S-adenosylmethionine synthetase family

SCOP classification

• Root: SCOP hierarchy in SUPERFAMILY [ 0] (11)
• Class: Alpha and beta proteins (a+b) [ 53931] (376)
• Fold: S-adenosylmethionine synthetase [ 55972]
• Superfamily: S-adenosylmethionine synthetase [ 55973]
• Family: S-adenosylmethionine synthetase [ 55974]

---

Family statistics

	Genomes (2,924)	Uniprot 2018_03 genome	PDB chains (SCOP 1.75)
Domains	10,675	72,373	9
Proteins	3,773	25,699	3

---

Enzyme Commission (EC)

Highlighted in gray are those with FDR_all>0.001

	EC term	FDR (all)	IC level	SDEO level	Annotation (direct or inherited)
Enzyme Commission (EC)	Methionine adenosyltransferase	0	2.741	--	DIRECT
Enzyme Commission (EC)	Transferases	0	0	--	DIRECT
Enzyme Commission (EC)	Transferring alkyl or aryl groups, other than meth	0	1.185	--	DIRECT
Enzyme Commission (EC)	Transferring alkyl or aryl groups, other than meth	1	1.185	Moderately Informative	INHERITED FROM: Methionine adenosyltransferase

---

Worm Phenotype (WP)

Highlighted in gray are those with FDR_all>0.001

	WP term	FDR (all)	IC level	SDWP level	Annotation (direct or inherited)
Worm Phenotype (WP)	organism physiology variant	0	0.1342	--	DIRECT
Worm Phenotype (WP)	hermaphrodite fertility variant	0	0.0947	--	DIRECT
Worm Phenotype (WP)	fertility variant	0	0.05937	--	DIRECT
Worm Phenotype (WP)	organism development variant	0	0.00297	--	DIRECT
Worm Phenotype (WP)	developmental growth variant	0	0.4991	--	DIRECT
Worm Phenotype (WP)	developmental timing variant	0	0.4548	--	DIRECT
Worm Phenotype (WP)	hermaphrodite fertility reduced	0	0.1193	--	DIRECT
Worm Phenotype (WP)	locomotion variant	0	1.053	--	DIRECT
Worm Phenotype (WP)	organ system morphology variant	0	0.7516	--	DIRECT
Worm Phenotype (WP)	morphology variant	0	0.046	--	DIRECT
Worm Phenotype (WP)	fertility reduced	0	0.06449	--	DIRECT
Worm Phenotype (WP)	organism homeostasis metabolism variant	0	0.1444	--	DIRECT
Worm Phenotype (WP)	growth variant	0	0.3438	--	DIRECT
Worm Phenotype (WP)	transgene expression variant	0	0.773	--	DIRECT
Worm Phenotype (WP)	larval development variant	0	0.4322	--	DIRECT
Worm Phenotype (WP)	larval growth variant	0	0.4991	--	DIRECT
Worm Phenotype (WP)	general pace of development variant	0	0.4786	--	DIRECT
Worm Phenotype (WP)	hermaphrodite sterile	0	0.1203	--	DIRECT
Worm Phenotype (WP)	gene expression variant	0	0.6256	--	DIRECT
Worm Phenotype (WP)	postembryonic development variant	0	0.269	--	DIRECT
Worm Phenotype (WP)	retarded heterochronic variations	0	0.4548	--	DIRECT
Worm Phenotype (WP)	maternal sterile	0	0.1213	--	DIRECT
Worm Phenotype (WP)	organism morphology variant	0	0.1372	--	DIRECT
Worm Phenotype (WP)	reproductive system physiology variant	0	0.05515	--	DIRECT
Worm Phenotype (WP)	development variant	0	0.001482	--	DIRECT
Worm Phenotype (WP)	behavior variant	0	0.6859	--	DIRECT
Worm Phenotype (WP)	organ system physiology variant	0	0.04518	--	DIRECT
Worm Phenotype (WP)	embryonic lethal	0	0.046	--	DIRECT
Worm Phenotype (WP)	lethal	0	0.00521	--	DIRECT
Worm Phenotype (WP)	sterile progeny	0	0.6547	--	DIRECT
Worm Phenotype (WP)	embryonic development variant	0	0.04518	--	DIRECT
Worm Phenotype (WP)	protruding vulva	0.00009547	1.623	--	DIRECT
Worm Phenotype (WP)	hermaphrodite reproductive system morphology variant	0.0001548	1.426	--	DIRECT
Worm Phenotype (WP)	body width variant	0.0002175	1.237	--	DIRECT
Worm Phenotype (WP)	body size variant	0.0003429	1.189	--	DIRECT
Worm Phenotype (WP)	body morphology variant	0.0004572	1.145	--	DIRECT
Worm Phenotype (WP)	activity level variant	0.02367	1.337	--	INHERITED FROM: sluggish || locomotion reduced
Worm Phenotype (WP)	physiology variant	1	0	--	INHERITED FROM: hermaphrodite fertility variant || developmental growth variant || organism metabolism processing variant || retarded heterochronic variations || reproductive system physiology variant || transgene expression variant || gene expression variant || organism homeostasis metabolism variant || sluggish || movement variant || lethal || larval development variant || sterile progeny || organism physiology variant || progeny variant || slow growth || development variant || developmental timing variant || hermaphrodite sterile || growth variant || hermaphrodite fertility reduced || embryonic development variant || embryonic lethal || locomotion reduced || larval growth variant || general pace of development variant || fertility variant || behavior variant || postembryonic development variant || larval arrest || organ system physiology variant || organism behavior variant || maternal sterile || organism development variant || locomotion variant || fertility reduced || transgene expression increased
Worm Phenotype (WP)	sterile	1	0.1135	--	INHERITED FROM: hermaphrodite sterile || maternal sterile || sterile progeny
Worm Phenotype (WP)	larval arrest	0	0.4991	Least Informative	DIRECT
Worm Phenotype (WP)	organism metabolism processing variant	0	0.4899	Least Informative	DIRECT
Worm Phenotype (WP)	organism behavior variant	0	0.6859	Least Informative	DIRECT
Worm Phenotype (WP)	progeny variant	0	0.6514	Least Informative	DIRECT
Worm Phenotype (WP)	slow growth	0	0.4945	Least Informative	DIRECT
Worm Phenotype (WP)	movement variant	0	1.02	Moderately Informative	DIRECT
Worm Phenotype (WP)	organism segment morphology variant	0.0008675	1.087	Moderately Informative	DIRECT
Worm Phenotype (WP)	body region morphology variant	0.0008786	1.087	Moderately Informative	DIRECT
Worm Phenotype (WP)	level of transgene expression variant	0.1444	1.125	Moderately Informative	INHERITED FROM: transgene expression increased
Worm Phenotype (WP)	reproductive system morphology variant	0.2106	1.078	Moderately Informative	INHERITED FROM: protruding vulva || hermaphrodite reproductive system morphology variant || vulva morphology variant
Worm Phenotype (WP)	locomotion reduced	0.00002514	1.49	Informative	DIRECT
Worm Phenotype (WP)	vulva morphology variant	0.0001529	1.426	Informative	DIRECT
Worm Phenotype (WP)	transgene expression increased	0.0002585	1.426	Informative	DIRECT
Worm Phenotype (WP)	sluggish	0.0000005441	2.07	Highly Informative	DIRECT

---

Arabidopsis Plant Ontology (AP)

Highlighted in gray are those with FDR_all>0.001

	AP term	FDR (all)	IC level	SDAP level	Annotation (direct or inherited)
Plant ANatomical entity (PAN)	epidermal cell	0	0.2152	--	DIRECT
Plant ANatomical entity (PAN)	guard cell	0	0.2279	--	DIRECT
Plant ANatomical entity (PAN)	stamen	0	0.5171	--	DIRECT
Plant ANatomical entity (PAN)	collective phyllome structure	0	0.3837	--	DIRECT
Plant ANatomical entity (PAN)	cotyledon	0	0.6432	--	DIRECT
Plant ANatomical entity (PAN)	inflorescence branch	0	0.5373	--	DIRECT
Plant ANatomical entity (PAN)	stem internode	0	0.5373	--	DIRECT
Plant ANatomical entity (PAN)	petiole	0	0.6385	--	DIRECT
Plant ANatomical entity (PAN)	leaf	0	0.4282	--	DIRECT
Plant ANatomical entity (PAN)	pollen sac	0	0.673	--	DIRECT
Plant ANatomical entity (PAN)	shoot epidermal cell	0	0.227	--	DIRECT
Plant ANatomical entity (PAN)	shoot axis	0	0.3985	--	DIRECT
Plant ANatomical entity (PAN)	shoot system	0	0.05272	--	DIRECT
Plant ANatomical entity (PAN)	sporophyll	0	0.3985	--	DIRECT
Plant ANatomical entity (PAN)	microsporangium	0	0.6705	--	DIRECT
Plant ANatomical entity (PAN)	lamina	0	0.6199	--	DIRECT
Plant ANatomical entity (PAN)	cauline leaf	0	0.6042	--	DIRECT
Plant ANatomical entity (PAN)	corolla	0	0.4893	--	DIRECT
Plant ANatomical entity (PAN)	phyllome	0	0.3234	--	DIRECT
Plant ANatomical entity (PAN)	perianth	0	0.4476	--	DIRECT
Plant ANatomical entity (PAN)	whole plant	0	0.3507	--	DIRECT
Plant ANatomical entity (PAN)	cardinal organ part	0	0.4385	--	DIRECT
Plant ANatomical entity (PAN)	shoot epidermis	0	0.2224	--	DIRECT
Plant ANatomical entity (PAN)	calyx	0	0.4728	--	DIRECT
Plant ANatomical entity (PAN)	pollen	0	0.673	--	DIRECT
Plant ANatomical entity (PAN)	leaf lamina base	0	0.6245	--	DIRECT
Plant ANatomical entity (PAN)	cardinal part of multi-tissue plant structure	0	0.437	--	DIRECT
Plant ANatomical entity (PAN)	pedicel	0	0.5373	--	DIRECT
Plant ANatomical entity (PAN)	inflorescence axis	0	0.5373	--	DIRECT
Plant ANatomical entity (PAN)	collective plant structure	0	0.01555	--	DIRECT
Plant ANatomical entity (PAN)	portion of plant tissue	0	0.1621	--	DIRECT
Plant ANatomical entity (PAN)	inflorescence meristem	0	0.6337	--	DIRECT
Plant ANatomical entity (PAN)	root system	0	0.4584	--	DIRECT
Plant ANatomical entity (PAN)	plant cell	0	0.1228	--	DIRECT
Plant ANatomical entity (PAN)	epidermis	0	0.2046	--	DIRECT
Plant ANatomical entity (PAN)	reproductive shoot system	0	0.3304	--	DIRECT
Plant ANatomical entity (PAN)	stomatal complex	0	0.2279	--	DIRECT
Plant ANatomical entity (PAN)	gamete	0	1.333	--	DIRECT
Plant ANatomical entity (PAN)	multi-tissue plant structure	0	0.2335	--	DIRECT
Plant ANatomical entity (PAN)	plant axis	0	0.3257	--	DIRECT
Plant ANatomical entity (PAN)	leaf apex	0	0.5999	--	DIRECT
Plant ANatomical entity (PAN)	carpel	0	0.5117	--	DIRECT
Plant ANatomical entity (PAN)	plant organ	0	0.2391	--	DIRECT
Plant ANatomical entity (PAN)	flower	0	0.3446	--	DIRECT
Plant ANatomical entity (PAN)	organ lamina	1	0.6199	--	INHERITED FROM: leaf lamina base || leaf lamina
Plant ANatomical entity (PAN)	collective plant organ structure	1	0.03998	--	INHERITED FROM: inflorescence axis || calyx || flower || sporophyll || inflorescence meristem || root system || inflorescence || root || perianth || stem || leaf || phyllome || shoot internode || sepal || vascular leaf || gynoecium || petiole || petal || reproductive shoot system || shoot apex || leaf apex || carpel || collective phyllome structure || guard cell || megasporophyll || cauline leaf || pollen || microsporophyll || pollen sac || leaf lamina || shoot epidermal cell || corolla || pedicel || androecium || stomatal complex || phyllome apex || cotyledon || stamen || stem internode || inflorescence branch || shoot axis || shoot system || leaf lamina base || collective leaf structure || branch || shoot epidermis
Plant ANatomical entity (PAN)	phyllome lamina	1	0.6199	--	INHERITED FROM: leaf lamina base || leaf lamina
Plant ANatomical entity (PAN)	plant structure	1	0	--	INHERITED FROM: perianth || root || sporophyll || calyx || inflorescence axis || flower || lamina || collective plant structure || plant embryo || leaf || shoot internode || phyllome || pollen sac || cardinal organ part || multi-tissue plant structure || microsporophyll || guard cell || megasporophyll || cauline leaf || reproductive shoot system || shoot apex || leaf apex || leaf lamina base || branch || collective leaf structure || stem internode || inflorescence branch || shoot system || sporangium || portion of plant tissue || stomatal complex || plant organ || portion of meristem tissue || stem || whole plant || inflorescence meristem || epidermis || root system || inflorescence || cardinal part of multi-tissue plant structure || plant sperm cell || petiole || stalk || gynoecium || vascular leaf || sepal || microsporangium || epidermal cell || leaf lamina || shoot epidermal cell || corolla || pollen || plant axis || collective phyllome structure || petal || plant cell || gamete || carpel || seed || shoot epidermis || phyllome apex || cotyledon || stamen || shoot axis || microgametophyte || pollen tube cell || pedicel || androecium
Plant ANatomical entity (PAN)	portion of meristem tissue	0	0.5892	Least Informative	DIRECT
Plant ANatomical entity (PAN)	seed	0	0.5189	Least Informative	DIRECT
Plant ANatomical entity (PAN)	phyllome apex	0	0.5956	Least Informative	DIRECT
Plant ANatomical entity (PAN)	megasporophyll	0	0.5117	Least Informative	DIRECT
Plant ANatomical entity (PAN)	gynoecium	0	0.5082	Least Informative	DIRECT
Plant ANatomical entity (PAN)	leaf lamina	0	0.6199	Least Informative	DIRECT
Plant ANatomical entity (PAN)	stalk	0	0.6176	Least Informative	DIRECT
Plant ANatomical entity (PAN)	plant embryo	0	0.4978	Least Informative	DIRECT
Plant ANatomical entity (PAN)	microgametophyte	0	0.673	Least Informative	DIRECT
Plant ANatomical entity (PAN)	sporangium	0	0.6679	Least Informative	DIRECT
Plant ANatomical entity (PAN)	shoot internode	0	0.5373	Least Informative	DIRECT
Plant ANatomical entity (PAN)	stem	0	0.4777	Least Informative	DIRECT
Plant ANatomical entity (PAN)	petal	0	0.4893	Least Informative	DIRECT
Plant ANatomical entity (PAN)	androecium	0	0.5153	Least Informative	DIRECT
Plant ANatomical entity (PAN)	branch	0	0.5373	Least Informative	DIRECT
Plant ANatomical entity (PAN)	vascular leaf	0	0.437	Least Informative	DIRECT
Plant ANatomical entity (PAN)	shoot apex	0	0.481	Least Informative	DIRECT
Plant ANatomical entity (PAN)	collective leaf structure	0	0.46	Least Informative	DIRECT
Plant ANatomical entity (PAN)	sepal	0	0.4728	Least Informative	DIRECT
Plant ANatomical entity (PAN)	inflorescence	0	0.4859	Least Informative	DIRECT
Plant ANatomical entity (PAN)	root	0	0.4679	Least Informative	DIRECT
Plant ANatomical entity (PAN)	microsporophyll	0	0.4415	Least Informative	DIRECT
Plant ANatomical entity (PAN)	plant sperm cell	0	1.396	Informative	DIRECT
Plant ANatomical entity (PAN)	pollen tube cell	0	1.454	Informative	DIRECT
Plant structure DEvelopment stage (PDE)	whole plant development stage	0	0.1547	--	DIRECT
Plant structure DEvelopment stage (PDE)	1 main shoot growth stage	0	0.3245	--	DIRECT
Plant structure DEvelopment stage (PDE)	androecium development stage	0	1.279	--	DIRECT
Plant structure DEvelopment stage (PDE)	plant embryo stage	0	0.2319	--	DIRECT
Plant structure DEvelopment stage (PDE)	plant organ development stage	0	0.06127	--	DIRECT
Plant structure DEvelopment stage (PDE)	pollen development stage	0	1.279	--	DIRECT
Plant structure DEvelopment stage (PDE)	corolla development stage	0	0.1484	--	DIRECT
Plant structure DEvelopment stage (PDE)	flowering stage	0	0.1648	--	DIRECT
Plant structure DEvelopment stage (PDE)	floral organ differentiation stage	0	0.07163	--	DIRECT
Plant structure DEvelopment stage (PDE)	collective plant organ structure development stage	0	0.0282	--	DIRECT
Plant structure DEvelopment stage (PDE)	floral organ formation stage	0	0.07163	--	DIRECT
Plant structure DEvelopment stage (PDE)	reproductive shoot system development stage	0	0.0371	--	DIRECT
Plant structure DEvelopment stage (PDE)	phyllome development stage	0	0.3879	--	DIRECT
Plant structure DEvelopment stage (PDE)	collective phyllome structure development stage	0	0.07163	--	DIRECT
Plant structure DEvelopment stage (PDE)	sporophyte vegetative stage	0	0.1593	--	DIRECT
Plant structure DEvelopment stage (PDE)	leaf production stage	1	0.3272	--	INHERITED FROM: LP.02 two leaves visible stage || LP.10 ten leaves visible stage || LP.04 four leaves visible stage || LP.08 eight leaves visible stage || LP.12 twelve leaves visible stage || LP.06 six leaves visible stage
Plant structure DEvelopment stage (PDE)	life of whole plant stage	1	0.1584	--	INHERITED FROM: sporophyte vegetative stage || C globular stage || LP.10 ten leaves visible stage || E expanded cotyledon stage || LP.12 twelve leaves visible stage || F mature embryo stage || LP.04 four leaves visible stage || D bilateral stage || LP.06 six leaves visible stage || LP.08 eight leaves visible stage || LP.02 two leaves visible stage || plant embryo stage || 1 main shoot growth stage
Plant structure DEvelopment stage (PDE)	flower development stage	1	0.05402	--	INHERITED FROM: corolla development stage || flowering stage || pollen development stage || L mature pollen stage || floral organ differentiation stage || floral organ formation stage || M germinated pollen stage || androecium development stage
Plant structure DEvelopment stage (PDE)	shoot system development stage	1	0.02956	--	INHERITED FROM: phyllome development stage || reproductive shoot system development stage || L mature pollen stage || floral organ formation stage || floral organ differentiation stage || flowering stage || corolla development stage || pollen development stage || M germinated pollen stage || plant organ development stage || androecium development stage || 4 leaf senescence stage
Plant structure DEvelopment stage (PDE)	leaf development stage	1	0.3879	--	INHERITED FROM: 4 leaf senescence stage
Plant structure DEvelopment stage (PDE)	sporophyte development stage	1	0.1584	--	INHERITED FROM: LP.08 eight leaves visible stage || LP.12 twelve leaves visible stage || E expanded cotyledon stage || LP.10 ten leaves visible stage || LP.06 six leaves visible stage || sporophyte vegetative stage || C globular stage || 1 main shoot growth stage || D bilateral stage || F mature embryo stage || LP.04 four leaves visible stage || plant embryo stage || LP.02 two leaves visible stage
Plant structure DEvelopment stage (PDE)	D bilateral stage	0	0.301	Least Informative	DIRECT
Plant structure DEvelopment stage (PDE)	4 leaf senescence stage	0	0.3895	Least Informative	DIRECT
Plant structure DEvelopment stage (PDE)	LP.04 four leaves visible stage	0	0.3479	Least Informative	DIRECT
Plant structure DEvelopment stage (PDE)	F mature embryo stage	0	0.3205	Least Informative	DIRECT
Plant structure DEvelopment stage (PDE)	LP.02 two leaves visible stage	0	0.4603	Least Informative	DIRECT
Plant structure DEvelopment stage (PDE)	LP.12 twelve leaves visible stage	0	0.479	Least Informative	DIRECT
Plant structure DEvelopment stage (PDE)	LP.08 eight leaves visible stage	0	0.4752	Least Informative	DIRECT
Plant structure DEvelopment stage (PDE)	LP.10 ten leaves visible stage	0	0.4234	Least Informative	DIRECT
Plant structure DEvelopment stage (PDE)	E expanded cotyledon stage	0	0.2861	Least Informative	DIRECT
Plant structure DEvelopment stage (PDE)	LP.06 six leaves visible stage	0	0.4268	Least Informative	DIRECT
Plant structure DEvelopment stage (PDE)	C globular stage	0	0.3087	Least Informative	DIRECT
Plant structure DEvelopment stage (PDE)	M germinated pollen stage	0	1.437	Informative	DIRECT
Plant structure DEvelopment stage (PDE)	L mature pollen stage	0	1.605	Informative	DIRECT
Plant structure DEvelopment stage (PDE)	seed development stage	0.000004347	1.304	Informative	DIRECT

---

Enzyme Commission (EC)

Highlighted in gray are those with FDR_all>0.001

	EC term	FDR (all)	IC level	SDEC level	Annotation (direct or inherited)
Enzyme Commission (EC)	Methionine adenosyltransferase	0	3.23	--	DIRECT
Enzyme Commission (EC)	Transferring alkyl or aryl groups, other than methyl groups	1	1.567	--	INHERITED FROM: Methionine adenosyltransferase
Enzyme Commission (EC)	Transferases	0	0.3972	Least Informative	DIRECT
Enzyme Commission (EC)	Transferring alkyl or aryl groups, other than methyl groups	0	1.558	Informative	DIRECT

---