Fibrinogen C-terminal domain-like family

SCOP classification

• Root: SCOP hierarchy in SUPERFAMILY [ 0] (11)
• Class: Alpha and beta proteins (a+b) [ 53931] (376)
• Fold: Fibrinogen C-terminal domain-like [ 56495]
• Superfamily: Fibrinogen C-terminal domain-like [ 56496]
• Family: Fibrinogen C-terminal domain-like [ 56497] (2)

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Family statistics

	Genomes (136)	Uniprot 2018_03 genome	PDB chains (SCOP 1.75)
Domains	3,650	10,260	21
Proteins	3,598	10,006	21

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Disease Ontology (DO)

Highlighted in gray are those with FDR_all>0.001

	DO term	FDR (all)	IC level	SDDO level	Annotation (direct or inherited)
Disease Ontology (DO)	blood coagulation disease	0.002353	1.258	--	INHERITED FROM: congenital afibrinogenemia
Disease Ontology (DO)	disease of anatomical entity	0.2347	0.2414	--	INHERITED FROM: congenital afibrinogenemia
Disease Ontology (DO)	hematopoietic system disease	0.06994	1.051	Moderately Informative	INHERITED FROM: congenital afibrinogenemia
Disease Ontology (DO)	inherited blood coagulation disease	0.00317	1.735	Informative	INHERITED FROM: congenital afibrinogenemia
Disease Ontology (DO)	congenital afibrinogenemia	0.0000002736	2.212	Highly Informative	DIRECT

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Human Phenotype (HP)

Highlighted in gray are those with FDR_all>0.001

	HP term	FDR (all)	IC level	SDHP level	Annotation (direct or inherited)
Phenotypic Abnormality (PA)	Abnormality of circulating fibrinogen	0.00002892	2.161	--	DIRECT
Phenotypic Abnormality (PA)	Venous thrombosis	0.0006248	1.763	--	DIRECT
Phenotypic Abnormality (PA)	Abnormality of the coagulation cascade	0.001285	1.684	--	INHERITED FROM: Abnormality of the common coagulation pathway || Abnormality of circulating fibrinogen
Phenotypic Abnormality (PA)	Abnormal oral mucosa morphology	0.001548	1.258	--	INHERITED FROM: Abnormality of the gingiva
Phenotypic Abnormality (PA)	Abnormal bleeding	0.001843	1.286	--	INHERITED FROM: Internal hemorrhage
Phenotypic Abnormality (PA)	Abnormal delivery	0.003134	1.763	--	INHERITED FROM: Spontaneous abortion
Phenotypic Abnormality (PA)	Abnormality of blood circulation	0.003725	1.421	--	INHERITED FROM: Internal hemorrhage
Phenotypic Abnormality (PA)	Abnormal thrombosis	0.005428	1.763	--	INHERITED FROM: Venous thrombosis
Phenotypic Abnormality (PA)	Abnormality of female internal genitalia	0.01864	1.258	--	INHERITED FROM: Menometrorrhagia
Phenotypic Abnormality (PA)	Abnormal spleen morphology	0.05486	1.348	--	INHERITED FROM: Splenic rupture
Phenotypic Abnormality (PA)	Menstrual irregularities	0.07052	1.559	--	INHERITED FROM: Menometrorrhagia
Phenotypic Abnormality (PA)	Abnormal internal genitalia	0.07295	1.232	--	INHERITED FROM: Menometrorrhagia
Phenotypic Abnormality (PA)	Abnormality of fluid regulation	0.07553	1.508	--	INHERITED FROM: Joint swelling
Phenotypic Abnormality (PA)	Abnormality of the vasculature	0.07585	0.7142	--	INHERITED FROM: Abnormality of the cerebral vasculature || Splenic rupture
Phenotypic Abnormality (PA)	Abnormality of the female genitalia	0.07697	1.207	--	INHERITED FROM: Menometrorrhagia
Phenotypic Abnormality (PA)	Abnormality of the spleen	0.08735	1.316	--	INHERITED FROM: Splenic rupture
Phenotypic Abnormality (PA)	Abnormality of brain morphology	0.09114	0.6631	--	INHERITED FROM: Abnormality of the cerebral vasculature
Phenotypic Abnormality (PA)	Puberty and gonadal disorders	0.1214	1.207	--	INHERITED FROM: Menometrorrhagia
Phenotypic Abnormality (PA)	Abnormality of the genital system	0.1257	0.9309	--	INHERITED FROM: Menometrorrhagia
Phenotypic Abnormality (PA)	Morphological abnormality of the central nervous system	0.1466	0.533	--	INHERITED FROM: Abnormality of the cerebral vasculature
Phenotypic Abnormality (PA)	Abnormal oral morphology	0.2755	0.7381	--	INHERITED FROM: Abnormality of the gingiva
Phenotypic Abnormality (PA)	Abnormality of the mouth	0.3272	0.7065	--	INHERITED FROM: Abnormality of the gingiva
Phenotypic Abnormality (PA)	Abnormality of the skeletal system	0.5052	0.4712	--	INHERITED FROM: Joint swelling
Phenotypic Abnormality (PA)	Abnormality of the nervous system	0.633	0.2371	--	INHERITED FROM: Abnormality of the cerebral vasculature
Phenotypic Abnormality (PA)	Abnormality of the head	0.743	0.4538	--	INHERITED FROM: Abnormality of the gingiva
Phenotypic Abnormality (PA)	Abnormality of head or neck	0.7528	0.4454	--	INHERITED FROM: Abnormality of the gingiva
Phenotypic Abnormality (PA)	Abnormality of the immune system	0.1009	0.7464	Least Informative	INHERITED FROM: Splenic rupture
Phenotypic Abnormality (PA)	Abnormality of nervous system morphology	0.2228	0.4756	Least Informative	INHERITED FROM: Abnormality of the cerebral vasculature
Phenotypic Abnormality (PA)	Abnormality of the cardiovascular system	0.31	0.5179	Least Informative	INHERITED FROM: Internal hemorrhage || Abnormality of the cerebral vasculature || Splenic rupture
Phenotypic Abnormality (PA)	Abnormality of the digestive system	0.384	0.5759	Least Informative	INHERITED FROM: Splenic rupture
Phenotypic Abnormality (PA)	Abnormality of skeletal morphology	0.4544	0.513	Least Informative	INHERITED FROM: Joint swelling
Phenotypic Abnormality (PA)	Abnormality of metabolism/homeostasis	0.4811	0.5486	Least Informative	INHERITED FROM: Joint swelling
Phenotypic Abnormality (PA)	Abnormality of the genitourinary system	0.4881	0.6051	Least Informative	INHERITED FROM: Menometrorrhagia
Phenotypic Abnormality (PA)	Abnormality of the face	0.6337	0.533	Least Informative	INHERITED FROM: Abnormality of the gingiva
Phenotypic Abnormality (PA)	Abnormal cardiovascular system physiology	0.02341	0.9309	Moderately Informative	INHERITED FROM: Internal hemorrhage
Phenotypic Abnormality (PA)	Abnormal joint morphology	0.04012	1.101	Moderately Informative	INHERITED FROM: Joint swelling
Phenotypic Abnormality (PA)	Abnormality of the endocrine system	0.08583	0.9183	Moderately Informative	INHERITED FROM: Menometrorrhagia
Phenotypic Abnormality (PA)	Abnormal reproductive system morphology	0.08858	1.031	Moderately Informative	INHERITED FROM: Menometrorrhagia
Phenotypic Abnormality (PA)	Abnormality of blood and blood-forming tissues	0.09926	0.9183	Moderately Informative	INHERITED FROM: Abnormality of the common coagulation pathway || Abnormality of circulating fibrinogen || Internal hemorrhage || Venous thrombosis
Phenotypic Abnormality (PA)	Abnormality of the abdominal organs	0.172	1.031	Moderately Informative	INHERITED FROM: Splenic rupture
Phenotypic Abnormality (PA)	Abnormality of the lymphatic system	0.2184	1.184	Moderately Informative	INHERITED FROM: Splenic rupture
Phenotypic Abnormality (PA)	Abnormal homeostasis	0.2766	0.7903	Moderately Informative	INHERITED FROM: Joint swelling
Phenotypic Abnormality (PA)	Abnormal oral cavity morphology	1	0.8289	Moderately Informative	INHERITED FROM: Abnormality of the gingiva
Phenotypic Abnormality (PA)	Abnormality of the cerebral vasculature	0.00001129	1.462	Informative	DIRECT
Phenotypic Abnormality (PA)	Internal hemorrhage	0.0002247	1.421	Informative	DIRECT
Phenotypic Abnormality (PA)	Abnormality of the gingiva	0.0002922	1.617	Informative	DIRECT
Phenotypic Abnormality (PA)	Abnormality of coagulation	0.0135	1.617	Informative	INHERITED FROM: Abnormality of the common coagulation pathway || Abnormality of circulating fibrinogen
Phenotypic Abnormality (PA)	Edema	0.05074	1.508	Informative	INHERITED FROM: Joint swelling
Phenotypic Abnormality (PA)	Abnormality of prenatal development or birth	0.05172	1.286	Informative	INHERITED FROM: Spontaneous abortion
Phenotypic Abnormality (PA)	Abnormality of the menstrual cycle	0.1161	1.559	Informative	INHERITED FROM: Menometrorrhagia
Phenotypic Abnormality (PA)	Splenic rupture	0.000000004439	2.161	Highly Informative	DIRECT
Phenotypic Abnormality (PA)	Menometrorrhagia	0.00000006839	2.161	Highly Informative	DIRECT
Phenotypic Abnormality (PA)	Spontaneous abortion	0.00007789	2.161	Highly Informative	DIRECT
Phenotypic Abnormality (PA)	Abnormality of the common coagulation pathway	0.0000856	1.985	Highly Informative	DIRECT
Phenotypic Abnormality (PA)	Joint swelling	0.00009827	2.161	Highly Informative	DIRECT

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Mouse Phenotype (MP)

Highlighted in gray are those with FDR_all>0.001

	MP term	FDR (all)	IC level	SDMP level	Annotation (direct or inherited)
Mammalian Phenotype (MP)	abnormal lymphatic vessel morphology	0.0003029	2.302	--	DIRECT
Mammalian Phenotype (MP)	abnormal immune system morphology	0.9362	0.7223	--	INHERITED FROM: abnormal lymphatic vessel morphology
Mammalian Phenotype (MP)	immune system phenotype	0.2721	0.5462	Least Informative	INHERITED FROM: abnormal lymphatic vessel morphology

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Worm Phenotype (WP)

Highlighted in gray are those with FDR_all>0.001

	WP term	FDR (all)	IC level	SDWP level	Annotation (direct or inherited)
Worm Phenotype (WP)	growth variant	0	0.3438	--	DIRECT
Worm Phenotype (WP)	developmental timing variant	0	0.4548	--	DIRECT
Worm Phenotype (WP)	general pace of development variant	0	0.4786	--	DIRECT
Worm Phenotype (WP)	postembryonic development variant	0	0.269	--	DIRECT
Worm Phenotype (WP)	embryonic lethal	0	0.046	--	DIRECT
Worm Phenotype (WP)	lethal	0	0.00521	--	DIRECT
Worm Phenotype (WP)	fertility variant	0	0.05937	--	DIRECT
Worm Phenotype (WP)	retarded heterochronic variations	0	0.4548	--	DIRECT
Worm Phenotype (WP)	development variant	0	0.001482	--	DIRECT
Worm Phenotype (WP)	morphology variant	0	0.046	--	DIRECT
Worm Phenotype (WP)	organism development variant	0	0.00297	--	DIRECT
Worm Phenotype (WP)	organism morphology variant	0	0.1372	--	DIRECT
Worm Phenotype (WP)	organ system physiology variant	0	0.04518	--	DIRECT
Worm Phenotype (WP)	organism physiology variant	0	0.1342	--	DIRECT
Worm Phenotype (WP)	organism homeostasis metabolism variant	0	0.1444	--	DIRECT
Worm Phenotype (WP)	reproductive system physiology variant	0	0.05515	--	DIRECT
Worm Phenotype (WP)	maternal sterile	0	0.1213	--	DIRECT
Worm Phenotype (WP)	hermaphrodite sterile	0	0.1203	--	DIRECT
Worm Phenotype (WP)	embryonic development variant	0	0.04518	--	DIRECT
Worm Phenotype (WP)	larval development variant	0	0.4322	--	DIRECT
Worm Phenotype (WP)	hermaphrodite fertility variant	0	0.0947	--	DIRECT
Worm Phenotype (WP)	developmental growth variant	0	0.4991	--	DIRECT
Worm Phenotype (WP)	larval growth variant	0	0.4991	--	DIRECT
Worm Phenotype (WP)	sterile progeny	0	0.6547	--	DIRECT
Worm Phenotype (WP)	hermaphrodite fertility reduced	0	0.1193	--	DIRECT
Worm Phenotype (WP)	fertility reduced	0	0.06449	--	DIRECT
Worm Phenotype (WP)	physiology variant	1	0	--	INHERITED FROM: hermaphrodite fertility variant || developmental growth variant || retarded heterochronic variations || larval lethal || reproductive system physiology variant || organism homeostasis metabolism variant || lethal || larval development variant || sterile progeny || organism physiology variant || progeny variant || slow growth || development variant || developmental timing variant || hermaphrodite sterile || growth variant || hermaphrodite fertility reduced || embryonic development variant || embryonic lethal || larval growth variant || general pace of development variant || fertility variant || postembryonic development variant || larval arrest || organ system physiology variant || maternal sterile || organism development variant || fertility reduced
Worm Phenotype (WP)	sterile	1	0.1135	--	INHERITED FROM: hermaphrodite sterile || maternal sterile || sterile progeny
Worm Phenotype (WP)	slow growth	0	0.4945	Least Informative	DIRECT
Worm Phenotype (WP)	larval lethal	0	0.5727	Least Informative	DIRECT
Worm Phenotype (WP)	larval arrest	0	0.4991	Least Informative	DIRECT
Worm Phenotype (WP)	progeny variant	0	0.6514	Least Informative	DIRECT

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Fly Anatomy (FA)

Highlighted in gray are those with FDR_all>0.001

	FA term	FDR (all)	IC level	SDFA level	Annotation (direct or inherited)
Fly Anatomy (FA)	external sensory organ	0	1.088	--	DIRECT
Fly Anatomy (FA)	sensillum	0	1.134	--	DIRECT
Fly Anatomy (FA)	external sensillum	0	1.159	--	DIRECT
Fly Anatomy (FA)	eo-type sensillum	0	1.486	--	DIRECT
Fly Anatomy (FA)	non-connected functional system	0	0.8451	--	DIRECT
Fly Anatomy (FA)	sensory system	0	0.8577	--	DIRECT
Fly Anatomy (FA)	multicellular structure	0	0.008955	--	DIRECT
Fly Anatomy (FA)	anatomical structure	1	0	--	INHERITED FROM: external sensory organ || sensillum || eo-type sensillum || chaeta || cell cluster organ || sense organ || external sensillum || multicellular structure
Fly Anatomy (FA)	material anatomical entity	1	0	--	INHERITED FROM: external sensillum || anatomical group || multicellular structure || sensory system || non-connected functional system || sense organ || cell cluster organ || chaeta || sensillum || eo-type sensillum || external sensory organ
Fly Anatomy (FA)	anatomical group	0	0.6816	Least Informative	DIRECT
Fly Anatomy (FA)	sense organ	0	1.047	Moderately Informative	DIRECT
Fly Anatomy (FA)	cell cluster organ	0	1.134	Moderately Informative	DIRECT
Fly Anatomy (FA)	chaeta	0	1.486	Informative	DIRECT

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Zebrafish Anatomy (ZA)

Highlighted in gray are those with FDR_all>0.001

	ZA term	FDR (all)	IC level	SDZA level	Annotation (direct or inherited)
Zebrafish Anatomy (ZA)	whole organism	0	0.00147	--	DIRECT
Zebrafish Anatomy (ZA)	anatomical structure	1	0	--	INHERITED FROM: whole organism

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Xenopus Anatomy (XA)

Highlighted in gray are those with FDR_all>0.001

	XA term	FDR (all)	IC level	SDXA level	Annotation (direct or inherited)
Xenopus ANatomical entity (XAN)	anatomical structure	0	0	--	DIRECT
Xenopus DEvelopment stage (XDE)	NF stage	0	0.01895	--	DIRECT

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