Laminin-type module family

SCOP classification

• Root: SCOP hierarchy in SUPERFAMILY [ 0] (11)
• Class: Small proteins [ 56992] (90)
• Fold: Knottins (small inhibitors, toxins, lectins) [ 57015] (19)
• Superfamily: EGF/Laminin [ 57196] (7)
• Family: Laminin-type module [ 57233]

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Family statistics

	Genomes (50)	Uniprot 2018_03 genome	PDB chains (SCOP 1.75)
Domains	57	127	3
Proteins	57	127	3

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Disease Ontology (DO)

Highlighted in gray are those with FDR_all>0.001

	DO term	FDR (all)	IC level	SDDO level	Annotation (direct or inherited)
Disease Ontology (DO)	junctional epidermolysis bullosa	0.00000000004158	2.513	--	DIRECT
Disease Ontology (DO)	skin disease	0.01858	1.022	--	INHERITED FROM: junctional epidermolysis bullosa || vesiculobullous skin disease
Disease Ontology (DO)	disease of anatomical entity	0.04804	0.2414	--	INHERITED FROM: vesiculobullous skin disease || junctional epidermolysis bullosa
Disease Ontology (DO)	epidermolysis bullosa	1	2.513	--	INHERITED FROM: junctional epidermolysis bullosa
Disease Ontology (DO)	integumentary system disease	0.05711	0.9817	Moderately Informative	INHERITED FROM: junctional epidermolysis bullosa || vesiculobullous skin disease
Disease Ontology (DO)	vesiculobullous skin disease	0.00000002909	2.036	Highly Informative	DIRECT

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Human Phenotype (HP)

Highlighted in gray are those with FDR_all>0.001

	HP term	FDR (all)	IC level	SDHP level	Annotation (direct or inherited)
	Variable expressivity	0	0.04347	--	DIRECT
	Phenotypic variability	1	0	--	INHERITED FROM: Variable expressivity
Phenotypic Abnormality (PA)	Congenital localized absence of skin	0.0000001111	2.462	--	DIRECT
Phenotypic Abnormality (PA)	Junctional split	0.000000227	2.462	--	DIRECT
Phenotypic Abnormality (PA)	Mitten deformity	0.000000227	2.462	--	DIRECT
Phenotypic Abnormality (PA)	Laryngeal stridor	0.000000227	2.462	--	DIRECT
Phenotypic Abnormality (PA)	Paronychia	0.0000004144	2.462	--	DIRECT
Phenotypic Abnormality (PA)	Abnormality of the periungual region	0.000001091	2.462	--	DIRECT
Phenotypic Abnormality (PA)	Weak cry	0.000001164	2.462	--	DIRECT
Phenotypic Abnormality (PA)	Palmar hyperhidrosis	0.00000163	2.462	--	DIRECT
Phenotypic Abnormality (PA)	Oral mucosal blisters	0.000002358	2.462	--	DIRECT
Phenotypic Abnormality (PA)	Esophageal stricture	0.000003287	2.462	--	DIRECT
Phenotypic Abnormality (PA)	Onycholysis	0.000004454	2.462	--	DIRECT
Phenotypic Abnormality (PA)	Esophageal stenosis	0.000005901	2.462	--	DIRECT
Phenotypic Abnormality (PA)	Skin erosion	0.000007076	2.462	--	DIRECT
Phenotypic Abnormality (PA)	Milia	0.00001188	2.462	--	DIRECT
Phenotypic Abnormality (PA)	Fragile nails	0.00003202	2.462	--	DIRECT
Phenotypic Abnormality (PA)	Aplasia cutis congenita	0.00005147	2.462	--	DIRECT
Phenotypic Abnormality (PA)	Muscle fiber atrophy	0.0001896	2.462	--	DIRECT
Phenotypic Abnormality (PA)	Alopecia of scalp	0.0002043	2.462	--	DIRECT
Phenotypic Abnormality (PA)	Squamous cell carcinoma	0.0002499	2.161	--	DIRECT
Phenotypic Abnormality (PA)	Sparse body hair	0.0003219	2.462	--	DIRECT
Phenotypic Abnormality (PA)	Abnormal oral frenulum morphology	0.0003423	2.462	--	DIRECT
Phenotypic Abnormality (PA)	Scarring alopecia of scalp	0.0003493	2.462	--	DIRECT
Phenotypic Abnormality (PA)	Ankyloglossia	0.0004074	2.462	--	DIRECT
Phenotypic Abnormality (PA)	Anonychia	0.0005474	2.462	--	DIRECT
Phenotypic Abnormality (PA)	Abnormality of dental enamel	0.0005698	2.462	--	DIRECT
Phenotypic Abnormality (PA)	Carious teeth	0.0007447	2.462	--	DIRECT
Phenotypic Abnormality (PA)	Abnormality of the larynx	0.0007749	1.86	--	DIRECT
Phenotypic Abnormality (PA)	Dermal atrophy	0.0008989	2.161	--	DIRECT
Phenotypic Abnormality (PA)	Abnormality of odontoid tissue	0.002015	2.462	--	INHERITED FROM: Abnormality of dental enamel
Phenotypic Abnormality (PA)	Abnormal tongue morphology	0.002549	2.161	--	INHERITED FROM: Ankyloglossia
Phenotypic Abnormality (PA)	Hyperkeratosis	0.003941	1.763	--	INHERITED FROM: Palmoplantar keratoderma
Phenotypic Abnormality (PA)	Hyperhidrosis	0.005169	2.462	--	INHERITED FROM: Palmar hyperhidrosis
Phenotypic Abnormality (PA)	Abnormality of the scalp hair	0.007698	1.86	--	INHERITED FROM: Alopecia of scalp || Scarring alopecia of scalp
Phenotypic Abnormality (PA)	Abnormality of the scalp	0.009263	1.86	--	INHERITED FROM: Scarring alopecia of scalp || Alopecia of scalp
Phenotypic Abnormality (PA)	Scarring	0.01352	2.161	--	INHERITED FROM: Scarring alopecia of scalp || Atypical scarring of skin
Phenotypic Abnormality (PA)	Abnormality of the skin of the palm	0.01702	1.763	--	INHERITED FROM: Palmar hyperhidrosis
Phenotypic Abnormality (PA)	Neoplasm of the skin	0.01797	1.763	--	INHERITED FROM: Squamous cell carcinoma of the skin || Squamous cell carcinoma
Phenotypic Abnormality (PA)	Abnormality of skin adnexa physiology	0.02001	2.161	--	INHERITED FROM: Palmar hyperhidrosis
Phenotypic Abnormality (PA)	Abnormal oral morphology	0.03034	0.7381	--	INHERITED FROM: Carious teeth || Abnormal oral frenulum morphology || Abnormality of dental enamel || Ankyloglossia || Oral mucosal blisters
Phenotypic Abnormality (PA)	Thickened skin	0.04324	1.684	--	INHERITED FROM: Palmoplantar keratoderma
Phenotypic Abnormality (PA)	Abnormality of the mouth	0.04461	0.7065	--	INHERITED FROM: Oral mucosal blisters || Ankyloglossia || Abnormality of dental enamel || Abnormal oral frenulum morphology || Carious teeth
Phenotypic Abnormality (PA)	Abnormal muscle fiber morphology	0.06289	1.763	--	INHERITED FROM: Muscle fiber atrophy
Phenotypic Abnormality (PA)	Abnormality of hair density	0.08088	2.161	--	INHERITED FROM: Sparse body hair
Phenotypic Abnormality (PA)	Abnormal oral mucosa morphology	0.1012	1.258	--	INHERITED FROM: Oral mucosal blisters
Phenotypic Abnormality (PA)	Abnormal hair morphology	0.1217	1.207	--	INHERITED FROM: Sparse body hair || Scarring alopecia of scalp || Alopecia of scalp
Phenotypic Abnormality (PA)	Abnormality of the respiratory system	0.1235	0.9183	--	INHERITED FROM: Respiratory insufficiency || Abnormality of the larynx || Abnormal larynx morphology || Laryngeal stridor
Phenotypic Abnormality (PA)	Abnormality of the skeletal system	0.1349	0.4712	--	INHERITED FROM: Abnormality of dental enamel
Phenotypic Abnormality (PA)	Abnormality of the upper limb	0.1406	0.9183	--	INHERITED FROM: Palmar hyperhidrosis || Mitten deformity
Phenotypic Abnormality (PA)	Abnormality of the head	0.1469	0.4538	--	INHERITED FROM: Oral mucosal blisters || Carious teeth || Abnormal oral frenulum morphology || Abnormality of dental enamel || Alopecia of scalp || Ankyloglossia || Scarring alopecia of scalp
Phenotypic Abnormality (PA)	Abnormality of the nail	0.1498	1.763	--	INHERITED FROM: Abnormality of the periungual region || Anonychia || Paronychia || Onycholysis || Fragile nails
Phenotypic Abnormality (PA)	Abnormality of head or neck	0.1536	0.4454	--	INHERITED FROM: Oral mucosal blisters || Abnormality of dental enamel || Carious teeth || Abnormal oral frenulum morphology || Scarring alopecia of scalp || Alopecia of scalp || Ankyloglossia
Phenotypic Abnormality (PA)	Abnormality of skin morphology	0.1815	0.7722	--	INHERITED FROM: Oral mucosal blisters || Palmoplantar keratoderma || Dermal atrophy || Palmar hyperhidrosis || Abnormality of the periungual region || Milia || Scarring alopecia of scalp || Skin erosion || Atypical scarring of skin || Junctional split || Paronychia || Congenital localized absence of skin || Aplasia cutis congenita
Phenotypic Abnormality (PA)	Neoplasm by anatomical site	0.1821	1.184	--	INHERITED FROM: Squamous cell carcinoma || Squamous cell carcinoma of the skin
Phenotypic Abnormality (PA)	Morphological abnormality of the gastrointestinal tract	0.2927	1.184	--	INHERITED FROM: Esophageal stenosis || Esophageal stricture
Phenotypic Abnormality (PA)	Abnormality of the skin	0.3707	0.722	--	INHERITED FROM: Junctional split || Atypical scarring of skin || Skin erosion || Squamous cell carcinoma of the skin || Scarring alopecia of scalp || Congenital localized absence of skin || Aplasia cutis congenita || Paronychia || Palmoplantar keratoderma || Dermal atrophy || Oral mucosal blisters || Milia || Abnormality of the periungual region || Squamous cell carcinoma || Palmar hyperhidrosis
Phenotypic Abnormality (PA)	Abnormal muscle physiology	0.9833	0.6915	--	INHERITED FROM: EMG abnormality
Phenotypic Abnormality (PA)	Abnormality of the musculature	0.01877	0.5433	Least Informative	INHERITED FROM: Muscle fiber atrophy || EMG abnormality
Phenotypic Abnormality (PA)	Abnormality of limbs	0.09657	0.6429	Least Informative	INHERITED FROM: Mitten deformity || Palmar hyperhidrosis
Phenotypic Abnormality (PA)	Abnormality of the integument	0.2533	0.6235	Least Informative	INHERITED FROM: Palmar hyperhidrosis || Squamous cell carcinoma || Milia || Abnormality of the periungual region || Oral mucosal blisters || Palmoplantar keratoderma || Fragile nails || Dermal atrophy || Paronychia || Onycholysis || Anonychia || Congenital localized absence of skin || Aplasia cutis congenita || Sparse body hair || Scarring alopecia of scalp || Alopecia of scalp || Junctional split || Skin erosion || Atypical scarring of skin || Squamous cell carcinoma of the skin
Phenotypic Abnormality (PA)	Abnormality of the digestive system	0.3413	0.5759	Least Informative	INHERITED FROM: Esophageal stenosis || Esophageal stricture
Phenotypic Abnormality (PA)	Abnormality of the face	0.5423	0.533	Least Informative	INHERITED FROM: Oral mucosal blisters || Abnormality of dental enamel || Carious teeth || Abnormal oral frenulum morphology || Ankyloglossia
Phenotypic Abnormality (PA)	Abnormality of connective tissue	0.00279	1.031	Moderately Informative	INHERITED FROM: Scarring alopecia of scalp || Abnormality of dental enamel || Atypical scarring of skin
Phenotypic Abnormality (PA)	Abnormal respiratory system morphology	0.0185	1.064	Moderately Informative	INHERITED FROM: Laryngeal stridor || Abnormal larynx morphology || Abnormality of the larynx
Phenotypic Abnormality (PA)	Abnormality of the hand	0.03406	1.031	Moderately Informative	INHERITED FROM: Mitten deformity || Palmar hyperhidrosis
Phenotypic Abnormality (PA)	Abnormal skeletal muscle morphology	0.1242	0.9061	Moderately Informative	INHERITED FROM: Muscle fiber atrophy
Phenotypic Abnormality (PA)	Abnormality of digestive system morphology	0.158	1.184	Moderately Informative	INHERITED FROM: Esophageal stenosis || Esophageal stricture
Phenotypic Abnormality (PA)	Abnormality of the gastrointestinal tract	0.1774	1.031	Moderately Informative	INHERITED FROM: Esophageal stenosis || Esophageal stricture
Phenotypic Abnormality (PA)	Neoplasm	0.205	1.14	Moderately Informative	INHERITED FROM: Squamous cell carcinoma of the skin || Squamous cell carcinoma
Phenotypic Abnormality (PA)	Abnormality of skin adnexa morphology	0.2679	1.184	Moderately Informative	INHERITED FROM: Alopecia of scalp || Fragile nails || Scarring alopecia of scalp || Sparse body hair || Anonychia || Abnormality of the periungual region || Onycholysis || Paronychia
Phenotypic Abnormality (PA)	Localized skin lesion	0.3097	1.161	Moderately Informative	INHERITED FROM: Scarring alopecia of scalp || Dermal atrophy || Aplasia cutis congenita || Milia || Skin erosion || Congenital localized absence of skin || Atypical scarring of skin
Phenotypic Abnormality (PA)	Abnormal oral cavity morphology	1	0.8289	Moderately Informative	INHERITED FROM: Oral mucosal blisters || Ankyloglossia || Abnormality of dental enamel || Abnormal oral frenulum morphology || Carious teeth
Phenotypic Abnormality (PA)	Abnormality of the voice	0.00006132	1.508	Informative	DIRECT
Phenotypic Abnormality (PA)	Epidermal thickening	0.01496	1.684	Informative	INHERITED FROM: Palmoplantar keratoderma
Phenotypic Abnormality (PA)	Functional respiratory abnormality	0.02441	1.348	Informative	INHERITED FROM: Respiratory insufficiency
Phenotypic Abnormality (PA)	Regional abnormality of skin	0.07725	1.508	Informative	INHERITED FROM: Palmar hyperhidrosis || Paronychia || Abnormality of the periungual region
Phenotypic Abnormality (PA)	Abnormal hair quantity	0.1364	1.559	Informative	INHERITED FROM: Alopecia of scalp || Scarring alopecia of scalp
Phenotypic Abnormality (PA)	Abnormality of the upper respiratory tract	0.1498	1.508	Informative	INHERITED FROM: Laryngeal stridor || Abnormal larynx morphology || Abnormality of the larynx
Phenotypic Abnormality (PA)	Abnormality of the palm	0.1667	1.617	Informative	INHERITED FROM: Palmar hyperhidrosis
Phenotypic Abnormality (PA)	Abnormality of the dentition	0.3208	1.421	Informative	INHERITED FROM: Carious teeth || Abnormality of dental enamel
Phenotypic Abnormality (PA)	Squamous cell carcinoma of the skin	0.000004454	2.161	Highly Informative	DIRECT
Phenotypic Abnormality (PA)	Abnormal larynx morphology	0.0001293	2.161	Highly Informative	DIRECT
Phenotypic Abnormality (PA)	Respiratory insufficiency	0.0001762	1.86	Highly Informative	DIRECT
Phenotypic Abnormality (PA)	Atypical scarring of skin	0.0002912	2.161	Highly Informative	DIRECT
Phenotypic Abnormality (PA)	EMG abnormality	0.0004502	1.985	Highly Informative	DIRECT
Phenotypic Abnormality (PA)	Palmoplantar keratoderma	0.0006176	2.161	Highly Informative	DIRECT
Phenotypic Abnormality (PA)	Abnormal blistering of the skin	0.002345	2.161	Highly Informative	INHERITED FROM: Oral mucosal blisters || Junctional split
Phenotypic Abnormality (PA)	Abnormal cry	0.004051	2.161	Highly Informative	INHERITED FROM: Weak cry
Phenotypic Abnormality (PA)	Aplasia/Hypoplasia of the nails	0.00917	1.985	Highly Informative	INHERITED FROM: Anonychia
Phenotypic Abnormality (PA)	Hypohidrosis or hyperhidrosis	0.01259	2.161	Highly Informative	INHERITED FROM: Palmar hyperhidrosis
Phenotypic Abnormality (PA)	Aplasia/Hypoplasia of the skin	0.01271	1.86	Highly Informative	INHERITED FROM: Aplasia cutis congenita || Congenital localized absence of skin || Dermal atrophy
Phenotypic Abnormality (PA)	Abnormality of dental structure	0.01867	1.763	Highly Informative	INHERITED FROM: Carious teeth || Abnormality of dental enamel
Phenotypic Abnormality (PA)	Abnormal esophagus morphology	0.0197	2.161	Highly Informative	INHERITED FROM: Esophageal stricture || Esophageal stenosis
Phenotypic Abnormality (PA)	Abnormality of the tongue	0.02881	1.985	Highly Informative	INHERITED FROM: Ankyloglossia
Phenotypic Abnormality (PA)	Sparse hair	0.02938	2.161	Highly Informative	INHERITED FROM: Sparse body hair
Phenotypic Abnormality (PA)	Abnormal larynx physiology	0.05085	1.985	Highly Informative	INHERITED FROM: Laryngeal stridor
Phenotypic Abnormality (PA)	Alopecia	0.06085	1.86	Highly Informative	INHERITED FROM: Alopecia of scalp || Scarring alopecia of scalp
Phenotypic Abnormality (PA)	Abnormal hand morphology	0.2038	1.985	Highly Informative	INHERITED FROM: Mitten deformity

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Mouse Phenotype (MP)

Highlighted in gray are those with FDR_all>0.001

	MP term	FDR (all)	IC level	SDMP level	Annotation (direct or inherited)
Mammalian Phenotype (MP)	abnormal extracellular matrix morphology	0.0000000007085	1.904	--	DIRECT
Mammalian Phenotype (MP)	abnormal neuromuscular synapse morphology	0.0000009335	2.302	--	DIRECT
Mammalian Phenotype (MP)	abnormal Schwann cell morphology	0.000001657	2.302	--	DIRECT
Mammalian Phenotype (MP)	increased renal glomerulus basement membrane thickness	0.00004943	2.603	--	DIRECT
Mammalian Phenotype (MP)	abnormal renal glomerulus basement membrane thickness	0.00005416	2.603	--	DIRECT
Mammalian Phenotype (MP)	limb grasping	0.0000731	2.603	--	DIRECT
Mammalian Phenotype (MP)	abnormal nervous system morphology	0.00009245	0.5861	--	DIRECT
Mammalian Phenotype (MP)	abnormal cranium morphology	0.0003549	1.205	--	DIRECT
Mammalian Phenotype (MP)	centrally nucleated skeletal muscle fibers	0.0004016	2.603	--	DIRECT
Mammalian Phenotype (MP)	abnormal Muller cell morphology	0.0004162	2.302	--	DIRECT
Mammalian Phenotype (MP)	decreased sensory neuron number	0.000562	1.7	--	DIRECT
Mammalian Phenotype (MP)	abnormal renal corpuscle morphology	0.005269	1.427	--	INHERITED FROM: abnormal renal glomerulus basement membrane thickness || increased renal glomerulus basement membrane thickness
Mammalian Phenotype (MP)	craniofacial phenotype	0.005624	1.047	--	INHERITED FROM: abnormal cranium morphology || abnormal jaw morphology || abnormal mouth morphology
Mammalian Phenotype (MP)	abnormal kidney morphology	0.006386	1.156	--	INHERITED FROM: abnormal renal glomerulus basement membrane thickness || increased renal glomerulus basement membrane thickness
Mammalian Phenotype (MP)	abnormal craniofacial bone morphology	0.007722	1.205	--	INHERITED FROM: abnormal jaw morphology || abnormal cranium morphology
Mammalian Phenotype (MP)	vision/eye phenotype	0.008723	0.8789	--	INHERITED FROM: abnormal Muller cell morphology
Mammalian Phenotype (MP)	abnormal PNS glial cell morphology	0.009135	2.302	--	INHERITED FROM: abnormal Schwann cell morphology
Mammalian Phenotype (MP)	abnormal somatic nervous system morphology	0.009276	0.931	--	INHERITED FROM: abnormal neuromuscular synapse morphology || decreased sensory neuron number
Mammalian Phenotype (MP)	abnormal retina morphology	0.0106	1.241	--	INHERITED FROM: abnormal Muller cell morphology
Mammalian Phenotype (MP)	abnormal ocular fundus morphology	0.011	1.241	--	INHERITED FROM: abnormal Muller cell morphology
Mammalian Phenotype (MP)	abnormal synapse morphology	0.01855	1.825	--	INHERITED FROM: abnormal neuromuscular synapse morphology
Mammalian Phenotype (MP)	muscle phenotype	0.0234	0.8473	--	INHERITED FROM: centrally nucleated skeletal muscle fibers || abnormal skeletal muscle mass
Mammalian Phenotype (MP)	renal/urinary system phenotype	0.0267	0.931	--	INHERITED FROM: increased renal glomerulus basement membrane thickness || abnormal renal glomerulus basement membrane thickness
Mammalian Phenotype (MP)	behavior/neurological phenotype	0.03007	0.8178	--	INHERITED FROM: limb grasping
Mammalian Phenotype (MP)	abnormal skeleton morphology	0.03325	0.8323	--	INHERITED FROM: abnormal jaw morphology || abnormal cranium morphology
Mammalian Phenotype (MP)	skeleton phenotype	0.04554	0.8038	--	INHERITED FROM: abnormal cranium morphology || abnormal jaw morphology
Mammalian Phenotype (MP)	integument phenotype	0.06788	0.797	--	INHERITED FROM: blistering
Mammalian Phenotype (MP)	abnormal motor capabilities/coordination/movement	0.08781	1.205	--	INHERITED FROM: limb grasping
Mammalian Phenotype (MP)	abnormal facial morphology	0.09967	1.348	--	INHERITED FROM: abnormal mouth morphology
Mammalian Phenotype (MP)	abnormal muscle fiber morphology	0.1525	1.825	--	INHERITED FROM: centrally nucleated skeletal muscle fibers
Mammalian Phenotype (MP)	abnormal kidney cortex morphology	0.1805	1.399	--	INHERITED FROM: abnormal renal glomerulus basement membrane thickness || increased renal glomerulus basement membrane thickness
Mammalian Phenotype (MP)	abnormal reflex	0.2134	2.126	--	INHERITED FROM: limb grasping
Mammalian Phenotype (MP)	abnormal viscerocranium morphology	0.2546	1.399	--	INHERITED FROM: abnormal jaw morphology
Mammalian Phenotype (MP)	abnormal posterior eye segment morphology	0.3273	1.223	--	INHERITED FROM: abnormal Muller cell morphology
Mammalian Phenotype (MP)	abnormal nephron morphology	0.361	1.261	--	INHERITED FROM: abnormal renal glomerulus basement membrane thickness || increased renal glomerulus basement membrane thickness
Mammalian Phenotype (MP)	abnormal sensory neuron morphology	0.5178	1.156	--	INHERITED FROM: decreased sensory neuron number
Mammalian Phenotype (MP)	abnormal CNS glial cell morphology	0.5965	1.758	--	INHERITED FROM: abnormal Muller cell morphology
Mammalian Phenotype (MP)	abnormal nervous system physiology	0.6007	0.825	--	INHERITED FROM: abnormal myelination
Mammalian Phenotype (MP)	abnormal neuron number	0.6455	1.399	--	INHERITED FROM: decreased sensory neuron number
Mammalian Phenotype (MP)	nervous system phenotype	0.0008421	0.4959	Least Informative	DIRECT
Mammalian Phenotype (MP)	growth/size/body region phenotype	0.005387	0.6254	Least Informative	INHERITED FROM: abnormal mouth morphology
Mammalian Phenotype (MP)	cellular phenotype	0.1364	0.5387	Least Informative	INHERITED FROM: abnormal basement membrane morphology || abnormal extracellular matrix morphology
Mammalian Phenotype (MP)	abnormal axial skeleton morphology	0.003196	1.001	Moderately Informative	INHERITED FROM: abnormal jaw morphology || abnormal cranium morphology
Mammalian Phenotype (MP)	abnormal neuron morphology	0.004845	0.8323	Moderately Informative	INHERITED FROM: abnormal neuromuscular synapse morphology || decreased sensory neuron number
Mammalian Phenotype (MP)	abnormal craniofacial morphology	0.005514	1.047	Moderately Informative	INHERITED FROM: abnormal cranium morphology || abnormal jaw morphology || abnormal mouth morphology
Mammalian Phenotype (MP)	abnormal eye morphology	0.005541	0.9129	Moderately Informative	INHERITED FROM: abnormal Muller cell morphology
Mammalian Phenotype (MP)	abnormal renal/urinary system morphology	0.009401	1.047	Moderately Informative	INHERITED FROM: increased renal glomerulus basement membrane thickness || abnormal renal glomerulus basement membrane thickness
Mammalian Phenotype (MP)	abnormal skin morphology	0.03627	1.188	Moderately Informative	INHERITED FROM: blistering
Mammalian Phenotype (MP)	abnormal head morphology	0.0715	1.241	Moderately Informative	INHERITED FROM: abnormal mouth morphology
Mammalian Phenotype (MP)	abnormal muscle morphology	0.1629	1.112	Moderately Informative	INHERITED FROM: centrally nucleated skeletal muscle fibers || abnormal skeletal muscle mass
Mammalian Phenotype (MP)	abnormal somatic sensory system morphology	1	1.023	Moderately Informative	INHERITED FROM: decreased sensory neuron number
Mammalian Phenotype (MP)	abnormal behavior	1	0.855	Moderately Informative	INHERITED FROM: limb grasping
Mammalian Phenotype (MP)	abnormal jaw morphology	0.0002519	1.427	Informative	DIRECT
Mammalian Phenotype (MP)	abnormal glial cell morphology	0.0005576	1.7	Informative	DIRECT
Mammalian Phenotype (MP)	abnormal mouth morphology	0.0005891	1.489	Informative	DIRECT
Mammalian Phenotype (MP)	decreased neuron number	0.01144	1.562	Informative	INHERITED FROM: decreased sensory neuron number
Mammalian Phenotype (MP)	abnormal sensory capabilities/reflexes/nociception	0.1573	1.562	Informative	INHERITED FROM: limb grasping
Mammalian Phenotype (MP)	abnormal skeletal muscle morphology	0.1671	1.427	Informative	INHERITED FROM: centrally nucleated skeletal muscle fibers || abnormal skeletal muscle mass
Mammalian Phenotype (MP)	abnormal skin appearance	0.3018	1.524	Informative	INHERITED FROM: blistering
Mammalian Phenotype (MP)	abnormal basement membrane morphology	0.0000000001008	2.001	Highly Informative	DIRECT
Mammalian Phenotype (MP)	abnormal skeletal muscle mass	0.0001899	2.001	Highly Informative	DIRECT
Mammalian Phenotype (MP)	abnormal myelination	0.0003005	2.001	Highly Informative	DIRECT
Mammalian Phenotype (MP)	blistering	0.0003057	2.001	Highly Informative	DIRECT
Mammalian Phenotype (MP)	abnormal somatic motor system morphology	0.002069	2.126	Highly Informative	INHERITED FROM: abnormal neuromuscular synapse morphology
Mammalian Phenotype (MP)	abnormal renal glomerulus basement membrane morphology	0.005322	2.126	Highly Informative	INHERITED FROM: abnormal renal glomerulus basement membrane thickness || increased renal glomerulus basement membrane thickness
Mammalian Phenotype (MP)	abnormal skeletal muscle fiber morphology	0.1172	2.001	Highly Informative	INHERITED FROM: centrally nucleated skeletal muscle fibers
Mammalian Phenotype (MP)	abnormal involuntary movement	0.1339	2.001	Highly Informative	INHERITED FROM: limb grasping

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Worm Phenotype (WP)

Highlighted in gray are those with FDR_all>0.001

	WP term	FDR (all)	IC level	SDWP level	Annotation (direct or inherited)
Worm Phenotype (WP)	embryonic lethal	0	0.046	--	DIRECT
Worm Phenotype (WP)	lethal	0	0.00521	--	DIRECT
Worm Phenotype (WP)	fertility variant	0	0.05937	--	DIRECT
Worm Phenotype (WP)	behavior variant	0	0.6859	--	DIRECT
Worm Phenotype (WP)	development variant	0	0.001482	--	DIRECT
Worm Phenotype (WP)	morphology variant	0	0.046	--	DIRECT
Worm Phenotype (WP)	organism development variant	0	0.00297	--	DIRECT
Worm Phenotype (WP)	organism morphology variant	0	0.1372	--	DIRECT
Worm Phenotype (WP)	organ system physiology variant	0	0.04518	--	DIRECT
Worm Phenotype (WP)	reproductive system physiology variant	0	0.05515	--	DIRECT
Worm Phenotype (WP)	locomotion variant	0	1.053	--	DIRECT
Worm Phenotype (WP)	maternal sterile	0	0.1213	--	DIRECT
Worm Phenotype (WP)	hermaphrodite sterile	0	0.1203	--	DIRECT
Worm Phenotype (WP)	embryonic development variant	0	0.04518	--	DIRECT
Worm Phenotype (WP)	hermaphrodite fertility variant	0	0.0947	--	DIRECT
Worm Phenotype (WP)	hermaphrodite fertility reduced	0	0.1193	--	DIRECT
Worm Phenotype (WP)	fertility reduced	0	0.06449	--	DIRECT
Worm Phenotype (WP)	body wall muscle development variant	0.000000000004435	2.468	--	DIRECT
Worm Phenotype (WP)	body wall muscle physiology variant	0.00000000003093	2.468	--	DIRECT
Worm Phenotype (WP)	muscle arm development variant	0.0000000002726	1.866	--	DIRECT
Worm Phenotype (WP)	body wall cell development variant	0.0000000004897	1.814	--	DIRECT
Worm Phenotype (WP)	muscle cell morphology variant	0.00000004272	1.337	--	DIRECT
Worm Phenotype (WP)	muscle system physiology variant	0.0000002867	1.306	--	DIRECT
Worm Phenotype (WP)	muscle cell development variant	0.0000007173	1.814	--	DIRECT
Worm Phenotype (WP)	body length variant	0.000001355	1.292	--	DIRECT
Worm Phenotype (WP)	body width variant	0.000002362	1.237	--	DIRECT
Worm Phenotype (WP)	body size variant	0.00000473	1.189	--	DIRECT
Worm Phenotype (WP)	body morphology variant	0.000007335	1.145	--	DIRECT
Worm Phenotype (WP)	adult lethal	0.00002187	2.468	--	DIRECT
Worm Phenotype (WP)	striated muscle development variant	0.00002485	2.468	--	DIRECT
Worm Phenotype (WP)	cell component morphology variant	0.0001119	0.8392	--	DIRECT
Worm Phenotype (WP)	organ system morphology variant	0.0003501	0.7516	--	DIRECT
Worm Phenotype (WP)	cell morphology variant	0.0003856	0.7558	--	DIRECT
Worm Phenotype (WP)	muscle system morphology variant	0.01497	1.407	--	INHERITED FROM: body wall muscle sarcomere morphology variant
Worm Phenotype (WP)	somatic gonad morphology variant	0.01874	1.866	--	INHERITED FROM: gonad arm morphology variant
Worm Phenotype (WP)	gonad morphology variant	0.06812	1.306	--	INHERITED FROM: gonad arm morphology variant
Worm Phenotype (WP)	germ cell compartment morphology variant	0.08555	1.354	--	INHERITED FROM: germ cell compartment expansion variant
Worm Phenotype (WP)	germ cell morphology variant	0.1002	1.156	--	INHERITED FROM: germ cell compartment expansion variant
Worm Phenotype (WP)	physiology variant	1	0	--	INHERITED FROM: hermaphrodite fertility variant || striated muscle development variant || muscle arm development variant || larval lethal || reproductive system physiology variant || muscle system development variant || adult lethal || cell migration variant || organ system development variant || movement variant || lethal || muscle cell physiology variant || muscle arm development defective || development variant || muscle cell development variant || cell physiology variant || hermaphrodite sterile || egg laying defective || hermaphrodite fertility reduced || body wall muscle development variant || embryonic development variant || embryonic lethal || body wall muscle physiology variant || fertility variant || behavior variant || muscle system physiology variant || body wall cell development variant || organ system physiology variant || organism behavior variant || maternal sterile || organism development variant || locomotion variant || fertility reduced || cell development variant
Worm Phenotype (WP)	sterile	1	0.1135	--	INHERITED FROM: hermaphrodite sterile || maternal sterile
Worm Phenotype (WP)	striated muscle morphology variant	1	1.407	--	INHERITED FROM: body wall muscle sarcomere morphology variant
Worm Phenotype (WP)	body wall muscle morphology variant	1	1.446	--	INHERITED FROM: body wall muscle sarcomere morphology variant
Worm Phenotype (WP)	larval lethal	0	0.5727	Least Informative	DIRECT
Worm Phenotype (WP)	organism behavior variant	0	0.6859	Least Informative	DIRECT
Worm Phenotype (WP)	cell development variant	0	0.6752	Least Informative	DIRECT
Worm Phenotype (WP)	cell physiology variant	0	0.5955	Least Informative	DIRECT
Worm Phenotype (WP)	organ system development variant	0	0.9113	Moderately Informative	DIRECT
Worm Phenotype (WP)	movement variant	0	1.02	Moderately Informative	DIRECT
Worm Phenotype (WP)	reproductive system morphology variant	0.00001714	1.078	Moderately Informative	DIRECT
Worm Phenotype (WP)	organism segment morphology variant	0.0000195	1.087	Moderately Informative	DIRECT
Worm Phenotype (WP)	body region morphology variant	0.00001988	1.087	Moderately Informative	DIRECT
Worm Phenotype (WP)	cell type morphology variant	0.00007101	0.8878	Moderately Informative	DIRECT
Worm Phenotype (WP)	cell migration variant	0	1.407	Informative	DIRECT
Worm Phenotype (WP)	muscle cell physiology variant	0.00005446	1.426	Informative	DIRECT
Worm Phenotype (WP)	germ cell compartment expansion variant	0.00007563	1.468	Informative	DIRECT
Worm Phenotype (WP)	body wall muscle sarcomere morphology variant	0.0001137	1.446	Informative	DIRECT
Worm Phenotype (WP)	egg laying variant	0.1322	1.513	Informative	INHERITED FROM: egg laying defective
Worm Phenotype (WP)	muscle arm development defective	0.0000000001578	1.99	Highly Informative	DIRECT
Worm Phenotype (WP)	muscle system development variant	0.000000159	2.07	Highly Informative	DIRECT
Worm Phenotype (WP)	gonad arm morphology variant	0.000006412	1.866	Highly Informative	DIRECT
Worm Phenotype (WP)	myopodia present	0.00005639	2.167	Highly Informative	DIRECT
Worm Phenotype (WP)	egg laying defective	0.0001546	1.99	Highly Informative	DIRECT

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Fly Phenotype (FP)

Highlighted in gray are those with FDR_all>0.001

	FP term	FDR (all)	IC level	SDFP level	Annotation (direct or inherited)
Fly Phenotype (FP)	lethal	0	0.678	--	DIRECT
Fly Phenotype (FP)	phenotype	0	0.06546	--	DIRECT
Fly Phenotype (FP)	lethal - all die before end of larval stage	0	1.306	--	DIRECT
Fly Phenotype (FP)	lethal - all die before end of second instar larval stage	0	1.687	--	DIRECT
Fly Phenotype (FP)	increased mortality during development	0	0.6148	--	DIRECT
Fly Phenotype (FP)	lethal - all die before end of prepupal stage	0	1.306	--	DIRECT
Fly Phenotype (FP)	lethal - all die before end of pupal stage	0	1.239	--	DIRECT
Fly Phenotype (FP)	increased mortality	0	0.5343	Least Informative	DIRECT
Fly Phenotype (FP)	lethal - all die before end of P-stage	0	1.181	Moderately Informative	DIRECT
Fly Phenotype (FP)	neuroanatomy defective	0	1.344	Informative	DIRECT
Fly Phenotype (FP)	lethal - all die before end of first instar larval stage	0	1.687	Informative	DIRECT
Fly Phenotype (FP)	lethal - all die before end of embryonic stage	0	1.908	Highly Informative	DIRECT
Fly Phenotype (FP)	some die during embryonic stage	0	2.085	Highly Informative	DIRECT

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Fly Anatomy (FA)

Highlighted in gray are those with FDR_all>0.001

	FA term	FDR (all)	IC level	SDFA level	Annotation (direct or inherited)
Fly Anatomy (FA)	organism	0	0.06695	--	DIRECT
Fly Anatomy (FA)	thorax	0	0.912	--	DIRECT
Fly Anatomy (FA)	thoracic segment	0	0.912	--	DIRECT
Fly Anatomy (FA)	mesothoracic segment	0	0.9578	--	DIRECT
Fly Anatomy (FA)	embryo	0	0.8978	--	DIRECT
Fly Anatomy (FA)	embryonic/larval muscle system	0	1.787	--	DIRECT
Fly Anatomy (FA)	embryonic/larval somatic muscle	0	1.912	--	DIRECT
Fly Anatomy (FA)	embryonic/larval pericardial cell	0	2.389	--	DIRECT
Fly Anatomy (FA)	adult tagma	0	0.6649	--	DIRECT
Fly Anatomy (FA)	adult segment	0	0.821	--	DIRECT
Fly Anatomy (FA)	adult thorax	0	0.942	--	DIRECT
Fly Anatomy (FA)	adult thoracic segment	0	0.942	--	DIRECT
Fly Anatomy (FA)	alimentary canal	0	1.348	--	DIRECT
Fly Anatomy (FA)	developing embryonic structure	0	1.243	--	DIRECT
Fly Anatomy (FA)	wing	0	1.243	--	DIRECT
Fly Anatomy (FA)	organ system	0	0.1823	--	DIRECT
Fly Anatomy (FA)	reproductive system	0	1.047	--	DIRECT
Fly Anatomy (FA)	integumentary system	0	0.8094	--	DIRECT
Fly Anatomy (FA)	excretory system	0	1.912	--	DIRECT
Fly Anatomy (FA)	pericardial cell	0	2.088	--	DIRECT
Fly Anatomy (FA)	muscle system	0	1.435	--	DIRECT
Fly Anatomy (FA)	somatic muscle	0	1.544	--	DIRECT
Fly Anatomy (FA)	external sensory organ	0	1.088	--	DIRECT
Fly Anatomy (FA)	adult integumentary system	0	0.9578	--	DIRECT
Fly Anatomy (FA)	cell	0	0.4069	--	DIRECT
Fly Anatomy (FA)	portion of tissue	0	0.7764	--	DIRECT
Fly Anatomy (FA)	organism subdivision	0	0.5027	--	DIRECT
Fly Anatomy (FA)	sensillum	0	1.134	--	DIRECT
Fly Anatomy (FA)	external sensillum	0	1.159	--	DIRECT
Fly Anatomy (FA)	eo-type sensillum	0	1.486	--	DIRECT
Fly Anatomy (FA)	non-connected functional system	0	0.8451	--	DIRECT
Fly Anatomy (FA)	region of integument	0	0.884	--	DIRECT
Fly Anatomy (FA)	tagmatic subdivision of integument	0	0.9742	--	DIRECT
Fly Anatomy (FA)	sensory system	0	0.8577	--	DIRECT
Fly Anatomy (FA)	non-connected developing system	0	1.389	--	DIRECT
Fly Anatomy (FA)	gut	0	1.348	--	DIRECT
Fly Anatomy (FA)	multicellular structure	0	0.008955	--	DIRECT
Fly Anatomy (FA)	gut section	0	1.348	--	DIRECT
Fly Anatomy (FA)	anatomical structure	1	0	--	INHERITED FROM: adult external thorax || digestive system || external sensory organ || alimentary canal || nephrocyte || organism || mesothoracic segment || muscle cell || epithelium || adult mesothoracic segment || adult || embryonic/larval circulatory system || sensillum || gut || eo-type sensillum || embryonic/larval dorsal vessel || developing embryonic structure || segment || larva || thoracic segment || pericardial cell || somatic cell || wing || embryonic/larval somatic muscle || tagmatic subdivision of integument || gonad || embryonic/larval pericardial cell || portion of tissue || chaeta || excretory system || cell || adult thorax || cell cluster organ || appendage || region of integument || muscle system || multi-tissue structure || late embryo || presumptive embryonic/larval system || circulatory system || adult tagma || adult segment || sense organ || tagma || organ system subdivision || thorax || embryonic/larval hypodermal muscle || adult integumentary system || extended germ band embryo || external sensillum || embryonic/larval muscle system || embryo || epithelial tube || somatic muscle || reproductive system || adult thoracic segment || organ system || syncytium || organism subdivision || integumentary system || multicellular structure || gut section
Fly Anatomy (FA)	material anatomical entity	1	0	--	INHERITED FROM: external sensillum || extended germ band embryo || embryo || embryonic/larval muscle system || epithelial tube || anatomical group || somatic muscle || adult thoracic segment || reproductive system || organ system || syncytium || organism subdivision || integumentary system || multicellular structure || developing material anatomical entity || gut section || thorax || sensory system || embryonic/larval hypodermal muscle || adult integumentary system || presumptive embryonic/larval system || circulatory system || adult tagma || non-connected functional system || adult segment || tagma || sense organ || organ system subdivision || adult thorax || cell || non-connected developing system || cell cluster organ || appendage || region of integument || muscle system || multi-tissue structure || late embryo || gonad || tagmatic subdivision of integument || primordium || embryonic/larval pericardial cell || portion of tissue || chaeta || excretory system || developing embryonic structure || segment || larva || thoracic segment || somatic cell || pericardial cell || wing || embryonic/larval somatic muscle || epithelium || adult mesothoracic segment || adult || embryonic/larval circulatory system || sensillum || gut || embryonic/larval dorsal vessel || eo-type sensillum || adult external thorax || digestive system || external sensory organ || nephrocyte || alimentary canal || organism || mesothoracic segment || muscle cell
Fly Anatomy (FA)	anterior-posterior subdivision of organism	1	0.5027	--	INHERITED FROM: mesothoracic segment || adult external thorax || adult thorax || tagma || adult segment || adult tagma || adult mesothoracic segment || wing || thorax || thoracic segment || segment || adult thoracic segment
Fly Anatomy (FA)	tagma	0	0.5027	Least Informative	DIRECT
Fly Anatomy (FA)	segment	0	0.6568	Least Informative	DIRECT
Fly Anatomy (FA)	larva	0	0.3763	Least Informative	DIRECT
Fly Anatomy (FA)	adult	0	0.4496	Least Informative	DIRECT
Fly Anatomy (FA)	multi-tissue structure	0	0.6038	Least Informative	DIRECT
Fly Anatomy (FA)	anatomical group	0	0.6816	Least Informative	DIRECT
Fly Anatomy (FA)	organ system subdivision	0	0.4301	Least Informative	DIRECT
Fly Anatomy (FA)	somatic cell	0	0.4861	Least Informative	DIRECT
Fly Anatomy (FA)	adult mesothoracic segment	0	0.9912	Moderately Informative	DIRECT
Fly Anatomy (FA)	adult external thorax	0	1.009	Moderately Informative	DIRECT
Fly Anatomy (FA)	gonad	0	1.047	Moderately Informative	DIRECT
Fly Anatomy (FA)	digestive system	0	1.243	Moderately Informative	DIRECT
Fly Anatomy (FA)	circulatory system	0	1.243	Moderately Informative	DIRECT
Fly Anatomy (FA)	sense organ	0	1.047	Moderately Informative	DIRECT
Fly Anatomy (FA)	late embryo	0	1.088	Moderately Informative	DIRECT
Fly Anatomy (FA)	appendage	0	1.047	Moderately Informative	DIRECT
Fly Anatomy (FA)	epithelium	0	1.159	Moderately Informative	DIRECT
Fly Anatomy (FA)	developing material anatomical entity	0	0.8329	Moderately Informative	DIRECT
Fly Anatomy (FA)	cell cluster organ	0	1.134	Moderately Informative	DIRECT
Fly Anatomy (FA)	embryonic/larval circulatory system	0	1.611	Informative	DIRECT
Fly Anatomy (FA)	muscle cell	0	1.486	Informative	DIRECT
Fly Anatomy (FA)	chaeta	0	1.486	Informative	DIRECT
Fly Anatomy (FA)	extended germ band embryo	0	1.435	Informative	DIRECT
Fly Anatomy (FA)	primordium	0	1.435	Informative	DIRECT
Fly Anatomy (FA)	presumptive embryonic/larval system	0	1.389	Informative	DIRECT
Fly Anatomy (FA)	syncytium	0	1.544	Informative	DIRECT
Fly Anatomy (FA)	epithelial tube	0	1.544	Informative	DIRECT
Fly Anatomy (FA)	embryonic/larval hypodermal muscle	0	1.912	Highly Informative	DIRECT
Fly Anatomy (FA)	embryonic/larval dorsal vessel	0	1.912	Highly Informative	DIRECT
Fly Anatomy (FA)	nephrocyte	0	1.912	Highly Informative	DIRECT

---

Zebrafish Anatomy (ZA)

Highlighted in gray are those with FDR_all>0.001

	ZA term	FDR (all)	IC level	SDZA level	Annotation (direct or inherited)
Zebrafish Anatomy (ZA)	whole organism	0	0.00147	--	DIRECT
Zebrafish Anatomy (ZA)	musculature system	0.004591	1.325	--	INHERITED FROM: slow muscle cell
Zebrafish Anatomy (ZA)	skeletal muscle cell	0.005211	1.693	--	INHERITED FROM: slow muscle cell
Zebrafish Anatomy (ZA)	striated muscle cell	0.02158	1.568	--	INHERITED FROM: slow muscle cell
Zebrafish Anatomy (ZA)	muscle	0.05591	1.43	--	INHERITED FROM: slow muscle cell
Zebrafish Anatomy (ZA)	anatomical system	0.4893	0.1857	--	INHERITED FROM: slow muscle cell
Zebrafish Anatomy (ZA)	anatomical group	0.5275	0.1532	--	INHERITED FROM: slow muscle cell
Zebrafish Anatomy (ZA)	anatomical structure	1	0	--	INHERITED FROM: portion of tissue || whole organism || slow muscle cell
Zebrafish Anatomy (ZA)	electrically responsive cell	1	1.216	--	INHERITED FROM: slow muscle cell
Zebrafish Anatomy (ZA)	cell	0.1121	0.6388	Least Informative	INHERITED FROM: slow muscle cell
Zebrafish Anatomy (ZA)	portion of tissue	0	0.7637	Moderately Informative	DIRECT
Zebrafish Anatomy (ZA)	electrically active cell	0.1958	1.17	Moderately Informative	INHERITED FROM: slow muscle cell
Zebrafish Anatomy (ZA)	muscle cell	0.2319	1.471	Informative	INHERITED FROM: slow muscle cell
Zebrafish Anatomy (ZA)	skeletal muscle	0.2356	1.626	Informative	INHERITED FROM: slow muscle cell
Zebrafish Anatomy (ZA)	slow muscle cell	0.0004114	2.17	Highly Informative	DIRECT

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Xenopus Anatomy (XA)

Highlighted in gray are those with FDR_all>0.001

	XA term	FDR (all)	IC level	SDXA level	Annotation (direct or inherited)
Xenopus ANatomical entity (XAN)	anatomical structure	0	0	--	DIRECT
Xenopus ANatomical entity (XAN)	organism subdivision	0	0.1679	--	DIRECT
Xenopus ANatomical entity (XAN)	multicellular anatomical structure	0	0.1131	--	DIRECT
Xenopus ANatomical entity (XAN)	whole organism	1	0.0884	--	INHERITED FROM: multicellular anatomical structure || organism subdivision
Xenopus DEvelopment stage (XDE)	NF stage	0	0.01895	--	DIRECT

---