Nitric oxide (NO) synthase oxygenase domain family

SCOP classification

• Root: SCOP hierarchy in SUPERFAMILY [ 0] (11)
• Class: Alpha and beta proteins (a+b) [ 53931] (376)
• Fold: Nitric oxide (NO) synthase oxygenase domain [ 56511]
• Superfamily: Nitric oxide (NO) synthase oxygenase domain [ 56512]
• Family: Nitric oxide (NO) synthase oxygenase domain [ 56513]

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Family statistics

	Genomes (341)	Uniprot 2018_03 genome	PDB chains (SCOP 1.75)
Domains	572	2,893	31
Proteins	558	2,882	31

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Enzyme Commission (EC)

Highlighted in gray are those with FDR_all>0.001

	EC term	FDR (all)	IC level	SDEO level	Annotation (direct or inherited)
Enzyme Commission (EC)	Oxidoreductases	0	0.3212	Least Informative	DIRECT
Enzyme Commission (EC)	Acting on paired donors, with incorporation or red	0	1.173	Moderately Informative	DIRECT
Enzyme Commission (EC)	With NADH or NADPH as one donor, and incorporation	0	1.741	Informative	DIRECT
Enzyme Commission (EC)	Nitric-oxide synthase	0	2.042	Highly Informative	DIRECT

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Disease Ontology (DO)

Highlighted in gray are those with FDR_all>0.001

	DO term	FDR (all)	IC level	SDDO level	Annotation (direct or inherited)
Disease Ontology (DO)	carbohydrate metabolism disease	0	1.559	--	DIRECT
Disease Ontology (DO)	hypersensitivity reaction disease	0	0.8505	--	DIRECT
Disease Ontology (DO)	acquired metabolic disease	0	1.191	--	DIRECT
Disease Ontology (DO)	muscular disease	0	1.399	--	DIRECT
Disease Ontology (DO)	pre-eclampsia	0	1.735	--	DIRECT
Disease Ontology (DO)	nephritis	0	1.309	--	DIRECT
Disease Ontology (DO)	bronchial disease	0	1.133	--	DIRECT
Disease Ontology (DO)	malaria	0	1.735	--	DIRECT
Disease Ontology (DO)	cardiovascular system disease	0	0.7889	--	DIRECT
Disease Ontology (DO)	disease of cellular proliferation	0	0.2322	--	DIRECT
Disease Ontology (DO)	cognitive disorder	0	1.151	--	DIRECT
Disease Ontology (DO)	respiratory system disease	0	0.9334	--	DIRECT
Disease Ontology (DO)	cancer	0	0.2555	--	DIRECT
Disease Ontology (DO)	musculoskeletal system disease	0	0.89	--	DIRECT
Disease Ontology (DO)	vascular disease	0	0.832	--	DIRECT
Disease Ontology (DO)	parasitic protozoa infectious disease	0	1.735	--	DIRECT
Disease Ontology (DO)	immune system disease	0	0.8411	--	DIRECT
Disease Ontology (DO)	central nervous system disease	0	0.8698	--	DIRECT
Disease Ontology (DO)	kidney disease	0	1.066	--	DIRECT
Disease Ontology (DO)	tauopathy	0	1.61	--	DIRECT
Disease Ontology (DO)	disease of anatomical entity	0	0.2414	--	DIRECT
Disease Ontology (DO)	lung disease	0	1.258	--	DIRECT
Disease Ontology (DO)	diabetes mellitus	0	1.61	--	DIRECT
Disease Ontology (DO)	brain disease	0	1.258	--	DIRECT
Disease Ontology (DO)	organ system cancer	0	0.4879	Least Informative	DIRECT
Disease Ontology (DO)	nervous system disease	0	0.7279	Least Informative	DIRECT
Disease Ontology (DO)	disease of metabolism	0	0.9817	Moderately Informative	DIRECT
Disease Ontology (DO)	disease by infectious agent	0	0.8142	Moderately Informative	DIRECT
Disease Ontology (DO)	lower respiratory tract disease	0	0.9947	Moderately Informative	DIRECT
Disease Ontology (DO)	artery disease	0	0.9817	Moderately Informative	DIRECT
Disease Ontology (DO)	neurodegenerative disease	0	1.022	Moderately Informative	DIRECT
Disease Ontology (DO)	disease of mental health	0	1.036	Moderately Informative	DIRECT
Disease Ontology (DO)	urinary system disease	0	1.051	Moderately Informative	DIRECT
Disease Ontology (DO)	syndrome	0	1.151	Moderately Informative	DIRECT
Disease Ontology (DO)	nervous system cancer	0	1.191	Moderately Informative	DIRECT
Disease Ontology (DO)	hypersensitivity reaction type II disease	0	0.8797	Moderately Informative	DIRECT
Disease Ontology (DO)	gastrointestinal system disease	0	0.8797	Moderately Informative	DIRECT
Disease Ontology (DO)	Alzheimer's disease	0	1.61	Informative	DIRECT
Disease Ontology (DO)	hypertension	0	1.434	Informative	DIRECT
Disease Ontology (DO)	peripheral nervous system neoplasm	0	1.668	Informative	DIRECT
Disease Ontology (DO)	parasitic infectious disease	0	1.61	Informative	DIRECT
Disease Ontology (DO)	asthma	0	1.258	Informative	DIRECT
Disease Ontology (DO)	lupus erythematosus	0	1.61	Informative	DIRECT
Disease Ontology (DO)	upper respiratory tract disease	0	1.472	Informative	DIRECT
Disease Ontology (DO)	glucose metabolism disease	1	1.559	Informative	INHERITED FROM: diabetes mellitus
Disease Ontology (DO)	obstructive lung disease	0	1.814	Highly Informative	DIRECT
Disease Ontology (DO)	autonomic nervous system neoplasm	0	1.814	Highly Informative	DIRECT
Disease Ontology (DO)	ischemia	0	1.814	Highly Informative	DIRECT
Disease Ontology (DO)	migraine	0	1.814	Highly Informative	DIRECT

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Mouse Phenotype (MP)

Highlighted in gray are those with FDR_all>0.001

	MP term	FDR (all)	IC level	SDMP level	Annotation (direct or inherited)
Mammalian Phenotype (MP)	increased kidney apoptosis	0	2.001	--	DIRECT
Mammalian Phenotype (MP)	abnormal kidney apoptosis	0	2.001	--	DIRECT
Mammalian Phenotype (MP)	abnormal renal corpuscle morphology	0	1.427	--	DIRECT
Mammalian Phenotype (MP)	abnormal heart ventricle morphology	0	1.261	--	DIRECT
Mammalian Phenotype (MP)	abnormal lung morphology	0	1.205	--	DIRECT
Mammalian Phenotype (MP)	abnormal mononuclear cell morphology	0	0.8473	--	DIRECT
Mammalian Phenotype (MP)	abnormal heart ventricle pressure	0	2.001	--	DIRECT
Mammalian Phenotype (MP)	abnormal urine homeostasis	0	1.758	--	DIRECT
Mammalian Phenotype (MP)	abnormal macrophage physiology	0	1.825	--	DIRECT
Mammalian Phenotype (MP)	abnormal sodium ion homeostasis	0	2.001	--	DIRECT
Mammalian Phenotype (MP)	abnormal circulating cholesterol level	0	1.524	--	DIRECT
Mammalian Phenotype (MP)	abnormal nephron morphology	0	1.261	--	DIRECT
Mammalian Phenotype (MP)	abnormal bone mineral density	0	2.001	--	DIRECT
Mammalian Phenotype (MP)	abnormal vascular development	0	1.223	--	DIRECT
Mammalian Phenotype (MP)	visceral vascular congestion	0	1.904	--	DIRECT
Mammalian Phenotype (MP)	abnormal kidney cortex morphology	0	1.399	--	DIRECT
Mammalian Phenotype (MP)	abnormal blood osmolality	0	1.904	--	DIRECT
Mammalian Phenotype (MP)	kidney degeneration	0	2.001	--	DIRECT
Mammalian Phenotype (MP)	abnormal myeloid leukocyte morphology	0	1.223	--	DIRECT
Mammalian Phenotype (MP)	abnormal macrophage cell number	0	1.758	--	DIRECT
Mammalian Phenotype (MP)	abnormal smooth muscle morphology	0	1.825	--	DIRECT
Mammalian Phenotype (MP)	homeostasis/metabolism phenotype	0	0.3626	--	DIRECT
Mammalian Phenotype (MP)	abnormal cell physiology	0	0.6209	--	DIRECT
Mammalian Phenotype (MP)	renal necrosis	0	2.001	--	DIRECT
Mammalian Phenotype (MP)	abnormal female reproductive system morphology	0	1.261	--	DIRECT
Mammalian Phenotype (MP)	abnormal immune system physiology	0	0.6789	--	DIRECT
Mammalian Phenotype (MP)	preweaning lethality	0	0.7055	--	DIRECT
Mammalian Phenotype (MP)	behavior/neurological phenotype	0	0.8178	--	DIRECT
Mammalian Phenotype (MP)	abnormal circulating LDL cholesterol level	0	1.904	--	DIRECT
Mammalian Phenotype (MP)	lethality, incomplete penetrance	0	1.904	--	DIRECT
Mammalian Phenotype (MP)	abnormal gland morphology	0	0.7519	--	DIRECT
Mammalian Phenotype (MP)	skeleton phenotype	0	0.8038	--	DIRECT
Mammalian Phenotype (MP)	abnormal leukocyte morphology	0	0.8108	--	DIRECT
Mammalian Phenotype (MP)	abnormal blood homeostasis	0	0.6893	--	DIRECT
Mammalian Phenotype (MP)	abnormal female reproductive system physiology	0	1.223	--	DIRECT
Mammalian Phenotype (MP)	abnormal female genitalia morphology	0	1.261	--	DIRECT
Mammalian Phenotype (MP)	abnormal circulating lipid level	0	1.241	--	DIRECT
Mammalian Phenotype (MP)	abnormal immune system morphology	0	0.7223	--	DIRECT
Mammalian Phenotype (MP)	abnormal circulating amino acid level	0	1.7	--	DIRECT
Mammalian Phenotype (MP)	increased cholesterol level	0	1.758	--	DIRECT
Mammalian Phenotype (MP)	abnormal thrombosis	0	2.001	--	DIRECT
Mammalian Phenotype (MP)	abnormal fertility/fecundity	0	1.302	--	DIRECT
Mammalian Phenotype (MP)	abnormal osteoclast cell number	0	1.825	--	DIRECT
Mammalian Phenotype (MP)	abnormal nervous system morphology	0	0.5861	--	DIRECT
Mammalian Phenotype (MP)	abnormal circulating protein level	0	1.205	--	DIRECT
Mammalian Phenotype (MP)	abnormal circulating enzyme level	0	1.7	--	DIRECT
Mammalian Phenotype (MP)	abnormal immune cell physiology	0	0.9219	--	DIRECT
Mammalian Phenotype (MP)	abnormal hepatobiliary system morphology	0	1.098	--	DIRECT
Mammalian Phenotype (MP)	muscle phenotype	0	0.8473	--	DIRECT
Mammalian Phenotype (MP)	increased apoptosis	0	1.241	--	DIRECT
Mammalian Phenotype (MP)	increased body weight	0	1.758	--	DIRECT
Mammalian Phenotype (MP)	abnormal postnatal growth/weight/body size	0	0.8956	--	DIRECT
Mammalian Phenotype (MP)	abnormal blood circulation	0	1.261	--	DIRECT
Mammalian Phenotype (MP)	abnormal glomerular capillary morphology	0	1.904	--	DIRECT
Mammalian Phenotype (MP)	abnormal wound healing	0	1.825	--	DIRECT
Mammalian Phenotype (MP)	abnormal phagocyte morphology	0	1.281	--	DIRECT
Mammalian Phenotype (MP)	abnormal cardiovascular system morphology	0	0.7902	--	DIRECT
Mammalian Phenotype (MP)	arteriosclerosis	0	1.758	--	DIRECT
Mammalian Phenotype (MP)	abnormal circulating creatinine level	0	1.904	--	DIRECT
Mammalian Phenotype (MP)	abnormal hematopoietic cell morphology	0	0.7167	--	DIRECT
Mammalian Phenotype (MP)	abnormal coronary vessel morphology	0	2.001	--	DIRECT
Mammalian Phenotype (MP)	abnormal cholesterol level	0	1.524	--	DIRECT
Mammalian Phenotype (MP)	abnormal seizure response to inducing agent	0	1.603	--	DIRECT
Mammalian Phenotype (MP)	abnormal circulating alkaline phosphatase level	0	2.001	--	DIRECT
Mammalian Phenotype (MP)	abnormal hematopoietic system physiology	0	0.8789	--	DIRECT
Mammalian Phenotype (MP)	increased sterol level	0	1.758	--	DIRECT
Mammalian Phenotype (MP)	increased macrophage cell number	0	2.001	--	DIRECT
Mammalian Phenotype (MP)	abnormal blood urea nitrogen level	0	1.825	--	DIRECT
Mammalian Phenotype (MP)	abnormal heart rate	0	1.825	--	DIRECT
Mammalian Phenotype (MP)	abnormal motor capabilities/coordination/movement	0	1.205	--	DIRECT
Mammalian Phenotype (MP)	abnormal kidney capillary morphology	0	1.904	--	DIRECT
Mammalian Phenotype (MP)	abnormal kidney thrombosis	0	2.001	--	DIRECT
Mammalian Phenotype (MP)	abnormal circulating lipoprotein level	0	1.758	--	DIRECT
Mammalian Phenotype (MP)	vision/eye phenotype	0	0.8789	--	DIRECT
Mammalian Phenotype (MP)	abnormal skeleton physiology	0	1.302	--	DIRECT
Mammalian Phenotype (MP)	abnormal immune system cell morphology	0	0.8038	--	DIRECT
Mammalian Phenotype (MP)	abnormal pyloric sphincter morphology	0	2.001	--	DIRECT
Mammalian Phenotype (MP)	uremia	0	1.825	--	DIRECT
Mammalian Phenotype (MP)	abnormal kidney morphology	0	1.156	--	DIRECT
Mammalian Phenotype (MP)	abnormal adaptive immunity	0	0.9219	--	DIRECT
Mammalian Phenotype (MP)	abnormal lipid level	0	1.156	--	DIRECT
Mammalian Phenotype (MP)	abnormal circulating leptin level	0	1.758	--	DIRECT
Mammalian Phenotype (MP)	abnormal skeleton morphology	0	0.8323	--	DIRECT
Mammalian Phenotype (MP)	abnormal respiratory system morphology	0	1.072	--	DIRECT
Mammalian Phenotype (MP)	increased leukocyte cell number	0	1.241	--	DIRECT
Mammalian Phenotype (MP)	abnormal bone remodeling	0	1.825	--	DIRECT
Mammalian Phenotype (MP)	abnormal white adipose tissue amount	0	1.758	--	DIRECT
Mammalian Phenotype (MP)	abnormal urine osmolality	0	1.904	--	DIRECT
Mammalian Phenotype (MP)	abnormal stomach morphology	0	1.825	--	DIRECT
Mammalian Phenotype (MP)	digestive/alimentary phenotype	0	0.9404	--	DIRECT
Mammalian Phenotype (MP)	abnormal hematopoietic system morphology/development	0	0.6686	--	DIRECT
Mammalian Phenotype (MP)	dehydration	0	2.603	--	DIRECT
Mammalian Phenotype (MP)	abnormal circulating non-HDL cholesterol level	0	1.904	--	DIRECT
Mammalian Phenotype (MP)	abnormal sensitivity to induced morbidity/mortality	0	1.302	--	DIRECT
Mammalian Phenotype (MP)	abnormal urination	0	1.758	--	DIRECT
Mammalian Phenotype (MP)	abnormal renal/urinary system physiology	0	1.281	--	DIRECT
Mammalian Phenotype (MP)	abnormal liver vasculature morphology	0	2.001	--	DIRECT
Mammalian Phenotype (MP)	abnormal nervous system physiology	0	0.825	--	DIRECT
Mammalian Phenotype (MP)	abnormal urine sodium level	0	2.001	--	DIRECT
Mammalian Phenotype (MP)	decreased cardiac muscle contractility	0	1.7	--	DIRECT
Mammalian Phenotype (MP)	increased triglyceride level	0	1.758	--	DIRECT
Mammalian Phenotype (MP)	abnormal body weight	0	1.156	--	DIRECT
Mammalian Phenotype (MP)	abnormal sex gland morphology	0	1.141	--	DIRECT
Mammalian Phenotype (MP)	abnormal cognition	0	1.399	--	DIRECT
Mammalian Phenotype (MP)	abnormal leukocyte cell number	0	0.9129	--	DIRECT
Mammalian Phenotype (MP)	abnormal prostaglandin level	0	2.001	--	DIRECT
Mammalian Phenotype (MP)	abnormal adiponectin level	0	2.001	--	DIRECT
Mammalian Phenotype (MP)	abnormal stomach pyloric region morphology	0	2.001	--	DIRECT
Mammalian Phenotype (MP)	abnormal internal female genitalia morphology	0	1.281	--	DIRECT
Mammalian Phenotype (MP)	increased cell death	0	1.241	--	DIRECT
Mammalian Phenotype (MP)	increased systemic arterial blood pressure	0	1.825	--	DIRECT
Mammalian Phenotype (MP)	abnormal survival	0	0.6441	--	DIRECT
Mammalian Phenotype (MP)	abnormal mononuclear phagocyte morphology	0	1.457	--	DIRECT
Mammalian Phenotype (MP)	increased total tissue mass	0	1.758	--	DIRECT
Mammalian Phenotype (MP)	abnormal kidney blood vessel morphology	0	1.904	--	DIRECT
Mammalian Phenotype (MP)	abnormal fluid intake	0	2.001	--	DIRECT
Mammalian Phenotype (MP)	abnormal adipose tissue morphology	0	1.223	--	DIRECT
Mammalian Phenotype (MP)	increased circulating cholesterol level	0	1.758	--	DIRECT
Mammalian Phenotype (MP)	abnormal muscle contractility	0	1.427	--	DIRECT
Mammalian Phenotype (MP)	abnormal artery morphology	0	1.302	--	DIRECT
Mammalian Phenotype (MP)	cortical renal glomerulopathies	0	1.7	--	DIRECT
Mammalian Phenotype (MP)	increased fluid intake	0	2.001	--	DIRECT
Mammalian Phenotype (MP)	abnormal liver morphology	0	1.156	--	DIRECT
Mammalian Phenotype (MP)	abnormal drinking behavior	0	2.001	--	DIRECT
Mammalian Phenotype (MP)	abnormal osteoclast morphology	0	1.758	--	DIRECT
Mammalian Phenotype (MP)	abnormal glucose homeostasis	0	1.261	--	DIRECT
Mammalian Phenotype (MP)	abnormal cell-mediated immunity	0	0.9219	--	DIRECT
Mammalian Phenotype (MP)	abnormal circulating hormone level	0	1.241	--	DIRECT
Mammalian Phenotype (MP)	reproductive system phenotype	0	0.8397	--	DIRECT
Mammalian Phenotype (MP)	renal/urinary system phenotype	0	0.931	--	DIRECT
Mammalian Phenotype (MP)	pathological neovascularization	0	1.649	--	DIRECT
Mammalian Phenotype (MP)	abnormal capillary morphology	0	1.904	--	DIRECT
Mammalian Phenotype (MP)	abnormal respiratory system physiology	0	1.281	--	DIRECT
Mammalian Phenotype (MP)	abnormal lung vasculature morphology	0	2.001	--	DIRECT
Mammalian Phenotype (MP)	abnormal apoptosis	0	1.023	--	DIRECT
Mammalian Phenotype (MP)	abnormal hematopoietic cell number	0	0.8473	--	DIRECT
Mammalian Phenotype (MP)	abnormal hemostasis	0	1.399	--	DIRECT
Mammalian Phenotype (MP)	vasculature congestion	0	1.904	--	DIRECT
Mammalian Phenotype (MP)	abnormal total tissue mass	0	1.188	--	DIRECT
Mammalian Phenotype (MP)	abnormal ovulation cycle	0	2.302	--	DIRECT
Mammalian Phenotype (MP)	abnormal blood cell physiology	0	0.8789	--	DIRECT
Mammalian Phenotype (MP)	increased body size	0	1.758	--	DIRECT
Mammalian Phenotype (MP)	growth/size/body region phenotype	0	0.6254	Least Informative	DIRECT
Mammalian Phenotype (MP)	hematopoietic system phenotype	0	0.5945	Least Informative	DIRECT
Mammalian Phenotype (MP)	immune system phenotype	0	0.5462	Least Informative	DIRECT
Mammalian Phenotype (MP)	abnormal homeostasis	0	0.4926	Least Informative	DIRECT
Mammalian Phenotype (MP)	nervous system phenotype	0	0.4959	Least Informative	DIRECT
Mammalian Phenotype (MP)	endocrine/exocrine gland phenotype	0	0.6947	Least Informative	DIRECT
Mammalian Phenotype (MP)	cardiovascular system phenotype	0	0.6737	Least Informative	DIRECT
Mammalian Phenotype (MP)	mortality/aging	0	0.5424	Least Informative	DIRECT
Mammalian Phenotype (MP)	cellular phenotype	0	0.5387	Least Informative	DIRECT
Mammalian Phenotype (MP)	abnormal bone structure	0	1.241	Moderately Informative	DIRECT
Mammalian Phenotype (MP)	abnormal hormone level	0	1.141	Moderately Informative	DIRECT
Mammalian Phenotype (MP)	prenatal lethality	0	0.9129	Moderately Informative	DIRECT
Mammalian Phenotype (MP)	abnormal leukocyte physiology	0	0.9219	Moderately Informative	DIRECT
Mammalian Phenotype (MP)	abnormal renal/urinary system morphology	0	1.047	Moderately Informative	DIRECT
Mammalian Phenotype (MP)	abnormal cell death	0	0.9904	Moderately Informative	DIRECT
Mammalian Phenotype (MP)	abnormal professional antigen presenting cell physiology	0	1.098	Moderately Informative	DIRECT
Mammalian Phenotype (MP)	abnormal reproductive system morphology	0	0.9404	Moderately Informative	DIRECT
Mammalian Phenotype (MP)	abnormal induced morbidity/mortality	0	1.241	Moderately Informative	DIRECT
Mammalian Phenotype (MP)	abnormal brain morphology	0	0.9799	Moderately Informative	DIRECT
Mammalian Phenotype (MP)	abnormal eye morphology	0	0.9129	Moderately Informative	DIRECT
Mammalian Phenotype (MP)	abnormal muscle morphology	0	1.112	Moderately Informative	DIRECT
Mammalian Phenotype (MP)	adipose tissue phenotype	0	1.205	Moderately Informative	DIRECT
Mammalian Phenotype (MP)	abnormal body composition	0	1.112	Moderately Informative	DIRECT
Mammalian Phenotype (MP)	abnormal blood vessel morphology	0	1.023	Moderately Informative	DIRECT
Mammalian Phenotype (MP)	abnormal professional antigen presenting cell morphology	0	1.098	Moderately Informative	DIRECT
Mammalian Phenotype (MP)	respiratory system phenotype	0	0.9404	Moderately Informative	DIRECT
Mammalian Phenotype (MP)	abnormal heart morphology	0	0.9597	Moderately Informative	DIRECT
Mammalian Phenotype (MP)	abnormal lipid homeostasis	0	1.141	Moderately Informative	DIRECT
Mammalian Phenotype (MP)	increased hematopoietic cell number	0	1.188	Moderately Informative	DIRECT
Mammalian Phenotype (MP)	abnormal cardiovascular development	0	1.059	Moderately Informative	DIRECT
Mammalian Phenotype (MP)	abnormal neuron morphology	0	0.8323	Moderately Informative	DIRECT
Mammalian Phenotype (MP)	abnormal protein level	0	1.112	Moderately Informative	DIRECT
Mammalian Phenotype (MP)	liver/biliary system phenotype	0	1.012	Moderately Informative	DIRECT
Mammalian Phenotype (MP)	abnormal cardiovascular system physiology	0	0.9499	Moderately Informative	DIRECT
Mammalian Phenotype (MP)	abnormal muscle physiology	0	1.085	Moderately Informative	DIRECT
Mammalian Phenotype (MP)	abnormal myeloid cell morphology	0	0.9904	Moderately Informative	DIRECT
Mammalian Phenotype (MP)	abnormal digestive system morphology	0	1.023	Moderately Informative	DIRECT
Mammalian Phenotype (MP)	abnormal body size	0	1.001	Moderately Informative	DIRECT
Mammalian Phenotype (MP)	abnormal inflammatory response	0	1.023	Moderately Informative	DIRECT
Mammalian Phenotype (MP)	abnormal reproductive system physiology	0	1.012	Moderately Informative	DIRECT
Mammalian Phenotype (MP)	abnormal behavior	1	0.855	Moderately Informative	INHERITED FROM: abnormal learning/memory/conditioning || abnormal seizure response to inducing agent || abnormal motor capabilities/coordination/movement || abnormal cognition || abnormal fluid intake || seizures || abnormal drinking behavior || increased fluid intake || abnormal consumption behavior || polydipsia
Mammalian Phenotype (MP)	abnormal innate immunity	0	1.427	Informative	DIRECT
Mammalian Phenotype (MP)	abnormal kidney physiology	0	1.427	Informative	DIRECT
Mammalian Phenotype (MP)	premature death	0	1.524	Informative	DIRECT
Mammalian Phenotype (MP)	abnormal response to injury	0	1.261	Informative	DIRECT
Mammalian Phenotype (MP)	abnormal learning/memory/conditioning	0	1.399	Informative	DIRECT
Mammalian Phenotype (MP)	abnormal ion homeostasis	0	1.524	Informative	DIRECT
Mammalian Phenotype (MP)	abnormal angiogenesis	0	1.427	Informative	DIRECT
Mammalian Phenotype (MP)	abnormal bone ossification	0	1.562	Informative	DIRECT
Mammalian Phenotype (MP)	abnormal blood coagulation	0	1.399	Informative	DIRECT
Mammalian Phenotype (MP)	abnormal neuron physiology	0	1.524	Informative	DIRECT
Mammalian Phenotype (MP)	abnormal systemic arterial blood pressure	0	1.7	Informative	DIRECT
Mammalian Phenotype (MP)	abnormal circulating glucose level	0	1.562	Informative	DIRECT
Mammalian Phenotype (MP)	abnormal sterol level	0	1.489	Informative	DIRECT
Mammalian Phenotype (MP)	abnormal lipoprotein level	0	1.7	Informative	DIRECT
Mammalian Phenotype (MP)	abnormal white adipose tissue morphology	0	1.603	Informative	DIRECT
Mammalian Phenotype (MP)	abnormal triglyceride level	0	1.457	Informative	DIRECT
Mammalian Phenotype (MP)	abnormal macrophage morphology	0	1.524	Informative	DIRECT
Mammalian Phenotype (MP)	abnormal heartbeat	0	1.649	Informative	DIRECT
Mammalian Phenotype (MP)	abnormal amino acid level	0	1.649	Informative	DIRECT
Mammalian Phenotype (MP)	abnormal cardiac muscle contractility	0	1.7	Informative	DIRECT
Mammalian Phenotype (MP)	abnormal trabecular bone morphology	0	1.489	Informative	DIRECT
Mammalian Phenotype (MP)	abnormal gas homeostasis	0	1.649	Informative	DIRECT
Mammalian Phenotype (MP)	abnormal renal glomerulus morphology	0	1.457	Informative	DIRECT
Mammalian Phenotype (MP)	abnormal digestive system physiology	0	1.399	Informative	DIRECT
Mammalian Phenotype (MP)	abnormal blood vessel physiology	0	1.373	Informative	DIRECT
Mammalian Phenotype (MP)	seizures	0	1.427	Informative	DIRECT
Mammalian Phenotype (MP)	abnormal renal tubule morphology	0	1.649	Informative	DIRECT
Mammalian Phenotype (MP)	abnormal consumption behavior	0	1.603	Informative	DIRECT
Mammalian Phenotype (MP)	abnormal adipose tissue amount	0	1.489	Informative	DIRECT
Mammalian Phenotype (MP)	abnormal fluid regulation	0	1.373	Informative	DIRECT
Mammalian Phenotype (MP)	abnormal heart ventricle wall thickness	0	1.7	Informative	DIRECT
Mammalian Phenotype (MP)	abnormal enzyme/coenzyme level	0	1.649	Informative	DIRECT
Mammalian Phenotype (MP)	abnormal circulating triglyceride level	0	1.562	Informative	DIRECT
Mammalian Phenotype (MP)	abnormal skeleton development	0	1.457	Informative	DIRECT
Mammalian Phenotype (MP)	impaired muscle contractility	0	1.457	Informative	DIRECT
Mammalian Phenotype (MP)	abnormal cholesterol homeostasis	0	1.524	Informative	DIRECT
Mammalian Phenotype (MP)	increased circulating LDL cholesterol level	0	2.001	Highly Informative	DIRECT
Mammalian Phenotype (MP)	pulmonary vascular congestion	0	2.001	Highly Informative	DIRECT
Mammalian Phenotype (MP)	abnormal coronary artery morphology	0	2.001	Highly Informative	DIRECT
Mammalian Phenotype (MP)	abnormal osteoclast physiology	0	2.001	Highly Informative	DIRECT
Mammalian Phenotype (MP)	abnormal neuron apoptosis	0	2.001	Highly Informative	DIRECT
Mammalian Phenotype (MP)	renal tubular necrosis	0	2.001	Highly Informative	DIRECT
Mammalian Phenotype (MP)	increased blood osmolality	0	1.904	Highly Informative	DIRECT
Mammalian Phenotype (MP)	perivascular fibrosis	0	2.001	Highly Informative	DIRECT
Mammalian Phenotype (MP)	increased circulating triglyceride level	0	1.825	Highly Informative	DIRECT
Mammalian Phenotype (MP)	pyloric sphincter hypertrophy	0	2.001	Highly Informative	DIRECT
Mammalian Phenotype (MP)	decreased urine sodium level	0	2.001	Highly Informative	DIRECT
Mammalian Phenotype (MP)	glomerulosclerosis	0	1.904	Highly Informative	DIRECT
Mammalian Phenotype (MP)	increased blood urea nitrogen level	0	1.825	Highly Informative	DIRECT
Mammalian Phenotype (MP)	increased prostaglandin level	0	2.001	Highly Informative	DIRECT
Mammalian Phenotype (MP)	abnormal heart left ventricle pressure	0	2.001	Highly Informative	DIRECT
Mammalian Phenotype (MP)	enlarged stomach	0	2.001	Highly Informative	DIRECT
Mammalian Phenotype (MP)	abnormal vascular wound healing	0	1.904	Highly Informative	DIRECT
Mammalian Phenotype (MP)	decreased urine osmolality	0	1.904	Highly Informative	DIRECT
Mammalian Phenotype (MP)	liver vascular congestion	0	2.001	Highly Informative	DIRECT
Mammalian Phenotype (MP)	decreased systemic arterial blood pressure	0	1.904	Highly Informative	DIRECT
Mammalian Phenotype (MP)	polyuria	0	1.904	Highly Informative	DIRECT
Mammalian Phenotype (MP)	reduced fertility	0	1.825	Highly Informative	DIRECT
Mammalian Phenotype (MP)	increased bone mineral density	0	2.001	Highly Informative	DIRECT
Mammalian Phenotype (MP)	abnormal nitric oxide homeostasis	0	2.001	Highly Informative	DIRECT
Mammalian Phenotype (MP)	decreased adiponectin level	0	2.001	Highly Informative	DIRECT
Mammalian Phenotype (MP)	increased systemic arterial systolic blood pressure	0	1.904	Highly Informative	DIRECT
Mammalian Phenotype (MP)	congestive heart failure	0	1.904	Highly Informative	DIRECT
Mammalian Phenotype (MP)	increased osteoclast cell number	0	2.001	Highly Informative	DIRECT
Mammalian Phenotype (MP)	increased white adipose tissue amount	0	1.904	Highly Informative	DIRECT
Mammalian Phenotype (MP)	increased circulating creatinine level	0	1.904	Highly Informative	DIRECT
Mammalian Phenotype (MP)	prenatal lethality, incomplete penetrance	0	1.904	Highly Informative	DIRECT
Mammalian Phenotype (MP)	increased circulating alkaline phosphatase level	0	2.001	Highly Informative	DIRECT
Mammalian Phenotype (MP)	increased renal tubule apoptosis	0	2.001	Highly Informative	DIRECT
Mammalian Phenotype (MP)	thick ventricular wall	0	1.904	Highly Informative	DIRECT
Mammalian Phenotype (MP)	glomerular capillary thrombosis	0	2.001	Highly Informative	DIRECT
Mammalian Phenotype (MP)	hypertension	0	2.001	Highly Informative	DIRECT
Mammalian Phenotype (MP)	decreased heart rate	0	1.904	Highly Informative	DIRECT
Mammalian Phenotype (MP)	abnormal vascular endothelial cell physiology	0	2.001	Highly Informative	DIRECT
Mammalian Phenotype (MP)	abnormal bone mineralization	0	1.825	Highly Informative	DIRECT
Mammalian Phenotype (MP)	polydipsia	0	2.001	Highly Informative	DIRECT
Mammalian Phenotype (MP)	decreased survivor rate	0	1.904	Highly Informative	DIRECT

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Xenopus Anatomy (XA)

Highlighted in gray are those with FDR_all>0.001

	XA term	FDR (all)	IC level	SDXA level	Annotation (direct or inherited)
Xenopus ANatomical entity (XAN)	anatomical structure	0	0	--	DIRECT
Xenopus ANatomical entity (XAN)	anatomical group	0	0.1408	--	DIRECT
Xenopus ANatomical entity (XAN)	whole organism	1	0.0884	--	INHERITED FROM: anatomical group

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Enzyme Commission (EC)

Highlighted in gray are those with FDR_all>0.001

	EC term	FDR (all)	IC level	SDEC level	Annotation (direct or inherited)
Enzyme Commission (EC)	Nitric-oxide synthase (NADPH)	0	2.531	--	DIRECT
Enzyme Commission (EC)	Nitric-oxide synthase (flavodoxin)	0	3.23	--	DIRECT
Enzyme Commission (EC)	Oxidoreductases	0	0.7328	Least Informative	DIRECT
Enzyme Commission (EC)	Acting on paired donors, with incorporation or reduction of molecular oxygen. The oxygen incorporate	0	1.514	Informative	DIRECT
Enzyme Commission (EC)	With NADH or NADPH as one donor, and incorporation of one atom of oxygen	0	2.026	Highly Informative	DIRECT
Enzyme Commission (EC)	With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen	1	2.151	Highly Informative	INHERITED FROM: Nitric-oxide synthase (flavodoxin)

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