Lipovitellin-phosvitin complex; beta-sheet shell regions superfamily

SCOP classification

• Root: SCOP hierarchy in SUPERFAMILY [ 0] (11)
• Class: Membrane and cell surface proteins and peptides [ 56835] (58)
• Fold: Lipovitellin-phosvitin complex; beta-sheet shell regions [ 56967]
• Superfamily: Lipovitellin-phosvitin complex; beta-sheet shell regions [ 56968]
• Families: Lipovitellin-phosvitin complex; beta-sheet shell regions [ 56969]

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Superfamily statistics

	Genomes (146)	Uniprot 2018_03 genome	PDB chains (SCOP 1.75)
Domains	1,494	6,908	3
Proteins	890	4,241	2

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Functional annotation

• General category: Metabolism
• Detailed category: Lipid metabolism and transport

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Worm Phenotype (WP)

Highlighted in gray are those with FDR_all>0.001

	WP term	FDR (all)	IC level	SDWP level	Annotation (direct or inherited)
Worm Phenotype (WP)	hermaphrodite fertility variant	0	0.1278	--	DIRECT
Worm Phenotype (WP)	fertility reduced	0	0.09267	--	DIRECT
Worm Phenotype (WP)	morphology variant	0	0.06117	--	DIRECT
Worm Phenotype (WP)	organism homeostasis metabolism variant	0	0.1501	--	DIRECT
Worm Phenotype (WP)	maternal sterile	0	0.171	--	DIRECT
Worm Phenotype (WP)	reproductive system physiology variant	0	0.07209	--	DIRECT
Worm Phenotype (WP)	embryonic lethal	0	0.07108	--	DIRECT
Worm Phenotype (WP)	organism physiology variant	0	0.1405	--	DIRECT
Worm Phenotype (WP)	fertility variant	0	0.08329	--	DIRECT
Worm Phenotype (WP)	organism development variant	0	0.004279	--	DIRECT
Worm Phenotype (WP)	hermaphrodite fertility reduced	0	0.1672	--	DIRECT
Worm Phenotype (WP)	hermaphrodite sterile	0	0.1685	--	DIRECT
Worm Phenotype (WP)	organism morphology variant	0	0.2011	--	DIRECT
Worm Phenotype (WP)	development variant	0	0.001706	--	DIRECT
Worm Phenotype (WP)	organ system physiology variant	0	0.05921	--	DIRECT
Worm Phenotype (WP)	lethal	0	0.01121	--	DIRECT
Worm Phenotype (WP)	embryonic development variant	0	0.06709	--	DIRECT
Worm Phenotype (WP)	peptide uptake by intestinal cell variant	0.000002075	2.23	--	DIRECT
Worm Phenotype (WP)	uptake by intestinal cell defective	0.000002255	2.23	--	DIRECT
Worm Phenotype (WP)	epithelial cell physiology variant	0.0005266	2.23	--	DIRECT
Worm Phenotype (WP)	protein metabolism variant	0.01518	1.23	--	INHERITED FROM: unfolded protein response variant
Worm Phenotype (WP)	response to bacteria variant	0.0169	1.26	--	INHERITED FROM: avoids bacterial lawn
Worm Phenotype (WP)	chemical response variant	0.06109	0.8045	--	INHERITED FROM: unfolded protein response variant
Worm Phenotype (WP)	behavior variant	0.08645	0.632	--	INHERITED FROM: avoids bacterial lawn || feeding behavior variant
Worm Phenotype (WP)	physiology variant	1	0	--	INHERITED FROM: hermaphrodite fertility variant || epithelial cell physiology variant || unfolded protein response variant || reproductive system physiology variant || metabolic pathway variant || pathogen susceptibility increased || organism homeostasis metabolism variant || epithelial system physiology variant || avoids bacterial lawn || lethal || uptake by intestinal cell defective || organism physiology variant || peptide uptake by intestinal cell variant || organism stress response variant || cell homeostasis metabolism variant || life span variant || development variant || organism pathogen response variant || cell physiology variant || hermaphrodite sterile || organism environmental stimulus response variant || hermaphrodite fertility reduced || embryonic development variant || embryonic lethal || fertility variant || feeding behavior variant || shortened life span || organ system physiology variant || maternal sterile || cell stress response variant || organism development variant || fertility reduced
Worm Phenotype (WP)	sterile	1	0.161	--	INHERITED FROM: hermaphrodite sterile || maternal sterile
Worm Phenotype (WP)	organism environmental stimulus response variant	0	0.5677	Least Informative	DIRECT
Worm Phenotype (WP)	cell physiology variant	0	0.5344	Least Informative	DIRECT
Worm Phenotype (WP)	organism metabolism processing variant	0.01161	0.4572	Least Informative	INHERITED FROM: unfolded protein response variant || metabolic pathway variant
Worm Phenotype (WP)	organism behavior variant	0.0845	0.632	Least Informative	INHERITED FROM: avoids bacterial lawn || feeding behavior variant
Worm Phenotype (WP)	cell homeostasis metabolism variant	0	0.9294	Moderately Informative	DIRECT
Worm Phenotype (WP)	organism stress response variant	0	0.8325	Moderately Informative	DIRECT
Worm Phenotype (WP)	metabolic pathway variant	0.0000004686	1.117	Moderately Informative	DIRECT
Worm Phenotype (WP)	feeding behavior variant	0.0004582	1.176	Moderately Informative	DIRECT
Worm Phenotype (WP)	life span variant	0	1.276	Informative	DIRECT
Worm Phenotype (WP)	organism pathogen response variant	0	1.365	Informative	DIRECT
Worm Phenotype (WP)	cell stress response variant	0	1.407	Informative	DIRECT
Worm Phenotype (WP)	avoids bacterial lawn	0.00006765	1.327	Informative	DIRECT
Worm Phenotype (WP)	shortened life span	0	1.929	Highly Informative	DIRECT
Worm Phenotype (WP)	pathogen susceptibility increased	0	1.862	Highly Informative	DIRECT
Worm Phenotype (WP)	unfolded protein response variant	0.0000000682	1.929	Highly Informative	DIRECT
Worm Phenotype (WP)	epithelial system physiology variant	0.000007744	1.929	Highly Informative	DIRECT

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Zebrafish Anatomy (ZA)

Highlighted in gray are those with FDR_all>0.001

	ZA term	FDR (all)	IC level	SDZA level	Annotation (direct or inherited)
Zebrafish Anatomy (ZA)	whole organism	0	0.004764	--	DIRECT
Zebrafish Anatomy (ZA)	anatomical system	0	0.2245	--	DIRECT
Zebrafish Anatomy (ZA)	cavitated compound organ	0	0.5472	--	DIRECT
Zebrafish Anatomy (ZA)	anatomical group	0	0.1889	--	DIRECT
Zebrafish Anatomy (ZA)	anatomical structure	1	0	--	INHERITED FROM: anatomical system || multi-tissue structure || anatomical group || whole organism || organism subdivision || compound organ || cavitated compound organ
Zebrafish Anatomy (ZA)	compound organ	0	0.4571	Least Informative	DIRECT
Zebrafish Anatomy (ZA)	organism subdivision	0	0.6264	Least Informative	DIRECT
Zebrafish Anatomy (ZA)	multi-tissue structure	0	0.6005	Least Informative	DIRECT

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Xenopus Anatomy (XA)

Highlighted in gray are those with FDR_all>0.001

	XA term	FDR (all)	IC level	SDXA level	Annotation (direct or inherited)
Xenopus ANatomical entity (XAN)	trunk region	0	0.4287	--	DIRECT
Xenopus ANatomical entity (XAN)	genital system	0	0.5909	--	DIRECT
Xenopus ANatomical entity (XAN)	male genitalia	0	0.8318	--	DIRECT
Xenopus ANatomical entity (XAN)	anatomical structure	0	0	--	DIRECT
Xenopus ANatomical entity (XAN)	anatomical group	0	0.1442	--	DIRECT
Xenopus ANatomical entity (XAN)	male organism	0	0.8318	--	DIRECT
Xenopus ANatomical entity (XAN)	organism subdivision	0	0.1871	--	DIRECT
Xenopus ANatomical entity (XAN)	compound organ	0	0.24	--	DIRECT
Xenopus ANatomical entity (XAN)	gonad	0	0.8318	--	DIRECT
Xenopus ANatomical entity (XAN)	anatomical cluster	0	0.7974	--	DIRECT
Xenopus ANatomical entity (XAN)	anatomical region	0	0.193	--	DIRECT
Xenopus ANatomical entity (XAN)	multicellular anatomical structure	0	0.1217	--	DIRECT
Xenopus ANatomical entity (XAN)	anatomical system	1	0.3094	--	INHERITED FROM: testis || alimentary system || urogenital system || genital system || male genitalia
Xenopus ANatomical entity (XAN)	whole organism	1	0.09747	--	INHERITED FROM: urogenital system || genital system || alimentary system || anatomical group || testis || cavitated compound organ || multicellular anatomical structure || gonad || compound organ || trunk || anatomical region || male genitalia || trunk region || anatomical cluster || viscus || male organism || organism subdivision
Xenopus ANatomical entity (XAN)	urogenital system	0	0.5011	Least Informative	DIRECT
Xenopus ANatomical entity (XAN)	trunk	0	0.4308	Least Informative	DIRECT
Xenopus ANatomical entity (XAN)	cavitated compound organ	0	0.3033	Least Informative	DIRECT
Xenopus ANatomical entity (XAN)	alimentary system	0	0.955	Moderately Informative	DIRECT
Xenopus ANatomical entity (XAN)	testis	0	0.8318	Moderately Informative	DIRECT
Xenopus ANatomical entity (XAN)	viscus	0	0.9618	Moderately Informative	DIRECT

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InterPro annotation

• Cross references: IPR015819 SSF56968 Protein matches
• Abstract:

  This entry represents beta-sheet shell domains found in lipid transport proteins such as vitellinogen. Vitellinogen precursors provide the major egg yolk proteins that are a source of nutrients during early development of oviparous vertebrates and invertebrates. Vitellinogen precursors are multi-domain apolipoproteins that are cleaved into distinct yolk proteins. Different vitellinogen precursors exist, which are composed of variable combinations of yolk protein components; however, the cleavage sites are conserved. In vertebrates, a complete vitellinogen is composed of an N-terminal signal peptide for export, followed by four regions that can be cleaved into yolk proteins: lipovitellin-1, phosvitin, lipovitellin-2, and a von Willebrand factor type D domain (YGP40) [17314313, 12135361]. Domains with a beta-sheet shell topology can be found within both lipovitellin-1 and lipoviteliin-2 peptide products.

InterPro database

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