with FDR_all>0.001

	MP term	FDR (all)	IC level	SDMP level	Annotation (direct or inherited)
Mammalian Phenotype (MP)	abnormal gland morphology	0	0.7519	--	DIRECT
Mammalian Phenotype (MP)	abnormal nervous system morphology	0	0.5861	--	DIRECT
Mammalian Phenotype (MP)	digestive/alimentary phenotype	0	0.9404	--	DIRECT
Mammalian Phenotype (MP)	nervous system phenotype	0	0.4959	Least Informative	DIRECT
Mammalian Phenotype (MP)	endocrine/exocrine gland phenotype	0	0.6947	Least Informative	DIRECT
Mammalian Phenotype (MP)	cellular phenotype	0	0.5387	Least Informative	DIRECT
Mammalian Phenotype (MP)	abnormal digestive system morphology	0	1.023	Moderately Informative	DIRECT

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Zebrafish Anatomy (ZA)

Highlighted in gray are those with FDR_all>0.001

	ZA term	FDR (all)	IC level	SDZA level	Annotation (direct or inherited)
Zebrafish Anatomy (ZA)	whole organism	0	0.00147	--	DIRECT
Zebrafish Anatomy (ZA)	anatomical structure	1	0	--	INHERITED FROM: whole organism

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Xenopus Anatomy (XA)

Highlighted in gray are those with FDR_all>0.001

	XA term	FDR (all)	IC level	SDXA level	Annotation (direct or inherited)
Xenopus ANatomical entity (XAN)	retinal pigmented epithelium	0	2.865	--	DIRECT
Xenopus ANatomical entity (XAN)	compound organ	0	0.2177	--	DIRECT
Xenopus ANatomical entity (XAN)	primary germ layer	0	0.6748	--	DIRECT
Xenopus ANatomical entity (XAN)	trunk region	0	0.388	--	DIRECT
Xenopus ANatomical entity (XAN)	head region	0	0.4759	--	DIRECT
Xenopus ANatomical entity (XAN)	anatomical group	0	0.1408	--	DIRECT
Xenopus ANatomical entity (XAN)	organism subdivision	0	0.1679	--	DIRECT
Xenopus ANatomical entity (XAN)	pharyngeal arch	0	1.689	--	DIRECT
Xenopus ANatomical entity (XAN)	anatomical structure	0	0	--	DIRECT
Xenopus ANatomical entity (XAN)	marginal zone	0	1.786	--	DIRECT
Xenopus ANatomical entity (XAN)	intestine	0	1.242	--	DIRECT
Xenopus ANatomical entity (XAN)	visual system	0	1.321	--	DIRECT
Xenopus ANatomical entity (XAN)	multicellular anatomical structure	0	0.1131	--	DIRECT
Xenopus ANatomical entity (XAN)	anatomical region	0	0.1803	--	DIRECT
Xenopus ANatomical entity (XAN)	retina	0	1.689	--	DIRECT
Xenopus ANatomical entity (XAN)	neural plate	0	1.635	--	DIRECT
Xenopus ANatomical entity (XAN)	central nervous system	0	0.5841	--	DIRECT
Xenopus ANatomical entity (XAN)	anatomical system	1	0.283	--	INHERITED FROM: retina || alimentary system || hindbrain || retinal pigmented epithelium || intestine || nervous system || brain || sensory system || central nervous system || eye || visual system
Xenopus ANatomical entity (XAN)	whole organism	1	0.0884	--	INHERITED FROM: neural plate || head region || brain || intestine || nervous system || retina || alimentary system || retinal pigmented epithelium || hindbrain || anatomical group || cavitated compound organ || multicellular anatomical structure || mesoderm || ectoderm || compound organ || trunk || tissue || anatomical region || marginal zone || central nervous system || epithelium || pharyngeal region || visual system || trunk region || eye || anatomical cluster || viscus || sensory system || pharyngeal arch || multi-tissue structure || neuroectoderm || organism subdivision || embryonic structure || head || primary germ layer
Xenopus ANatomical entity (XAN)	embryo	0	0.5979	Least Informative	DIRECT
Xenopus ANatomical entity (XAN)	nervous system	0	0.5619	Least Informative	DIRECT
Xenopus ANatomical entity (XAN)	trunk	0	0.3894	Least Informative	DIRECT
Xenopus ANatomical entity (XAN)	cavitated compound organ	0	0.2685	Least Informative	DIRECT
Xenopus ANatomical entity (XAN)	tissue	0	0.4672	Least Informative	DIRECT
Xenopus ANatomical entity (XAN)	anatomical cluster	0	0.7159	Least Informative	DIRECT
Xenopus ANatomical entity (XAN)	head	0	0.4777	Least Informative	DIRECT
Xenopus ANatomical entity (XAN)	multi-tissue structure	0	1.066	Moderately Informative	DIRECT
Xenopus ANatomical entity (XAN)	sensory system	0	1.158	Moderately Informative	DIRECT
Xenopus ANatomical entity (XAN)	embryonic structure	0	1.149	Moderately Informative	DIRECT
Xenopus ANatomical entity (XAN)	brain	0	0.7859	Moderately Informative	DIRECT
Xenopus ANatomical entity (XAN)	viscus	0	0.8828	Moderately Informative	DIRECT
Xenopus ANatomical entity (XAN)	ectoderm	0	0.9357	Moderately Informative	DIRECT
Xenopus ANatomical entity (XAN)	alimentary system	0	0.8739	Moderately Informative	DIRECT
Xenopus ANatomical entity (XAN)	neuroectoderm	0	1.374	Informative	DIRECT
Xenopus ANatomical entity (XAN)	epithelium	0	1.586	Informative	DIRECT
Xenopus ANatomical entity (XAN)	eye	0	1.403	Informative	DIRECT
Xenopus ANatomical entity (XAN)	pharyngeal region	0	1.467	Informative	DIRECT
Xenopus ANatomical entity (XAN)	mesoderm	0	1.285	Informative	DIRECT
Xenopus ANatomical entity (XAN)	hindbrain	0	1.824	Highly Informative	DIRECT
Xenopus DEvelopment stage (XDE)	NF stage 10	0	2.183	--	DIRECT
Xenopus DEvelopment stage (XDE)	NF stage	0	0.01895	--	DIRECT
Xenopus DEvelopment stage (XDE)	embryonic stage	0	1.006	Moderately Informative	DIRECT
Xenopus DEvelopment stage (XDE)	gastrula stage	0	1.83	Highly Informative	DIRECT

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