Extracellular domain of cell surface receptors family

SCOP classification

• Root: SCOP hierarchy in SUPERFAMILY [ 0] (11)
• Class: Small proteins [ 56992] (90)
• Fold: Snake toxin-like [ 57301]
• Superfamily: Snake toxin-like [ 57302] (3)
• Family: Extracellular domain of cell surface receptors [ 57354] (6)

---

Family statistics

	Genomes (66)	Uniprot 2018_03 genome	PDB chains (SCOP 1.75)
Domains	442	1,240	32
Proteins	410	1,130	24

---

Enzyme Commission (EC)

Highlighted in gray are those with FDR_all>0.001

	EC term	FDR (all)	IC level	SDEO level	Annotation (direct or inherited)
Enzyme Commission (EC)	Receptor protein serine/threonine kinase	0	2.741	--	DIRECT
Enzyme Commission (EC)	Transferring phosphorous-containing groups	0	0.2728	--	DIRECT
Enzyme Commission (EC)	Transferases	0	0	--	DIRECT
Enzyme Commission (EC)	Protein-serine/threonine kinases	0	1.042	Moderately Informative	DIRECT

---

Disease Ontology (DO)

Highlighted in gray are those with FDR_all>0.001

	DO term	FDR (all)	IC level	SDDO level	Annotation (direct or inherited)
Disease Ontology (DO)	disease of cellular proliferation	0	0.2322	--	DIRECT
Disease Ontology (DO)	cancer	0	0.2555	--	DIRECT
Disease Ontology (DO)	disease of anatomical entity	0	0.2414	--	DIRECT
Disease Ontology (DO)	retinal cancer	0.0000005399	1.668	--	DIRECT
Disease Ontology (DO)	vascular disease	0.00003393	0.832	--	DIRECT
Disease Ontology (DO)	lung cancer	0.0002962	1.513	--	DIRECT
Disease Ontology (DO)	ovary epithelial cancer	0.0006371	1.735	--	DIRECT
Disease Ontology (DO)	ovarian cancer	0.0006945	1.735	--	DIRECT
Disease Ontology (DO)	renal cell carcinoma	0.0009762	1.735	--	DIRECT
Disease Ontology (DO)	renal carcinoma	0.001491	1.735	--	INHERITED FROM: renal cell carcinoma
Disease Ontology (DO)	kidney cancer	0.002259	1.61	--	INHERITED FROM: renal cell carcinoma
Disease Ontology (DO)	cardiovascular system disease	0.00235	0.7889	--	INHERITED FROM: vascular disease || artery disease
Disease Ontology (DO)	respiratory system cancer	0.009236	1.434	--	INHERITED FROM: lung carcinoma || lung cancer
Disease Ontology (DO)	reproductive organ cancer	0.01074	1.367	--	INHERITED FROM: ovarian cancer || ovary epithelial cancer
Disease Ontology (DO)	sensory system cancer	0.01225	1.668	--	INHERITED FROM: retinal cell cancer || retinal cancer
Disease Ontology (DO)	ocular cancer	1	1.668	--	INHERITED FROM: retinal cancer || retinal cell cancer
Disease Ontology (DO)	organ system cancer	0	0.4879	Least Informative	DIRECT
Disease Ontology (DO)	artery disease	0.00001349	0.9817	Moderately Informative	DIRECT
Disease Ontology (DO)	nervous system cancer	0.00005036	1.191	Moderately Informative	DIRECT
Disease Ontology (DO)	retinal cell cancer	0.0000005128	1.668	Informative	DIRECT
Disease Ontology (DO)	lung carcinoma	0.0002943	1.513	Informative	DIRECT
Disease Ontology (DO)	urinary system cancer	0.03151	1.559	Informative	INHERITED FROM: renal cell carcinoma
Disease Ontology (DO)	female reproductive organ cancer	0.5184	1.472	Informative	INHERITED FROM: ovarian cancer || ovary epithelial cancer

---

Human Phenotype (HP)

Highlighted in gray are those with FDR_all>0.001

	HP term	FDR (all)	IC level	SDHP level	Annotation (direct or inherited)
Phenotypic Abnormality (PA)	Abnormality of female internal genitalia	0.0139	1.258	--	INHERITED FROM: Abnormality of the uterus
Phenotypic Abnormality (PA)	Abnormal internal genitalia	0.01757	1.232	--	INHERITED FROM: Abnormality of the uterus
Phenotypic Abnormality (PA)	Abnormality of the female genitalia	0.01839	1.207	--	INHERITED FROM: Abnormality of the uterus
Phenotypic Abnormality (PA)	Abnormality of cardiovascular system morphology	0.04995	0.8391	--	INHERITED FROM: Abnormal morphology of the great vessels || Abnormal cardiac ventricle morphology
Phenotypic Abnormality (PA)	Abnormality of the vasculature	0.06858	0.7142	--	INHERITED FROM: Abnormal morphology of the great vessels
Phenotypic Abnormality (PA)	Abnormality of the genital system	0.2601	0.9309	--	INHERITED FROM: Abnormality of the uterus
Phenotypic Abnormality (PA)	Abnormality of the genitourinary system	0.2039	0.6051	Least Informative	INHERITED FROM: Abnormality of the uterus
Phenotypic Abnormality (PA)	Abnormality of the cardiovascular system	0.225	0.5179	Least Informative	INHERITED FROM: Abnormal cardiac ventricle morphology || Abnormal morphology of the great vessels
Phenotypic Abnormality (PA)	Abnormal vascular morphology	0.004276	1.207	Moderately Informative	INHERITED FROM: Abnormal morphology of the great vessels
Phenotypic Abnormality (PA)	Abnormal heart morphology	0.02213	0.9183	Moderately Informative	INHERITED FROM: Abnormal cardiac ventricle morphology
Phenotypic Abnormality (PA)	Abnormal reproductive system morphology	0.1271	1.031	Moderately Informative	INHERITED FROM: Abnormality of the uterus
Phenotypic Abnormality (PA)	Abnormality of the uterus	0.0005757	1.684	Informative	DIRECT
Phenotypic Abnormality (PA)	Abnormal cardiac ventricle morphology	0.0006618	1.508	Informative	DIRECT
Phenotypic Abnormality (PA)	Abnormal morphology of the great vessels	0.0007556	1.617	Informative	DIRECT

---

Mouse Phenotype (MP)

Highlighted in gray are those with FDR_all>0.001

	MP term	FDR (all)	IC level	SDMP level	Annotation (direct or inherited)
Mammalian Phenotype (MP)	abnormal cell physiology	0	0.6209	--	DIRECT
Mammalian Phenotype (MP)	absent mesoderm	0.000000255	2.603	--	DIRECT
Mammalian Phenotype (MP)	abnormal mesoderm morphology	0.000004338	2.302	--	DIRECT
Mammalian Phenotype (MP)	failure to gastrulate	0.00000612	2.603	--	DIRECT
Mammalian Phenotype (MP)	abnormal embryonic-extraembryonic boundary morphology	0.00000702	2.302	--	DIRECT
Mammalian Phenotype (MP)	abnormal lung morphology	0.00001853	1.205	--	DIRECT
Mammalian Phenotype (MP)	abnormal embryonic tissue morphology	0.00002046	1.281	--	DIRECT
Mammalian Phenotype (MP)	abnormal secondary sex determination	0.0000364	2.302	--	DIRECT
Mammalian Phenotype (MP)	abnormal apoptosis	0.0001334	1.023	--	DIRECT
Mammalian Phenotype (MP)	embryonic lethality between implantation and somite formation	0.0001508	1.825	--	DIRECT
Mammalian Phenotype (MP)	abnormal retinal ganglion layer morphology	0.0001511	1.904	--	DIRECT
Mammalian Phenotype (MP)	abnormal cardiovascular system morphology	0.0001616	0.7902	--	DIRECT
Mammalian Phenotype (MP)	increased embryonic epiblast cell apoptosis	0.0001848	2.603	--	DIRECT
Mammalian Phenotype (MP)	delayed bone ossification	0.0001959	2.603	--	DIRECT
Mammalian Phenotype (MP)	abnormal heart and great vessel attachment	0.0002159	1.825	--	DIRECT
Mammalian Phenotype (MP)	embryonic lethality between implantation and placentation	0.000666	1.7	--	DIRECT
Mammalian Phenotype (MP)	abnormal ovarian follicle morphology	0.0007079	1.758	--	DIRECT
Mammalian Phenotype (MP)	embryo phenotype	0.0007216	0.8708	--	DIRECT
Mammalian Phenotype (MP)	abnormal bilaminar embryonic disc	0.0007474	2.126	--	DIRECT
Mammalian Phenotype (MP)	skeleton phenotype	0.002231	0.8038	--	INHERITED FROM: abnormal tooth morphology || abnormal vertebral column morphology || delayed bone ossification
Mammalian Phenotype (MP)	abnormal facial morphology	0.004773	1.348	--	INHERITED FROM: abnormal tooth morphology
Mammalian Phenotype (MP)	abnormal retinal layer morphology	0.00649	1.399	--	INHERITED FROM: abnormal retinal ganglion layer morphology || abnormal retinal ganglion cell morphology
Mammalian Phenotype (MP)	abnormal internal female genitalia morphology	0.00673	1.281	--	INHERITED FROM: abnormal ovarian follicle morphology || abnormal uterus morphology
Mammalian Phenotype (MP)	abnormal female genitalia morphology	0.00723	1.261	--	INHERITED FROM: abnormal ovarian follicle morphology || abnormal uterus morphology
Mammalian Phenotype (MP)	reproductive system phenotype	0.008974	0.8397	--	INHERITED FROM: abnormal reproductive system morphology || abnormal uterus morphology || abnormal ovarian follicle morphology || abnormal secondary sex determination
Mammalian Phenotype (MP)	abnormal viscerocranium morphology	0.01063	1.399	--	INHERITED FROM: abnormal tooth morphology
Mammalian Phenotype (MP)	abnormal gland morphology	0.01273	0.7519	--	INHERITED FROM: abnormal ovarian follicle morphology
Mammalian Phenotype (MP)	vision/eye phenotype	0.01489	0.8789	--	INHERITED FROM: abnormal retinal ganglion cell morphology || abnormal retinal ganglion layer morphology
Mammalian Phenotype (MP)	increased embryonic tissue cell apoptosis	0.01586	2.603	--	INHERITED FROM: increased embryonic epiblast cell apoptosis
Mammalian Phenotype (MP)	craniofacial phenotype	0.02087	1.047	--	INHERITED FROM: abnormal tooth morphology
Mammalian Phenotype (MP)	abnormal cranium morphology	0.02314	1.205	--	INHERITED FROM: abnormal tooth morphology
Mammalian Phenotype (MP)	abnormal retina morphology	0.02361	1.241	--	INHERITED FROM: abnormal retinal ganglion cell morphology || abnormal retinal ganglion layer morphology
Mammalian Phenotype (MP)	abnormal ocular fundus morphology	0.02418	1.241	--	INHERITED FROM: abnormal retinal ganglion layer morphology || abnormal retinal ganglion cell morphology
Mammalian Phenotype (MP)	abnormal embryonic tissue cell apoptosis	0.0257	2.603	--	INHERITED FROM: increased embryonic epiblast cell apoptosis
Mammalian Phenotype (MP)	preweaning lethality	0.0698	0.7055	--	INHERITED FROM: embryonic lethality between implantation and placentation || embryonic lethality between implantation and somite formation, complete penetrance || lethality throughout fetal growth and development, complete penetrance || embryonic lethality between implantation and somite formation
Mammalian Phenotype (MP)	abnormal female reproductive gland morphology	0.07178	1.427	--	INHERITED FROM: abnormal ovarian follicle morphology
Mammalian Phenotype (MP)	abnormal somatic nervous system morphology	0.07703	0.931	--	INHERITED FROM: abnormal retinal ganglion cell morphology
Mammalian Phenotype (MP)	abnormal sex gland morphology	0.09202	1.141	--	INHERITED FROM: abnormal ovarian follicle morphology
Mammalian Phenotype (MP)	abnormal skeleton physiology	0.09694	1.302	--	INHERITED FROM: delayed bone ossification
Mammalian Phenotype (MP)	abnormal sensory neuron morphology	0.09718	1.156	--	INHERITED FROM: abnormal retinal ganglion cell morphology
Mammalian Phenotype (MP)	embryonic lethality prior to tooth bud stage	0.1423	1.457	--	INHERITED FROM: embryonic lethality between implantation and somite formation, complete penetrance || embryonic lethality between implantation and somite formation || embryonic lethality between implantation and placentation
Mammalian Phenotype (MP)	abnormal embryo development	0.225	1.427	--	INHERITED FROM: failure to gastrulate || abnormal rostral-caudal axis patterning
Mammalian Phenotype (MP)	embryonic lethality	0.2363	1.126	--	INHERITED FROM: embryonic lethality between implantation and placentation || embryonic lethality between implantation and somite formation || embryonic lethality between implantation and somite formation, complete penetrance
Mammalian Phenotype (MP)	abnormal female reproductive system morphology	0.2478	1.261	--	INHERITED FROM: abnormal ovarian follicle morphology || abnormal uterus morphology
Mammalian Phenotype (MP)	increased cell death	0.2591	1.241	--	INHERITED FROM: increased embryonic epiblast cell apoptosis
Mammalian Phenotype (MP)	abnormal respiratory system morphology	0.2865	1.072	--	INHERITED FROM: abnormal lung morphology
Mammalian Phenotype (MP)	abnormal craniofacial bone morphology	0.3577	1.205	--	INHERITED FROM: abnormal tooth morphology
Mammalian Phenotype (MP)	increased apoptosis	0.3644	1.241	--	INHERITED FROM: increased embryonic epiblast cell apoptosis
Mammalian Phenotype (MP)	abnormal posterior eye segment morphology	0.3696	1.223	--	INHERITED FROM: abnormal retinal ganglion cell morphology || abnormal retinal ganglion layer morphology
Mammalian Phenotype (MP)	abnormal nervous system morphology	0.3923	0.5861	--	INHERITED FROM: abnormal retinal ganglion cell morphology
Mammalian Phenotype (MP)	abnormal sex determination	0.4296	1.348	--	INHERITED FROM: abnormal secondary sex determination
Mammalian Phenotype (MP)	abnormal skeleton morphology	0.7452	0.8323	--	INHERITED FROM: abnormal tooth morphology || abnormal vertebral column morphology
Mammalian Phenotype (MP)	abnormal survival	0.9369	0.6441	--	INHERITED FROM: embryonic lethality between implantation and somite formation, complete penetrance || embryonic lethality between implantation and somite formation || lethality throughout fetal growth and development, complete penetrance || embryonic lethality between implantation and placentation
Mammalian Phenotype (MP)	cellular phenotype	0	0.5387	Least Informative	DIRECT
Mammalian Phenotype (MP)	cardiovascular system phenotype	0.0009735	0.6737	Least Informative	DIRECT
Mammalian Phenotype (MP)	mortality/aging	0.01057	0.5424	Least Informative	INHERITED FROM: embryonic lethality between implantation and somite formation, complete penetrance || embryonic lethality between implantation and somite formation || embryonic lethality between implantation and placentation || lethality throughout fetal growth and development, complete penetrance
Mammalian Phenotype (MP)	endocrine/exocrine gland phenotype	0.01828	0.6947	Least Informative	INHERITED FROM: abnormal ovarian follicle morphology
Mammalian Phenotype (MP)	growth/size/body region phenotype	0.01852	0.6254	Least Informative	INHERITED FROM: abnormal tooth morphology
Mammalian Phenotype (MP)	nervous system phenotype	0.02986	0.4959	Least Informative	INHERITED FROM: abnormal retinal ganglion cell morphology
Mammalian Phenotype (MP)	respiratory system phenotype	0.00001435	0.9404	Moderately Informative	DIRECT
Mammalian Phenotype (MP)	abnormal embryo morphology	0.0001544	1.112	Moderately Informative	DIRECT
Mammalian Phenotype (MP)	abnormal reproductive system morphology	0.0009286	0.9404	Moderately Informative	DIRECT
Mammalian Phenotype (MP)	abnormal axial skeleton morphology	0.001103	1.001	Moderately Informative	INHERITED FROM: abnormal tooth morphology || abnormal vertebral column morphology
Mammalian Phenotype (MP)	prenatal lethality	0.003997	0.9129	Moderately Informative	INHERITED FROM: embryonic lethality between implantation and somite formation, complete penetrance || embryonic lethality between implantation and placentation || lethality throughout fetal growth and development, complete penetrance || embryonic lethality between implantation and somite formation
Mammalian Phenotype (MP)	abnormal eye morphology	0.01089	0.9129	Moderately Informative	INHERITED FROM: abnormal retinal ganglion cell morphology || abnormal retinal ganglion layer morphology
Mammalian Phenotype (MP)	abnormal craniofacial morphology	0.02063	1.047	Moderately Informative	INHERITED FROM: abnormal tooth morphology
Mammalian Phenotype (MP)	abnormal head morphology	0.05933	1.241	Moderately Informative	INHERITED FROM: abnormal tooth morphology
Mammalian Phenotype (MP)	lethality during fetal growth through weaning	0.09147	1.035	Moderately Informative	INHERITED FROM: lethality throughout fetal growth and development, complete penetrance
Mammalian Phenotype (MP)	abnormal cell death	0.09799	0.9904	Moderately Informative	INHERITED FROM: increased embryonic epiblast cell apoptosis || abnormal apoptosis
Mammalian Phenotype (MP)	abnormal neuron morphology	0.1119	0.8323	Moderately Informative	INHERITED FROM: abnormal retinal ganglion cell morphology
Mammalian Phenotype (MP)	abnormal heart morphology	0.4222	0.9597	Moderately Informative	INHERITED FROM: abnormal heart and great vessel attachment
Mammalian Phenotype (MP)	abnormal somatic sensory system morphology	0.4586	1.023	Moderately Informative	INHERITED FROM: abnormal retinal ganglion cell morphology
Mammalian Phenotype (MP)	abnormal vertebral column morphology	0.00006343	1.399	Informative	DIRECT
Mammalian Phenotype (MP)	abnormal ovary morphology	0.002351	1.457	Informative	INHERITED FROM: abnormal ovarian follicle morphology
Mammalian Phenotype (MP)	abnormal retinal neuronal layer morphology	0.003263	1.427	Informative	INHERITED FROM: abnormal retinal ganglion cell morphology || abnormal retinal ganglion layer morphology
Mammalian Phenotype (MP)	embryonic lethality prior to organogenesis	0.00366	1.457	Informative	INHERITED FROM: embryonic lethality between implantation and somite formation || embryonic lethality between implantation and placentation || embryonic lethality between implantation and somite formation, complete penetrance
Mammalian Phenotype (MP)	abnormal jaw morphology	0.007351	1.427	Informative	INHERITED FROM: abnormal tooth morphology
Mammalian Phenotype (MP)	lethality throughout fetal growth and development	0.009569	1.7	Informative	INHERITED FROM: lethality throughout fetal growth and development, complete penetrance
Mammalian Phenotype (MP)	abnormal bone ossification	0.2612	1.562	Informative	INHERITED FROM: delayed bone ossification
Mammalian Phenotype (MP)	abnormal developmental patterning	0.2736	1.524	Informative	INHERITED FROM: failure to gastrulate || abnormal rostral-caudal axis patterning
Mammalian Phenotype (MP)	abnormal mouth morphology	0.423	1.489	Informative	INHERITED FROM: abnormal tooth morphology
Mammalian Phenotype (MP)	abnormal embryonic epiblast morphology	0.0000003029	2.126	Highly Informative	DIRECT
Mammalian Phenotype (MP)	abnormal retinal ganglion cell morphology	0.00007392	1.904	Highly Informative	DIRECT
Mammalian Phenotype (MP)	embryonic lethality between implantation and somite formation, complete penetrance	0.0001085	1.904	Highly Informative	DIRECT
Mammalian Phenotype (MP)	abnormal rostral-caudal axis patterning	0.0002084	1.904	Highly Informative	DIRECT
Mammalian Phenotype (MP)	lethality throughout fetal growth and development, complete penetrance	0.000295	1.825	Highly Informative	DIRECT
Mammalian Phenotype (MP)	abnormal uterus morphology	0.0006512	2.001	Highly Informative	DIRECT
Mammalian Phenotype (MP)	abnormal tooth morphology	0.000749	2.001	Highly Informative	DIRECT
Mammalian Phenotype (MP)	abnormal gastrulation	0.00401	1.758	Highly Informative	INHERITED FROM: failure to gastrulate
Mammalian Phenotype (MP)	abnormal embryonic tissue physiology	0.01442	2.126	Highly Informative	INHERITED FROM: increased embryonic epiblast cell apoptosis
Mammalian Phenotype (MP)	abnormal germ layer morphology	0.01495	2.126	Highly Informative	INHERITED FROM: absent mesoderm || abnormal mesoderm morphology

---

Fly Phenotype (FP)

Highlighted in gray are those with FDR_all>0.001

	FP term	FDR (all)	IC level	SDFP level	Annotation (direct or inherited)
Fly Phenotype (FP)	lethal	0	0.678	--	DIRECT
Fly Phenotype (FP)	phenotype	0	0.06546	--	DIRECT
Fly Phenotype (FP)	increased mortality during development	0	0.6148	--	DIRECT
Fly Phenotype (FP)	decreased cell number	0.0002182	1.687	--	DIRECT
Fly Phenotype (FP)	increased mortality	0	0.5343	Least Informative	DIRECT
Fly Phenotype (FP)	lethal - all die before end of P-stage	0	1.181	Moderately Informative	DIRECT
Fly Phenotype (FP)	wild-type	0	1.687	Informative	DIRECT
Fly Phenotype (FP)	size defective	0	1.541	Informative	DIRECT
Fly Phenotype (FP)	neuroanatomy defective	0	1.344	Informative	DIRECT
Fly Phenotype (FP)	cell number defective	0.002345	1.344	Informative	INHERITED FROM: decreased cell number
Fly Phenotype (FP)	decreased occurrence of cell division	0.0001264	1.784	Highly Informative	DIRECT

---

Fly Anatomy (FA)

Highlighted in gray are those with FDR_all>0.001

	FA term	FDR (all)	IC level	SDFA level	Annotation (direct or inherited)
Fly Anatomy (FA)	organism	0	0.06695	--	DIRECT
Fly Anatomy (FA)	thorax	0	0.912	--	DIRECT
Fly Anatomy (FA)	thoracic segment	0	0.912	--	DIRECT
Fly Anatomy (FA)	embryo	0	0.8978	--	DIRECT
Fly Anatomy (FA)	embryonic/larval nervous system	0	0.7171	--	DIRECT
Fly Anatomy (FA)	adult tagma	0	0.6649	--	DIRECT
Fly Anatomy (FA)	adult segment	0	0.821	--	DIRECT
Fly Anatomy (FA)	adult thorax	0	0.942	--	DIRECT
Fly Anatomy (FA)	adult thoracic segment	0	0.942	--	DIRECT
Fly Anatomy (FA)	adult nervous system	0	0.7764	--	DIRECT
Fly Anatomy (FA)	organ system	0	0.1823	--	DIRECT
Fly Anatomy (FA)	integumentary system	0	0.8094	--	DIRECT
Fly Anatomy (FA)	neuromuscular junction	0	1.787	--	DIRECT
Fly Anatomy (FA)	adult integumentary system	0	0.9578	--	DIRECT
Fly Anatomy (FA)	cell	0	0.4069	--	DIRECT
Fly Anatomy (FA)	organism subdivision	0	0.5027	--	DIRECT
Fly Anatomy (FA)	non-connected functional system	0	0.8451	--	DIRECT
Fly Anatomy (FA)	region of integument	0	0.884	--	DIRECT
Fly Anatomy (FA)	tagmatic subdivision of integument	0	0.9742	--	DIRECT
Fly Anatomy (FA)	segmental subdivision of organ system	0	1.486	--	DIRECT
Fly Anatomy (FA)	multicellular structure	0	0.008955	--	DIRECT
Fly Anatomy (FA)	tarsal segment	0.0000348	1.787	--	DIRECT
Fly Anatomy (FA)	adult optic lobe	0.00009117	2.389	--	DIRECT
Fly Anatomy (FA)	adult labral segment	0.0003525	1.912	--	DIRECT
Fly Anatomy (FA)	adult cerebral ganglion	0.000483	1.69	--	DIRECT
Fly Anatomy (FA)	tracheal system	0.0008112	1.611	--	DIRECT
Fly Anatomy (FA)	wing vein	0.0009972	1.611	--	DIRECT
Fly Anatomy (FA)	synaptic neuropil	0.001336	1.435	--	INHERITED FROM: adult optic lobe
Fly Anatomy (FA)	procephalic segment	0.004548	1.31	--	INHERITED FROM: adult labral segment || adult optic lobe || adult protocerebrum
Fly Anatomy (FA)	adult head segment	0.0159	1.435	--	INHERITED FROM: adult labral segment || adult optic lobe || adult protocerebrum
Fly Anatomy (FA)	adult central nervous system	0.02407	1.69	--	INHERITED FROM: adult optic lobe || adult protocerebrum || adult cerebral ganglion
Fly Anatomy (FA)	head segment	0.02536	1.31	--	INHERITED FROM: adult protocerebrum || adult labral segment || adult optic lobe
Fly Anatomy (FA)	brain	0.049	1.544	--	INHERITED FROM: adult protocerebrum || adult cerebral ganglion || adult optic lobe
Fly Anatomy (FA)	segment of leg	0.1252	1.611	--	INHERITED FROM: tarsal segment
Fly Anatomy (FA)	neuropil	0.1329	1.243	--	INHERITED FROM: adult optic lobe
Fly Anatomy (FA)	cuticle	0.1656	1.31	--	INHERITED FROM: wing vein
Fly Anatomy (FA)	head	0.3303	0.912	--	INHERITED FROM: adult labral segment || adult protocerebrum || adult cerebral ganglion || adult optic lobe
Fly Anatomy (FA)	protocerebrum	0.4957	1.611	--	INHERITED FROM: adult optic lobe || adult protocerebrum
Fly Anatomy (FA)	wing	0.5378	1.243	--	INHERITED FROM: wing vein
Fly Anatomy (FA)	mesothoracic segment	0.8672	0.9578	--	INHERITED FROM: wing vein
Fly Anatomy (FA)	anatomical structure	1	0	--	INHERITED FROM: adult cerebral ganglion || adult external thorax || organism || nervous system || peripheral nervous system || embryonic/larval neuromuscular junction || neuron || adult || embryonic/larval nervous system || adult nervous system || wing vein || tracheal system || segment || larva || leg || thoracic segment || somatic cell || neuromuscular junction || tagmatic subdivision of integument || adult labral segment || cell component || cell || larval tagma || adult thorax || tarsal segment || appendage || region of integument || segmental subdivision of organ system || multi-tissue structure || larval segment || late embryo || neuromere || adult tagma || adult segment || tagma || organ system subdivision || embryonic/larval tracheal system || thorax || central nervous system || adult protocerebrum || adult integumentary system || adult optic lobe || embryo || embryonic/larval peripheral nervous system || adult thoracic segment || organ system || ganglion || organism subdivision || integumentary system || multicellular structure
Fly Anatomy (FA)	material anatomical entity	1	0	--	INHERITED FROM: embryo || anatomical group || adult thoracic segment || embryonic/larval peripheral nervous system || organ system || ganglion || organism subdivision || integumentary system || multicellular structure || thorax || central nervous system || adult protocerebrum || adult integumentary system || adult optic lobe || adult tagma || non-connected functional system || adult segment || tagma || organ system subdivision || embryonic/larval tracheal system || larval tagma || adult thorax || cell || tarsal segment || appendage || region of integument || segmental subdivision of organ system || larval segment || multi-tissue structure || late embryo || neuromere || tagmatic subdivision of integument || adult labral segment || cell component || tracheal system || segment || leg || larva || thoracic segment || somatic cell || neuromuscular junction || neuron || adult || embryonic/larval nervous system || adult nervous system || wing vein || adult external thorax || adult cerebral ganglion || organism || nervous system || peripheral nervous system || embryonic/larval neuromuscular junction
Fly Anatomy (FA)	anterior-posterior subdivision of organism	1	0.5027	--	INHERITED FROM: larval segment || adult external thorax || larval tagma || adult thorax || adult cerebral ganglion || tarsal segment || tagma || adult segment || wing vein || adult tagma || adult optic lobe || thorax || thoracic segment || adult protocerebrum || leg || segment || adult labral segment || adult thoracic segment
Fly Anatomy (FA)	tagma	0	0.5027	Least Informative	DIRECT
Fly Anatomy (FA)	segment	0	0.6568	Least Informative	DIRECT
Fly Anatomy (FA)	larva	0	0.3763	Least Informative	DIRECT
Fly Anatomy (FA)	adult	0	0.4496	Least Informative	DIRECT
Fly Anatomy (FA)	nervous system	0	0.6333	Least Informative	DIRECT
Fly Anatomy (FA)	multi-tissue structure	0	0.6038	Least Informative	DIRECT
Fly Anatomy (FA)	anatomical group	0	0.6816	Least Informative	DIRECT
Fly Anatomy (FA)	organ system subdivision	0	0.4301	Least Informative	DIRECT
Fly Anatomy (FA)	somatic cell	0	0.4861	Least Informative	DIRECT
Fly Anatomy (FA)	larval tagma	0	1.159	Moderately Informative	DIRECT
Fly Anatomy (FA)	larval segment	0	1.243	Moderately Informative	DIRECT
Fly Anatomy (FA)	adult external thorax	0	1.009	Moderately Informative	DIRECT
Fly Anatomy (FA)	central nervous system	0	1.009	Moderately Informative	DIRECT
Fly Anatomy (FA)	peripheral nervous system	0	0.8978	Moderately Informative	DIRECT
Fly Anatomy (FA)	neuron	0	0.8451	Moderately Informative	DIRECT
Fly Anatomy (FA)	ganglion	0	1.185	Moderately Informative	DIRECT
Fly Anatomy (FA)	late embryo	0	1.088	Moderately Informative	DIRECT
Fly Anatomy (FA)	appendage	0	1.047	Moderately Informative	DIRECT
Fly Anatomy (FA)	multi-cell-component structure	0.00637	1.088	Moderately Informative	INHERITED FROM: adult optic lobe
Fly Anatomy (FA)	acellular anatomical structure	0.02258	1.134	Moderately Informative	INHERITED FROM: wing vein
Fly Anatomy (FA)	adult head	0.2324	1.009	Moderately Informative	INHERITED FROM: adult labral segment || adult cerebral ganglion || adult protocerebrum || adult optic lobe
Fly Anatomy (FA)	adult mesothoracic segment	0.6916	0.9912	Moderately Informative	INHERITED FROM: wing vein
Fly Anatomy (FA)	leg	0	1.486	Informative	DIRECT
Fly Anatomy (FA)	neuromere	0	1.486	Informative	DIRECT
Fly Anatomy (FA)	embryonic/larval peripheral nervous system	0	1.544	Informative	DIRECT
Fly Anatomy (FA)	cell component	0	1.544	Informative	DIRECT
Fly Anatomy (FA)	embryonic/larval tracheal system	0.0007865	1.611	Informative	DIRECT
Fly Anatomy (FA)	appendage segment	0.001232	1.611	Informative	INHERITED FROM: tarsal segment
Fly Anatomy (FA)	labral segment	0.001249	1.611	Informative	INHERITED FROM: adult labral segment || adult protocerebrum || adult optic lobe
Fly Anatomy (FA)	adult brain	0.001728	1.69	Informative	INHERITED FROM: adult cerebral ganglion || adult protocerebrum || adult optic lobe
Fly Anatomy (FA)	adult procephalic segment	0.001815	1.435	Informative	INHERITED FROM: adult protocerebrum || adult optic lobe || adult labral segment
Fly Anatomy (FA)	synaptic neuropil block	0.005113	1.69	Informative	INHERITED FROM: adult optic lobe
Fly Anatomy (FA)	cuticular specialization	0.005786	1.486	Informative	INHERITED FROM: wing vein
Fly Anatomy (FA)	wing blade	0.007628	1.486	Informative	INHERITED FROM: wing vein
Fly Anatomy (FA)	supraesophageal ganglion	0.1052	1.544	Informative	INHERITED FROM: adult optic lobe || adult protocerebrum || adult cerebral ganglion
Fly Anatomy (FA)	embryonic/larval neuromuscular junction	0	2.088	Highly Informative	DIRECT
Fly Anatomy (FA)	adult protocerebrum	0.0003525	1.912	Highly Informative	DIRECT

---

Zebrafish Anatomy (ZA)

Highlighted in gray are those with FDR_all>0.001

	ZA term	FDR (all)	IC level	SDZA level	Annotation (direct or inherited)
Zebrafish Anatomy (ZA)	compound organ	0	0.4299	--	DIRECT
Zebrafish Anatomy (ZA)	whole organism	0	0.00147	--	DIRECT
Zebrafish Anatomy (ZA)	anatomical system	0	0.1857	--	DIRECT
Zebrafish Anatomy (ZA)	anatomical group	0	0.1532	--	DIRECT
Zebrafish Anatomy (ZA)	caudal vein plexus	0.00001543	2.471	--	DIRECT
Zebrafish Anatomy (ZA)	lining cell	0.000218	2.17	--	DIRECT
Zebrafish Anatomy (ZA)	barrier cell	0.0003818	2.17	--	DIRECT
Zebrafish Anatomy (ZA)	anatomical structure	1	0	--	INHERITED FROM: endothelial cell || caudal vein plexus || anatomical system || multi-tissue structure || lining cell || anatomical group || whole organism || barrier cell || organism subdivision || compound organ || cavitated compound organ
Zebrafish Anatomy (ZA)	organism subdivision	0	0.614	Least Informative	DIRECT
Zebrafish Anatomy (ZA)	multi-tissue structure	0	0.5848	Least Informative	DIRECT
Zebrafish Anatomy (ZA)	cavitated compound organ	0	0.5123	Least Informative	DIRECT
Zebrafish Anatomy (ZA)	cell	0.6711	0.6388	Least Informative	INHERITED FROM: lining cell || endothelial cell || barrier cell
Zebrafish Anatomy (ZA)	cardiovascular system	0.08496	1.216	Moderately Informative	INHERITED FROM: caudal vein plexus
Zebrafish Anatomy (ZA)	vasculature	0.08191	1.471	Informative	INHERITED FROM: caudal vein plexus
Zebrafish Anatomy (ZA)	post-vent region	0.1047	1.568	Informative	INHERITED FROM: caudal vein plexus
Zebrafish Anatomy (ZA)	endothelial cell	0.0002009	2.17	Highly Informative	DIRECT
Zebrafish Anatomy (ZA)	post-vent vasculature	0.02562	1.869	Highly Informative	INHERITED FROM: caudal vein plexus

---

Xenopus Anatomy (XA)

Highlighted in gray are those with FDR_all>0.001

	XA term	FDR (all)	IC level	SDXA level	Annotation (direct or inherited)
Xenopus ANatomical entity (XAN)	head region	0	0.4759	--	DIRECT
Xenopus ANatomical entity (XAN)	pre-chordal neural plate	0	1.824	--	DIRECT
Xenopus ANatomical entity (XAN)	central nervous system	0	0.5841	--	DIRECT
Xenopus ANatomical entity (XAN)	neural plate	0	1.635	--	DIRECT
Xenopus ANatomical entity (XAN)	anatomical structure	0	0	--	DIRECT
Xenopus ANatomical entity (XAN)	anatomical group	0	0.1408	--	DIRECT
Xenopus ANatomical entity (XAN)	primary germ layer	0	0.6748	--	DIRECT
Xenopus ANatomical entity (XAN)	organism subdivision	0	0.1679	--	DIRECT
Xenopus ANatomical entity (XAN)	compound organ	0	0.2177	--	DIRECT
Xenopus ANatomical entity (XAN)	anatomical region	0	0.1803	--	DIRECT
Xenopus ANatomical entity (XAN)	multicellular anatomical structure	0	0.1131	--	DIRECT
Xenopus ANatomical entity (XAN)	dorsal aorta	0.0000001464	2.564	--	DIRECT
Xenopus ANatomical entity (XAN)	aorta	0.0000002977	2.564	--	DIRECT
Xenopus ANatomical entity (XAN)	artery	0.0000006746	2.564	--	DIRECT
Xenopus ANatomical entity (XAN)	trunk vasculature	0.000006228	2.263	--	DIRECT
Xenopus ANatomical entity (XAN)	hematological system	0.00002255	1.865	--	DIRECT
Xenopus ANatomical entity (XAN)	cranium	0.0006617	1.911	--	DIRECT
Xenopus ANatomical entity (XAN)	visual system	0.0007307	1.321	--	DIRECT
Xenopus ANatomical entity (XAN)	dorsal lateral plate mesoderm	0.0009227	2.865	--	DIRECT
Xenopus ANatomical entity (XAN)	blood vessel	0.002745	2.263	--	INHERITED FROM: artery || dorsal aorta || aorta
Xenopus ANatomical entity (XAN)	trunk region	0.5514	0.388	--	INHERITED FROM: trunk vasculature || dorsal aorta
Xenopus ANatomical entity (XAN)	anatomical system	1	0.283	--	INHERITED FROM: splanchnocranium || spinal cord || artery || cardiovascular system || aorta || cranium || circulatory system || nervous system || dorsal aorta || trunk vasculature || central nervous system || visual system || hematological system
Xenopus ANatomical entity (XAN)	whole organism	1	0.0884	--	INHERITED FROM: intersomitic region || aorta || neural plate || head mesenchyme || chordal neural plate || head region || animal hemisphere || circulatory system || nervous system || cranium || anatomical group || splanchnocranium || cavitated compound organ || multicellular anatomical structure || head mesoderm || cardiovascular system || artery || mesoderm || ectoderm || compound organ || spinal cord || tissue || anatomical region || dorsal lateral plate mesoderm || central nervous system || pre-chordal neural plate || pharyngeal region || visual system || notochord || hematological system || mesenchyme || trunk vasculature || multi-tissue structure || neuroectoderm || dorsal aorta || organism subdivision || embryonic structure || head || primary germ layer || lateral plate mesoderm
Xenopus ANatomical entity (XAN)	embryo	0	0.5979	Least Informative	DIRECT
Xenopus ANatomical entity (XAN)	nervous system	0	0.5619	Least Informative	DIRECT
Xenopus ANatomical entity (XAN)	head	0	0.4777	Least Informative	DIRECT
Xenopus ANatomical entity (XAN)	tissue	0	0.4672	Least Informative	DIRECT
Xenopus ANatomical entity (XAN)	cavitated compound organ	0	0.2685	Least Informative	DIRECT
Xenopus ANatomical entity (XAN)	anatomical cluster	0.4823	0.7159	Least Informative	INHERITED FROM: cranium || splanchnocranium
Xenopus ANatomical entity (XAN)	trunk	0.5284	0.3894	Least Informative	INHERITED FROM: trunk vasculature || dorsal aorta
Xenopus ANatomical entity (XAN)	ectoderm	0	0.9357	Moderately Informative	DIRECT
Xenopus ANatomical entity (XAN)	multi-tissue structure	0	1.066	Moderately Informative	DIRECT
Xenopus ANatomical entity (XAN)	embryonic structure	0	1.149	Moderately Informative	DIRECT
Xenopus ANatomical entity (XAN)	sensory system	0.001729	1.158	Moderately Informative	INHERITED FROM: visual system
Xenopus ANatomical entity (XAN)	musculoskeletal system	0.2854	1.087	Moderately Informative	INHERITED FROM: splanchnocranium || cranium
Xenopus ANatomical entity (XAN)	neuroectoderm	0	1.374	Informative	DIRECT
Xenopus ANatomical entity (XAN)	mesoderm	0	1.285	Informative	DIRECT
Xenopus ANatomical entity (XAN)	cardiovascular system	0.0000002575	1.586	Informative	DIRECT
Xenopus ANatomical entity (XAN)	notochord	0.00003661	1.689	Informative	DIRECT
Xenopus ANatomical entity (XAN)	mesenchyme	0.00004169	1.586	Informative	DIRECT
Xenopus ANatomical entity (XAN)	pharyngeal region	0.0001191	1.467	Informative	DIRECT
Xenopus ANatomical entity (XAN)	animal hemisphere	0.0002082	1.689	Informative	DIRECT
Xenopus ANatomical entity (XAN)	spinal cord	0.0009545	1.45	Informative	DIRECT
Xenopus ANatomical entity (XAN)	skeletal system	0.06603	1.635	Informative	INHERITED FROM: splanchnocranium || cranium
Xenopus ANatomical entity (XAN)	head mesoderm	0.000000006035	2.087	Highly Informative	DIRECT
Xenopus ANatomical entity (XAN)	head mesenchyme	0.0000001228	2.166	Highly Informative	DIRECT
Xenopus ANatomical entity (XAN)	intersomitic region	0.000001068	1.911	Highly Informative	DIRECT
Xenopus ANatomical entity (XAN)	chordal neural plate	0.000007918	2.087	Highly Informative	DIRECT
Xenopus ANatomical entity (XAN)	circulatory system	0.00003336	2.02	Highly Informative	DIRECT
Xenopus ANatomical entity (XAN)	lateral plate mesoderm	0.0001434	1.824	Highly Informative	DIRECT
Xenopus ANatomical entity (XAN)	splanchnocranium	0.0001499	2.087	Highly Informative	DIRECT
Xenopus DEvelopment stage (XDE)	NF stage	0	0.01895	--	DIRECT

---

Enzyme Commission (EC)

Highlighted in gray are those with FDR_all>0.001

	EC term	FDR (all)	IC level	SDEC level	Annotation (direct or inherited)
Enzyme Commission (EC)	Transferring phosphorus-containing groups	0	0.7021	--	DIRECT
Enzyme Commission (EC)	Receptor protein serine/threonine kinase	0	3.23	--	DIRECT
Enzyme Commission (EC)	Transferases	0	0.3972	Least Informative	DIRECT
Enzyme Commission (EC)	Protein-serine/threonine kinases	0	1.437	Informative	DIRECT

---