SUPERFAMILY 2 can be accessed from supfam.org. Please contact us if you experience any problems.
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Cell cycle regulatory proteins superfamily
SCOP classification
Superfamily statistics
Functional annotation
| General category | Processes_IC |
| Detailed category | Cell cycle, Apoptosis |
Document: Function annotation of SCOP domain superfamilies
InterPro annotation
| Cross references | IPR000789 SSF55637 Protein matches |
| Abstract | In eukaryotes, cyclin-dependent protein kinases interact with cyclins to regulate cell cycle
progression, and are required for the G1 and G2 stages of cell division [ 3322810]. The
proteins bind to a regulatory subunit, cyclin-dependent kinase regulatory subunit (CKS),
which is essential for their function. This regulatory subunit is a small protein of 79 to 150
residues. In yeast (gene CKS1) and in fission yeast (gene suc1) a single isoform is known,
while mammals have two highly related isoforms. The regulatory subunits exist as hexamers,
formed by the symmetrical assembly of 3 interlocked homodimers, creating an unusual
12-stranded beta-barrel structure [8211159]. Through the barrel centre runs a 12A diameter
tunnel, lined by 6 exposed helix pairs [8491379]. Six kinase units can be modelled to bind the
hexameric structure, which may thus act as a hub for cyclin-dependent protein kinase
multimerisation [8491379, 8211159].
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InterPro database
PDBeMotif information about ligands, sequence and structure motifs
PDBeMotif resource
Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation ]
Internal database links
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Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry
out SCOP domain assignments to all genomes at the superfamily level.
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Alignments of sequences to 5 models
in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical
are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.
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Browse and view proteins in genomes which have
different domain combinations including a Cell cycle regulatory proteins domain.
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Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.
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Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.
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There are 5 hidden Markov models representing the Cell cycle regulatory proteins superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.
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Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Internal database links ]
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