Bcl-2 inhibitors of programmed cell death family

SCOP classification

• Root: SCOP hierarchy in SUPERFAMILY [ 0] (11)
• Class: Membrane and cell surface proteins and peptides [ 56835] (58)
• Fold: Toxins' membrane translocation domains [ 56836] (5)
• Superfamily: Bcl-2 inhibitors of programmed cell death [ 56854]
• Family: Bcl-2 inhibitors of programmed cell death [ 56855] (10)

---

Family statistics

	Genomes (87)	Uniprot 2018_03 genome	PDB chains (SCOP 1.75)
Domains	501	1,437	29
Proteins	500	1,436	29

---

Disease Ontology (DO)

Highlighted in gray are those with FDR_all>0.001

	DO term	FDR (all)	IC level	SDDO level	Annotation (direct or inherited)
Disease Ontology (DO)	toxic encephalopathy	0.00001491	2.513	--	DIRECT
Disease Ontology (DO)	vaccinia	0.00001567	2.513	--	DIRECT
Disease Ontology (DO)	connective tissue cancer	0.0001415	1.367	--	DIRECT
Disease Ontology (DO)	stomach carcinoma	0.0001617	2.212	--	DIRECT
Disease Ontology (DO)	carcinoma	0.0001877	1.098	--	DIRECT
Disease Ontology (DO)	leukemia	0.0008889	1.151	--	DIRECT
Disease Ontology (DO)	stomach cancer	0.003121	2.212	--	INHERITED FROM: stomach carcinoma || gastric adenocarcinoma
Disease Ontology (DO)	primary bacterial infectious disease	0.003307	1.212	--	INHERITED FROM: tuberculosis
Disease Ontology (DO)	autoimmune disease of endocrine system	0.005879	1.911	--	INHERITED FROM: Graves' disease
Disease Ontology (DO)	hypersensitivity reaction disease	0.007234	0.8505	--	INHERITED FROM: Graves' disease
Disease Ontology (DO)	musculoskeletal system cancer	0.008181	1.283	--	INHERITED FROM: osteosarcoma || connective tissue cancer
Disease Ontology (DO)	cancer	0.02677	0.2555	--	INHERITED FROM: chronic lymphocytic leukemia || connective tissue cancer || carcinoma || leukemia || stomach carcinoma || organ system cancer || osteosarcoma || gastric adenocarcinoma
Disease Ontology (DO)	disease of cellular proliferation	0.03093	0.2322	--	INHERITED FROM: carcinoma || connective tissue cancer || osteosarcoma || leukemia || chronic lymphocytic leukemia || gastric adenocarcinoma || organ system cancer || stomach carcinoma
Disease Ontology (DO)	immune system disease	0.03138	0.8411	--	INHERITED FROM: Graves' disease
Disease Ontology (DO)	viral infectious disease	0.07529	1.212	--	INHERITED FROM: vaccinia
Disease Ontology (DO)	bacterial infectious disease	0.08412	1.191	--	INHERITED FROM: tuberculosis
Disease Ontology (DO)	immune system cancer	0.1012	0.89	--	INHERITED FROM: chronic lymphocytic leukemia || leukemia
Disease Ontology (DO)	disease of anatomical entity	0.1264	0.2414	--	INHERITED FROM: Graves' disease || toxic encephalopathy
Disease Ontology (DO)	bone cancer	0.2357	1.61	--	INHERITED FROM: osteosarcoma
Disease Ontology (DO)	organ system cancer	0.0004907	0.4879	Least Informative	DIRECT
Disease Ontology (DO)	nervous system disease	0.4668	0.7279	Least Informative	INHERITED FROM: toxic encephalopathy
Disease Ontology (DO)	hematologic cancer	0.002353	0.89	Moderately Informative	INHERITED FROM: leukemia || chronic lymphocytic leukemia
Disease Ontology (DO)	disease by infectious agent	0.002814	0.8142	Moderately Informative	INHERITED FROM: tuberculosis || vaccinia
Disease Ontology (DO)	hypersensitivity reaction type II disease	0.004085	0.8797	Moderately Informative	INHERITED FROM: Graves' disease
Disease Ontology (DO)	cell type cancer	0.005064	0.9112	Moderately Informative	INHERITED FROM: carcinoma
Disease Ontology (DO)	gastrointestinal system cancer	0.1766	1.151	Moderately Informative	INHERITED FROM: stomach carcinoma || gastric adenocarcinoma
Disease Ontology (DO)	osteosarcoma	0.0002171	1.61	Informative	DIRECT
Disease Ontology (DO)	lymphoblastic leukemia	0.03387	1.668	Informative	INHERITED FROM: chronic lymphocytic leukemia
Disease Ontology (DO)	chronic lymphocytic leukemia	0.000003825	2.036	Highly Informative	DIRECT
Disease Ontology (DO)	Graves' disease	0.0001295	1.911	Highly Informative	DIRECT
Disease Ontology (DO)	gastric adenocarcinoma	0.0001487	2.212	Highly Informative	DIRECT
Disease Ontology (DO)	tuberculosis	0.0009815	1.911	Highly Informative	DIRECT

---

Mouse Phenotype (MP)

Highlighted in gray are those with FDR_all>0.001

	MP term	FDR (all)	IC level	SDMP level	Annotation (direct or inherited)
Mammalian Phenotype (MP)	abnormal pre-B cell morphology	0.000003033	2.302	--	DIRECT
Mammalian Phenotype (MP)	abnormal immature B cell number	0.000008161	1.7	--	DIRECT
Mammalian Phenotype (MP)	abnormal immature B cell morphology	0.000009661	1.7	--	DIRECT
Mammalian Phenotype (MP)	abnormal spleen physiology	0.00002458	2.126	--	DIRECT
Mammalian Phenotype (MP)	abnormal lymphopoiesis	0.0002059	1.205	--	DIRECT
Mammalian Phenotype (MP)	abnormal B cell physiology	0.000228	1.172	--	DIRECT
Mammalian Phenotype (MP)	absent germ cells	0.0002972	1.825	--	DIRECT
Mammalian Phenotype (MP)	increased tumor incidence	0.0003846	1.172	--	DIRECT
Mammalian Phenotype (MP)	cortical renal glomerulopathies	0.0004084	1.7	--	DIRECT
Mammalian Phenotype (MP)	abnormal internal female genitalia morphology	0.0004141	1.281	--	DIRECT
Mammalian Phenotype (MP)	abnormal leukopoiesis	0.0004241	1.156	--	DIRECT
Mammalian Phenotype (MP)	abnormal IgG level	0.0004507	1.562	--	DIRECT
Mammalian Phenotype (MP)	abnormal female genitalia morphology	0.0004566	1.261	--	DIRECT
Mammalian Phenotype (MP)	abnormal female reproductive system morphology	0.0004673	1.261	--	DIRECT
Mammalian Phenotype (MP)	abnormal ovarian follicle morphology	0.0004726	1.758	--	DIRECT
Mammalian Phenotype (MP)	abnormal apoptosis	0.0005512	1.023	--	DIRECT
Mammalian Phenotype (MP)	decreased cell death	0.0005547	1.904	--	DIRECT
Mammalian Phenotype (MP)	abnormal tumor incidence	0.0007046	1.141	--	DIRECT
Mammalian Phenotype (MP)	altered tumor susceptibility	0.0007581	1.141	--	DIRECT
Mammalian Phenotype (MP)	increased pre-B cell number	0.0007628	2.603	--	DIRECT
Mammalian Phenotype (MP)	abnormal pons morphology	0.0008901	2.302	--	DIRECT
Mammalian Phenotype (MP)	abnormal T cell number	0.0009092	1.261	--	DIRECT
Mammalian Phenotype (MP)	abnormal definitive hematopoiesis	0.001369	1.072	--	INHERITED FROM: abnormal T cell differentiation || abnormal immature B cell morphology || abnormal lymphopoiesis || abnormal immature B cell number || abnormal leukopoiesis
Mammalian Phenotype (MP)	abnormal hemopoiesis	0.001498	1.072	--	INHERITED FROM: abnormal T cell differentiation || abnormal lymphopoiesis || abnormal immature B cell morphology || abnormal immature B cell number || abnormal leukopoiesis
Mammalian Phenotype (MP)	decreased lymphocyte cell number	0.001565	1.156	--	INHERITED FROM: decreased mature B cell number
Mammalian Phenotype (MP)	abnormal mature B cell morphology	0.001846	1.281	--	INHERITED FROM: decreased mature B cell number || abnormal immature B cell number || increased pre-B cell number || abnormal mature B cell number
Mammalian Phenotype (MP)	abnormal female reproductive gland morphology	0.00221	1.427	--	INHERITED FROM: abnormal ovarian follicle morphology
Mammalian Phenotype (MP)	abnormal renal corpuscle morphology	0.002849	1.427	--	INHERITED FROM: cortical renal glomerulopathies
Mammalian Phenotype (MP)	abnormal kidney cortex morphology	0.003562	1.399	--	INHERITED FROM: cortical renal glomerulopathies
Mammalian Phenotype (MP)	decreased leukocyte cell number	0.004319	1.156	--	INHERITED FROM: decreased mature B cell number
Mammalian Phenotype (MP)	abnormal gametes	0.004646	1.825	--	INHERITED FROM: absent gametes
Mammalian Phenotype (MP)	decreased germ cell number	0.004646	1.562	--	INHERITED FROM: absent germ cells || absent gametes
Mammalian Phenotype (MP)	abnormal lymphocyte morphology	0.006012	0.9404	--	INHERITED FROM: abnormal immature B cell number || abnormal mature B cell number || abnormal immature B cell morphology || abnormal T cell differentiation || abnormal T cell number || decreased mature B cell number || increased pre-B cell number || abnormal pre-B cell morphology || abnormal lymphopoiesis
Mammalian Phenotype (MP)	abnormal nephron morphology	0.007178	1.261	--	INHERITED FROM: cortical renal glomerulopathies
Mammalian Phenotype (MP)	abnormal brainstem morphology	0.01121	1.904	--	INHERITED FROM: abnormal pons morphology
Mammalian Phenotype (MP)	abnormal mononuclear cell morphology	0.01338	0.8473	--	INHERITED FROM: abnormal immature B cell morphology || abnormal mature B cell number || abnormal immature B cell number || increased pre-B cell number || decreased mature B cell number || abnormal T cell number || abnormal T cell differentiation || abnormal lymphopoiesis || abnormal pre-B cell morphology
Mammalian Phenotype (MP)	abnormal leukocyte cell number	0.01464	0.9129	--	INHERITED FROM: abnormal mature B cell number || abnormal immature B cell number || increased pre-B cell number || decreased mature B cell number || abnormal T cell number
Mammalian Phenotype (MP)	abnormal hindbrain morphology	0.01838	1.649	--	INHERITED FROM: abnormal metencephalon morphology || abnormal pons morphology
Mammalian Phenotype (MP)	reproductive system phenotype	0.02207	0.8397	--	INHERITED FROM: absent germ cells || abnormal female reproductive system morphology || abnormal ovarian follicle morphology || abnormal internal female genitalia morphology || abnormal female genitalia morphology || absent gametes
Mammalian Phenotype (MP)	abnormal leukocyte morphology	0.02335	0.8108	--	INHERITED FROM: increased pre-B cell number || abnormal T cell differentiation || decreased mature B cell number || abnormal T cell number || abnormal mature B cell number || abnormal immature B cell number || abnormal immature B cell morphology || abnormal lymphopoiesis || abnormal pre-B cell morphology
Mammalian Phenotype (MP)	abnormal hematopoietic cell number	0.02513	0.8473	--	INHERITED FROM: abnormal mature B cell number || abnormal immature B cell number || decreased mature B cell number || abnormal T cell number || increased pre-B cell number
Mammalian Phenotype (MP)	abnormal hematopoietic system physiology	0.02754	0.8789	--	INHERITED FROM: abnormal B cell physiology || abnormal IgG level || abnormal T cell apoptosis || abnormal T cell physiology
Mammalian Phenotype (MP)	abnormal kidney morphology	0.03026	1.156	--	INHERITED FROM: cortical renal glomerulopathies
Mammalian Phenotype (MP)	abnormal cell physiology	0.04389	0.6209	--	INHERITED FROM: decreased cell death || abnormal cell death || decreased apoptosis || abnormal T cell apoptosis || abnormal apoptosis
Mammalian Phenotype (MP)	increased B cell number	0.05039	1.7	--	INHERITED FROM: increased pre-B cell number
Mammalian Phenotype (MP)	abnormal humoral immune response	0.05122	1.457	--	INHERITED FROM: abnormal IgG level
Mammalian Phenotype (MP)	abnormal lymph node size	0.06537	1.7	--	INHERITED FROM: enlarged lymph nodes
Mammalian Phenotype (MP)	renal/urinary system phenotype	0.0701	0.931	--	INHERITED FROM: cortical renal glomerulopathies
Mammalian Phenotype (MP)	abnormal B cell number	0.07592	1.348	--	INHERITED FROM: increased pre-B cell number || abnormal immature B cell number || abnormal mature B cell number || decreased mature B cell number
Mammalian Phenotype (MP)	abnormal nervous system morphology	0.08084	0.5861	--	INHERITED FROM: abnormal autonomic nervous system morphology || abnormal pons morphology || abnormal metencephalon morphology
Mammalian Phenotype (MP)	abnormal immune cell physiology	0.1104	0.9219	--	INHERITED FROM: abnormal B cell physiology || abnormal IgG level || abnormal T cell apoptosis || abnormal T cell physiology
Mammalian Phenotype (MP)	abnormal cell-mediated immunity	0.1143	0.9219	--	INHERITED FROM: abnormal IgG level || abnormal B cell physiology || abnormal T cell physiology || abnormal T cell apoptosis
Mammalian Phenotype (MP)	abnormal adaptive immunity	0.1229	0.9219	--	INHERITED FROM: abnormal IgG level || abnormal B cell physiology || abnormal T cell apoptosis || abnormal T cell physiology
Mammalian Phenotype (MP)	abnormal cell morphology	0.1548	1.324	--	INHERITED FROM: absent gametes || absent germ cells
Mammalian Phenotype (MP)	abnormal immune system physiology	0.1642	0.6789	--	INHERITED FROM: abnormal IgG level || abnormal B cell physiology || abnormal T cell physiology || abnormal T cell apoptosis || abnormal spleen physiology
Mammalian Phenotype (MP)	increased leukocyte cell number	0.1669	1.241	--	INHERITED FROM: increased pre-B cell number
Mammalian Phenotype (MP)	abnormal gametogenesis	0.2162	1.324	--	INHERITED FROM: absent germ cells || absent gametes
Mammalian Phenotype (MP)	abnormal spleen size	0.2263	1.758	--	INHERITED FROM: enlarged spleen
Mammalian Phenotype (MP)	abnormal lymphocyte physiology	0.2939	1.112	--	INHERITED FROM: abnormal T cell apoptosis || abnormal IgG level || abnormal B cell physiology || abnormal T cell physiology
Mammalian Phenotype (MP)	abnormal sex gland morphology	0.3889	1.141	--	INHERITED FROM: abnormal ovarian follicle morphology
Mammalian Phenotype (MP)	abnormal immune system morphology	0.4441	0.7223	--	INHERITED FROM: enlarged spleen || enlarged lymph nodes || decreased mature B cell number || increased pre-B cell number || abnormal immune system organ morphology || abnormal immature B cell morphology || abnormal pre-B cell morphology || abnormal lymphopoiesis || abnormal T cell number || abnormal T cell differentiation || abnormal leukopoiesis || abnormal immature B cell number || abnormal mature B cell number
Mammalian Phenotype (MP)	abnormal immune system cell morphology	0.4475	0.8038	--	INHERITED FROM: abnormal leukopoiesis || abnormal immature B cell number || abnormal mature B cell number || abnormal immature B cell morphology || increased pre-B cell number || abnormal T cell differentiation || abnormal T cell number || decreased mature B cell number || abnormal lymphopoiesis || abnormal pre-B cell morphology
Mammalian Phenotype (MP)	abnormal hematopoietic cell morphology	0.639	0.7167	--	INHERITED FROM: abnormal immature B cell morphology || increased pre-B cell number || decreased mature B cell number || abnormal lymphopoiesis || abnormal pre-B cell morphology || abnormal immature B cell number || abnormal leukopoiesis || abnormal mature B cell number || abnormal T cell differentiation || abnormal T cell number
Mammalian Phenotype (MP)	abnormal gland morphology	0.6938	0.7519	--	INHERITED FROM: abnormal endocrine gland morphology || abnormal ovarian follicle morphology
Mammalian Phenotype (MP)	abnormal blood cell physiology	0.7518	0.8789	--	INHERITED FROM: abnormal T cell physiology || abnormal T cell apoptosis || abnormal IgG level || abnormal B cell physiology
Mammalian Phenotype (MP)	abnormal hematopoietic system morphology/development	0.82	0.6686	--	INHERITED FROM: increased pre-B cell number || decreased mature B cell number || abnormal immature B cell morphology || enlarged spleen || abnormal T cell number || abnormal T cell differentiation || abnormal immature B cell number || abnormal leukopoiesis || abnormal mature B cell number || abnormal lymphopoiesis || abnormal pre-B cell morphology
Mammalian Phenotype (MP)	hematopoietic system phenotype	0.001148	0.5945	Least Informative	INHERITED FROM: abnormal B cell physiology || abnormal IgG level || abnormal T cell differentiation || abnormal T cell number || abnormal mature B cell number || abnormal leukopoiesis || abnormal immature B cell number || abnormal lymphopoiesis || abnormal pre-B cell morphology || increased pre-B cell number || decreased mature B cell number || abnormal immature B cell morphology || enlarged spleen || abnormal T cell apoptosis || abnormal T cell physiology
Mammalian Phenotype (MP)	endocrine/exocrine gland phenotype	0.001165	0.6947	Least Informative	INHERITED FROM: abnormal endocrine gland morphology || abnormal ovarian follicle morphology
Mammalian Phenotype (MP)	immune system phenotype	0.001332	0.5462	Least Informative	INHERITED FROM: abnormal lymphopoiesis || abnormal immature B cell number || abnormal IgG level || abnormal B cell physiology || abnormal T cell physiology || enlarged lymph nodes || abnormal spleen physiology || abnormal immature B cell morphology || abnormal immune system organ morphology || abnormal pre-B cell morphology || abnormal mature B cell number || abnormal leukopoiesis || abnormal T cell number || abnormal T cell differentiation || abnormal T cell apoptosis || enlarged spleen || increased pre-B cell number || decreased mature B cell number
Mammalian Phenotype (MP)	cellular phenotype	0.07492	0.5387	Least Informative	INHERITED FROM: decreased apoptosis || absent germ cells || abnormal apoptosis || absent gametes || abnormal T cell apoptosis || decreased cell death || abnormal cell death
Mammalian Phenotype (MP)	nervous system phenotype	0.1566	0.4959	Least Informative	INHERITED FROM: abnormal pons morphology || abnormal autonomic nervous system morphology || abnormal metencephalon morphology
Mammalian Phenotype (MP)	abnormal endocrine gland morphology	0.0001025	1.141	Moderately Informative	DIRECT
Mammalian Phenotype (MP)	abnormal immune system organ morphology	0.0005761	1.112	Moderately Informative	DIRECT
Mammalian Phenotype (MP)	abnormal cell death	0.0009726	0.9904	Moderately Informative	DIRECT
Mammalian Phenotype (MP)	abnormal leukocyte physiology	0.001037	0.9219	Moderately Informative	INHERITED FROM: abnormal IgG level || abnormal B cell physiology || abnormal T cell apoptosis || abnormal T cell physiology
Mammalian Phenotype (MP)	neoplasm	0.001208	1.035	Moderately Informative	INHERITED FROM: altered tumor susceptibility || increased tumor incidence || abnormal tumor incidence
Mammalian Phenotype (MP)	abnormal T cell morphology	0.001353	1.205	Moderately Informative	INHERITED FROM: abnormal T cell number || abnormal T cell differentiation
Mammalian Phenotype (MP)	increased hematopoietic cell number	0.004057	1.188	Moderately Informative	INHERITED FROM: increased pre-B cell number
Mammalian Phenotype (MP)	abnormal lymphocyte cell number	0.004221	1.023	Moderately Informative	INHERITED FROM: increased pre-B cell number || abnormal T cell number || decreased mature B cell number || abnormal immature B cell number || abnormal mature B cell number
Mammalian Phenotype (MP)	decreased hematopoietic cell number	0.008842	1.072	Moderately Informative	INHERITED FROM: decreased mature B cell number
Mammalian Phenotype (MP)	abnormal brain morphology	0.01347	0.9799	Moderately Informative	INHERITED FROM: abnormal pons morphology || abnormal metencephalon morphology
Mammalian Phenotype (MP)	abnormal blood cell morphology	0.01845	0.9129	Moderately Informative	INHERITED FROM: abnormal T cell differentiation || abnormal immature B cell number || abnormal leukopoiesis || abnormal immature B cell morphology || abnormal lymphopoiesis
Mammalian Phenotype (MP)	abnormal blood cell morphology/development	0.0228	1.059	Moderately Informative	INHERITED FROM: abnormal immature B cell morphology || abnormal lymphopoiesis || abnormal leukopoiesis || abnormal immature B cell number || abnormal T cell differentiation
Mammalian Phenotype (MP)	abnormal renal/urinary system morphology	0.03769	1.047	Moderately Informative	INHERITED FROM: cortical renal glomerulopathies
Mammalian Phenotype (MP)	abnormal B cell morphology	0.09202	1.156	Moderately Informative	INHERITED FROM: increased pre-B cell number || abnormal immature B cell number || abnormal mature B cell number || abnormal immature B cell morphology || abnormal pre-B cell morphology || decreased mature B cell number
Mammalian Phenotype (MP)	abnormal professional antigen presenting cell morphology	0.104	1.098	Moderately Informative	INHERITED FROM: increased pre-B cell number || decreased mature B cell number || abnormal immature B cell number || abnormal mature B cell number
Mammalian Phenotype (MP)	abnormal professional antigen presenting cell physiology	0.1881	1.098	Moderately Informative	INHERITED FROM: abnormal IgG level || abnormal B cell physiology
Mammalian Phenotype (MP)	abnormal reproductive system morphology	0.218	0.9404	Moderately Informative	INHERITED FROM: abnormal female genitalia morphology || absent gametes || absent germ cells || abnormal female reproductive system morphology || abnormal ovarian follicle morphology || abnormal internal female genitalia morphology
Mammalian Phenotype (MP)	abnormal immune serum protein physiology	0.3306	1.001	Moderately Informative	INHERITED FROM: abnormal IgG level
Mammalian Phenotype (MP)	abnormal T cell differentiation	0.00002685	1.649	Informative	DIRECT
Mammalian Phenotype (MP)	abnormal mature B cell number	0.0002245	1.603	Informative	DIRECT
Mammalian Phenotype (MP)	abnormal T cell physiology	0.0002639	1.427	Informative	DIRECT
Mammalian Phenotype (MP)	abnormal metencephalon morphology	0.0006715	1.649	Informative	DIRECT
Mammalian Phenotype (MP)	abnormal renal glomerulus morphology	0.002265	1.457	Informative	INHERITED FROM: cortical renal glomerulopathies
Mammalian Phenotype (MP)	abnormal germ cell morphology	0.01056	1.524	Informative	INHERITED FROM: absent germ cells || absent gametes
Mammalian Phenotype (MP)	abnormal B cell differentiation	0.03496	1.373	Informative	INHERITED FROM: abnormal immature B cell number || abnormal immature B cell morphology
Mammalian Phenotype (MP)	decreased B cell number	0.05541	1.562	Informative	INHERITED FROM: decreased mature B cell number
Mammalian Phenotype (MP)	abnormal immunoglobulin level	0.05634	1.524	Informative	INHERITED FROM: abnormal IgG level
Mammalian Phenotype (MP)	abnormal spleen morphology	0.07021	1.427	Informative	INHERITED FROM: enlarged spleen
Mammalian Phenotype (MP)	increased lymphocyte cell number	0.08531	1.524	Informative	INHERITED FROM: increased pre-B cell number
Mammalian Phenotype (MP)	abnormal lymph node morphology	0.1825	1.603	Informative	INHERITED FROM: enlarged lymph nodes
Mammalian Phenotype (MP)	abnormal lymph organ size	0.3293	1.399	Informative	INHERITED FROM: enlarged lymph nodes || enlarged spleen
Mammalian Phenotype (MP)	abnormal ovary morphology	0.3775	1.457	Informative	INHERITED FROM: abnormal ovarian follicle morphology
Mammalian Phenotype (MP)	decreased mature B cell number	0.0000743	1.758	Highly Informative	DIRECT
Mammalian Phenotype (MP)	abnormal autonomic nervous system morphology	0.0001708	1.904	Highly Informative	DIRECT
Mammalian Phenotype (MP)	absent gametes	0.0002373	2.126	Highly Informative	DIRECT
Mammalian Phenotype (MP)	abnormal T cell apoptosis	0.0004411	2.126	Highly Informative	DIRECT
Mammalian Phenotype (MP)	enlarged lymph nodes	0.0005836	1.904	Highly Informative	DIRECT
Mammalian Phenotype (MP)	decreased apoptosis	0.0008746	1.904	Highly Informative	DIRECT
Mammalian Phenotype (MP)	enlarged spleen	0.0009489	1.825	Highly Informative	DIRECT
Mammalian Phenotype (MP)	abnormal immune organ physiology	0.008842	1.904	Highly Informative	INHERITED FROM: abnormal spleen physiology

---

Xenopus Anatomy (XA)

Highlighted in gray are those with FDR_all>0.001

	XA term	FDR (all)	IC level	SDXA level	Annotation (direct or inherited)
Xenopus ANatomical entity (XAN)	anatomical structure	0	0	--	DIRECT
Xenopus ANatomical entity (XAN)	anatomical group	0	0.1408	--	DIRECT
Xenopus ANatomical entity (XAN)	organism subdivision	0	0.1679	--	DIRECT
Xenopus ANatomical entity (XAN)	anatomical region	0	0.1803	--	DIRECT
Xenopus ANatomical entity (XAN)	multicellular anatomical structure	0	0.1131	--	DIRECT
Xenopus ANatomical entity (XAN)	whole organism	1	0.0884	--	INHERITED FROM: anatomical group || multicellular anatomical structure || anatomical region || organism subdivision
Xenopus ANatomical entity (XAN)	embryo	0	0.5979	Least Informative	DIRECT
Xenopus DEvelopment stage (XDE)	NF stage	0	0.01895	--	DIRECT

---