ADC synthase superfamily

SCOP classification

• Root: SCOP hierarchy in SUPERFAMILY [ 0] (11)
• Class: Alpha and beta proteins (a+b) [ 53931] (376)
• Fold: ADC synthase [ 56321]
• Superfamily: ADC synthase [ 56322]
• Families: ADC synthase [ 56323] (5)

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Superfamily statistics

	Genomes (2,563)	Uniprot 2018_03 genome	PDB chains (SCOP 1.75)
Domains	6,762	51,552	8
Proteins	6,741	51,481	8

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Functional annotation

• General category: Metabolism
• Detailed category: Other enzymes

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Enzyme Commission (EC)

Highlighted in gray are those with FDR_all>0.001

	EC term	FDR (all)	IC level	SDEO level	Annotation (direct or inherited)
Enzyme Commission (EC)	Isochorismate synthase	0	2.56	--	DIRECT
Enzyme Commission (EC)	Aminodeoxychorismate synthase	0	2.259	--	DIRECT
Enzyme Commission (EC)	Transferring hydroxy groups	0	2.56	--	DIRECT
Enzyme Commission (EC)	Carbon-carbon lyases	0	0.8275	--	DIRECT
Enzyme Commission (EC)	Intramolecular transferases (mutases)	0.0000000002728	1.259	--	DIRECT
Enzyme Commission (EC)	Transaminases (aminotransferases)	0.0000000374	1.715	--	DIRECT
Enzyme Commission (EC)	Transferases	1	0	--	INHERITED FROM: Transferring nitrogenous groups || Aminodeoxychorismate synthase || Transaminases (aminotransferases)
Enzyme Commission (EC)	Lyases	0	0.4169	Least Informative	DIRECT
Enzyme Commission (EC)	Isomerases	0.0005844	0.5914	Least Informative	DIRECT
Enzyme Commission (EC)	Oxo-acid-lyases	0	1.606	Informative	DIRECT
Enzyme Commission (EC)	Transferring nitrogenous groups	0.0000001323	1.657	Informative	DIRECT
Enzyme Commission (EC)	Anthranilate synthase	0	2.083	Highly Informative	DIRECT

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Arabidopsis Plant Ontology (AP)

Highlighted in gray are those with FDR_all>0.001

	AP term	FDR (all)	IC level	SDAP level	Annotation (direct or inherited)
Plant ANatomical entity (PAN)	sepal	0	0.5715	--	DIRECT
Plant ANatomical entity (PAN)	multi-tissue plant structure	0	0.2691	--	DIRECT
Plant ANatomical entity (PAN)	carpel	0	0.6087	--	DIRECT
Plant ANatomical entity (PAN)	plant organ	0	0.2816	--	DIRECT
Plant ANatomical entity (PAN)	calyx	0	0.5715	--	DIRECT
Plant ANatomical entity (PAN)	collective plant structure	0	0.01577	--	DIRECT
Plant ANatomical entity (PAN)	reproductive shoot system	0	0.4141	--	DIRECT
Plant ANatomical entity (PAN)	shoot system	0	0.05747	--	DIRECT
Plant ANatomical entity (PAN)	sporophyll	0	0.4713	--	DIRECT
Plant ANatomical entity (PAN)	phyllome	0	0.3809	--	DIRECT
Plant ANatomical entity (PAN)	perianth	0	0.5448	--	DIRECT
Plant ANatomical entity (PAN)	gynoecium	0	0.6058	--	DIRECT
Plant ANatomical entity (PAN)	plant structure	1	0	--	INHERITED FROM: perianth || sporophyll || calyx || flower || collective plant structure || phyllome || multi-tissue plant structure || microsporophyll || megasporophyll || reproductive shoot system || shoot system || plant organ || whole plant || gynoecium || sepal || collective phyllome structure || carpel
Plant ANatomical entity (PAN)	collective plant organ structure	1	0.04502	--	INHERITED FROM: calyx || flower || sporophyll || perianth || phyllome || sepal || gynoecium || reproductive shoot system || carpel || collective phyllome structure || megasporophyll || microsporophyll || shoot system
Plant ANatomical entity (PAN)	microsporophyll	0	0.5029	Least Informative	DIRECT
Plant ANatomical entity (PAN)	flower	0	0.4337	Least Informative	DIRECT
Plant ANatomical entity (PAN)	whole plant	0	0.4218	Least Informative	DIRECT
Plant ANatomical entity (PAN)	collective phyllome structure	0	0.4648	Least Informative	DIRECT
Plant ANatomical entity (PAN)	megasporophyll	0	0.6087	Least Informative	DIRECT
Plant structure DEvelopment stage (PDE)	reproductive shoot system development stage	0	0.05008	--	DIRECT
Plant structure DEvelopment stage (PDE)	collective phyllome structure development stage	0	0.0937	--	DIRECT
Plant structure DEvelopment stage (PDE)	corolla development stage	0	0.1981	--	DIRECT
Plant structure DEvelopment stage (PDE)	flowering stage	0	0.2162	--	DIRECT
Plant structure DEvelopment stage (PDE)	floral organ differentiation stage	0	0.0937	--	DIRECT
Plant structure DEvelopment stage (PDE)	floral organ formation stage	0	0.0937	--	DIRECT
Plant structure DEvelopment stage (PDE)	collective plant organ structure development stage	0	0.03771	--	DIRECT
Plant structure DEvelopment stage (PDE)	plant organ development stage	0	0.08108	--	DIRECT
Plant structure DEvelopment stage (PDE)	shoot system development stage	1	0.04053	--	INHERITED FROM: reproductive shoot system development stage || floral organ formation stage || floral organ differentiation stage || flowering stage || corolla development stage || plant organ development stage
Plant structure DEvelopment stage (PDE)	flower development stage	1	0.07083	--	INHERITED FROM: corolla development stage || flowering stage || floral organ differentiation stage || floral organ formation stage

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Enzyme Commission (EC)

Highlighted in gray are those with FDR_all>0.001

	EC term	FDR (all)	IC level	SDEC level	Annotation (direct or inherited)
Enzyme Commission (EC)	Aminodeoxychorismate synthase	0	2.651	--	DIRECT
Enzyme Commission (EC)	Anthranilate synthase	0	2.475	--	DIRECT
Enzyme Commission (EC)	Transferring hydroxy groups	0	2.253	--	DIRECT
Enzyme Commission (EC)	Isochorismate synthase	0	2.952	--	DIRECT
Enzyme Commission (EC)	Transaminases	0.00000000000006002	2.107	--	DIRECT
Enzyme Commission (EC)	Transferases	1	0.3035	--	INHERITED FROM: Transaminases || Transferring nitrogenous groups || Aminodeoxychorismate synthase
Enzyme Commission (EC)	Lyases	0	0.6918	Least Informative	DIRECT
Enzyme Commission (EC)	Carbon-carbon lyases	0	1.101	Moderately Informative	DIRECT
Enzyme Commission (EC)	Isomerases	0.0009781	0.8446	Moderately Informative	DIRECT
Enzyme Commission (EC)	Intramolecular transferases	0.0000000005305	1.408	Informative	DIRECT
Enzyme Commission (EC)	Oxo-acid-lyases	0	1.838	Highly Informative	DIRECT
Enzyme Commission (EC)	Transferring nitrogenous groups	0.0000000000003846	2.049	Highly Informative	DIRECT

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InterPro annotation

• Cross references: IPR005801 SSF56322 Protein matches
• Abstract: This entry represents the catalytic regions of the chorismate binding enzymes anthranilate synthase, isochorismate synthase, aminodeoxychorismate synthase and para-aminobenzoate synthase. Anthranilate synthase catalyses the reaction: chorismate + l-glutamine = anthranilate + pyruvate + l-glutamate. The enzyme is a tetramer comprising 2 I and 2 II components: this entry is restricted to component I that catalyses the formation of anthranilate using ammonia rather than glutamine, while component II provides glutamine amidotransferase activity .

InterPro database

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