Class II aminoacyl-tRNA synthetase (aaRS)-like, catalytic domain family

SCOP classification

• Root: SCOP hierarchy in SUPERFAMILY [ 0] (11)
• Class: Alpha and beta proteins (a+b) [ 53931] (376)
• Fold: Class II aaRS and biotin synthetases [ 55680]
• Superfamily: Class II aaRS and biotin synthetases [ 55681] (4)
• Family: Class II aminoacyl-tRNA synthetase (aaRS)-like, catalytic domain [ 55682] (15)

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Family statistics

	Genomes (3,258)	Uniprot 2018_03 genome	PDB chains (SCOP 1.75)
Domains	36,163	249,493	37
Proteins	36,146	249,446	37

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Enzyme Commission (EC)

Highlighted in gray are those with FDR_all>0.001

	EC term	FDR (all)	IC level	SDEO level	Annotation (direct or inherited)
Enzyme Commission (EC)	Lysine--tRNA ligase	0	2.264	--	DIRECT
Enzyme Commission (EC)	Aspartate--tRNA ligase	0	2.264	--	DIRECT
Enzyme Commission (EC)	Lysyltransferase	0	2.44	--	DIRECT
Enzyme Commission (EC)	Glycine--tRNA ligase	0	2.44	--	DIRECT
Enzyme Commission (EC)	Forming carbon-oxygen bonds	0	1.25	--	DIRECT
Enzyme Commission (EC)	Serine--tRNA ligase	0	2.44	--	DIRECT
Enzyme Commission (EC)	Asparagine--tRNA ligase	0	2.44	--	DIRECT
Enzyme Commission (EC)	Aspartate--ammonia ligase	0	2.741	--	DIRECT
Enzyme Commission (EC)	Histidine--tRNA ligase	0	2.264	--	DIRECT
Enzyme Commission (EC)	Transferases	1	0	--	INHERITED FROM: Lysyltransferase
Enzyme Commission (EC)	Acyltransferases	1	0.8778	--	INHERITED FROM: Lysyltransferase
Enzyme Commission (EC)	Ligases	0	0.7455	Least Informative	DIRECT
Enzyme Commission (EC)	Ligases forming aminoacyl-tRNA and related compoun	0	1.25	Moderately Informative	DIRECT
Enzyme Commission (EC)	Forming carbon-nitrogen bonds	1	0.993	Moderately Informative	INHERITED FROM: Acid--ammonia (or amide) ligases (amide synthases) || Aspartate--ammonia ligase
Enzyme Commission (EC)	Aminoacyltransferases	0.07742	1.662	Informative	INHERITED FROM: Lysyltransferase
Enzyme Commission (EC)	Phenylalanine--tRNA ligase	0	1.963	Highly Informative	DIRECT
Enzyme Commission (EC)	Acid--ammonia (or amide) ligases (amide synthases)	0	1.963	Highly Informative	DIRECT
Enzyme Commission (EC)	Threonine--tRNA ligase	0	2.139	Highly Informative	DIRECT
Enzyme Commission (EC)	Proline--tRNA ligase	0	2.139	Highly Informative	DIRECT
Enzyme Commission (EC)	Alanine--tRNA ligase	0	2.139	Highly Informative	DIRECT

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Disease Ontology (DO)

Highlighted in gray are those with FDR_all>0.001

	DO term	FDR (all)	IC level	SDDO level	Annotation (direct or inherited)
Disease Ontology (DO)	Charcot-Marie-Tooth disease	0.0000003259	2.513	--	DIRECT
Disease Ontology (DO)	neuropathy	0.0006182	1.814	--	DIRECT
Disease Ontology (DO)	peripheral nervous system disease	0.00623	1.814	--	INHERITED FROM: neuropathy || neuromuscular disease || Charcot-Marie-Tooth disease
Disease Ontology (DO)	disease of anatomical entity	0.114	0.2414	--	INHERITED FROM: neuromuscular disease || Charcot-Marie-Tooth disease || neuropathy
Disease Ontology (DO)	nervous system disease	0.06825	0.7279	Least Informative	INHERITED FROM: neuropathy || neuromuscular disease || Charcot-Marie-Tooth disease
Disease Ontology (DO)	neuromuscular disease	0.00002403	2.036	Highly Informative	DIRECT

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Human Phenotype (HP)

Highlighted in gray are those with FDR_all>0.001

	HP term	FDR (all)	IC level	SDHP level	Annotation (direct or inherited)
	Variable expressivity	0	0.04347	--	DIRECT
	Phenotypic variability	1	0	--	INHERITED FROM: Variable expressivity
Mode of Inheritance (MI)	Autosomal recessive inheritance	0.0005922	0.2218	--	DIRECT
Phenotypic Abnormality (PA)	Increased serum lactate	0.00001684	2.462	--	DIRECT
Phenotypic Abnormality (PA)	Hammertoe	0.0003824	2.462	--	DIRECT
Phenotypic Abnormality (PA)	Abnormality of the cerebral white matter	0.000407	1.617	--	DIRECT
Phenotypic Abnormality (PA)	Abnormality of acid-base homeostasis	0.0005404	1.258	--	DIRECT
Phenotypic Abnormality (PA)	Abnormal myelination	0.007245	1.763	--	INHERITED FROM: Abnormal CNS myelination
Phenotypic Abnormality (PA)	Abnormality of forebrain morphology	0.01338	0.9572	--	INHERITED FROM: Abnormality of the cerebral white matter || Hypoplasia of the corpus callosum
Phenotypic Abnormality (PA)	Sensory impairment	0.01441	1.86	--	INHERITED FROM: Distal sensory impairment
Phenotypic Abnormality (PA)	Abnormal cerebellum morphology	0.05046	1.763	--	INHERITED FROM: Cerebellar atrophy
Phenotypic Abnormality (PA)	Aplasia/Hypoplasia of the cerebrum	0.07554	1.184	--	INHERITED FROM: Hypoplasia of the corpus callosum
Phenotypic Abnormality (PA)	Aplasia/Hypoplasia of the corpus callosum	0.08679	1.684	--	INHERITED FROM: Hypoplasia of the corpus callosum
Phenotypic Abnormality (PA)	Abnormality of brain morphology	0.1107	0.6631	--	INHERITED FROM: Hypoplasia of the corpus callosum || Abnormality of the cerebral white matter || Cerebellar atrophy
Phenotypic Abnormality (PA)	Abnormality of hindbrain morphology	0.1281	1.763	--	INHERITED FROM: Cerebellar atrophy
Phenotypic Abnormality (PA)	Abnormality of the nervous system	0.388	0.2371	--	INHERITED FROM: Hypoplasia of the corpus callosum || Distal sensory impairment || Cerebellar atrophy || Abnormal CNS myelination || Abnormality of the cerebral white matter
Phenotypic Abnormality (PA)	Abnormal corpus callosum morphology	0.4031	1.617	--	INHERITED FROM: Hypoplasia of the corpus callosum
Phenotypic Abnormality (PA)	Abnormality of the skeletal system	0.5993	0.4712	--	INHERITED FROM: Hammertoe
Phenotypic Abnormality (PA)	Abnormality of the foot	0.7147	1.082	--	INHERITED FROM: Hammertoe
Phenotypic Abnormality (PA)	Abnormal digit morphology	0.8195	1.14	--	INHERITED FROM: Hammertoe
Phenotypic Abnormality (PA)	Abnormal appendicular skeleton morphology	0.8779	0.8289	--	INHERITED FROM: Hammertoe
Phenotypic Abnormality (PA)	Morphological abnormality of the central nervous system	0.8981	0.533	--	INHERITED FROM: Hypoplasia of the corpus callosum || Abnormality of the cerebral white matter || Abnormal CNS myelination || Cerebellar atrophy
Phenotypic Abnormality (PA)	Abnormality of limb bone	0.9598	0.9572	--	INHERITED FROM: Hammertoe
Phenotypic Abnormality (PA)	Abnormality of the metencephalon	1	1.763	--	INHERITED FROM: Cerebellar atrophy
Phenotypic Abnormality (PA)	Abnormality of the musculature	0.007017	0.5433	Least Informative	INHERITED FROM: Abnormality of the musculature of the limbs
Phenotypic Abnormality (PA)	Abnormality of nervous system morphology	0.04164	0.4756	Least Informative	INHERITED FROM: Distal sensory impairment || Hypoplasia of the corpus callosum || Cerebellar atrophy || Abnormal CNS myelination || Abnormality of the cerebral white matter
Phenotypic Abnormality (PA)	Abnormality of limbs	0.195	0.6429	Least Informative	INHERITED FROM: Hammertoe || Abnormality of the musculature of the limbs
Phenotypic Abnormality (PA)	Abnormality of skeletal morphology	0.5279	0.513	Least Informative	INHERITED FROM: Hammertoe
Phenotypic Abnormality (PA)	Abnormality of metabolism/homeostasis	0.7368	0.5486	Least Informative	INHERITED FROM: Increased serum lactate || Abnormality of acid-base homeostasis
Phenotypic Abnormality (PA)	Abnormality of the cerebrum	0.0117	0.971	Moderately Informative	INHERITED FROM: Abnormality of the cerebral white matter || Hypoplasia of the corpus callosum
Phenotypic Abnormality (PA)	Aplasia/Hypoplasia involving the central nervous system	0.01556	1.047	Moderately Informative	INHERITED FROM: Hypoplasia of the corpus callosum
Phenotypic Abnormality (PA)	Abnormal peripheral nervous system morphology	0.1804	1.232	Moderately Informative	INHERITED FROM: Distal sensory impairment
Phenotypic Abnormality (PA)	Abnormal homeostasis	0.3193	0.7903	Moderately Informative	INHERITED FROM: Abnormality of acid-base homeostasis || Increased serum lactate
Phenotypic Abnormality (PA)	Abnormality of the lower limb	0.3523	0.9309	Moderately Informative	INHERITED FROM: Hammertoe
Phenotypic Abnormality (PA)	Abnormal skeletal muscle morphology	0.38	0.9061	Moderately Informative	INHERITED FROM: Abnormality of the musculature of the limbs
Phenotypic Abnormality (PA)	Abnormality of limb bone morphology	0.8983	0.9572	Moderately Informative	INHERITED FROM: Hammertoe
Phenotypic Abnormality (PA)	Abnormality of the musculature of the limbs	0.0004145	1.421	Informative	DIRECT
Phenotypic Abnormality (PA)	Abnormality of the cerebral subcortex	0.02471	1.508	Informative	INHERITED FROM: Abnormality of the cerebral white matter || Hypoplasia of the corpus callosum
Phenotypic Abnormality (PA)	Peripheral neuropathy	0.1503	1.421	Informative	INHERITED FROM: Distal sensory impairment
Phenotypic Abnormality (PA)	Abnormality of toe	0.3099	1.617	Informative	INHERITED FROM: Hammertoe
Phenotypic Abnormality (PA)	Acidosis	0.6255	1.383	Informative	INHERITED FROM: Increased serum lactate
Phenotypic Abnormality (PA)	Hypoplasia of the corpus callosum	0.00006748	1.763	Highly Informative	DIRECT
Phenotypic Abnormality (PA)	Distal sensory impairment	0.00006864	1.985	Highly Informative	DIRECT
Phenotypic Abnormality (PA)	Abnormal CNS myelination	0.0002029	2.161	Highly Informative	DIRECT
Phenotypic Abnormality (PA)	Cerebellar atrophy	0.000893	1.985	Highly Informative	DIRECT

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Worm Phenotype (WP)

Highlighted in gray are those with FDR_all>0.001

	WP term	FDR (all)	IC level	SDWP level	Annotation (direct or inherited)
Worm Phenotype (WP)	embryonic lethal	0	0.046	--	DIRECT
Worm Phenotype (WP)	lethal	0	0.00521	--	DIRECT
Worm Phenotype (WP)	development variant	0	0.001482	--	DIRECT
Worm Phenotype (WP)	organism development variant	0	0.00297	--	DIRECT
Worm Phenotype (WP)	organ system physiology variant	0	0.04518	--	DIRECT
Worm Phenotype (WP)	reproductive system physiology variant	0	0.05515	--	DIRECT
Worm Phenotype (WP)	embryonic development variant	0	0.04518	--	DIRECT
Worm Phenotype (WP)	hypoxia resistant	0	2.07	--	DIRECT
Worm Phenotype (WP)	oxygen response variant	0.000000000000003755	1.99	--	DIRECT
Worm Phenotype (WP)	transgene expression variant	0.0000001356	0.773	--	DIRECT
Worm Phenotype (WP)	germ cell morphology variant	0.0000004745	1.156	--	DIRECT
Worm Phenotype (WP)	receptor mediated endocytosis defective	0.0000007041	1.689	--	DIRECT
Worm Phenotype (WP)	oocyte physiology variant	0.0000009521	1.593	--	DIRECT
Worm Phenotype (WP)	gene expression variant	0.0000013	0.6256	--	DIRECT
Worm Phenotype (WP)	sexually dimorphic physiology variant	0.000002167	1.426	--	DIRECT
Worm Phenotype (WP)	gonad morphology variant	0.000003867	1.306	--	DIRECT
Worm Phenotype (WP)	response to bacteria variant	0.000006458	1.426	--	DIRECT
Worm Phenotype (WP)	meiotic progression prophase variant	0.000006892	1.407	--	DIRECT
Worm Phenotype (WP)	endocytic transport variant	0.00001094	1.354	--	DIRECT
Worm Phenotype (WP)	cell component morphology variant	0.00003231	0.8392	--	DIRECT
Worm Phenotype (WP)	other abnormality early emb	0.00004474	1.99	--	DIRECT
Worm Phenotype (WP)	feeding behavior variant	0.00004685	1.25	--	DIRECT
Worm Phenotype (WP)	cell morphology variant	0.0002204	0.7558	--	DIRECT
Worm Phenotype (WP)	vesicle trafficking variant	0.0007126	1.354	--	DIRECT
Worm Phenotype (WP)	diakinesis region organization variant	0.0007741	2.292	--	DIRECT
Worm Phenotype (WP)	behavior variant	0.001012	0.6859	--	INHERITED FROM: organism behavior variant || avoids bacterial lawn || feeding behavior variant
Worm Phenotype (WP)	oogenesis variant	0.004181	1.237	--	INHERITED FROM: pachytene progression during oogenesis variant || meiotic progression prophase variant || diakinesis region organization variant
Worm Phenotype (WP)	organ system morphology variant	0.004909	0.7516	--	INHERITED FROM: gonad morphology variant || diakinesis region organization variant
Worm Phenotype (WP)	germ cell cytoplasmic morphology variant	0.005099	1.866	--	INHERITED FROM: cytoplasmic processing body variant
Worm Phenotype (WP)	meiosis variant	0.02951	1.263	--	INHERITED FROM: pachytene progression during oogenesis variant || meiotic progression prophase variant || diakinesis region organization variant
Worm Phenotype (WP)	gametogenesis variant	0.05893	1.013	--	INHERITED FROM: germ cell differentiation variant || pachytene progression during oogenesis variant || meiotic progression prophase variant || germ cell development variant || diakinesis region organization variant
Worm Phenotype (WP)	germ cell compartment morphology variant	0.06826	1.354	--	INHERITED FROM: germ cell compartment anucleate || germ cell compartment expansion variant
Worm Phenotype (WP)	organism homeostasis metabolism variant	0.1925	0.1444	--	INHERITED FROM: gene expression variant || transgene expression variant || organism environmental stimulus response variant || oxygen response variant || hypoxia response variant || hypoxia resistant || response to bacteria variant || organism metabolism processing variant || avoids bacterial lawn
Worm Phenotype (WP)	organism physiology variant	0.2094	0.1342	--	INHERITED FROM: oxygen response variant || organism environmental stimulus response variant || transgene expression variant || oocyte physiology variant || gene expression variant || receptor mediated endocytosis defective || hermaphrodite physiology variant || sexually dimorphic physiology variant || hypoxia response variant || organism metabolism processing variant || avoids bacterial lawn || response to bacteria variant || hypoxia resistant
Worm Phenotype (WP)	meiotic progression during oogenesis variant	0.2692	1.321	--	INHERITED FROM: pachytene progression during oogenesis variant || meiotic progression prophase variant || diakinesis region organization variant
Worm Phenotype (WP)	organelle organization biogenesis variant	0.2928	1.306	--	INHERITED FROM: germline nuclear positioning variant
Worm Phenotype (WP)	germ cell compartment nuclei number variant	0.5546	1.814	--	INHERITED FROM: germ cell compartment anucleate
Worm Phenotype (WP)	physiology variant	1	0	--	INHERITED FROM: hypoxia response variant || organism metabolism processing variant || hypoxia resistant || response to bacteria variant || reproductive system physiology variant || pleiotropic defects severe early emb || transgene expression variant || gene expression variant || early embryonic lethal || endocytic transport variant || diakinesis region organization variant || avoids bacterial lawn || lethal || germ cell physiology variant || germ cell development variant || oocyte physiology variant || germ cell differentiation variant || sexually dimorphic physiology variant || cell differentiation variant || endocytic transport defect || development variant || organism environmental stimulus response variant || embryonic development variant || embryonic lethal || germline nuclear positioning variant || other abnormality early emb || feeding behavior variant || pachytene progression during oogenesis variant || meiotic progression prophase variant || organ system physiology variant || oxygen response variant || organism behavior variant || organism development variant || vesicle trafficking variant || hermaphrodite physiology variant || receptor mediated endocytosis defective || cell development variant
Worm Phenotype (WP)	morphology variant	1	0.046	--	INHERITED FROM: gonad morphology variant || germline nuclear positioning variant || germ cell morphology variant || diakinesis region organization variant || cytoplasmic processing body variant || cell morphology variant || germ cell compartment anucleate || germ cell compartment expansion variant || cell component morphology variant
Worm Phenotype (WP)	organism metabolism processing variant	0.00001272	0.4899	Least Informative	DIRECT
Worm Phenotype (WP)	organism environmental stimulus response variant	0.00007065	0.6614	Least Informative	DIRECT
Worm Phenotype (WP)	cell development variant	0.0004393	0.6752	Least Informative	DIRECT
Worm Phenotype (WP)	organism behavior variant	0.0009685	0.6859	Least Informative	DIRECT
Worm Phenotype (WP)	cell physiology variant	0.002782	0.5955	Least Informative	INHERITED FROM: endocytic transport defect || endocytic transport variant || oocyte physiology variant || diakinesis region organization variant || pachytene progression during oogenesis variant || meiotic progression prophase variant || germline nuclear positioning variant || germ cell physiology variant || vesicle trafficking variant || receptor mediated endocytosis defective
Worm Phenotype (WP)	early embryonic lethal	0.0000001079	1.178	Moderately Informative	DIRECT
Worm Phenotype (WP)	germ cell differentiation variant	0.000007593	1.167	Moderately Informative	DIRECT
Worm Phenotype (WP)	germ cell development variant	0.0002308	1.013	Moderately Informative	DIRECT
Worm Phenotype (WP)	organism stress response variant	0.002648	0.9693	Moderately Informative	INHERITED FROM: hypoxia response variant || hypoxia resistant
Worm Phenotype (WP)	cell cycle variant	0.02139	1.225	Moderately Informative	INHERITED FROM: diakinesis region organization variant || meiotic progression prophase variant || pachytene progression during oogenesis variant
Worm Phenotype (WP)	reproductive system morphology variant	0.02214	1.078	Moderately Informative	INHERITED FROM: diakinesis region organization variant || gonad morphology variant
Worm Phenotype (WP)	cell division variant	0.04106	1.036	Moderately Informative	INHERITED FROM: meiotic progression prophase variant || pachytene progression during oogenesis variant || diakinesis region organization variant
Worm Phenotype (WP)	cell type morphology variant	0.08914	0.8878	Moderately Informative	INHERITED FROM: germ cell morphology variant || cytoplasmic processing body variant || germ cell compartment expansion variant || germ cell compartment anucleate
Worm Phenotype (WP)	cell organization biogenesis variant	0.5437	1.135	Moderately Informative	INHERITED FROM: germline nuclear positioning variant
Worm Phenotype (WP)	avoids bacterial lawn	0.0000000019	1.49	Informative	DIRECT
Worm Phenotype (WP)	germ cell compartment expansion variant	0.0000004172	1.468	Informative	DIRECT
Worm Phenotype (WP)	pachytene progression during oogenesis variant	0.000000891	1.565	Informative	DIRECT
Worm Phenotype (WP)	hermaphrodite physiology variant	0.000001452	1.446	Informative	DIRECT
Worm Phenotype (WP)	germ cell physiology variant	0.000006203	1.49	Informative	DIRECT
Worm Phenotype (WP)	endocytic transport defect	0.000009329	1.407	Informative	DIRECT
Worm Phenotype (WP)	nuclear positioning variant	0.006144	1.623	Informative	INHERITED FROM: germline nuclear positioning variant
Worm Phenotype (WP)	hypoxia response variant	0	1.99	Highly Informative	DIRECT
Worm Phenotype (WP)	cell differentiation variant	0.00000000000003307	1.99	Highly Informative	DIRECT
Worm Phenotype (WP)	pleiotropic defects severe early emb	0.00000000007122	1.99	Highly Informative	DIRECT
Worm Phenotype (WP)	cytoplasmic processing body variant	0.000005596	2.07	Highly Informative	DIRECT
Worm Phenotype (WP)	germline nuclear positioning variant	0.0001032	1.769	Highly Informative	DIRECT
Worm Phenotype (WP)	germ cell compartment anucleate	0.0001261	1.924	Highly Informative	DIRECT
Worm Phenotype (WP)	diakinesis progression during oogenesis variant	0.09021	2.167	Highly Informative	INHERITED FROM: diakinesis region organization variant

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Yeast Phenotype (YP)

Highlighted in gray are those with FDR_all>0.001

	YP term	FDR (all)	IC level	SDYP level	Annotation (direct or inherited)
Yeast Phenotype (YP)	utilization of carbon source	0.02162	1.33	--	INHERITED FROM: mitochondrial genome maintenance
Yeast Phenotype (YP)	metabolism and growth	0.5193	0.5867	Least Informative	INHERITED FROM: mitochondrial genome maintenance
Yeast Phenotype (YP)	nutrient utilization	0.0498	1.189	Moderately Informative	INHERITED FROM: mitochondrial genome maintenance
Yeast Phenotype (YP)	respiratory metabolism	0.004254	1.599	Informative	INHERITED FROM: mitochondrial genome maintenance
Yeast Phenotype (YP)	mitochondrial genome maintenance	0.0001023	1.967	Highly Informative	DIRECT

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Zebrafish Anatomy (ZA)

Highlighted in gray are those with FDR_all>0.001

	ZA term	FDR (all)	IC level	SDZA level	Annotation (direct or inherited)
Zebrafish Anatomy (ZA)	compound organ	0	0.4299	--	DIRECT
Zebrafish Anatomy (ZA)	whole organism	0	0.00147	--	DIRECT
Zebrafish Anatomy (ZA)	anatomical system	0	0.1857	--	DIRECT
Zebrafish Anatomy (ZA)	anatomical group	0	0.1532	--	DIRECT
Zebrafish Anatomy (ZA)	brain vasculature	0.00000162	2.471	--	DIRECT
Zebrafish Anatomy (ZA)	blood vessel	0.00978	1.626	--	INHERITED FROM: artery
Zebrafish Anatomy (ZA)	blood vasculature	0.02618	1.626	--	INHERITED FROM: artery
Zebrafish Anatomy (ZA)	brain	0.2399	1.193	--	INHERITED FROM: brain vasculature
Zebrafish Anatomy (ZA)	anatomical structure	1	0	--	INHERITED FROM: anatomical system || brain vasculature || cranial vasculature || anatomical group || whole organism || artery || organism subdivision || compound organ || cavitated compound organ || head || nervous system
Zebrafish Anatomy (ZA)	nervous system	0	0.7079	Least Informative	DIRECT
Zebrafish Anatomy (ZA)	organism subdivision	0	0.614	Least Informative	DIRECT
Zebrafish Anatomy (ZA)	cavitated compound organ	0	0.5123	Least Informative	DIRECT
Zebrafish Anatomy (ZA)	multi-tissue structure	0.2296	0.5848	Least Informative	INHERITED FROM: artery || brain vasculature || cranial vasculature
Zebrafish Anatomy (ZA)	head	0	0.9398	Moderately Informative	DIRECT
Zebrafish Anatomy (ZA)	cardiovascular system	0.02803	1.216	Moderately Informative	INHERITED FROM: artery || cranial vasculature || brain vasculature
Zebrafish Anatomy (ZA)	central nervous system	0.5928	1.04	Moderately Informative	INHERITED FROM: brain vasculature
Zebrafish Anatomy (ZA)	vasculature	0.01329	1.471	Informative	INHERITED FROM: brain vasculature || cranial vasculature || artery
Zebrafish Anatomy (ZA)	cranial vasculature	0.0005153	2.17	Highly Informative	DIRECT
Zebrafish Anatomy (ZA)	artery	0.0007073	1.869	Highly Informative	DIRECT

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Xenopus Anatomy (XA)

Highlighted in gray are those with FDR_all>0.001

	XA term	FDR (all)	IC level	SDXA level	Annotation (direct or inherited)
Xenopus ANatomical entity (XAN)	anatomical structure	0	0	--	DIRECT
Xenopus ANatomical entity (XAN)	anatomical group	0	0.1408	--	DIRECT
Xenopus ANatomical entity (XAN)	organism subdivision	0	0.1679	--	DIRECT
Xenopus ANatomical entity (XAN)	anatomical region	0	0.1803	--	DIRECT
Xenopus ANatomical entity (XAN)	multicellular anatomical structure	0	0.1131	--	DIRECT
Xenopus ANatomical entity (XAN)	whole organism	1	0.0884	--	INHERITED FROM: anatomical group || multicellular anatomical structure || tail || anatomical region || organism subdivision
Xenopus ANatomical entity (XAN)	tail region	0.002291	1.242	Moderately Informative	INHERITED FROM: tail
Xenopus ANatomical entity (XAN)	tail	0.0008636	1.334	Informative	DIRECT

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Arabidopsis Plant Ontology (AP)

Highlighted in gray are those with FDR_all>0.001

	AP term	FDR (all)	IC level	SDAP level	Annotation (direct or inherited)
Plant ANatomical entity (PAN)	guard cell	0	0.2279	--	DIRECT
Plant ANatomical entity (PAN)	stomatal complex	0	0.2279	--	DIRECT
Plant ANatomical entity (PAN)	epidermal cell	0	0.2152	--	DIRECT
Plant ANatomical entity (PAN)	epidermis	0	0.2046	--	DIRECT
Plant ANatomical entity (PAN)	shoot epidermis	0	0.2224	--	DIRECT
Plant ANatomical entity (PAN)	plant cell	0	0.1228	--	DIRECT
Plant ANatomical entity (PAN)	shoot system	0	0.05272	--	DIRECT
Plant ANatomical entity (PAN)	portion of plant tissue	0	0.1621	--	DIRECT
Plant ANatomical entity (PAN)	shoot epidermal cell	0	0.227	--	DIRECT
Plant ANatomical entity (PAN)	collective plant structure	0	0.01555	--	DIRECT
Plant ANatomical entity (PAN)	plant structure	1	0	--	INHERITED FROM: collective plant structure || guard cell || shoot system || portion of plant tissue || stomatal complex || epidermis || epidermal cell || shoot epidermal cell || plant cell || shoot epidermis
Plant ANatomical entity (PAN)	collective plant organ structure	1	0.03998	--	INHERITED FROM: guard cell || shoot epidermal cell || stomatal complex || shoot system || shoot epidermis
Plant structure DEvelopment stage (PDE)	collective plant organ structure development stage	0	0.0282	--	DIRECT
Plant structure DEvelopment stage (PDE)	reproductive shoot system development stage	0	0.0371	--	DIRECT
Plant structure DEvelopment stage (PDE)	sporophyte vegetative stage	0.5401	0.1593	--	INHERITED FROM: 0 seed germination stage
Plant structure DEvelopment stage (PDE)	whole plant development stage	0.5449	0.1547	--	INHERITED FROM: 0 seed germination stage
Plant structure DEvelopment stage (PDE)	life of whole plant stage	1	0.1584	--	INHERITED FROM: 0 seed germination stage
Plant structure DEvelopment stage (PDE)	shoot system development stage	1	0.02956	--	INHERITED FROM: reproductive shoot system development stage
Plant structure DEvelopment stage (PDE)	sporophyte development stage	1	0.1584	--	INHERITED FROM: 0 seed germination stage
Plant structure DEvelopment stage (PDE)	0 seed germination stage	0.000002682	1.689	Informative	DIRECT

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Enzyme Commission (EC)

Highlighted in gray are those with FDR_all>0.001

	EC term	FDR (all)	IC level	SDEC level	Annotation (direct or inherited)
Enzyme Commission (EC)	Lysyltransferase	0	2.929	--	DIRECT
Enzyme Commission (EC)	Serine--tRNA ligase	0	2.929	--	DIRECT
Enzyme Commission (EC)	Aspartate--tRNA ligase	0	2.753	--	DIRECT
Enzyme Commission (EC)	Glycine--tRNA ligase	0	2.753	--	DIRECT
Enzyme Commission (EC)	Proline--tRNA ligase	0	2.628	--	DIRECT
Enzyme Commission (EC)	Phenylalanine--tRNA ligase	0	2.452	--	DIRECT
Enzyme Commission (EC)	Histidine--tRNA ligase	0	2.753	--	DIRECT
Enzyme Commission (EC)	Asparagine--tRNA ligase	0	2.929	--	DIRECT
Enzyme Commission (EC)	Aspartate--tRNA(Asn) ligase	0	2.753	--	DIRECT
Enzyme Commission (EC)	Threonine--tRNA ligase	0	2.628	--	DIRECT
Enzyme Commission (EC)	Lysine--tRNA ligase	0	2.753	--	DIRECT
Enzyme Commission (EC)	Alanine--tRNA ligase	0	2.628	--	DIRECT
Enzyme Commission (EC)	Aspartate--ammonia ligase	0	3.23	--	DIRECT
Enzyme Commission (EC)	Transferases	1	0.3972	Least Informative	INHERITED FROM: Lysyltransferase
Enzyme Commission (EC)	Ligases	0	1.14	Moderately Informative	DIRECT
Enzyme Commission (EC)	Acyltransferases	1	1.034	Moderately Informative	INHERITED FROM: Lysyltransferase
Enzyme Commission (EC)	Forming carbon-oxygen bonds	0	1.738	Informative	DIRECT
Enzyme Commission (EC)	Aminoacyltransferases	1	1.391	Informative	INHERITED FROM: Lysyltransferase
Enzyme Commission (EC)	Forming carbon-nitrogen bonds	1	1.338	Informative	INHERITED FROM: Acid--ammonia (or amine) ligases (amide synthases) || Aspartate--ammonia ligase
Enzyme Commission (EC)	Ligases forming aminoacyl-tRNA and related compounds	0	1.753	Highly Informative	DIRECT
Enzyme Commission (EC)	Acid--ammonia (or amine) ligases (amide synthases)	0	2.188	Highly Informative	DIRECT

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