Phosphatidylinositol phosphate kinase IIbeta, PIPK IIbeta family

SCOP classification

• Root: SCOP hierarchy in SUPERFAMILY [ 0] (11)
• Class: Alpha and beta proteins (a+b) [ 53931] (376)
• Fold: SAICAR synthase-like [ 56103]
• Superfamily: SAICAR synthase-like [ 56104] (3)
• Family: Phosphatidylinositol phosphate kinase IIbeta, PIPK IIbeta [ 56108]

---

Family statistics

	Genomes (482)	Uniprot 2018_03 genome	PDB chains (SCOP 1.75)
Domains	1,942	4,995	1
Proteins	1,923	4,947	1

---

Enzyme Commission (EC)

Highlighted in gray are those with FDR_all>0.001

	EC term	FDR (all)	IC level	SDEO level	Annotation (direct or inherited)
Enzyme Commission (EC)	1-phosphatidylinositol-5-phosphate 4-kinase	0	2.741	--	DIRECT
Enzyme Commission (EC)	Transferring phosphorous-containing groups	0	0.2728	--	DIRECT
Enzyme Commission (EC)	Transferases	0	0	--	DIRECT
Enzyme Commission (EC)	1-phosphatidylinositol-4-phosphate 5-kinase	0	2.44	--	DIRECT
Enzyme Commission (EC)	1-phosphatidylinositol-3-phosphate 5-kinase	0.0000000000003059	2.264	--	DIRECT
Enzyme Commission (EC)	Phosphotransferases with an alcohol group as accep	0	0.8381	Moderately Informative	DIRECT

---

Worm Phenotype (WP)

Highlighted in gray are those with FDR_all>0.001

	WP term	FDR (all)	IC level	SDWP level	Annotation (direct or inherited)
Worm Phenotype (WP)	postembryonic development variant	0	0.269	--	DIRECT
Worm Phenotype (WP)	embryonic lethal	0	0.046	--	DIRECT
Worm Phenotype (WP)	lethal	0	0.00521	--	DIRECT
Worm Phenotype (WP)	fertility variant	0	0.05937	--	DIRECT
Worm Phenotype (WP)	development variant	0	0.001482	--	DIRECT
Worm Phenotype (WP)	morphology variant	0	0.046	--	DIRECT
Worm Phenotype (WP)	organism development variant	0	0.00297	--	DIRECT
Worm Phenotype (WP)	organ system physiology variant	0	0.04518	--	DIRECT
Worm Phenotype (WP)	organism physiology variant	0	0.1342	--	DIRECT
Worm Phenotype (WP)	organism homeostasis metabolism variant	0	0.1444	--	DIRECT
Worm Phenotype (WP)	reproductive system physiology variant	0	0.05515	--	DIRECT
Worm Phenotype (WP)	maternal sterile	0	0.1213	--	DIRECT
Worm Phenotype (WP)	hermaphrodite sterile	0	0.1203	--	DIRECT
Worm Phenotype (WP)	gene expression variant	0	0.6256	--	DIRECT
Worm Phenotype (WP)	embryonic development variant	0	0.04518	--	DIRECT
Worm Phenotype (WP)	hermaphrodite fertility variant	0	0.0947	--	DIRECT
Worm Phenotype (WP)	hermaphrodite fertility reduced	0	0.1193	--	DIRECT
Worm Phenotype (WP)	fertility reduced	0	0.06449	--	DIRECT
Worm Phenotype (WP)	physiology variant	1	0	--	INHERITED FROM: hermaphrodite fertility variant || organism metabolism processing variant || reproductive system physiology variant || gene expression variant || organism homeostasis metabolism variant || lethal || organism physiology variant || development variant || hermaphrodite sterile || hermaphrodite fertility reduced || embryonic development variant || embryonic lethal || fertility variant || postembryonic development variant || organ system physiology variant || protein expression variant || maternal sterile || organism development variant || fertility reduced
Worm Phenotype (WP)	sterile	1	0.1135	--	INHERITED FROM: hermaphrodite sterile || maternal sterile
Worm Phenotype (WP)	organism metabolism processing variant	0	0.4899	Least Informative	DIRECT
Worm Phenotype (WP)	protein expression variant	0	1.125	Moderately Informative	DIRECT

---

Fly Phenotype (FP)

Highlighted in gray are those with FDR_all>0.001

	FP term	FDR (all)	IC level	SDFP level	Annotation (direct or inherited)
Fly Phenotype (FP)	phenotype	0	0.06546	--	DIRECT

---

Fly Anatomy (FA)

Highlighted in gray are those with FDR_all>0.001

	FA term	FDR (all)	IC level	SDFA level	Annotation (direct or inherited)
Fly Anatomy (FA)	organism	0	0.06695	--	DIRECT
Fly Anatomy (FA)	adult nervous system	0	0.7764	--	DIRECT
Fly Anatomy (FA)	organ system	0	0.1823	--	DIRECT
Fly Anatomy (FA)	cell	0	0.4069	--	DIRECT
Fly Anatomy (FA)	non-connected functional system	0	0.8451	--	DIRECT
Fly Anatomy (FA)	sensory system	0	0.8577	--	DIRECT
Fly Anatomy (FA)	multicellular structure	0	0.008955	--	DIRECT
Fly Anatomy (FA)	anatomical structure	1	0	--	INHERITED FROM: organism || nervous system || adult || adult nervous system || larva || somatic cell || cell || organ system subdivision || organ system || multicellular structure
Fly Anatomy (FA)	material anatomical entity	1	0	--	INHERITED FROM: anatomical group || organ system || multicellular structure || sensory system || non-connected functional system || organ system subdivision || cell || larva || somatic cell || adult || adult nervous system || organism || nervous system
Fly Anatomy (FA)	larva	0	0.3763	Least Informative	DIRECT
Fly Anatomy (FA)	adult	0	0.4496	Least Informative	DIRECT
Fly Anatomy (FA)	nervous system	0	0.6333	Least Informative	DIRECT
Fly Anatomy (FA)	anatomical group	0	0.6816	Least Informative	DIRECT
Fly Anatomy (FA)	organ system subdivision	0	0.4301	Least Informative	DIRECT
Fly Anatomy (FA)	somatic cell	0	0.4861	Least Informative	DIRECT

---

Zebrafish Anatomy (ZA)

Highlighted in gray are those with FDR_all>0.001

	ZA term	FDR (all)	IC level	SDZA level	Annotation (direct or inherited)
Zebrafish Anatomy (ZA)	compound organ	0	0.4299	--	DIRECT
Zebrafish Anatomy (ZA)	whole organism	0	0.00147	--	DIRECT
Zebrafish Anatomy (ZA)	anatomical system	0	0.1857	--	DIRECT
Zebrafish Anatomy (ZA)	anatomical group	0	0.1532	--	DIRECT
Zebrafish Anatomy (ZA)	anatomical structure	1	0	--	INHERITED FROM: anatomical system || multi-tissue structure || anatomical cluster || anatomical group || portion of tissue || whole organism || compound organ || cavitated compound organ
Zebrafish Anatomy (ZA)	anatomical cluster	0	0.7389	Least Informative	DIRECT
Zebrafish Anatomy (ZA)	multi-tissue structure	0	0.5848	Least Informative	DIRECT
Zebrafish Anatomy (ZA)	cavitated compound organ	0	0.5123	Least Informative	DIRECT
Zebrafish Anatomy (ZA)	portion of tissue	0	0.7637	Moderately Informative	DIRECT

---

Xenopus Anatomy (XA)

Highlighted in gray are those with FDR_all>0.001

	XA term	FDR (all)	IC level	SDXA level	Annotation (direct or inherited)
Xenopus ANatomical entity (XAN)	trunk region	0	0.388	--	DIRECT
Xenopus ANatomical entity (XAN)	central nervous system	0	0.5841	--	DIRECT
Xenopus ANatomical entity (XAN)	anatomical structure	0	0	--	DIRECT
Xenopus ANatomical entity (XAN)	anatomical group	0	0.1408	--	DIRECT
Xenopus ANatomical entity (XAN)	organism subdivision	0	0.1679	--	DIRECT
Xenopus ANatomical entity (XAN)	compound organ	0	0.2177	--	DIRECT
Xenopus ANatomical entity (XAN)	anatomical region	0	0.1803	--	DIRECT
Xenopus ANatomical entity (XAN)	multicellular anatomical structure	0	0.1131	--	DIRECT
Xenopus ANatomical entity (XAN)	anatomical system	1	0.283	--	INHERITED FROM: urogenital system || nervous system || central nervous system
Xenopus ANatomical entity (XAN)	whole organism	1	0.0884	--	INHERITED FROM: urogenital system || nervous system || anatomical group || cavitated compound organ || multicellular anatomical structure || compound organ || trunk || anatomical region || central nervous system || trunk region || organism subdivision
Xenopus ANatomical entity (XAN)	urogenital system	0	0.4777	Least Informative	DIRECT
Xenopus ANatomical entity (XAN)	nervous system	0	0.5619	Least Informative	DIRECT
Xenopus ANatomical entity (XAN)	trunk	0	0.3894	Least Informative	DIRECT
Xenopus ANatomical entity (XAN)	cavitated compound organ	0	0.2685	Least Informative	DIRECT
Xenopus DEvelopment stage (XDE)	NF stage	0	0.01895	--	DIRECT

---

Arabidopsis Plant Ontology (AP)

Highlighted in gray are those with FDR_all>0.001

	AP term	FDR (all)	IC level	SDAP level	Annotation (direct or inherited)
Plant ANatomical entity (PAN)	plant cell	0	0.1228	--	DIRECT
Plant ANatomical entity (PAN)	plant organ	0	0.2391	--	DIRECT
Plant ANatomical entity (PAN)	multi-tissue plant structure	0	0.2335	--	DIRECT
Plant ANatomical entity (PAN)	collective plant structure	0	0.01555	--	DIRECT
Plant ANatomical entity (PAN)	root epidermis	0.0002418	1.947	--	DIRECT
Plant ANatomical entity (PAN)	root system	0.1369	0.4584	--	INHERITED FROM: root epidermis || root epidermal cell
Plant ANatomical entity (PAN)	epidermis	0.1828	0.2046	--	INHERITED FROM: root epidermis || root epidermal cell
Plant ANatomical entity (PAN)	portion of plant tissue	0.2809	0.1621	--	INHERITED FROM: root epidermal cell || root epidermis
Plant ANatomical entity (PAN)	epidermal cell	0.5615	0.2152	--	INHERITED FROM: root epidermal cell
Plant ANatomical entity (PAN)	plant structure	1	0	--	INHERITED FROM: collective plant structure || multi-tissue plant structure || root epidermal cell || plant organ || root epidermis || plant cell
Plant ANatomical entity (PAN)	collective plant organ structure	1	0.03998	--	INHERITED FROM: root epidermal cell || root epidermis
Plant ANatomical entity (PAN)	root epidermal cell	0.0001832	1.998	Highly Informative	DIRECT
Plant structure DEvelopment stage (PDE)	floral organ differentiation stage	0	0.07163	--	DIRECT
Plant structure DEvelopment stage (PDE)	flowering stage	0	0.1648	--	DIRECT
Plant structure DEvelopment stage (PDE)	collective plant organ structure development stage	0	0.0282	--	DIRECT
Plant structure DEvelopment stage (PDE)	plant organ development stage	0	0.06127	--	DIRECT
Plant structure DEvelopment stage (PDE)	reproductive shoot system development stage	0	0.0371	--	DIRECT
Plant structure DEvelopment stage (PDE)	collective phyllome structure development stage	0	0.07163	--	DIRECT
Plant structure DEvelopment stage (PDE)	floral organ formation stage	0	0.07163	--	DIRECT
Plant structure DEvelopment stage (PDE)	flower development stage	1	0.05402	--	INHERITED FROM: flowering stage || floral organ differentiation stage || floral organ formation stage
Plant structure DEvelopment stage (PDE)	shoot system development stage	1	0.02956	--	INHERITED FROM: reproductive shoot system development stage || floral organ formation stage || floral organ differentiation stage || flowering stage || plant organ development stage

---

Enzyme Commission (EC)

Highlighted in gray are those with FDR_all>0.001

	EC term	FDR (all)	IC level	SDEC level	Annotation (direct or inherited)
Enzyme Commission (EC)	Transferring phosphorus-containing groups	0	0.7021	--	DIRECT
Enzyme Commission (EC)	1-phosphatidylinositol-5-phosphate 4-kinase	0	3.23	--	DIRECT
Enzyme Commission (EC)	1-phosphatidylinositol-3-phosphate 5-kinase	0	2.753	--	DIRECT
Enzyme Commission (EC)	1-phosphatidylinositol-4-phosphate 5-kinase	0	2.929	--	DIRECT
Enzyme Commission (EC)	Transferases	0	0.3972	Least Informative	DIRECT
Enzyme Commission (EC)	Phosphotransferases with an alcohol group as acceptor	0	1.238	Moderately Informative	DIRECT

---