ADP-ribosylation superfamily

SCOP classification

• Root: SCOP hierarchy in SUPERFAMILY [ 0] (11)
• Class: Alpha and beta proteins (a+b) [ 53931] (376)
• Fold: ADP-ribosylation [ 56398]
• Superfamily: ADP-ribosylation [ 56399] (7)
• Families:
  • ADP-ribosylating toxins [ 56400] (9)
  • Ecto-ART [ 82814]
  • Poly(ADP-ribose) polymerase, C-terminal domain [ 56416]
  • AvrPphF ORF2, a type III effector [ 111257]
  • Tpt1/KptA [ 118162]
  • BC2332-like [ 143947]
  • CC0527-like [ 143950]

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Superfamily statistics

	Genomes (1,378)	Uniprot 2018_03 genome	PDB chains (SCOP 1.75)
Domains	8,115	30,979	57
Proteins	7,996	30,491	54

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Functional annotation

• General category: Metabolism
• Detailed category: Secondary metabolism

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Enzyme Commission (EC)

Highlighted in gray are those with FDR_all>0.001

	EC term	FDR (all)	IC level	SDEO level	Annotation (direct or inherited)
Enzyme Commission (EC)	2'-phosphotransferase	0	2.56	--	DIRECT
Enzyme Commission (EC)	Transferases	0	0	--	DIRECT
Enzyme Commission (EC)	NAD(+)--protein-arginine ADP-ribosyltransferase	0	2.56	--	DIRECT
Enzyme Commission (EC)	Pentosyltransferases	0	1.238	--	DIRECT
Enzyme Commission (EC)	NAD(+)--diphthamide ADP-ribosyltransferase	0.000000005076	2.56	--	DIRECT
Enzyme Commission (EC)	Transferring phosphorous-containing groups	1	0.2175	--	INHERITED FROM: 2'-phosphotransferase || 1-phosphatidylinositol 4-kinase || Phosphotransferases with an alcohol group as accep
Enzyme Commission (EC)	Glycosyltransferases	0	0.9165	Moderately Informative	DIRECT
Enzyme Commission (EC)	Phosphotransferases with an alcohol group as accep	0.0003869	0.8195	Moderately Informative	DIRECT
Enzyme Commission (EC)	NAD(+) ADP-ribosyltransferase	0	1.657	Informative	DIRECT
Enzyme Commission (EC)	1-phosphatidylinositol 4-kinase	0.00000000002686	2.083	Highly Informative	DIRECT

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Mouse Phenotype (MP)

Highlighted in gray are those with FDR_all>0.001

	MP term	FDR (all)	IC level	SDMP level	Annotation (direct or inherited)
Mammalian Phenotype (MP)	abnormal mortality induced by ionizing radiation	0.00005718	1.73	--	DIRECT
Mammalian Phenotype (MP)	homeostasis/metabolism phenotype	0.7988	0.3617	--	INHERITED FROM: increased mortality induced by ionizing radiation || abnormal response to radiation || abnormal mortality induced by ionizing radiation
Mammalian Phenotype (MP)	mortality/aging	0.7129	0.5888	Least Informative	INHERITED FROM: abnormal mortality induced by ionizing radiation || increased mortality induced by ionizing radiation
Mammalian Phenotype (MP)	abnormal induced morbidity/mortality	0.07751	1.186	Moderately Informative	INHERITED FROM: abnormal mortality induced by ionizing radiation || increased mortality induced by ionizing radiation
Mammalian Phenotype (MP)	abnormal metabolism	0.08448	1.093	Moderately Informative	INHERITED FROM: abnormal mortality induced by ionizing radiation || abnormal response to radiation || increased mortality induced by ionizing radiation
Mammalian Phenotype (MP)	abnormal response to radiation	0.00006629	1.73	Informative	DIRECT
Mammalian Phenotype (MP)	abnormal sensitivity to induced morbidity/mortality	0.04388	1.304	Informative	INHERITED FROM: increased mortality induced by ionizing radiation || abnormal mortality induced by ionizing radiation
Mammalian Phenotype (MP)	increased mortality induced by ionizing radiation	0.00004881	1.809	Highly Informative	DIRECT

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Worm Phenotype (WP)

Highlighted in gray are those with FDR_all>0.001

	WP term	FDR (all)	IC level	SDWP level	Annotation (direct or inherited)
Worm Phenotype (WP)	growth variant	0	0.4022	--	DIRECT
Worm Phenotype (WP)	slow growth	0	0.5903	--	DIRECT
Worm Phenotype (WP)	developmental timing variant	0	0.5373	--	DIRECT
Worm Phenotype (WP)	postembryonic development variant	0	0.3347	--	DIRECT
Worm Phenotype (WP)	embryonic lethal	0	0.07108	--	DIRECT
Worm Phenotype (WP)	larval arrest	0	0.5677	--	DIRECT
Worm Phenotype (WP)	lethal	0	0.01121	--	DIRECT
Worm Phenotype (WP)	progeny variant	0	0.7582	--	DIRECT
Worm Phenotype (WP)	fertility variant	0	0.08329	--	DIRECT
Worm Phenotype (WP)	development variant	0	0.001706	--	DIRECT
Worm Phenotype (WP)	morphology variant	0	0.06117	--	DIRECT
Worm Phenotype (WP)	organism development variant	0	0.004279	--	DIRECT
Worm Phenotype (WP)	organism morphology variant	0	0.2011	--	DIRECT
Worm Phenotype (WP)	organ system physiology variant	0	0.05921	--	DIRECT
Worm Phenotype (WP)	organism physiology variant	0	0.1405	--	DIRECT
Worm Phenotype (WP)	organism homeostasis metabolism variant	0	0.1501	--	DIRECT
Worm Phenotype (WP)	reproductive system physiology variant	0	0.07209	--	DIRECT
Worm Phenotype (WP)	maternal sterile	0	0.171	--	DIRECT
Worm Phenotype (WP)	hermaphrodite sterile	0	0.1685	--	DIRECT
Worm Phenotype (WP)	embryonic development variant	0	0.06709	--	DIRECT
Worm Phenotype (WP)	hermaphrodite fertility variant	0	0.1278	--	DIRECT
Worm Phenotype (WP)	developmental growth variant	0	0.5677	--	DIRECT
Worm Phenotype (WP)	hermaphrodite fertility reduced	0	0.1672	--	DIRECT
Worm Phenotype (WP)	fertility reduced	0	0.09267	--	DIRECT
Worm Phenotype (WP)	physiology variant	1	0	--	INHERITED FROM: hermaphrodite fertility variant || developmental growth variant || retarded heterochronic variations || larval lethal || reproductive system physiology variant || organism homeostasis metabolism variant || lethal || larval development variant || sterile progeny || organism physiology variant || progeny variant || slow growth || development variant || developmental timing variant || hermaphrodite sterile || growth variant || hermaphrodite fertility reduced || embryonic development variant || embryonic lethal || larval growth variant || general pace of development variant || fertility variant || postembryonic development variant || larval arrest || organ system physiology variant || maternal sterile || organism development variant || fertility reduced
Worm Phenotype (WP)	sterile	1	0.161	--	INHERITED FROM: hermaphrodite sterile || maternal sterile || sterile progeny
Worm Phenotype (WP)	general pace of development variant	0	0.5708	Least Informative	DIRECT
Worm Phenotype (WP)	larval lethal	0	0.6947	Least Informative	DIRECT
Worm Phenotype (WP)	retarded heterochronic variations	0	0.5373	Least Informative	DIRECT
Worm Phenotype (WP)	larval development variant	0	0.5007	Least Informative	DIRECT
Worm Phenotype (WP)	larval growth variant	0	0.5677	Least Informative	DIRECT
Worm Phenotype (WP)	sterile progeny	0	0.7582	Moderately Informative	DIRECT

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Zebrafish Anatomy (ZA)

Highlighted in gray are those with FDR_all>0.001

	ZA term	FDR (all)	IC level	SDZA level	Annotation (direct or inherited)
Zebrafish Anatomy (ZA)	whole organism	0	0.004764	--	DIRECT
Zebrafish Anatomy (ZA)	anatomical structure	1	0	--	INHERITED FROM: whole organism

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Xenopus Anatomy (XA)

Highlighted in gray are those with FDR_all>0.001

	XA term	FDR (all)	IC level	SDXA level	Annotation (direct or inherited)
Xenopus ANatomical entity (XAN)	anatomical structure	0	0	--	DIRECT
Xenopus ANatomical entity (XAN)	multicellular anatomical structure	0	0.1217	--	DIRECT
Xenopus ANatomical entity (XAN)	whole organism	1	0.09747	--	INHERITED FROM: multicellular anatomical structure
Xenopus DEvelopment stage (XDE)	NF stage	0	0.02327	--	DIRECT

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Arabidopsis Plant Ontology (AP)

Highlighted in gray are those with FDR_all>0.001

	AP term	FDR (all)	IC level	SDAP level	Annotation (direct or inherited)
Plant ANatomical entity (PAN)	stomatal complex	0	0.2774	--	DIRECT
Plant ANatomical entity (PAN)	epidermal cell	0	0.2569	--	DIRECT
Plant ANatomical entity (PAN)	epidermis	0	0.2464	--	DIRECT
Plant ANatomical entity (PAN)	shoot epidermis	0	0.2691	--	DIRECT
Plant ANatomical entity (PAN)	plant cell	0	0.1489	--	DIRECT
Plant ANatomical entity (PAN)	shoot system	0	0.05747	--	DIRECT
Plant ANatomical entity (PAN)	portion of plant tissue	0	0.1892	--	DIRECT
Plant ANatomical entity (PAN)	shoot epidermal cell	0	0.276	--	DIRECT
Plant ANatomical entity (PAN)	collective plant structure	0	0.01577	--	DIRECT
Plant ANatomical entity (PAN)	plant structure	1	0	--	INHERITED FROM: collective plant structure || guard cell || shoot system || portion of plant tissue || stomatal complex || epidermis || epidermal cell || shoot epidermal cell || plant cell || shoot epidermis
Plant ANatomical entity (PAN)	collective plant organ structure	1	0.04502	--	INHERITED FROM: guard cell || shoot epidermal cell || stomatal complex || shoot system || shoot epidermis
Plant ANatomical entity (PAN)	guard cell	0	0.2774	Least Informative	DIRECT
Plant structure DEvelopment stage (PDE)	floral organ differentiation stage	0	0.0937	--	DIRECT
Plant structure DEvelopment stage (PDE)	collective plant organ structure development stage	0	0.03771	--	DIRECT
Plant structure DEvelopment stage (PDE)	plant organ development stage	0	0.08108	--	DIRECT
Plant structure DEvelopment stage (PDE)	reproductive shoot system development stage	0	0.05008	--	DIRECT
Plant structure DEvelopment stage (PDE)	collective phyllome structure development stage	0	0.0937	--	DIRECT
Plant structure DEvelopment stage (PDE)	floral organ formation stage	0	0.0937	--	DIRECT
Plant structure DEvelopment stage (PDE)	flower development stage	1	0.07083	--	INHERITED FROM: floral organ differentiation stage || floral organ formation stage
Plant structure DEvelopment stage (PDE)	shoot system development stage	1	0.04053	--	INHERITED FROM: reproductive shoot system development stage || floral organ formation stage || floral organ differentiation stage || plant organ development stage

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Enzyme Commission (EC)

Highlighted in gray are those with FDR_all>0.001

	EC term	FDR (all)	IC level	SDEC level	Annotation (direct or inherited)
Enzyme Commission (EC)	Transferases	0	0.3035	--	DIRECT
Enzyme Commission (EC)	NAD(+)--protein-arginine ADP-ribosyltransferase	0	2.952	--	DIRECT
Enzyme Commission (EC)	2'-phosphotransferase	0	2.952	--	DIRECT
Enzyme Commission (EC)	NAD(+) glycohydrolase	2.574e-16	2.952	--	DIRECT
Enzyme Commission (EC)	1-phosphatidylinositol 4-kinase	0.00000000008016	2.35	--	DIRECT
Enzyme Commission (EC)	NAD(+)--diphthamide ADP-ribosyltransferase	0.0000000225	2.952	--	DIRECT
Enzyme Commission (EC)	Transferring phosphorus-containing groups	1	0.5453	Least Informative	INHERITED FROM: Phosphotransferases with an alcohol group as acceptor || 2'-phosphotransferase || 1-phosphatidylinositol 4-kinase
Enzyme Commission (EC)	Hydrolases	1	0.3541	Least Informative	INHERITED FROM: NAD(+) glycohydrolase || Hydrolyzing N-glycosyl compounds
Enzyme Commission (EC)	Glycosyltransferases	0	1.204	Moderately Informative	DIRECT
Enzyme Commission (EC)	Phosphotransferases with an alcohol group as acceptor	0.00003617	1.119	Moderately Informative	DIRECT
Enzyme Commission (EC)	Glycosylases	0.04722	1.094	Moderately Informative	INHERITED FROM: Hydrolyzing N-glycosyl compounds || NAD(+) glycohydrolase
Enzyme Commission (EC)	Pentosyltransferases	0	1.447	Informative	DIRECT
Enzyme Commission (EC)	Hydrolyzing N-glycosyl compounds	0.0001639	1.63	Informative	DIRECT
Enzyme Commission (EC)	NAD(+) ADP-ribosyltransferase	0	2.049	Highly Informative	DIRECT

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