Ribonuclease Rh-like superfamily

SCOP classification

• Root: SCOP hierarchy in SUPERFAMILY [ 0] (11)
• Class: Alpha and beta proteins (a+b) [ 53931] (376)
• Fold: Ribonuclease Rh-like [ 55894]
• Superfamily: Ribonuclease Rh-like [ 55895]
• Families: Ribonuclease Rh-like [ 55896] (8)

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Superfamily statistics

	Genomes (902)	Uniprot 2018_03 genome	PDB chains (SCOP 1.75)
Domains	1,917	10,202	12
Proteins	1,884	10,160	12

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Functional annotation

• General category: Information
• Detailed category: RNA processing

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Enzyme Commission (EC)

Highlighted in gray are those with FDR_all>0.001

	EC term	FDR (all)	IC level	SDEO level	Annotation (direct or inherited)
Enzyme Commission (EC)	Hydrolases	0	0.04271	--	DIRECT
Enzyme Commission (EC)	Ribonuclease T(2)	0	2.56	--	DIRECT
Enzyme Commission (EC)	RNA helicase	0.00000403	1.217	--	DIRECT
Enzyme Commission (EC)	Transferring phosphorous-containing groups	0.8065	0.2175	--	INHERITED FROM: RNA-directed RNA polymerase
Enzyme Commission (EC)	Transferases	1	0	--	INHERITED FROM: RNA-directed RNA polymerase
Enzyme Commission (EC)	Acting on ester bonds	0	0.4665	Least Informative	DIRECT
Enzyme Commission (EC)	Acting on acid anhydrides	1	0.6408	Least Informative	INHERITED FROM: Acting on acid anhydrides; involved in cellular an || Nucleoside-triphosphatase || RNA helicase || In phosphorous-containing anhydrides
Enzyme Commission (EC)	Acting on peptide bonds (peptide hydrolases)	0.8302	0.5513	Least Informative	INHERITED FROM: Serine endopeptidases || Pestivirus NS3 polyprotein peptidase
Enzyme Commission (EC)	Nucleotidyltransferases	0.05259	0.6105	Least Informative	INHERITED FROM: RNA-directed RNA polymerase
Enzyme Commission (EC)	Serine endopeptidases	0.00001407	0.9917	Moderately Informative	DIRECT
Enzyme Commission (EC)	In phosphorous-containing anhydrides	0.00004815	1.016	Moderately Informative	DIRECT
Enzyme Commission (EC)	Acting on acid anhydrides; involved in cellular an	0.0004788	0.8971	Moderately Informative	DIRECT
Enzyme Commission (EC)	Nucleoside-triphosphatase	0.0000000001751	1.519	Informative	DIRECT
Enzyme Commission (EC)	RNA-directed RNA polymerase	0.00000001353	1.305	Informative	DIRECT
Enzyme Commission (EC)	Pestivirus NS3 polyprotein peptidase	0	2.083	Highly Informative	DIRECT
Enzyme Commission (EC)	Endoribonucleases producing other than 5'-phosphom	0	1.861	Highly Informative	DIRECT

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Arabidopsis Plant Ontology (AP)

Highlighted in gray are those with FDR_all>0.001

	AP term	FDR (all)	IC level	SDAP level	Annotation (direct or inherited)
Plant ANatomical entity (PAN)	collective plant structure	0	0.01577	--	DIRECT
Plant ANatomical entity (PAN)	plant axis	0	0.3881	--	DIRECT
Plant ANatomical entity (PAN)	multi-tissue plant structure	0	0.2691	--	DIRECT
Plant ANatomical entity (PAN)	plant organ	0	0.2816	--	DIRECT
Plant ANatomical entity (PAN)	plant structure	1	0	--	INHERITED FROM: collective plant structure || multi-tissue plant structure || plant organ || plant axis
Plant structure DEvelopment stage (PDE)	collective plant organ structure development stage	0	0.03771	--	DIRECT
Plant structure DEvelopment stage (PDE)	floral organ formation stage	0	0.0937	--	DIRECT
Plant structure DEvelopment stage (PDE)	floral organ differentiation stage	0	0.0937	--	DIRECT
Plant structure DEvelopment stage (PDE)	flowering stage	0	0.2162	--	DIRECT
Plant structure DEvelopment stage (PDE)	corolla development stage	0	0.1981	--	DIRECT
Plant structure DEvelopment stage (PDE)	collective phyllome structure development stage	0	0.0937	--	DIRECT
Plant structure DEvelopment stage (PDE)	sporophyte vegetative stage	0	0.2036	--	DIRECT
Plant structure DEvelopment stage (PDE)	reproductive shoot system development stage	0	0.05008	--	DIRECT
Plant structure DEvelopment stage (PDE)	whole plant development stage	0	0.1968	--	DIRECT
Plant structure DEvelopment stage (PDE)	plant organ development stage	0	0.08108	--	DIRECT
Plant structure DEvelopment stage (PDE)	plant embryo stage	0	0.2833	--	DIRECT
Plant structure DEvelopment stage (PDE)	shoot system development stage	1	0.04053	--	INHERITED FROM: reproductive shoot system development stage || floral organ formation stage || floral organ differentiation stage || flowering stage || corolla development stage || plant organ development stage
Plant structure DEvelopment stage (PDE)	sporophyte development stage	1	0.2022	--	INHERITED FROM: sporophyte vegetative stage || C globular stage || plant embryo stage
Plant structure DEvelopment stage (PDE)	life of whole plant stage	1	0.2022	--	INHERITED FROM: sporophyte vegetative stage || C globular stage || plant embryo stage
Plant structure DEvelopment stage (PDE)	flower development stage	1	0.07083	--	INHERITED FROM: corolla development stage || flowering stage || floral organ differentiation stage || floral organ formation stage
Plant structure DEvelopment stage (PDE)	C globular stage	0	0.3937	Least Informative	DIRECT

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Enzyme Commission (EC)

Highlighted in gray are those with FDR_all>0.001

	EC term	FDR (all)	IC level	SDEC level	Annotation (direct or inherited)
Enzyme Commission (EC)	Pestivirus NS3 polyprotein peptidase	0	2.475	--	DIRECT
Enzyme Commission (EC)	Phosphorus-oxygen lyases	0	1.651	--	DIRECT
Enzyme Commission (EC)	Ribonuclease T(2)	0	2.952	--	DIRECT
Enzyme Commission (EC)	Acting on ATP; involved in cellular and subcellular movement	0.0008696	1.196	--	DIRECT
Enzyme Commission (EC)	Transferases	1	0.3035	--	INHERITED FROM: RNA-directed RNA polymerase
Enzyme Commission (EC)	Lyases	0	0.6918	Least Informative	DIRECT
Enzyme Commission (EC)	Transferring phosphorus-containing groups	0.881	0.5453	Least Informative	INHERITED FROM: RNA-directed RNA polymerase
Enzyme Commission (EC)	Hydrolases	1	0.3541	Least Informative	INHERITED FROM: Nucleoside-triphosphate phosphatase || Acting on ATP; involved in cellular and subcellular movement || Serine endopeptidases || Pestivirus NS3 polyprotein peptidase || RNA helicase || In phosphorus-containing anhydrides
Enzyme Commission (EC)	Acting on peptide bonds (peptidases)	0.007929	0.8949	Moderately Informative	INHERITED FROM: Pestivirus NS3 polyprotein peptidase || Serine endopeptidases
Enzyme Commission (EC)	Acting on acid anhydrides	0.01747	0.9562	Moderately Informative	INHERITED FROM: Acting on ATP; involved in cellular and subcellular movement || Nucleoside-triphosphate phosphatase || RNA helicase || In phosphorus-containing anhydrides
Enzyme Commission (EC)	Nucleotidyltransferases	0.07425	0.9432	Moderately Informative	INHERITED FROM: RNA-directed RNA polymerase
Enzyme Commission (EC)	RNA-directed RNA polymerase	0.00000002518	1.63	Informative	DIRECT
Enzyme Commission (EC)	RNA helicase	0.000008437	1.52	Informative	DIRECT
Enzyme Commission (EC)	Serine endopeptidases	0.00002385	1.35	Informative	DIRECT
Enzyme Commission (EC)	In phosphorus-containing anhydrides	0.0001766	1.28	Informative	DIRECT
Enzyme Commission (EC)	Phosphorus-oxygen lyases	1	1.651	Informative	INHERITED FROM: Ribonuclease T(2)
Enzyme Commission (EC)	Nucleoside-triphosphate phosphatase	0.0000000003137	1.873	Highly Informative	DIRECT

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InterPro annotation

• Cross references: IPR001568 SSF55895 Protein matches
• Abstract:

  The fungal ribonucleases T2 from Aspergillus oryzae, M from Aspergillus saitoi and Rh from Rhizopus niveus are structurally and functionally related 30 Kd glycoproteins [2229029] that cleave the 3'-5' internucleotide linkage of RNA via a nucleotide 2',3'-cyclic phosphate intermediate .

  Two histidines residues have been shown [2298207, 1633875] to be involved in the catalytic mechanism of RNase T2 and Rh. These residues and the region around them are highly conserved in a number of other RNAses that have been found to be evolutionary related to these fungal enzymes.

InterPro database

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