SUPERFAMILY 1.75 HMM library and genome assignments server

SUPERFAMILY 2 can be accessed from Please contact us if you experience any problems.

Metalloproteases ("zincins"), catalytic domain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a+b) [ 53931] (376)
Fold:   Zincin-like [ 55485] (2)
Superfamily:   Metalloproteases ("zincins"), catalytic domain [ 55486] (17)
Families:   Zinc protease [ 55487]
  Fungal zinc peptidase [ 64335]
  Thermolysin-like [ 55490] (4)
  Leukotriene A4 hydrolase catalytic domain [ 64338]
  Neutral endopeptidase (neprilysin) [ 55502]
  Neurolysin-like [ 55505] (4)
  Anthrax toxin lethal factor, N- and C-terminal domains [ 69775]
  Leishmanolysin [ 55499]
  Serralysin-like metalloprotease, catalytic (N-terminal) domain [ 55508]
  Clostridium neurotoxins, catalytic domain [ 55512]
  Astacin [ 55516]
  Reprolysin-like [ 55519] (2)
  TNF-alpha converting enzyme, TACE, catalytic domain [ 55525]
  Matrix metalloproteases, catalytic domain [ 55528] (13)
  Predicted metal-dependent hydrolase [ 103132] (3)
  Caur0242-like [ 160552]
  TTHA0227-like [ 160555] (2)

Superfamily statistics
Genomes (3,225) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 41,885 260,990 143
Proteins 40,939 257,291 141

Functional annotation
General category Processes_IC
Detailed category Proteases

Function annotation of SCOP domain superfamilies

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on peptide bonds (peptide hydrolases)0Least InformativeDirect
Enzyme Commission (EC)Metalloendopeptidases0InformativeDirect
Enzyme Commission (EC)Acting on ether bonds0InformativeDirect
Enzyme Commission (EC)Aminopeptidases1InformativeInherited
Enzyme Commission (EC)Leukotriene-A(4) hydrolase0Highly InformativeDirect
Enzyme Commission (EC)Metallocarboxypeptidases0.1001Highly InformativeInherited

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)organ system cancer0.01398Least InformativeInherited
Disease Ontology (DO)nervous system disease0.5678Least InformativeInherited
Disease Ontology (DO)artery disease0.00000008961Moderately InformativeDirect
Disease Ontology (DO)cell type cancer0.0005481Moderately InformativeDirect
Disease Ontology (DO)sensory system disease0.0751Moderately InformativeInherited
Disease Ontology (DO)gastrointestinal system disease0.2908Moderately InformativeInherited
Disease Ontology (DO)atherosclerosis0.000000007109InformativeDirect
Disease Ontology (DO)myopia0.000001984InformativeDirect
Disease Ontology (DO)breast cancer0.00006099InformativeDirect
Disease Ontology (DO)intrinsic cardiomyopathy0.0006442InformativeDirect
Disease Ontology (DO)prostate cancer0.0006658InformativeDirect
Disease Ontology (DO)female reproductive system disease0.0008742InformativeDirect
Disease Ontology (DO)connective tissue cancer0.1284InformativeInherited
Disease Ontology (DO)malignant glioma0.1771InformativeInherited
Disease Ontology (DO)female reproductive organ cancer0.8334InformativeInherited
Disease Ontology (DO)adult astrocytic tumour0.000001474Highly InformativeDirect
Disease Ontology (DO)Kawasaki disease0.00002411Highly InformativeDirect
Disease Ontology (DO)chondrosarcoma0.00004642Highly InformativeDirect
Disease Ontology (DO)salivary gland adenoid cystic carcinoma0.00006504Highly InformativeDirect
Disease Ontology (DO)integumentary system cancer0.00009716Highly InformativeDirect
Disease Ontology (DO)abdominal aortic aneurysm0.0001068Highly InformativeDirect
Disease Ontology (DO)otitis media0.000572Highly InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of limbs0.2221Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of skeletal morphology0.6367Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of limb bone morphology0.1655Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the upper limb0.2847Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal upper limb bone morphology0.1415InformativeInherited

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)cardiovascular system phenotype0.02672Least InformativeInherited
Mammalian Phenotype (MP)abnormal craniofacial morphology0.03884Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal reproductive system physiology0.1087Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal blood vessel morphology0.1707Moderately InformativeInherited
Mammalian Phenotype (MP)neoplasm0.2244Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal muscle morphology0.2495Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal eye morphology0.2557Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal renal/urinary system morphology0.2897Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal heart morphology0.3364Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cardiovascular system physiology0.7221Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal skeleton morphology0.7754Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cartilage morphology0.001635InformativeInherited
Mammalian Phenotype (MP)abnormal blood vessel physiology0.002728InformativeInherited
Mammalian Phenotype (MP)altered tumor pathology0.003183InformativeInherited
Mammalian Phenotype (MP)abnormal limb morphology0.01425InformativeInherited
Mammalian Phenotype (MP)abnormal skeleton development0.02863InformativeInherited
Mammalian Phenotype (MP)abnormal uvea morphology0.04186InformativeInherited
Mammalian Phenotype (MP)abnormal appendicular skeleton morphology0.04245InformativeInherited
Mammalian Phenotype (MP)abnormal hypaxial muscle morphology0.05466InformativeInherited
Mammalian Phenotype (MP)abnormal bone ossification0.3854InformativeInherited
Mammalian Phenotype (MP)double outlet right ventricle0.00002033Highly InformativeDirect
Mammalian Phenotype (MP)abnormal long bone hypertrophic chondrocyte zone0.00008238Highly InformativeDirect
Mammalian Phenotype (MP)decreased susceptibility to induced choroidal neovascularization0.0001468Highly InformativeDirect
Mammalian Phenotype (MP)abnormal kidney corticomedullary boundary morphology0.0002113Highly InformativeDirect
Mammalian Phenotype (MP)abnormal fertilization0.0006896Highly InformativeDirect
Mammalian Phenotype (MP)decreased length of long bones0.001044Highly InformativeInherited
Mammalian Phenotype (MP)abnormal retinal vasculature morphology0.02474Highly InformativeInherited
Mammalian Phenotype (MP)abnormal hindlimb morphology0.1158Highly InformativeInherited
Mammalian Phenotype (MP)abnormal limb long bone morphology0.1648Highly InformativeInherited
Mammalian Phenotype (MP)abnormal diaphragm morphology0.2226Highly InformativeInherited
Mammalian Phenotype (MP)abnormal bone mineralization0.5451Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)pericellular component development variant0Moderately InformativeDirect
Worm Phenotype (WP)basement membrane remodeling variant0.00000006089InformativeDirect

Document: WP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)cell0.4885Least InformativeInherited
Fly Anatomy (FA)embryo0.1088Moderately InformativeInherited
Fly Anatomy (FA)somatic precursor cell0.33Moderately InformativeInherited
Fly Anatomy (FA)primordium0.09392InformativeInherited
Fly Anatomy (FA)dorsal closure embryo0.2902InformativeInherited
Fly Anatomy (FA)embryonic heart cardioblast0.00007157Highly InformativeDirect
Fly Anatomy (FA)heart primordium0.0002048Highly InformativeDirect

Document: FA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)embryo1Least InformativeInherited
Xenopus ANatomical entity (XAN)urogenital system1Least InformativeInherited
Xenopus ANatomical entity (XAN)tissue1Least InformativeInherited
Xenopus ANatomical entity (XAN)multi-tissue structure0.639Moderately InformativeInherited
Xenopus ANatomical entity (XAN)alimentary system0.773Moderately InformativeInherited
Xenopus ANatomical entity (XAN)notochord0.01843InformativeInherited
Xenopus ANatomical entity (XAN)mesoderm0.1834InformativeInherited
Xenopus ANatomical entity (XAN)urinary system0.6658InformativeInherited
Xenopus ANatomical entity (XAN)tail bud0.1076Highly InformativeInherited
Xenopus DEvelopment stage (XDE)post-embryonic stage0.07849Least InformativeInherited
Xenopus DEvelopment stage (XDE)premetamorphosis stage0.00000001697Highly InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details) Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Hydrolases0Least InformativeDirect
Enzyme Commission (EC)Acting on peptide bonds (peptidases)0Moderately InformativeDirect
Enzyme Commission (EC)Metalloendopeptidases0InformativeDirect
Enzyme Commission (EC)Omega peptidases1InformativeInherited
Enzyme Commission (EC)Acting on ether bonds0Highly InformativeDirect
Enzyme Commission (EC)Metallocarboxypeptidases0.007296Highly InformativeInherited
Enzyme Commission (EC)Aminopeptidases1Highly InformativeInherited

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details) Document: KW annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.

Alignments of sequences to 92 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.

Browse and view proteins in genomes which have different domain combinations including a Metalloproteases ("zincins"), catalytic domain domain.

Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.

Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 92 hidden Markov models representing the Metalloproteases ("zincins"), catalytic domain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.

Jump to [ Top of page · SCOP classification · Functional annotation · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · Internal database links ]