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EGF/Laminin superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Small proteins [ 56992] (90)
Fold:   Knottins (small inhibitors, toxins, lectins) [ 57015] (19)
Superfamily:   EGF/Laminin [ 57196] (7)
Families:   EGF-type module [ 57197] (22)
  Integrin beta EGF-like domains [ 69940]
  EGF-like domain of nidogen-1 [ 64541]
  Laminin-type module [ 57233]
  Follistatin (FS) module N-terminal domain, FS-N [ 57236] (2)
  Merozoite surface protein 1 (MSP-1) [ 57239]
  Cripto EGF-like domain-like [ 144100]


Superfamily statistics
Genomes (281) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 76,348 214,533 117
Proteins 23,656 69,342 88


Functional annotation
General category Processes_EC
Detailed category Cell adhesion

Document:
Function annotation of SCOP domain superfamilies

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on peptide bonds (peptide hydrolases)0Least InformativeDirect
Enzyme Commission (EC)Oxidoreductases0.0002233Least InformativeDirect
Enzyme Commission (EC)Serine endopeptidases0Moderately InformativeDirect
Enzyme Commission (EC)Acting on paired donors, with incorporation or red0Moderately InformativeDirect
Enzyme Commission (EC)Miscellaneous (requires further characterization)0InformativeDirect
Enzyme Commission (EC)Peroxidases0.000006591InformativeDirect
Enzyme Commission (EC)Coagulation factor IXa0.00000000002266Highly InformativeDirect
Enzyme Commission (EC)Complement subcomponent C1s0.0000000002421Highly InformativeDirect
Enzyme Commission (EC)Complement subcomponent C1r0.0000000002421Highly InformativeDirect
Enzyme Commission (EC)Protein C (activated)0.0000000146Highly InformativeDirect
Enzyme Commission (EC)Coagulation factor Xa0.00001257Highly InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)artery disease0.02338Moderately InformativeInherited
Disease Ontology (DO)hematopoietic system disease0.03217Moderately InformativeInherited
Disease Ontology (DO)hypersensitivity reaction type II disease0.1466Moderately InformativeInherited
Disease Ontology (DO)skin disease0.6968Moderately InformativeInherited
Disease Ontology (DO)bullous pemphigoid0.0003067InformativeDirect
Disease Ontology (DO)atherosclerosis0.0009695InformativeDirect
Disease Ontology (DO)vesiculobullous skin disease0.0002288Highly InformativeDirect
Disease Ontology (DO)primary thrombocytopenia0.0004279Highly InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of limbs0.1568Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the integument0.1695Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the eye0.7519Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of skin morphology0.03016Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the upper limb0.04682Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal anterior eye segment morphology0.2039Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the respiratory system0.2543Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of skin adnexa morphology0.5417Moderately InformativeInherited
Phenotypic Abnormality (PA)Localized skin lesion0.1653InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the nail0.4035InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the upper respiratory tract0.4052InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the palm0.4455InformativeInherited
Phenotypic Abnormality (PA)Regional abnormality of skin0.5991InformativeInherited
Phenotypic Abnormality (PA)Abnormal blistering of the skin0.1369Highly InformativeInherited
Phenotypic Abnormality (PA)Abnormal larynx physiology0.3662Highly InformativeInherited
Phenotypic Abnormality (PA)Hypohidrosis or hyperhidrosis0.3994Highly InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the skin of the palm0.493Highly InformativeInherited

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)cardiovascular system phenotype0.0000000802Least InformativeDirect
Mammalian Phenotype (MP)mortality/aging0.01163Least InformativeInherited
Mammalian Phenotype (MP)nervous system phenotype0.02282Least InformativeInherited
Mammalian Phenotype (MP)immune system phenotype0.02905Least InformativeInherited
Mammalian Phenotype (MP)cellular phenotype0.1283Least InformativeInherited
Mammalian Phenotype (MP)hematopoietic system phenotype0.5268Least InformativeInherited
Mammalian Phenotype (MP)abnormal homeostasis0.8257Least InformativeInherited
Mammalian Phenotype (MP)abnormal blood vessel morphology0.0000146Moderately InformativeDirect
Mammalian Phenotype (MP)integument phenotype0.0001009Moderately InformativeDirect
Mammalian Phenotype (MP)respiratory system phenotype0.0001315Moderately InformativeDirect
Mammalian Phenotype (MP)lethality during fetal growth through weaning0.0002139Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal craniofacial morphology0.001208Moderately InformativeInherited
Mammalian Phenotype (MP)hearing/vestibular/ear phenotype0.004001Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal nervous system development0.01067Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal somatic nervous system morphology0.01488Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal neuron morphology0.03625Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cardiovascular system physiology0.2877Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal professional antigen presenting cell physiology0.3606Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal gland morphology0.3811Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal brain morphology0.4039Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal skeleton morphology0.5444Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal eye morphology0.6988Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal leukocyte physiology0.7653Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal reproductive system physiology0.8862Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal blood coagulation0.0000002995InformativeDirect
Mammalian Phenotype (MP)perinatal lethality0.0001832InformativeDirect
Mammalian Phenotype (MP)abnormal leukocyte migration0.0006656InformativeDirect
Mammalian Phenotype (MP)abnormal cochlear hair cell morphology0.00667InformativeInherited
Mammalian Phenotype (MP)abnormal systemic artery morphology0.0364InformativeInherited
Mammalian Phenotype (MP)abnormal gas homeostasis0.03784InformativeInherited
Mammalian Phenotype (MP)abnormal compact bone morphology0.06193InformativeInherited
Mammalian Phenotype (MP)abnormal macrophage physiology0.1025InformativeInherited
Mammalian Phenotype (MP)abnormal mammary gland morphology0.1272InformativeInherited
Mammalian Phenotype (MP)abnormal angiogenesis0.1707InformativeInherited
Mammalian Phenotype (MP)abnormal brain development0.1788InformativeInherited
Mammalian Phenotype (MP)abnormal spinal cord morphology0.2291InformativeInherited
Mammalian Phenotype (MP)abnormal skin appearance0.2416InformativeInherited
Mammalian Phenotype (MP)abnormal sensory neuron morphology0.4679InformativeInherited
Mammalian Phenotype (MP)abnormal female reproductive system physiology0.5869InformativeInherited
Mammalian Phenotype (MP)hemorrhage0.5952InformativeInherited
Mammalian Phenotype (MP)abnormal neuron number0.7464InformativeInherited
Mammalian Phenotype (MP)abnormal basement membrane morphology0.0000000005128Highly InformativeDirect
Mammalian Phenotype (MP)abnormal spinal cord ventral commissure morphology0.00002189Highly InformativeDirect
Mammalian Phenotype (MP)dermal-epidermal separation0.00002189Highly InformativeDirect
Mammalian Phenotype (MP)abnormal cardinal vein morphology0.00008176Highly InformativeDirect
Mammalian Phenotype (MP)abnormal aorta tunica media morphology0.00008802Highly InformativeDirect
Mammalian Phenotype (MP)skin hemorrhage0.0001158Highly InformativeDirect
Mammalian Phenotype (MP)abnormal pregnancy0.000509Highly InformativeDirect
Mammalian Phenotype (MP)abnormal compact bone thickness0.000562Highly InformativeDirect
Mammalian Phenotype (MP)abnormal mammary gland duct morphology0.0006458Highly InformativeDirect
Mammalian Phenotype (MP)decreased organ of Corti supporting cell number0.0008817Highly InformativeDirect
Mammalian Phenotype (MP)aneurysm0.0009369Highly InformativeDirect
Mammalian Phenotype (MP)increased sensory neuron number0.008611Highly InformativeInherited
Mammalian Phenotype (MP)abnormal olfactory bulb development0.01291Highly InformativeInherited
Mammalian Phenotype (MP)skin lesions0.3172Highly InformativeInherited
Mammalian Phenotype (MP)abnormal dorsal root ganglion morphology0.3572Highly InformativeInherited
Mammalian Phenotype (MP)abnormal cochlear inner hair cell morphology0.9275Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)cell development variant0.000001498Least InformativeDirect
Worm Phenotype (WP)organism behavior variant0.009042Least InformativeInherited
Worm Phenotype (WP)organ system morphology variant0.01149Least InformativeInherited
Worm Phenotype (WP)cell morphology variant0.01459Least InformativeInherited
Worm Phenotype (WP)cell physiology variant0.1071Least InformativeInherited
Worm Phenotype (WP)organism environmental stimulus response variant0.6851Least InformativeInherited
Worm Phenotype (WP)movement variant0.0006624Moderately InformativeDirect
Worm Phenotype (WP)reproductive system development variant0.05357Moderately InformativeInherited
Worm Phenotype (WP)nervous system morphology variant0.1658Moderately InformativeInherited
Worm Phenotype (WP)neuron development variant0.3481Moderately InformativeInherited
Worm Phenotype (WP)germ cell development variant0.8669Moderately InformativeInherited
Worm Phenotype (WP)cell number increased0.0000001852InformativeDirect
Worm Phenotype (WP)muscle cell physiology variant0.00009728InformativeDirect
Worm Phenotype (WP)anchor cell invasion variant0.0002604InformativeDirect
Worm Phenotype (WP)cell fate specification variant0.000435InformativeDirect
Worm Phenotype (WP)axon outgrowth variant0.0005532InformativeDirect
Worm Phenotype (WP)body wall muscle sarcomere morphology variant0.0006176InformativeDirect
Worm Phenotype (WP)chemotaxis variant0.004096InformativeInherited
Worm Phenotype (WP)pigmentation variant0.008346InformativeInherited
Worm Phenotype (WP)neuron morphology variant0.05729InformativeInherited
Worm Phenotype (WP)odorant chemosensory response variant0.5622InformativeInherited
Worm Phenotype (WP)muscle arm development defective0.00000359Highly InformativeDirect
Worm Phenotype (WP)axon guidance variant0.00003758Highly InformativeDirect
Worm Phenotype (WP)odorant negative chemotaxis defective0.00008941Highly InformativeDirect
Worm Phenotype (WP)octanol chemotaxis variant0.0003242Highly InformativeDirect
Worm Phenotype (WP)developmental morphology variant0.0003508Highly InformativeDirect
Worm Phenotype (WP)axon trajectory variant0.0004651Highly InformativeDirect
Worm Phenotype (WP)clear0.0006071Highly InformativeDirect
Worm Phenotype (WP)germline proliferation variant0.008082Highly InformativeInherited
Worm Phenotype (WP)neuropil development variant0.01864Highly InformativeInherited
Worm Phenotype (WP)alimentary system morphology variant0.0198Highly InformativeInherited
Worm Phenotype (WP)loss of left right asymmetry0.1508Highly InformativeInherited
Worm Phenotype (WP)neuronal cell fate specification variant0.426Highly InformativeInherited

Document: WP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)increased mortality0.4326Least InformativeInherited
Fly Phenotype (FP)lethal0.2905Moderately InformativeInherited
Fly Phenotype (FP)planar polarity defective0.000005509InformativeDirect
Fly Phenotype (FP)lethal - all die before end of larval stage0.000009193InformativeDirect
Fly Phenotype (FP)cell polarity defective0.0008197InformativeDirect
Fly Phenotype (FP)lethal - all die before end of embryonic stage0.0000002214Highly InformativeDirect
Fly Phenotype (FP)some die during embryonic stage0.000005137Highly InformativeDirect
Fly Phenotype (FP)immune response defective0.0001247Highly InformativeDirect

Document: FP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)multi-tissue structure0.07574Least InformativeInherited
Fly Anatomy (FA)organ system subdivision0.07986Least InformativeInherited
Fly Anatomy (FA)adult0.08234Least InformativeInherited
Fly Anatomy (FA)organism subdivision0.08281Least InformativeInherited
Fly Anatomy (FA)cell0.08661Least InformativeInherited
Fly Anatomy (FA)nervous system0.2019Least InformativeInherited
Fly Anatomy (FA)larva0.208Least InformativeInherited
Fly Anatomy (FA)acellular anatomical structure0.000008338Moderately InformativeDirect
Fly Anatomy (FA)peripheral nervous system0.004857Moderately InformativeInherited
Fly Anatomy (FA)embryo0.006391Moderately InformativeInherited
Fly Anatomy (FA)multi-cell-component structure0.01894Moderately InformativeInherited
Fly Anatomy (FA)gonad0.02091Moderately InformativeInherited
Fly Anatomy (FA)appendage0.02477Moderately InformativeInherited
Fly Anatomy (FA)sensory system0.02652Moderately InformativeInherited
Fly Anatomy (FA)region of integument0.05723Moderately InformativeInherited
Fly Anatomy (FA)neuron0.09595Moderately InformativeInherited
Fly Anatomy (FA)adult segment0.1211Moderately InformativeInherited
Fly Anatomy (FA)adult integumentary system0.1667Moderately InformativeInherited
Fly Anatomy (FA)thorax0.2343Moderately InformativeInherited
Fly Anatomy (FA)central nervous system0.2952Moderately InformativeInherited
Fly Anatomy (FA)head0.3356Moderately InformativeInherited
Fly Anatomy (FA)adult tagma0.5802Moderately InformativeInherited
Fly Anatomy (FA)somatic precursor cell0.8835Moderately InformativeInherited
Fly Anatomy (FA)sensory organ cell0.0001476InformativeDirect
Fly Anatomy (FA)primordium0.0001634InformativeDirect
Fly Anatomy (FA)presumptive embryonic/larval system0.0001961InformativeDirect
Fly Anatomy (FA)larval segment0.0002057InformativeDirect
Fly Anatomy (FA)muscle system0.0004337InformativeDirect
Fly Anatomy (FA)adult head sensillum0.0004626InformativeDirect
Fly Anatomy (FA)syncytium0.0004973InformativeDirect
Fly Anatomy (FA)anatomical space0.0008377InformativeDirect
Fly Anatomy (FA)embryonic/larval digestive system0.001155InformativeInherited
Fly Anatomy (FA)abdominal segment0.001776InformativeInherited
Fly Anatomy (FA)embryonic/larval circulatory system0.001994InformativeInherited
Fly Anatomy (FA)tracheal system0.002797InformativeInherited
Fly Anatomy (FA)gut section0.004643InformativeInherited
Fly Anatomy (FA)histaminergic neuron0.004647InformativeInherited
Fly Anatomy (FA)retina0.006794InformativeInherited
Fly Anatomy (FA)integumentary specialisation0.01127InformativeInherited
Fly Anatomy (FA)adult optic lobe neuron0.01129InformativeInherited
Fly Anatomy (FA)dorsal closure embryo0.02355InformativeInherited
Fly Anatomy (FA)head capsule0.02918InformativeInherited
Fly Anatomy (FA)cell component0.03608InformativeInherited
Fly Anatomy (FA)larval abdomen0.03917InformativeInherited
Fly Anatomy (FA)extended germ band embryo0.04141InformativeInherited
Fly Anatomy (FA)wing0.06675InformativeInherited
Fly Anatomy (FA)rhabdomeric photoreceptor cell0.1244InformativeInherited
Fly Anatomy (FA)male-specific anatomical entity0.2077InformativeInherited
Fly Anatomy (FA)proventriculus0.00001331Highly InformativeDirect
Fly Anatomy (FA)embryonic/larval dorsal vessel0.00008164Highly InformativeDirect
Fly Anatomy (FA)nephrocyte0.0001734Highly InformativeDirect
Fly Anatomy (FA)germinal proliferation center hub0.0003843Highly InformativeDirect
Fly Anatomy (FA)ventral nervous system0.0005448Highly InformativeDirect
Fly Anatomy (FA)ocellus0.000921Highly InformativeDirect
Fly Anatomy (FA)somatic cell of testis0.001969Highly InformativeInherited
Fly Anatomy (FA)muscle attachment site0.002288Highly InformativeInherited
Fly Anatomy (FA)early extended germ band embryo0.01996Highly InformativeInherited
Fly Anatomy (FA)embryonic/larval midgut0.0613Highly InformativeInherited
Fly Anatomy (FA)A1-7 acute muscle0.1222Highly InformativeInherited
Fly Anatomy (FA)longitudinal muscle0.2035Highly InformativeInherited
Fly Anatomy (FA)larval abdominal segment A2-70.4086Highly InformativeInherited
Fly Anatomy (FA)dorsal acute muscle0.4316Highly InformativeInherited

Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details)
ZA termFDR (all)SDZA levelAnnotation (direct or inherited)
Zebrafish Anatomy (ZA)multi-tissue structure0.008381Least InformativeInherited
Zebrafish Anatomy (ZA)compound organ0.3023Least InformativeInherited
Zebrafish Anatomy (ZA)nervous system0.9078Least InformativeInherited
Zebrafish Anatomy (ZA)portion of tissue0.02023Moderately InformativeInherited
Zebrafish Anatomy (ZA)cardiovascular system0.02665Moderately InformativeInherited
Zebrafish Anatomy (ZA)anatomical cluster0.695Moderately InformativeInherited
Zebrafish Anatomy (ZA)sensory system0.985Moderately InformativeInherited
Zebrafish Anatomy (ZA)blood vasculature0.0009473InformativeDirect
Zebrafish Anatomy (ZA)lymphatic system0.00008842Highly InformativeDirect
Zebrafish Anatomy (ZA)epithelium0.07911Highly InformativeInherited
Zebrafish Anatomy (ZA)inner ear0.08004Highly InformativeInherited
Zebrafish Anatomy (ZA)lateral line system0.2433Highly InformativeInherited
Zebrafish Anatomy (ZA)cranial ganglion0.4488Highly InformativeInherited

Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)trunk0.6535Least InformativeInherited
Xenopus ANatomical entity (XAN)tissue0.8315Least InformativeInherited
Xenopus ANatomical entity (XAN)embryo1Least InformativeInherited
Xenopus ANatomical entity (XAN)nervous system1Least InformativeInherited
Xenopus ANatomical entity (XAN)cavitated compound organ1Least InformativeInherited
Xenopus ANatomical entity (XAN)multi-tissue structure0.0906Moderately InformativeInherited
Xenopus ANatomical entity (XAN)embryonic structure0.2757Moderately InformativeInherited
Xenopus ANatomical entity (XAN)viscus0.4629Moderately InformativeInherited
Xenopus ANatomical entity (XAN)ectoderm1Moderately InformativeInherited
Xenopus ANatomical entity (XAN)notochord0.00001163InformativeDirect
Xenopus ANatomical entity (XAN)spinal cord0.0002398InformativeDirect
Xenopus ANatomical entity (XAN)cardiovascular system0.002989InformativeInherited
Xenopus ANatomical entity (XAN)neural plate0.03788InformativeInherited
Xenopus ANatomical entity (XAN)endoderm0.05695InformativeInherited
Xenopus ANatomical entity (XAN)hypochord0.00001027Highly InformativeDirect
Xenopus ANatomical entity (XAN)neural groove0.0003316Highly InformativeDirect
Xenopus ANatomical entity (XAN)axial mesoderm0.0005525Highly InformativeDirect
Xenopus ANatomical entity (XAN)cell part0.0427Highly InformativeInherited
Xenopus DEvelopment stage (XDE)embryonic stage0.00006378Moderately InformativeDirect
Xenopus DEvelopment stage (XDE)late tailbud stage0.8769InformativeInherited
Xenopus DEvelopment stage (XDE)NF stage 35 and 360.0005667Highly InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant structure DEvelopment stage (PDE)4 leaf senescence stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.12 twelve leaves visible stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.08 eight leaves visible stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.02 two leaves visible stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.10 ten leaves visible stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.04 four leaves visible stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.06 six leaves visible stage0Least InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Hydrolases0Least InformativeDirect
Enzyme Commission (EC)Oxidoreductases0.00005826Least InformativeDirect
Enzyme Commission (EC)Acting on peptide bonds (peptidases)0Moderately InformativeDirect
Enzyme Commission (EC)Serine endopeptidases0InformativeDirect
Enzyme Commission (EC)Acting on paired donors, with incorporation or reduction of molecular oxygen. The oxygen incorporate5.111e-16InformativeDirect
Enzyme Commission (EC)Acting on a peroxide as acceptor0.0004175InformativeDirect
Enzyme Commission (EC)Metalloendopeptidases0.1256InformativeInherited
Enzyme Commission (EC)Miscellaneous0Highly InformativeDirect

Document: EC annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 83 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a EGF/Laminin domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 83 hidden Markov models representing the EGF/Laminin superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · Internal database links ]