SUPERFAMILY 1.75 HMM library and genome assignments server

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Insulin-like family

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Small proteins [ 56992] (90)
Fold:   Insulin-like [ 56993]
Superfamily:   Insulin-like [ 56994]
Family:   Insulin-like [ 56995] (4)

Family statistics
Genomes (64) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 212 941 9
Proteins 212 941 9

Disease Ontology (DO)

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DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)organ system cancer0Least InformativeDirect
Disease Ontology (DO)nervous system disease0.3432Least InformativeInherited
Disease Ontology (DO)cell type cancer0Moderately InformativeDirect
Disease Ontology (DO)artery disease0Moderately InformativeDirect
Disease Ontology (DO)disease of metabolism0.0003298Moderately InformativeDirect
Disease Ontology (DO)lower respiratory tract disease0.005833Moderately InformativeInherited
Disease Ontology (DO)neurodegenerative disease0.0146Moderately InformativeInherited
Disease Ontology (DO)syndrome0.01467Moderately InformativeInherited
Disease Ontology (DO)gastrointestinal system disease0.0995Moderately InformativeInherited
Disease Ontology (DO)hypertension0InformativeDirect
Disease Ontology (DO)overnutrition0.00002751InformativeDirect
Disease Ontology (DO)interstitial lung disease0.00009403InformativeDirect
Disease Ontology (DO)endocrine gland cancer0.001419InformativeInherited
Disease Ontology (DO)liver disease0.004786InformativeInherited
Disease Ontology (DO)pancreas disease0.1238InformativeInherited
Disease Ontology (DO)polycystic ovary syndrome0.0000008597Highly InformativeDirect
Disease Ontology (DO)endocrine pancreas disease0.000002395Highly InformativeDirect
Disease Ontology (DO)Parkinson's disease0.00005966Highly InformativeDirect
Disease Ontology (DO)in situ carcinoma0.00006756Highly InformativeDirect
Disease Ontology (DO)thyroid carcinoma0.0000841Highly InformativeDirect
Disease Ontology (DO)liver cirrhosis0.0001379Highly InformativeDirect
Disease Ontology (DO)gonadal disease0.006323Highly InformativeInherited

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of the genitourinary system0Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of limbs0.0805Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of metabolism/homeostasis0.1364Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of skeletal morphology0.2138Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the hand0.02314Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of limb bone morphology0.02999Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal homeostasis0.03535Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of body weight0.04246Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal glucose homeostasis0.002435InformativeInherited
Phenotypic Abnormality (PA)Deviation of finger0.0004303Highly InformativeDirect
Phenotypic Abnormality (PA)Intrauterine growth retardation0.0007637Highly InformativeDirect
Phenotypic Abnormality (PA)Clinodactyly0.0007637Highly InformativeDirect

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)endocrine/exocrine gland phenotype0.00007082Least InformativeDirect
Mammalian Phenotype (MP)cellular phenotype0.0185Least InformativeInherited
Mammalian Phenotype (MP)abnormal homeostasis0.03306Least InformativeInherited
Mammalian Phenotype (MP)growth/size/body region phenotype0.1132Least InformativeInherited
Mammalian Phenotype (MP)abnormal hormone level0.0007937Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal reproductive system morphology0.1603Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal endocrine gland morphology0.4512Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal primary sex determination0.001014InformativeInherited
Mammalian Phenotype (MP)abnormal germ cell morphology0.001245InformativeInherited
Mammalian Phenotype (MP)abnormal circulating glucose level0.008058InformativeInherited
Mammalian Phenotype (MP)abnormal pancreas morphology0.09718InformativeInherited
Mammalian Phenotype (MP)abnormal prenatal body size0.457InformativeInherited
Mammalian Phenotype (MP)decreased birth weight0.000001373Highly InformativeDirect
Mammalian Phenotype (MP)hyperglycemia0.0001232Highly InformativeDirect
Mammalian Phenotype (MP)abnormal pancreatic beta cell morphology0.000204Highly InformativeDirect
Mammalian Phenotype (MP)decreased fetal size0.0004344Highly InformativeDirect

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism behavior variant0.0000002218Least InformativeDirect
Worm Phenotype (WP)organism environmental stimulus response variant0.02179Least InformativeInherited
Worm Phenotype (WP)cell development variant0.3599Least InformativeInherited
Worm Phenotype (WP)organism segment morphology variant0.00000001482Moderately InformativeDirect
Worm Phenotype (WP)body region morphology variant0.00000001555Moderately InformativeDirect
Worm Phenotype (WP)movement variant0.00224Moderately InformativeInherited
Worm Phenotype (WP)organism stress response variant0.5559Moderately InformativeInherited
Worm Phenotype (WP)tail bend angle variant0.00000000001137InformativeDirect
Worm Phenotype (WP)head movement variant0.00000000003928InformativeDirect
Worm Phenotype (WP)body posture variant0.000001025InformativeDirect
Worm Phenotype (WP)forward locomotion variant0.0001InformativeDirect
Worm Phenotype (WP)small0.0001634InformativeDirect
Worm Phenotype (WP)velocity of movement variant0.0002141InformativeDirect
Worm Phenotype (WP)foraging behavior variant0.0002999InformativeDirect
Worm Phenotype (WP)locomotor coordination variant0.00399InformativeInherited
Worm Phenotype (WP)organism temperature response variant0.05285InformativeInherited
Worm Phenotype (WP)locomotion reduced0.768InformativeInherited
Worm Phenotype (WP)dauer larva physiology variant1InformativeInherited
Worm Phenotype (WP)amplitude of sinusoidal movement variant0.00000000004411Highly InformativeDirect
Worm Phenotype (WP)forward point velocity variant0.0000000001533Highly InformativeDirect
Worm Phenotype (WP)backward point velocity variant0.0000000002108Highly InformativeDirect
Worm Phenotype (WP)coiling frequency variant0.00001587Highly InformativeDirect
Worm Phenotype (WP)pausing variant0.0005745Highly InformativeDirect
Worm Phenotype (WP)dauer formation variant1Highly InformativeInherited

Document: WP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)viable0Least InformativeDirect
Fly Phenotype (FP)decreased fecundity0.0002018Highly InformativeDirect

Document: FP annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details) Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)trunk0Least InformativeDirect
Xenopus DEvelopment stage (XDE)embryonic stage0Moderately InformativeDirect

Document: XA annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) ]

Internal database links

Superfamily level     Family level

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.

Superfamily level     Family level

Alignments of sequences to 13 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.

Superfamily level

Browse and view proteins in genomes which have different domain combinations including a Insulin-like domain.

Superfamily level     Family level

Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.

Jump to [ Top of page · SCOP classification · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Internal database links ]