FAD/NAD-linked reductases, dimerisation (C-terminal) domain family

SCOP classification

• Root: SCOP hierarchy in SUPERFAMILY [ 0] (11)
• Class: Alpha and beta proteins (a+b) [ 53931] (376)
• Fold: CO dehydrogenase flavoprotein C-domain-like [ 55423] (2)
• Superfamily: FAD/NAD-linked reductases, dimerisation (C-terminal) domain [ 55424]
• Family: FAD/NAD-linked reductases, dimerisation (C-terminal) domain [ 55425] (11)

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Family statistics

	Genomes (2,705)	Uniprot 2018_03 genome	PDB chains (SCOP 1.75)
Domains	6,446	43,717	38
Proteins	6,440	43,708	38

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Enzyme Commission (EC)

Highlighted in gray are those with FDR_all>0.001

	EC term	FDR (all)	IC level	SDEO level	Annotation (direct or inherited)
Enzyme Commission (EC)	Mercury(II) reductase	0	2.264	--	DIRECT
Enzyme Commission (EC)	With NAD(+) or NADP(+) as acceptor	0	1.7	--	DIRECT
Enzyme Commission (EC)	Dihydrolipoyl dehydrogenase	0	2.44	--	DIRECT
Enzyme Commission (EC)	NAD(P)(+) transhydrogenase (B-specific)	0	2.44	--	DIRECT
Enzyme Commission (EC)	Acting on NADH or NADPH	0	1.31	--	DIRECT
Enzyme Commission (EC)	Ferredoxin--NAD(+) reductase	0.000000000001109	2.44	--	DIRECT
Enzyme Commission (EC)	Glutathione-disulfide reductase	0.0000000001867	2.44	--	DIRECT
Enzyme Commission (EC)	Oxidizing metal ions	0.00000000194	1.896	--	DIRECT
Enzyme Commission (EC)	Monodehydroascorbate reductase (NADH)	0.000000007331	2.44	--	DIRECT
Enzyme Commission (EC)	Acting on iron-sulfur proteins as donors	0.0000000175	1.838	--	DIRECT
Enzyme Commission (EC)	CoA-disulfide reductase	0.000008024	2.44	--	DIRECT
Enzyme Commission (EC)	Oxidoreductases	0	0.3212	Least Informative	DIRECT
Enzyme Commission (EC)	Acting on a sulfur group of donors	0	1.361	Informative	DIRECT
Enzyme Commission (EC)	With other acceptors	1	1.627	Informative	INHERITED FROM: NADH dehydrogenase
Enzyme Commission (EC)	With a quinone or similar compound as acceptor	0.3295	1.595	Informative	INHERITED FROM: Monodehydroascorbate reductase (NADH)
Enzyme Commission (EC)	With NAD(+) or NADP(+) as acceptor	0	2.042	Highly Informative	DIRECT
Enzyme Commission (EC)	With NAD(+) or NADP(+) as acceptor	0	2.042	Highly Informative	DIRECT
Enzyme Commission (EC)	With NAD(+) or NADP(+) as acceptor	0	1.963	Highly Informative	DIRECT
Enzyme Commission (EC)	NADH dehydrogenase	0.000000001212	1.896	Highly Informative	DIRECT

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Human Phenotype (HP)

Highlighted in gray are those with FDR_all>0.001

	HP term	FDR (all)	IC level	SDHP level	Annotation (direct or inherited)
Phenotypic Abnormality (PA)	Abnormality of the nervous system	0	0.2371	--	DIRECT
Phenotypic Abnormality (PA)	Upper motor neuron dysfunction	0	1.286	--	DIRECT
Phenotypic Abnormality (PA)	Abdominal symptom	0	1.161	--	DIRECT
Phenotypic Abnormality (PA)	Abnormal muscle physiology	0	0.6915	--	DIRECT
Phenotypic Abnormality (PA)	Neurodevelopmental abnormality	0	0.7381	--	DIRECT
Phenotypic Abnormality (PA)	Abnormality of metabolism/homeostasis	0	0.5486	Least Informative	DIRECT
Phenotypic Abnormality (PA)	Abnormality of the musculature	0	0.5433	Least Informative	DIRECT
Phenotypic Abnormality (PA)	Abnormality of nervous system physiology	0	0.3869	Least Informative	DIRECT
Phenotypic Abnormality (PA)	Abnormality of the digestive system	0	0.5759	Least Informative	DIRECT
Phenotypic Abnormality (PA)	Abnormality of central motor function	0	1.047	Moderately Informative	DIRECT
Phenotypic Abnormality (PA)	Abnormality of higher mental function	0	0.8092	Moderately Informative	DIRECT
Phenotypic Abnormality (PA)	Abnormal homeostasis	0	0.7903	Moderately Informative	DIRECT
Phenotypic Abnormality (PA)	Abnormality of digestive system physiology	0	0.9572	Moderately Informative	DIRECT
Phenotypic Abnormality (PA)	Abnormal circulating metabolite concentration	0	0.971	Moderately Informative	DIRECT
Phenotypic Abnormality (PA)	Seizures	0	1.316	Informative	DIRECT

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Worm Phenotype (WP)

Highlighted in gray are those with FDR_all>0.001

	WP term	FDR (all)	IC level	SDWP level	Annotation (direct or inherited)
Worm Phenotype (WP)	embryonic lethal	0	0.046	--	DIRECT
Worm Phenotype (WP)	lethal	0	0.00521	--	DIRECT
Worm Phenotype (WP)	fertility variant	0	0.05937	--	DIRECT
Worm Phenotype (WP)	development variant	0	0.001482	--	DIRECT
Worm Phenotype (WP)	organism development variant	0	0.00297	--	DIRECT
Worm Phenotype (WP)	organ system physiology variant	0	0.04518	--	DIRECT
Worm Phenotype (WP)	organism physiology variant	0	0.1342	--	DIRECT
Worm Phenotype (WP)	organism homeostasis metabolism variant	0	0.1444	--	DIRECT
Worm Phenotype (WP)	reproductive system physiology variant	0	0.05515	--	DIRECT
Worm Phenotype (WP)	maternal sterile	0	0.1213	--	DIRECT
Worm Phenotype (WP)	hermaphrodite sterile	0	0.1203	--	DIRECT
Worm Phenotype (WP)	embryonic development variant	0	0.04518	--	DIRECT
Worm Phenotype (WP)	hermaphrodite fertility variant	0	0.0947	--	DIRECT
Worm Phenotype (WP)	hermaphrodite fertility reduced	0	0.1193	--	DIRECT
Worm Phenotype (WP)	fertility reduced	0	0.06449	--	DIRECT
Worm Phenotype (WP)	organism toxic chemical response variant	0.00000573	1.924	--	DIRECT
Worm Phenotype (WP)	pesticide response variant	0.00001047	1.769	--	DIRECT
Worm Phenotype (WP)	organism oxidative stress response variant	0.00003231	1.924	--	DIRECT
Worm Phenotype (WP)	physiology variant	1	0	--	INHERITED FROM: hermaphrodite fertility variant || pesticide response variant || organism metabolism processing variant || reproductive system physiology variant || organism homeostasis metabolism variant || paraquat response variant || lethal || organism physiology variant || development variant || organism oxidative stress response variant || hermaphrodite sterile || hermaphrodite fertility reduced || embryonic development variant || organism toxic chemical response variant || embryonic lethal || fertility variant || organ system physiology variant || maternal sterile || organism development variant || fertility reduced
Worm Phenotype (WP)	sterile	1	0.1135	--	INHERITED FROM: hermaphrodite sterile || maternal sterile
Worm Phenotype (WP)	organism metabolism processing variant	0	0.4899	Least Informative	DIRECT
Worm Phenotype (WP)	organism environmental stimulus response variant	0.1394	0.6614	Least Informative	INHERITED FROM: pesticide response variant || paraquat response variant || organism toxic chemical response variant || organism oxidative stress response variant
Worm Phenotype (WP)	chemical response variant	0.01501	0.9053	Moderately Informative	INHERITED FROM: paraquat response variant || organism toxic chemical response variant
Worm Phenotype (WP)	organism stress response variant	0.0181	0.9693	Moderately Informative	INHERITED FROM: organism oxidative stress response variant || paraquat response variant
Worm Phenotype (WP)	paraquat response variant	0.000003309	1.924	Highly Informative	DIRECT

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Yeast Phenotype (YP)

Highlighted in gray are those with FDR_all>0.001

	YP term	FDR (all)	IC level	SDYP level	Annotation (direct or inherited)
Yeast Phenotype (YP)	cellular processes	0	0.09186	--	DIRECT
Yeast Phenotype (YP)	stress resistance	0	0.1452	--	DIRECT
Yeast Phenotype (YP)	competitive fitness	0	0.1116	--	DIRECT
Yeast Phenotype (YP)	fitness	0	0.1096	--	DIRECT
Yeast Phenotype (YP)	resistance to chemicals	0	0.3202	Least Informative	DIRECT
Yeast Phenotype (YP)	metabolism and growth	0	0.5867	Least Informative	DIRECT

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Xenopus Anatomy (XA)

Highlighted in gray are those with FDR_all>0.001

	XA term	FDR (all)	IC level	SDXA level	Annotation (direct or inherited)
Xenopus ANatomical entity (XAN)	anatomical structure	0	0	--	DIRECT
Xenopus ANatomical entity (XAN)	multicellular anatomical structure	0	0.1131	--	DIRECT
Xenopus ANatomical entity (XAN)	whole organism	1	0.0884	--	INHERITED FROM: multicellular anatomical structure
Xenopus DEvelopment stage (XDE)	NF stage	0	0.01895	--	DIRECT

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Arabidopsis Plant Ontology (AP)

Highlighted in gray are those with FDR_all>0.001

	AP term	FDR (all)	IC level	SDAP level	Annotation (direct or inherited)
Plant ANatomical entity (PAN)	whole plant	0	0.3507	--	DIRECT
Plant ANatomical entity (PAN)	cauline leaf	0	0.6042	--	DIRECT
Plant ANatomical entity (PAN)	inflorescence meristem	0	0.6337	--	DIRECT
Plant ANatomical entity (PAN)	guard cell	0	0.2279	--	DIRECT
Plant ANatomical entity (PAN)	stomatal complex	0	0.2279	--	DIRECT
Plant ANatomical entity (PAN)	epidermal cell	0	0.2152	--	DIRECT
Plant ANatomical entity (PAN)	epidermis	0	0.2046	--	DIRECT
Plant ANatomical entity (PAN)	phyllome	0	0.3234	--	DIRECT
Plant ANatomical entity (PAN)	shoot epidermis	0	0.2224	--	DIRECT
Plant ANatomical entity (PAN)	plant cell	0	0.1228	--	DIRECT
Plant ANatomical entity (PAN)	shoot system	0	0.05272	--	DIRECT
Plant ANatomical entity (PAN)	portion of plant tissue	0	0.1621	--	DIRECT
Plant ANatomical entity (PAN)	plant organ	0	0.2391	--	DIRECT
Plant ANatomical entity (PAN)	sporophyll	0	0.3985	--	DIRECT
Plant ANatomical entity (PAN)	stamen	0	0.5171	--	DIRECT
Plant ANatomical entity (PAN)	flower	0	0.3446	--	DIRECT
Plant ANatomical entity (PAN)	perianth	0	0.4476	--	DIRECT
Plant ANatomical entity (PAN)	calyx	0	0.4728	--	DIRECT
Plant ANatomical entity (PAN)	cotyledon	0	0.6432	--	DIRECT
Plant ANatomical entity (PAN)	leaf apex	0	0.5999	--	DIRECT
Plant ANatomical entity (PAN)	stem internode	0	0.5373	--	DIRECT
Plant ANatomical entity (PAN)	cardinal organ part	0	0.4385	--	DIRECT
Plant ANatomical entity (PAN)	plant axis	0	0.3257	--	DIRECT
Plant ANatomical entity (PAN)	collective phyllome structure	0	0.3837	--	DIRECT
Plant ANatomical entity (PAN)	root system	0	0.4584	--	DIRECT
Plant ANatomical entity (PAN)	shoot axis	0	0.3985	--	DIRECT
Plant ANatomical entity (PAN)	leaf	0	0.4282	--	DIRECT
Plant ANatomical entity (PAN)	reproductive shoot system	0	0.3304	--	DIRECT
Plant ANatomical entity (PAN)	shoot epidermal cell	0	0.227	--	DIRECT
Plant ANatomical entity (PAN)	microsporangium	0	0.6705	--	DIRECT
Plant ANatomical entity (PAN)	pollen sac	0	0.673	--	DIRECT
Plant ANatomical entity (PAN)	pollen	0	0.673	--	DIRECT
Plant ANatomical entity (PAN)	multi-tissue plant structure	0	0.2335	--	DIRECT
Plant ANatomical entity (PAN)	collective plant structure	0	0.01555	--	DIRECT
Plant ANatomical entity (PAN)	cardinal part of multi-tissue plant structure	0	0.437	--	DIRECT
Plant ANatomical entity (PAN)	plant structure	1	0	--	INHERITED FROM: perianth || root || sporophyll || calyx || flower || collective plant structure || leaf || shoot internode || phyllome || pollen sac || cardinal organ part || multi-tissue plant structure || microsporophyll || guard cell || cauline leaf || reproductive shoot system || leaf apex || collective leaf structure || stem internode || shoot system || sporangium || portion of plant tissue || stomatal complex || plant organ || portion of meristem tissue || stem || whole plant || inflorescence meristem || epidermis || root system || inflorescence || cardinal part of multi-tissue plant structure || vascular leaf || sepal || microsporangium || epidermal cell || shoot epidermal cell || pollen || plant axis || collective phyllome structure || plant cell || shoot epidermis || phyllome apex || cotyledon || stamen || shoot axis || microgametophyte || androecium
Plant ANatomical entity (PAN)	collective plant organ structure	1	0.03998	--	INHERITED FROM: calyx || flower || sporophyll || inflorescence meristem || root system || inflorescence || root || perianth || stem || leaf || phyllome || shoot internode || sepal || vascular leaf || reproductive shoot system || leaf apex || collective phyllome structure || guard cell || cauline leaf || pollen || microsporophyll || pollen sac || shoot epidermal cell || androecium || stomatal complex || phyllome apex || cotyledon || stamen || stem internode || shoot axis || shoot system || collective leaf structure || shoot epidermis
Plant ANatomical entity (PAN)	shoot internode	0	0.5373	Least Informative	DIRECT
Plant ANatomical entity (PAN)	root	0	0.4679	Least Informative	DIRECT
Plant ANatomical entity (PAN)	portion of meristem tissue	0	0.5892	Least Informative	DIRECT
Plant ANatomical entity (PAN)	vascular leaf	0	0.437	Least Informative	DIRECT
Plant ANatomical entity (PAN)	microsporophyll	0	0.4415	Least Informative	DIRECT
Plant ANatomical entity (PAN)	sepal	0	0.4728	Least Informative	DIRECT
Plant ANatomical entity (PAN)	stem	0	0.4777	Least Informative	DIRECT
Plant ANatomical entity (PAN)	inflorescence	0	0.4859	Least Informative	DIRECT
Plant ANatomical entity (PAN)	androecium	0	0.5153	Least Informative	DIRECT
Plant ANatomical entity (PAN)	collective leaf structure	0	0.46	Least Informative	DIRECT
Plant ANatomical entity (PAN)	sporangium	0	0.6679	Least Informative	DIRECT
Plant ANatomical entity (PAN)	phyllome apex	0	0.5956	Least Informative	DIRECT
Plant ANatomical entity (PAN)	microgametophyte	0	0.673	Least Informative	DIRECT
Plant structure DEvelopment stage (PDE)	whole plant development stage	0	0.1547	--	DIRECT
Plant structure DEvelopment stage (PDE)	1 main shoot growth stage	0	0.3245	--	DIRECT
Plant structure DEvelopment stage (PDE)	sporophyte vegetative stage	0	0.1593	--	DIRECT
Plant structure DEvelopment stage (PDE)	floral organ differentiation stage	0	0.07163	--	DIRECT
Plant structure DEvelopment stage (PDE)	corolla development stage	0	0.1484	--	DIRECT
Plant structure DEvelopment stage (PDE)	flowering stage	0	0.1648	--	DIRECT
Plant structure DEvelopment stage (PDE)	collective plant organ structure development stage	0	0.0282	--	DIRECT
Plant structure DEvelopment stage (PDE)	plant organ development stage	0	0.06127	--	DIRECT
Plant structure DEvelopment stage (PDE)	reproductive shoot system development stage	0	0.0371	--	DIRECT
Plant structure DEvelopment stage (PDE)	collective phyllome structure development stage	0	0.07163	--	DIRECT
Plant structure DEvelopment stage (PDE)	floral organ formation stage	0	0.07163	--	DIRECT
Plant structure DEvelopment stage (PDE)	leaf production stage	1	0.3272	--	INHERITED FROM: LP.10 ten leaves visible stage || LP.04 four leaves visible stage || LP.08 eight leaves visible stage || LP.06 six leaves visible stage
Plant structure DEvelopment stage (PDE)	flower development stage	1	0.05402	--	INHERITED FROM: corolla development stage || flowering stage || floral organ differentiation stage || floral organ formation stage
Plant structure DEvelopment stage (PDE)	life of whole plant stage	1	0.1584	--	INHERITED FROM: sporophyte vegetative stage || LP.10 ten leaves visible stage || LP.04 four leaves visible stage || LP.06 six leaves visible stage || LP.08 eight leaves visible stage || 1 main shoot growth stage
Plant structure DEvelopment stage (PDE)	shoot system development stage	1	0.02956	--	INHERITED FROM: reproductive shoot system development stage || floral organ formation stage || floral organ differentiation stage || flowering stage || corolla development stage || plant organ development stage
Plant structure DEvelopment stage (PDE)	sporophyte development stage	1	0.1584	--	INHERITED FROM: LP.08 eight leaves visible stage || LP.10 ten leaves visible stage || LP.06 six leaves visible stage || sporophyte vegetative stage || 1 main shoot growth stage || LP.04 four leaves visible stage
Plant structure DEvelopment stage (PDE)	LP.08 eight leaves visible stage	0	0.4752	Least Informative	DIRECT
Plant structure DEvelopment stage (PDE)	LP.10 ten leaves visible stage	0	0.4234	Least Informative	DIRECT
Plant structure DEvelopment stage (PDE)	LP.04 four leaves visible stage	0	0.3479	Least Informative	DIRECT
Plant structure DEvelopment stage (PDE)	LP.06 six leaves visible stage	0	0.4268	Least Informative	DIRECT
Plant structure DEvelopment stage (PDE)	seed development stage	0.000001078	1.304	Informative	DIRECT

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Enzyme Commission (EC)

Highlighted in gray are those with FDR_all>0.001

	EC term	FDR (all)	IC level	SDEC level	Annotation (direct or inherited)
Enzyme Commission (EC)	With NAD(+) or NADP(+) as acceptor	0	2.452	--	DIRECT
Enzyme Commission (EC)	Mercury(II) reductase	0	2.753	--	DIRECT
Enzyme Commission (EC)	With NAD(+) or NADP(+) as acceptor	0	2.327	--	DIRECT
Enzyme Commission (EC)	Acting on NADH or NADPH	0	1.783	--	DIRECT
Enzyme Commission (EC)	With NAD(+) or NADP(+) as acceptor	0	2.929	--	DIRECT
Enzyme Commission (EC)	Acting on a sulfur group of donors	0	1.783	--	DIRECT
Enzyme Commission (EC)	Dihydrolipoyl dehydrogenase	0	2.929	--	DIRECT
Enzyme Commission (EC)	Ferredoxin--NAD(+) reductase	0.00000000000001226	2.753	--	DIRECT
Enzyme Commission (EC)	Monodehydroascorbate reductase (NADH)	0.0000000000004566	2.929	--	DIRECT
Enzyme Commission (EC)	Glutathione-disulfide reductase	0.0000000002377	2.929	--	DIRECT
Enzyme Commission (EC)	NADH dehydrogenase	0.000000001215	2.151	--	DIRECT
Enzyme Commission (EC)	Oxidizing metal ions	0.000000002681	2.275	--	DIRECT
Enzyme Commission (EC)	CoA-disulfide reductase	0.00001223	2.929	--	DIRECT
Enzyme Commission (EC)	With a quinone or similar compound as acceptor	1	2.385	--	INHERITED FROM: Monodehydroascorbate reductase (NADH)
Enzyme Commission (EC)	Oxidoreductases	0	0.7328	Least Informative	DIRECT
Enzyme Commission (EC)	With NAD(+) or NADP(+) as acceptor	0	2.151	Highly Informative	DIRECT
Enzyme Commission (EC)	Acting on iron-sulfur proteins as donors	0.0000000000002168	2.23	Highly Informative	DIRECT
Enzyme Commission (EC)	With other acceptors	1	2.116	Highly Informative	INHERITED FROM: NADH dehydrogenase

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