DNA/RNA polymerases superfamily

SCOP classification

• Root: SCOP hierarchy in SUPERFAMILY [ 0] (11)
• Class: Multi-domain proteins (alpha and beta) [ 56572] (66)
• Fold: DNA/RNA polymerases [ 56671]
• Superfamily: DNA/RNA polymerases [ 56672] (6)
• Families:
  • DNA polymerase I [ 56673] (4)
  • Lesion bypass DNA polymerase (Y-family), catalytic domain [ 100888] (4)
  • Reverse transcriptase [ 56686] (2)
  • T7 RNA polymerase [ 56691]
  • RNA-dependent RNA-polymerase [ 56694] (2)
  • dsRNA phage RNA-dependent RNA-polymerase [ 64480]

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Superfamily statistics

	Genomes (3,191)	Uniprot 2018_03 genome	PDB chains (SCOP 1.75)
Domains	58,500	658,000	164
Proteins	57,724	655,670	164

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Functional annotation

• General category: Information
• Detailed category: DNA replication/repair

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Enzyme Commission (EC)

Highlighted in gray are those with FDR_all>0.001

	EC term	FDR (all)	IC level	SDEO level	Annotation (direct or inherited)
Enzyme Commission (EC)	Transferases	0	0	--	DIRECT
Enzyme Commission (EC)	HIV-1 retropepsin	0	1.657	--	DIRECT
Enzyme Commission (EC)	Exoribonucleases producing 5'-phosphomonoesters	0	1.305	--	DIRECT
Enzyme Commission (EC)	RNA helicase	0	1.217	--	DIRECT
Enzyme Commission (EC)	Transferring phosphorous-containing groups	0	0.2175	--	DIRECT
Enzyme Commission (EC)	Hydrolases	0	0.04271	--	DIRECT
Enzyme Commission (EC)	Ubiquitinyl hydrolase 1	0	1.238	--	DIRECT
Enzyme Commission (EC)	HIV-2 retropepsin	0.00002937	1.657	--	DIRECT
Enzyme Commission (EC)	Nucleotidyltransferases	0	0.6105	Least Informative	DIRECT
Enzyme Commission (EC)	Acting on peptide bonds (peptide hydrolases)	0	0.5513	Least Informative	DIRECT
Enzyme Commission (EC)	Acting on acid anhydrides	0	0.6408	Least Informative	DIRECT
Enzyme Commission (EC)	Acting on ester bonds	0	0.4665	Least Informative	DIRECT
Enzyme Commission (EC)	Transferring one-carbon groups	1	0.7211	Least Informative	INHERITED FROM: mRNA (nucleoside-2'-O-)-methyltransferase || mRNA (guanine-N(7)-)-methyltransferase
Enzyme Commission (EC)	Endoribonucleases producing 5'-phosphomonoesters	0	1.238	Moderately Informative	DIRECT
Enzyme Commission (EC)	In phosphorous-containing anhydrides	0	1.016	Moderately Informative	DIRECT
Enzyme Commission (EC)	Acting on acid anhydrides; involved in cellular an	0	0.8971	Moderately Informative	DIRECT
Enzyme Commission (EC)	Cysteine endopeptidases	0	1.238	Moderately Informative	DIRECT
Enzyme Commission (EC)	DNA-directed DNA polymerase	0	1.238	Moderately Informative	DIRECT
Enzyme Commission (EC)	Serine endopeptidases	1	0.9917	Moderately Informative	INHERITED FROM: Pestivirus NS3 polyprotein peptidase || Hepacivirin || Flavivirin
Enzyme Commission (EC)	Omega peptidases	0.587	1.145	Moderately Informative	INHERITED FROM: Ubiquitinyl hydrolase 1
Enzyme Commission (EC)	Phosphoric monoester hydrolases	1	0.9165	Moderately Informative	INHERITED FROM: Polynucleotide 5'-phosphatase
Enzyme Commission (EC)	Methyltransferases	1	0.8609	Moderately Informative	INHERITED FROM: mRNA (nucleoside-2'-O-)-methyltransferase || mRNA (guanine-N(7)-)-methyltransferase
Enzyme Commission (EC)	mRNA (nucleoside-2'-O-)-methyltransferase	0	1.715	Informative	DIRECT
Enzyme Commission (EC)	mRNA (guanine-N(7)-)-methyltransferase	0	1.715	Informative	DIRECT
Enzyme Commission (EC)	Retroviral ribonuclease H	0	1.56	Informative	DIRECT
Enzyme Commission (EC)	Flavivirin	0	1.715	Informative	DIRECT
Enzyme Commission (EC)	RNA-directed DNA polymerase	0	1.519	Informative	DIRECT
Enzyme Commission (EC)	Nucleoside-triphosphatase	0	1.519	Informative	DIRECT
Enzyme Commission (EC)	Exoribonuclease H	0	1.56	Informative	DIRECT
Enzyme Commission (EC)	Aspartic endopeptidases	0	1.56	Informative	DIRECT
Enzyme Commission (EC)	RNA-directed RNA polymerase	0	1.305	Informative	DIRECT
Enzyme Commission (EC)	Hepacivirin	0	2.083	Highly Informative	DIRECT
Enzyme Commission (EC)	Picornain 3C	0	1.861	Highly Informative	DIRECT
Enzyme Commission (EC)	Polynucleotide 5'-phosphatase	0	1.782	Highly Informative	DIRECT
Enzyme Commission (EC)	Ribonuclease H	0.00000000000002098	2.083	Highly Informative	DIRECT
Enzyme Commission (EC)	Picornain 2A	0.0000000002396	1.861	Highly Informative	DIRECT
Enzyme Commission (EC)	Nuclear-inclusion-a endopeptidase	0.000000001069	2.083	Highly Informative	DIRECT
Enzyme Commission (EC)	Pestivirus NS3 polyprotein peptidase	0.0000001803	2.083	Highly Informative	DIRECT
Enzyme Commission (EC)	Calicivirin	0.000002573	1.958	Highly Informative	DIRECT
Enzyme Commission (EC)	Helper-component proteinase	0.000003673	1.958	Highly Informative	DIRECT

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Human Phenotype (HP)

Highlighted in gray are those with FDR_all>0.001

	HP term	FDR (all)	IC level	SDHP level	Annotation (direct or inherited)
Phenotypic Abnormality (PA)	Abnormality of head or neck	0	0.472	--	DIRECT
Phenotypic Abnormality (PA)	Abnormality of the face	0	0.5614	--	DIRECT
Phenotypic Abnormality (PA)	Abnormality of the nervous system	0	0.2543	--	DIRECT
Phenotypic Abnormality (PA)	Telangiectasia	0.000009384	2.407	--	DIRECT
Phenotypic Abnormality (PA)	Abnormal inflammatory response	0.0002955	1.176	--	DIRECT
Phenotypic Abnormality (PA)	Abnormality of the breast	0.001019	1.708	--	INHERITED FROM: Abnormal breast morphology
Phenotypic Abnormality (PA)	Abnormality of the immune system	0.009564	0.8268	--	INHERITED FROM: Abnormal inflammatory response
Phenotypic Abnormality (PA)	Vascular skin abnormality	0.01453	1.628	--	INHERITED FROM: Telangiectasia
Phenotypic Abnormality (PA)	Abnormality of the skin	0.01737	0.8751	--	INHERITED FROM: Telangiectasia || Dermal atrophy
Phenotypic Abnormality (PA)	Aplasia/Hypoplasia of the skin	0.01832	1.804	--	INHERITED FROM: Dermal atrophy
Phenotypic Abnormality (PA)	Abnormality of the head	0	0.4771	Least Informative	DIRECT
Phenotypic Abnormality (PA)	Abnormality of the integument	0.04358	0.7253	Least Informative	INHERITED FROM: Dermal atrophy || Telangiectasia
Phenotypic Abnormality (PA)	Abnormality of the cardiovascular system	0.04585	0.6284	Least Informative	INHERITED FROM: Telangiectasia
Phenotypic Abnormality (PA)	Abnormality of immune system physiology	0.002762	0.9441	Moderately Informative	INHERITED FROM: Abnormal inflammatory response
Phenotypic Abnormality (PA)	Abnormality of skin morphology	0.01182	0.9441	Moderately Informative	INHERITED FROM: Dermal atrophy || Telangiectasia
Phenotypic Abnormality (PA)	Neoplasm	0.02925	1.106	Moderately Informative	INHERITED FROM: Neoplasm by histology
Phenotypic Abnormality (PA)	Abnormality of the vasculature	0.2292	0.8625	Moderately Informative	INHERITED FROM: Telangiectasia
Phenotypic Abnormality (PA)	Neoplasm by histology	0.0005915	1.708	Informative	DIRECT
Phenotypic Abnormality (PA)	Abnormal breast morphology	0.0009877	1.708	Informative	DIRECT
Phenotypic Abnormality (PA)	Localized skin lesion	0.2022	1.327	Informative	INHERITED FROM: Dermal atrophy
Phenotypic Abnormality (PA)	Generalized abnormality of skin	0.2504	1.503	Informative	INHERITED FROM: Telangiectasia
Phenotypic Abnormality (PA)	Dermal atrophy	0.0001027	2.106	Highly Informative	DIRECT

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Mouse Phenotype (MP)

Highlighted in gray are those with FDR_all>0.001

	MP term	FDR (all)	IC level	SDMP level	Annotation (direct or inherited)
Mammalian Phenotype (MP)	abnormal somatic hypermutation frequency	0.00001544	2.508	--	DIRECT
Mammalian Phenotype (MP)	increased tumor incidence	0.00003152	1.11	--	DIRECT
Mammalian Phenotype (MP)	abnormal tumor incidence	0.0000737	1.11	--	DIRECT
Mammalian Phenotype (MP)	altered tumor susceptibility	0.00008221	1.11	--	DIRECT
Mammalian Phenotype (MP)	abnormal chromosome stability	0.001269	1.73	--	INHERITED FROM: chromosomal instability
Mammalian Phenotype (MP)	abnormal lymphopoiesis	0.0114	1.229	--	INHERITED FROM: abnormal somatic hypermutation frequency
Mammalian Phenotype (MP)	abnormal B cell morphology	0.01358	1.253	--	INHERITED FROM: abnormal somatic hypermutation frequency
Mammalian Phenotype (MP)	abnormal leukopoiesis	0.01829	1.229	--	INHERITED FROM: abnormal somatic hypermutation frequency
Mammalian Phenotype (MP)	abnormal definitive hematopoiesis	0.03879	1.128	--	INHERITED FROM: abnormal somatic hypermutation frequency
Mammalian Phenotype (MP)	abnormal hemopoiesis	0.04131	1.11	--	INHERITED FROM: abnormal somatic hypermutation frequency
Mammalian Phenotype (MP)	abnormal lymphocyte morphology	0.1016	1.061	--	INHERITED FROM: abnormal somatic hypermutation frequency
Mammalian Phenotype (MP)	abnormal adaptive immunity	0.2005	0.9516	--	INHERITED FROM: abnormal somatic hypermutation frequency
Mammalian Phenotype (MP)	increased malignant tumor incidence	0.2178	1.663	--	INHERITED FROM: increased carcinoma incidence
Mammalian Phenotype (MP)	abnormal classified tumor incidence	0.2297	1.207	--	INHERITED FROM: increased carcinoma incidence
Mammalian Phenotype (MP)	abnormal leukocyte morphology	0.2316	0.9397	--	INHERITED FROM: abnormal somatic hypermutation frequency
Mammalian Phenotype (MP)	increased classified tumor incidence	0.3708	1.207	--	INHERITED FROM: increased carcinoma incidence
Mammalian Phenotype (MP)	abnormal immune system morphology	0.424	0.8003	--	INHERITED FROM: abnormal somatic hypermutation frequency
Mammalian Phenotype (MP)	abnormal cell physiology	0.5407	0.6214	--	INHERITED FROM: chromosomal instability
Mammalian Phenotype (MP)	abnormal immune system physiology	0.6631	0.737	--	INHERITED FROM: abnormal somatic hypermutation frequency
Mammalian Phenotype (MP)	abnormal hematopoietic system morphology/development	0.816	0.7444	--	INHERITED FROM: abnormal somatic hypermutation frequency
Mammalian Phenotype (MP)	abnormal immune system cell morphology	0.9512	0.9281	--	INHERITED FROM: abnormal somatic hypermutation frequency
Mammalian Phenotype (MP)	abnormal hematopoietic cell morphology	0.999	0.8177	--	INHERITED FROM: abnormal somatic hypermutation frequency
Mammalian Phenotype (MP)	hematopoietic system phenotype	0.01045	0.6505	Least Informative	INHERITED FROM: abnormal somatic hypermutation frequency
Mammalian Phenotype (MP)	immune system phenotype	0.01164	0.627	Least Informative	INHERITED FROM: abnormal somatic hypermutation frequency
Mammalian Phenotype (MP)	cellular phenotype	0.06258	0.5301	Least Informative	INHERITED FROM: chromosomal instability
Mammalian Phenotype (MP)	neoplasm	0.0001514	1.003	Moderately Informative	DIRECT
Mammalian Phenotype (MP)	abnormal mononuclear cell morphology	0.1678	0.9764	Moderately Informative	INHERITED FROM: abnormal somatic hypermutation frequency
Mammalian Phenotype (MP)	abnormal blood cell morphology	0.1983	1.016	Moderately Informative	INHERITED FROM: abnormal somatic hypermutation frequency
Mammalian Phenotype (MP)	abnormal blood cell morphology/development	0.2344	1.093	Moderately Informative	INHERITED FROM: abnormal somatic hypermutation frequency
Mammalian Phenotype (MP)	increased carcinoma incidence	0.00005674	1.663	Informative	DIRECT
Mammalian Phenotype (MP)	chromosomal instability	0.0003338	1.73	Informative	DIRECT
Mammalian Phenotype (MP)	abnormal B cell differentiation	0.001212	1.429	Informative	INHERITED FROM: abnormal somatic hypermutation frequency

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Worm Phenotype (WP)

Highlighted in gray are those with FDR_all>0.001

	WP term	FDR (all)	IC level	SDWP level	Annotation (direct or inherited)
Worm Phenotype (WP)	embryonic lethal	0	0.07108	--	DIRECT
Worm Phenotype (WP)	lethal	0	0.01121	--	DIRECT
Worm Phenotype (WP)	development variant	0	0.001706	--	DIRECT
Worm Phenotype (WP)	morphology variant	0	0.06117	--	DIRECT
Worm Phenotype (WP)	organism development variant	0	0.004279	--	DIRECT
Worm Phenotype (WP)	embryonic development variant	0	0.06709	--	DIRECT
Worm Phenotype (WP)	DNA metabolism variant	0.0000006683	2.708	--	DIRECT
Worm Phenotype (WP)	light response variant	0.000002506	1.862	--	DIRECT
Worm Phenotype (WP)	organism UV response variant	0.00000575	1.862	--	DIRECT
Worm Phenotype (WP)	behavior variant	0.06367	0.632	--	INHERITED FROM: light response variant || organism UV hypersensitive || organism UV response variant
Worm Phenotype (WP)	organism physiology variant	0.3134	0.1405	--	INHERITED FROM: organism UV response variant || DNA metabolism variant || organism UV hypersensitive
Worm Phenotype (WP)	physiology variant	1	0	--	INHERITED FROM: lethal || organism UV hypersensitive || development variant || cell physiology variant || embryonic development variant || embryonic lethal || light response variant || DNA metabolism variant || organism development variant || organism UV response variant
Worm Phenotype (WP)	organism homeostasis metabolism variant	1	0.1501	--	INHERITED FROM: organism UV response variant || organism UV hypersensitive || DNA metabolism variant
Worm Phenotype (WP)	cell physiology variant	0.00003942	0.5344	Least Informative	DIRECT
Worm Phenotype (WP)	organism environmental stimulus response variant	0.01089	0.5677	Least Informative	INHERITED FROM: organism UV hypersensitive || organism UV response variant
Worm Phenotype (WP)	organism behavior variant	0.06148	0.632	Least Informative	INHERITED FROM: organism UV hypersensitive || light response variant || organism UV response variant
Worm Phenotype (WP)	organism metabolism processing variant	0.1051	0.4572	Least Informative	INHERITED FROM: DNA metabolism variant
Worm Phenotype (WP)	metabolic pathway variant	0.01047	1.117	Moderately Informative	INHERITED FROM: DNA metabolism variant
Worm Phenotype (WP)	organism stress response variant	0.2666	0.8325	Moderately Informative	INHERITED FROM: organism UV response variant || organism UV hypersensitive
Worm Phenotype (WP)	cell homeostasis metabolism variant	0.4079	0.9294	Moderately Informative	INHERITED FROM: DNA metabolism variant
Worm Phenotype (WP)	organism UV hypersensitive	0.0000001141	1.929	Highly Informative	DIRECT

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Yeast Phenotype (YP)

Highlighted in gray are those with FDR_all>0.001

	YP term	FDR (all)	IC level	SDYP level	Annotation (direct or inherited)
Yeast Phenotype (YP)	cellular processes	0	0.1328	--	DIRECT
Yeast Phenotype (YP)	stress resistance	0	0.2018	--	DIRECT
Yeast Phenotype (YP)	chromosome/plasmid maintenance	0.04325	1.392	Informative	INHERITED FROM: mutation frequency
Yeast Phenotype (YP)	mutation frequency	0.00005115	1.994	Highly Informative	DIRECT

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Fly Phenotype (FP)

Highlighted in gray are those with FDR_all>0.001

	FP term	FDR (all)	IC level	SDFP level	Annotation (direct or inherited)
Fly Phenotype (FP)	phenotype	0	0.05522	--	DIRECT

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Fly Anatomy (FA)

Highlighted in gray are those with FDR_all>0.001

	FA term	FDR (all)	IC level	SDFA level	Annotation (direct or inherited)
Fly Anatomy (FA)	organism	0	0.07918	--	DIRECT
Fly Anatomy (FA)	developing material anatomical entity	0	0.8487	--	DIRECT
Fly Anatomy (FA)	multicellular structure	0	0.009143	--	DIRECT
Fly Anatomy (FA)	anatomical structure	1	0	--	INHERITED FROM: organism || larva || multicellular structure
Fly Anatomy (FA)	material anatomical entity	1	0	--	INHERITED FROM: multicellular structure || developing material anatomical entity || larva || organism
Fly Anatomy (FA)	larva	0	0.4611	Least Informative	DIRECT

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Zebrafish Anatomy (ZA)

Highlighted in gray are those with FDR_all>0.001

	ZA term	FDR (all)	IC level	SDZA level	Annotation (direct or inherited)
Zebrafish Anatomy (ZA)	whole organism	0	0.004764	--	DIRECT
Zebrafish Anatomy (ZA)	anatomical structure	1	0	--	INHERITED FROM: whole organism

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Xenopus Anatomy (XA)

Highlighted in gray are those with FDR_all>0.001

	XA term	FDR (all)	IC level	SDXA level	Annotation (direct or inherited)
Xenopus ANatomical entity (XAN)	anatomical structure	0	0	--	DIRECT
Xenopus DEvelopment stage (XDE)	NF stage	0	0.02327	--	DIRECT

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Arabidopsis Plant Ontology (AP)

Highlighted in gray are those with FDR_all>0.001

	AP term	FDR (all)	IC level	SDAP level	Annotation (direct or inherited)
Plant ANatomical entity (PAN)	plant cell	0	0.1489	--	DIRECT
Plant ANatomical entity (PAN)	shoot system	0	0.05747	--	DIRECT
Plant ANatomical entity (PAN)	collective plant structure	0	0.01577	--	DIRECT
Plant ANatomical entity (PAN)	plant structure	1	0	--	INHERITED FROM: collective plant structure || shoot system || plant cell
Plant ANatomical entity (PAN)	collective plant organ structure	1	0.04502	--	INHERITED FROM: shoot system
Plant structure DEvelopment stage (PDE)	sporophyte vegetative stage	0.8488	0.2036	--	INHERITED FROM: 0 seed germination stage
Plant structure DEvelopment stage (PDE)	whole plant development stage	0.8526	0.1968	--	INHERITED FROM: 0 seed germination stage
Plant structure DEvelopment stage (PDE)	life of whole plant stage	1	0.2022	--	INHERITED FROM: 0 seed germination stage
Plant structure DEvelopment stage (PDE)	sporophyte development stage	1	0.2022	--	INHERITED FROM: 0 seed germination stage
Plant structure DEvelopment stage (PDE)	0 seed germination stage	0.00000004209	1.624	Informative	DIRECT

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Enzyme Commission (EC)

Highlighted in gray are those with FDR_all>0.001

	EC term	FDR (all)	IC level	SDEC level	Annotation (direct or inherited)
Enzyme Commission (EC)	Transferases	0	0.3035	--	DIRECT
Enzyme Commission (EC)	Acting on ester bonds	0	0.7559	--	DIRECT
Enzyme Commission (EC)	Ribonuclease H	0	2.475	--	DIRECT
Enzyme Commission (EC)	ADP-ribose 1''-phosphate phosphatase	0	2.35	--	DIRECT
Enzyme Commission (EC)	Ubiquitinyl hydrolase 1	0	1.59	--	DIRECT
Enzyme Commission (EC)	Hepacivirin	0	2.475	--	DIRECT
Enzyme Commission (EC)	Aspartic endopeptidases	0	1.91	--	DIRECT
Enzyme Commission (EC)	Acting on ATP; involved in cellular and subcellular movement	0.00000000001436	1.196	--	DIRECT
Enzyme Commission (EC)	Picornain 2A	0.000000001363	2.253	--	DIRECT
Enzyme Commission (EC)	Nuclear-inclusion-a endopeptidase	0.00000002267	2.475	--	DIRECT
Enzyme Commission (EC)	Pestivirus NS3 polyprotein peptidase	0.0000003919	2.475	--	DIRECT
Enzyme Commission (EC)	Calicivirin	0.00001519	2.475	--	DIRECT
Enzyme Commission (EC)	Helper-component proteinase	0.00003043	2.35	--	DIRECT
Enzyme Commission (EC)	Methyltransferases	1	1.181	--	INHERITED FROM: mRNA (guanine-N(7)-)-methyltransferase || Methyltransferase cap1
Enzyme Commission (EC)	Transferring phosphorus-containing groups	0	0.5453	Least Informative	DIRECT
Enzyme Commission (EC)	Hydrolases	0	0.3541	Least Informative	DIRECT
Enzyme Commission (EC)	Nucleotidyltransferases	0	0.9432	Moderately Informative	DIRECT
Enzyme Commission (EC)	Acting on peptide bonds (peptidases)	0	0.8949	Moderately Informative	DIRECT
Enzyme Commission (EC)	Acting on acid anhydrides	0	0.9562	Moderately Informative	DIRECT
Enzyme Commission (EC)	Transferring one-carbon groups	1	1.054	Moderately Informative	INHERITED FROM: Methyltransferase cap1 || mRNA (guanine-N(7)-)-methyltransferase
Enzyme Commission (EC)	Phosphoric monoester hydrolases	1	1.174	Moderately Informative	INHERITED FROM: ADP-ribose 1''-phosphate phosphatase || Polynucleotide 5'-phosphatase
Enzyme Commission (EC)	RNA-directed RNA polymerase	0	1.63	Informative	DIRECT
Enzyme Commission (EC)	DNA-directed DNA polymerase	0	1.59	Informative	DIRECT
Enzyme Commission (EC)	Exoribonucleases producing 5'-phosphomonoesters	0	1.673	Informative	DIRECT
Enzyme Commission (EC)	Endoribonucleases producing 5'-phosphomonoesters	0	1.572	Informative	DIRECT
Enzyme Commission (EC)	Cysteine endopeptidases	0	1.572	Informative	DIRECT
Enzyme Commission (EC)	In phosphorus-containing anhydrides	0	1.28	Informative	DIRECT
Enzyme Commission (EC)	RNA helicase	0	1.52	Informative	DIRECT
Enzyme Commission (EC)	Omega peptidases	0.9407	1.447	Informative	INHERITED FROM: Ubiquitinyl hydrolase 1
Enzyme Commission (EC)	Serine endopeptidases	1	1.35	Informative	INHERITED FROM: Hepacivirin || Pestivirus NS3 polyprotein peptidase || Flavivirin
Enzyme Commission (EC)	mRNA (guanine-N(7)-)-methyltransferase	0	1.998	Highly Informative	DIRECT
Enzyme Commission (EC)	Methyltransferase cap1	0	2.107	Highly Informative	DIRECT
Enzyme Commission (EC)	RNA-directed DNA polymerase	0	1.91	Highly Informative	DIRECT
Enzyme Commission (EC)	Exoribonuclease H	0	1.952	Highly Informative	DIRECT
Enzyme Commission (EC)	Retroviral ribonuclease H	0	1.952	Highly Informative	DIRECT
Enzyme Commission (EC)	Polynucleotide 5'-phosphatase	0	2.174	Highly Informative	DIRECT
Enzyme Commission (EC)	Flavivirin	0	2.107	Highly Informative	DIRECT
Enzyme Commission (EC)	Picornain 3C	0	2.174	Highly Informative	DIRECT
Enzyme Commission (EC)	HIV-1 retropepsin	0	2.049	Highly Informative	DIRECT
Enzyme Commission (EC)	Nucleoside-triphosphate phosphatase	0	1.873	Highly Informative	DIRECT
Enzyme Commission (EC)	HIV-2 retropepsin	0.00002425	2.049	Highly Informative	DIRECT

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