SUPERFAMILY 1.75 HMM library and genome assignments server

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Aquaporin-like family

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Membrane and cell surface proteins and peptides [ 56835] (58)
Fold:   Aquaporin-like [ 81339]
Superfamily:   Aquaporin-like [ 81338]
Family:   Aquaporin-like [ 56895] (4)

Family statistics
Genomes (1,944) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 6,630 29,511 8
Proteins 6,617 29,478 8

Disease Ontology (DO)

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DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)nervous system disease0.08759Least InformativeInherited
Disease Ontology (DO)gastrointestinal system disease0.008097Moderately InformativeInherited
Disease Ontology (DO)female reproductive system disease0.0006537InformativeDirect
Disease Ontology (DO)inner ear disease0.0000004416Highly InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Mode of Inheritance (MI)Autosomal dominant inheritance0Least InformativeDirect

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)abnormal homeostasis0.006361Least InformativeInherited
Mammalian Phenotype (MP)abnormal lipid homeostasis0.03033Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal kidney physiology0.09598InformativeInherited
Mammalian Phenotype (MP)decreased urine osmolality0.0000000000001841Highly InformativeDirect
Mammalian Phenotype (MP)polyuria0.00000002777Highly InformativeDirect
Mammalian Phenotype (MP)increased blood osmolality0.0000001571Highly InformativeDirect
Mammalian Phenotype (MP)increased blood urea nitrogen level0.0007327Highly InformativeDirect

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism environmental stimulus response variant0.004157Least InformativeInherited
Worm Phenotype (WP)organism stress response variant0.00007139Moderately InformativeDirect
Worm Phenotype (WP)organism osmotic stress response variant0.00001628Highly InformativeDirect

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details)
YP termFDR (all)SDYP levelAnnotation (direct or inherited)
Yeast Phenotype (YP)resistance to chemicals0Least InformativeDirect

Document: YP annotation of SCOP domains

Fly Phenotype (FP)

(show details) Document: FP annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details)
ZA termFDR (all)SDZA levelAnnotation (direct or inherited)
Zebrafish Anatomy (ZA)organism subdivision0Least InformativeDirect
Zebrafish Anatomy (ZA)anatomical cluster0Least InformativeDirect
Zebrafish Anatomy (ZA)cavitated compound organ0Least InformativeDirect
Zebrafish Anatomy (ZA)cell0Least InformativeDirect
Zebrafish Anatomy (ZA)nervous system0.2749Least InformativeInherited
Zebrafish Anatomy (ZA)portion of tissue0Moderately InformativeDirect
Zebrafish Anatomy (ZA)sensory system0.0795Moderately InformativeInherited
Zebrafish Anatomy (ZA)head0.3552Moderately InformativeInherited
Zebrafish Anatomy (ZA)eye0.07227InformativeInherited

Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details) Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)root0.0004789Least InformativeDirect
Plant ANatomical entity (PAN)portion of ground tissue0.00001077InformativeDirect
Plant ANatomical entity (PAN)vascular system0.001158InformativeInherited
Plant ANatomical entity (PAN)lateral root0.0000113Highly InformativeDirect
Plant ANatomical entity (PAN)plant axis elongation zone0.00008503Highly InformativeDirect
Plant ANatomical entity (PAN)cortex0.03644Highly InformativeInherited

Document: AP annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) ]

Internal database links

Superfamily level     Family level

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.

Superfamily level     Family level

Alignments of sequences to 12 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.

Superfamily level

Browse and view proteins in genomes which have different domain combinations including a Aquaporin-like domain.

Superfamily level     Family level

Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.

Jump to [ Top of page · SCOP classification · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Internal database links ]