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Kringle-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Small proteins [ 56992] (90)
Fold:   Kringle-like [ 57439]
Superfamily:   Kringle-like [ 57440] (2)
Families:   Kringle modules [ 57441] (6)
  Fibronectin type II module [ 57459] (4)

Superfamily statistics
Genomes (187) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 4,878 12,453 59
Proteins 2,742 7,169 47

Functional annotation
General category Processes_EC
Detailed category Blood clotting

Function annotation of SCOP domain superfamilies

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on peptide bonds (peptide hydrolases)0Least InformativeDirect
Enzyme Commission (EC)Serine endopeptidases0.0000000000001313Moderately InformativeDirect
Enzyme Commission (EC)Receptor protein-tyrosine kinase0.000000000001212InformativeDirect
Enzyme Commission (EC)Metalloendopeptidases0.0002463InformativeDirect
Enzyme Commission (EC)Plasmin0Highly InformativeDirect
Enzyme Commission (EC)T-plasminogen activator0.000000000000002098Highly InformativeDirect
Enzyme Commission (EC)Gelatinase B0.0000000001879Highly InformativeDirect
Enzyme Commission (EC)Gelatinase A0.0000000001879Highly InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)organ system cancer0.009473Least InformativeInherited
Disease Ontology (DO)nervous system disease0.01928Least InformativeInherited
Disease Ontology (DO)artery disease0.00008454Moderately InformativeDirect
Disease Ontology (DO)urinary system disease0.0002676Moderately InformativeDirect
Disease Ontology (DO)syndrome0.000865Moderately InformativeDirect
Disease Ontology (DO)lower respiratory tract disease0.001046Moderately InformativeInherited
Disease Ontology (DO)skin disease0.001625Moderately InformativeInherited
Disease Ontology (DO)gastrointestinal system disease0.007165Moderately InformativeInherited
Disease Ontology (DO)hematologic cancer0.0459Moderately InformativeInherited
Disease Ontology (DO)nervous system cancer0.2343Moderately InformativeInherited
Disease Ontology (DO)sensory system disease0.2608Moderately InformativeInherited
Disease Ontology (DO)brain disease0.4432Moderately InformativeInherited
Disease Ontology (DO)atherosclerosis0.00000006024InformativeDirect
Disease Ontology (DO)myocardial infarction0.0000001405InformativeDirect
Disease Ontology (DO)periodontal disease0.00006971InformativeDirect
Disease Ontology (DO)myopia0.0001018InformativeDirect
Disease Ontology (DO)connective tissue cancer0.0001327InformativeDirect
Disease Ontology (DO)liver disease0.0006886InformativeDirect
Disease Ontology (DO)female reproductive system disease0.0007793InformativeDirect
Disease Ontology (DO)meningioma0.0008495InformativeDirect
Disease Ontology (DO)respiratory system cancer0.003013InformativeInherited
Disease Ontology (DO)lymphoma0.007545InformativeInherited
Disease Ontology (DO)breast cancer0.009107InformativeInherited
Disease Ontology (DO)endocrine gland cancer0.0128InformativeInherited
Disease Ontology (DO)muscle tissue disease0.03224InformativeInherited
Disease Ontology (DO)interstitial lung disease0.2419InformativeInherited
Disease Ontology (DO)meningitis0.00004214Highly InformativeDirect
Disease Ontology (DO)cholesteatoma0.00004492Highly InformativeDirect
Disease Ontology (DO)Hodgkin's lymphoma0.00005148Highly InformativeDirect
Disease Ontology (DO)laryngeal carcinoma0.0000807Highly InformativeDirect
Disease Ontology (DO)dermatomyositis0.0001121Highly InformativeDirect
Disease Ontology (DO)leukodystrophy0.0001472Highly InformativeDirect
Disease Ontology (DO)pancreatic ductal adenocarcinoma0.0001856Highly InformativeDirect
Disease Ontology (DO)endometriosis0.0002022Highly InformativeDirect
Disease Ontology (DO)invasive ductal carcinoma0.0005252Highly InformativeDirect
Disease Ontology (DO)cerebrovascular disease0.001445Highly InformativeInherited

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of blood and blood-forming tissues0.06582Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal thrombosis0.03724InformativeInherited
Phenotypic Abnormality (PA)Deep venous thrombosis0.00001642Highly InformativeDirect

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)cardiovascular system phenotype0.04113Least InformativeInherited
Mammalian Phenotype (MP)nervous system phenotype0.1679Least InformativeInherited
Mammalian Phenotype (MP)immune system phenotype0.1778Least InformativeInherited
Mammalian Phenotype (MP)abnormal homeostasis0.8456Least InformativeInherited
Mammalian Phenotype (MP)respiratory system phenotype0.009211Moderately InformativeInherited
Mammalian Phenotype (MP)liver/biliary system phenotype0.01462Moderately InformativeInherited
Mammalian Phenotype (MP)neoplasm0.09072Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal protein level0.101Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal eye morphology0.1385Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cardiovascular system physiology0.1628Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal inflammatory response0.1834Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal nervous system physiology0.2547Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal blood vessel morphology0.2954Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal immune serum protein physiology0.8069Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal digestive system morphology0.8275Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal uvea morphology0.0001284InformativeDirect
Mammalian Phenotype (MP)abnormal lung morphology0.0001877InformativeDirect
Mammalian Phenotype (MP)abnormal response to injury0.000578InformativeDirect
Mammalian Phenotype (MP)abnormal liver physiology0.000874InformativeDirect
Mammalian Phenotype (MP)abnormal blood coagulation0.0009174InformativeDirect
Mammalian Phenotype (MP)abnormal limb morphology0.004173InformativeInherited
Mammalian Phenotype (MP)abnormal respiratory function0.006008InformativeInherited
Mammalian Phenotype (MP)joint inflammation0.008909InformativeInherited
Mammalian Phenotype (MP)altered tumor pathology0.02435InformativeInherited
Mammalian Phenotype (MP)abnormal blood vessel physiology0.06593InformativeInherited
Mammalian Phenotype (MP)abnormal intestine morphology0.1931InformativeInherited
Mammalian Phenotype (MP)decreased susceptibility to induced choroidal neovascularization0.00000000005142Highly InformativeDirect
Mammalian Phenotype (MP)arthritis0.00005146Highly InformativeDirect
Mammalian Phenotype (MP)decreased tumor growth/size0.0003209Highly InformativeDirect
Mammalian Phenotype (MP)altered response to CNS ischemic injury0.0004696Highly InformativeDirect
Mammalian Phenotype (MP)abnormal breathing pattern0.002977Highly InformativeInherited
Mammalian Phenotype (MP)abnormal digit morphology0.007825Highly InformativeInherited
Mammalian Phenotype (MP)abnormal large intestine morphology0.1126Highly InformativeInherited
Mammalian Phenotype (MP)altered metastatic potential0.1292Highly InformativeInherited
Mammalian Phenotype (MP)altered susceptibility to atherosclerosis0.3889Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)larval development variant0Least InformativeDirect

Document: WP annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details) Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)tissue0.5697Least InformativeInherited
Xenopus ANatomical entity (XAN)embryo0.5905Least InformativeInherited
Xenopus ANatomical entity (XAN)ectoderm0.9228Moderately InformativeInherited
Xenopus ANatomical entity (XAN)epithelium0.00005756InformativeDirect
Xenopus ANatomical entity (XAN)neural plate0.05713InformativeInherited
Xenopus ANatomical entity (XAN)neural groove0.00002487Highly InformativeDirect

Document: XA annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Hydrolases0Least InformativeDirect
Enzyme Commission (EC)Transferring phosphorus-containing groups0.9785Least InformativeInherited
Enzyme Commission (EC)Acting on peptide bonds (peptidases)0Moderately InformativeDirect
Enzyme Commission (EC)Serine endopeptidases0.0000000000001672InformativeDirect
Enzyme Commission (EC)Protein-tyrosine kinases0.000000001905InformativeDirect
Enzyme Commission (EC)Metalloendopeptidases0.00007645InformativeDirect
Enzyme Commission (EC)Receptor protein-tyrosine kinase0.00000000005301Highly InformativeDirect

Document: EC annotation of SCOP domains

InterPro annotation
Cross references IPR013806 SSF57440 Protein matches

This entry represents proteins displaying a Kringle-like structure, which consists of a nearly all-beta, disulphide-rich fold. Proteins displaying this fold include both Kringle modules as well as fibronectin type II modules, the latter displaying a shorter two-disulphide version of the Kringle module.

Kringle modules occur in blood clotting and fibrinolytic proteins, such as plasminogen, prothrombin, meizothrombin, and urokinase-type plasminogen activator, as well as in apolipoprotein and hepatocyte growth factor. Kringle domains are believed to play a role in binding mediators (e.g., membranes, other proteins or phospholipids), and in the regulation of proteolytic activity [PubMed6373375, PubMed2157850].

Fibronectin type II modules occur in fibronectin, as well as in gelatinase A (MMP-2), gelatinase B (MMP-9), and the collagen-binding domain of PDC-109. Fibronectin is a multi-domain glycoprotein, found in a soluble form in plasma, and in an insoluble form in loose connective tissue and basement membranes, that binds cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin [PubMed3780752]. Fibronectins are involved in a number of important functions e.g., wound healing; cell adhesion; blood coagulation; cell differentiation and migration; maintenance of the cellular cytoskeleton; and tumour metastasis. Gelatinases A and B are members of the matrix metalloproteinase family that act as neutral proteinases in the breakdown and remodelling of the extracellular matrix. These gelatinases play important roles in the pathogenesis of inflammation, infection and in neoplastic diseases [PubMed16019990]. In gelatinase A, the three fibronectin-like modules are inserted within a catalytic domain, these modules acting to target the enzyme to matrix macromolecules [PubMed16085117].

InterPro database

PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Enzyme Commission (EC) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.

Alignments of sequences to 30 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.

Browse and view proteins in genomes which have different domain combinations including a Kringle-like domain.

Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.

Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 30 hidden Markov models representing the Kringle-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Enzyme Commission (EC) · Internal database links ]