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Defensin-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Small proteins [ 56992] (90)
Fold:   Defensin-like [ 57391]
Superfamily:   Defensin-like [ 57392] (3)
Families:   Defensin [ 57393] (10)
  Myotoxin [ 90157]
  Tick carboxypeptidase inhibitor-like [ 161135]

 Superfamily statistics
Genomes (48) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 360 1,427 23
Proteins 359 1,404 21

 Functional annotation
General category Processes_EC
Detailed category Toxins/defense

Document: Function annotation of SCOP domain superfamilies

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)organ system cancer0.1857Least InformativeInherited
Disease Ontology (DO)disease by infectious agent0Moderately InformativeDirect
Disease Ontology (DO)gastrointestinal system disease0.002013Moderately InformativeInherited
Disease Ontology (DO)hematologic cancer0.005877Moderately InformativeInherited
Disease Ontology (DO)skin disease0.01183Moderately InformativeInherited
Disease Ontology (DO)periodontal disease0.00000464InformativeDirect
Disease Ontology (DO)primary bacterial infectious disease0.00004173InformativeDirect
Disease Ontology (DO)lymphoma0.007041InformativeInherited
Disease Ontology (DO)mycosis fungoides0.000001183Highly InformativeDirect
Disease Ontology (DO)gastritis0.000013Highly InformativeDirect
Disease Ontology (DO)atopic dermatitis0.0001712Highly InformativeDirect

Document: DO annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Disease Ontology (DO) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.

Alignments of sequences to 23 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Defensin-like domain.

Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 23 hidden Markov models representing the Defensin-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Disease Ontology (DO) · Internal database links ]
Please cite: Gough, J., Karplus, K., Hughey, R. and Chothia, C. (2001). "Assignment of Homology to Genome Sequences using a Library of Hidden Markov Models that Represent all Proteins of Known Structure." J. Mol. Biol., 313(4), 903-919.

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© Copyright 2013 The SUPERFAMILY authors and Julian Gough.