SUPERFAMILY 1.75 HMM library and genome assignments server

SUPERFAMILY 2 can be accessed from Please contact us if you experience any problems.

Kringle modules family

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Small proteins [ 56992] (90)
Fold:   Kringle-like [ 57439]
Superfamily:   Kringle-like [ 57440] (2)
Family:   Kringle modules [ 57441] (6)

Family statistics
Genomes (68) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 740 2,124 40
Proteins 370 1,027 36

Enzyme Commission (EC)

show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on peptide bonds (peptide hydrolases)0Least InformativeDirect
Enzyme Commission (EC)Serine endopeptidases0Moderately InformativeDirect
Enzyme Commission (EC)Receptor protein-tyrosine kinase0.0000000000002718InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)nervous system disease0.0121Least InformativeInherited
Disease Ontology (DO)organ system cancer0.0902Least InformativeInherited
Disease Ontology (DO)artery disease0.0001827Moderately InformativeDirect
Disease Ontology (DO)hematopoietic system disease0.0118Moderately InformativeInherited
Disease Ontology (DO)atherosclerosis0.000001955InformativeDirect
Disease Ontology (DO)coronary artery disease0.02079InformativeInherited
Disease Ontology (DO)breast carcinoma0.03901InformativeInherited
Disease Ontology (DO)endocrine gland cancer0.05745InformativeInherited
Disease Ontology (DO)leukodystrophy0.00002088Highly InformativeDirect
Disease Ontology (DO)pancreatic ductal adenocarcinoma0.0003738Highly InformativeDirect
Disease Ontology (DO)invasive ductal carcinoma0.0008141Highly InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of blood and blood-forming tissues0.02868Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of coagulation0.000823InformativeDirect
Phenotypic Abnormality (PA)Deep venous thrombosis0.000004176Highly InformativeDirect

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)cardiovascular system phenotype0.07141Least InformativeInherited
Mammalian Phenotype (MP)immune system phenotype0.3659Least InformativeInherited
Mammalian Phenotype (MP)abnormal homeostasis0.9565Least InformativeInherited
Mammalian Phenotype (MP)respiratory system phenotype0.01771Moderately InformativeInherited
Mammalian Phenotype (MP)liver/biliary system phenotype0.03533Moderately InformativeInherited
Mammalian Phenotype (MP)limbs/digits/tail phenotype0.04908Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal protein level0.07219Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal eye morphology0.137Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal bone structure0.2254Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal blood vessel morphology0.3222Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cardiovascular system physiology0.3772Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal immune serum protein physiology0.4514Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal digestive system morphology0.9003Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal eyelid morphology0.0005751InformativeDirect
Mammalian Phenotype (MP)abnormal blood coagulation0.0006759InformativeDirect
Mammalian Phenotype (MP)abnormal respiratory function0.003763InformativeInherited
Mammalian Phenotype (MP)abnormal innate immunity0.03263InformativeInherited
Mammalian Phenotype (MP)abnormal blood vessel physiology0.06946InformativeInherited
Mammalian Phenotype (MP)abnormal intestine morphology0.1108InformativeInherited
Mammalian Phenotype (MP)abnormal autopod morphology0.1266InformativeInherited
Mammalian Phenotype (MP)abnormal bone volume0.0009441Highly InformativeDirect
Mammalian Phenotype (MP)abnormal breathing pattern0.001908Highly InformativeInherited
Mammalian Phenotype (MP)abnormal large intestine morphology0.002481Highly InformativeInherited

Document: MP annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)embryo0.5605Least InformativeInherited
Xenopus ANatomical entity (XAN)tissue0.6664Least InformativeInherited
Xenopus ANatomical entity (XAN)ectoderm1Moderately InformativeInherited
Xenopus ANatomical entity (XAN)neuroectoderm0.1469InformativeInherited
Xenopus ANatomical entity (XAN)neural groove0.0001596Highly InformativeDirect

Document: XA annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Hydrolases0Least InformativeDirect
Enzyme Commission (EC)Transferases1Least InformativeInherited
Enzyme Commission (EC)Acting on peptide bonds (peptidases)0Moderately InformativeDirect
Enzyme Commission (EC)Serine endopeptidases0InformativeDirect
Enzyme Commission (EC)Receptor protein-tyrosine kinase0.00000000001543Highly InformativeDirect

Document: EC annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Xenopus Anatomy (XA) · Enzyme Commission (EC) ]

Internal database links

Superfamily level     Family level

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.

Superfamily level     Family level

Alignments of sequences to 30 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.

Superfamily level

Browse and view proteins in genomes which have different domain combinations including a Kringle-like domain.

Superfamily level     Family level

Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.

Jump to [ Top of page · SCOP classification · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Xenopus Anatomy (XA) · Enzyme Commission (EC) · Internal database links ]