Fibronectin type II module family

SCOP classification

• Root: SCOP hierarchy in SUPERFAMILY [ 0] (11)
• Class: Small proteins [ 56992] (90)
• Fold: Kringle-like [ 57439]
• Superfamily: Kringle-like [ 57440] (2)
• Family: Fibronectin type II module [ 57459] (4)

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Family statistics

	Genomes (59)	Uniprot 2018_03 genome	PDB chains (SCOP 1.75)
Domains	384	1,059	16
Proteins	187	508	9

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Enzyme Commission (EC)

Highlighted in gray are those with FDR_all>0.001

	EC term	FDR (all)	IC level	SDEO level	Annotation (direct or inherited)
Enzyme Commission (EC)	Coagulation factor XIIa	0	2.264	--	DIRECT
Enzyme Commission (EC)	Hydrolases	0	0.01852	--	DIRECT
Enzyme Commission (EC)	Acting on peptide bonds (peptide hydrolases)	0	0.5709	Least Informative	DIRECT
Enzyme Commission (EC)	Serine endopeptidases	0.3704	1.139	Moderately Informative	INHERITED FROM: Coagulation factor XIIa
Enzyme Commission (EC)	Metalloendopeptidases	0.0000000000116	1.326	Informative	DIRECT
Enzyme Commission (EC)	Gelatinase A	0.000000000174	2.139	Highly Informative	DIRECT
Enzyme Commission (EC)	Gelatinase B	0.000000000174	2.139	Highly Informative	DIRECT

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Disease Ontology (DO)

Highlighted in gray are those with FDR_all>0.001

	DO term	FDR (all)	IC level	SDDO level	Annotation (direct or inherited)
Disease Ontology (DO)	thymoma	0.000000923	2.513	--	DIRECT
Disease Ontology (DO)	thymus cancer	0.00002731	2.513	--	DIRECT
Disease Ontology (DO)	bone cancer	0.0001185	1.61	--	DIRECT
Disease Ontology (DO)	aortic disease	0.0001252	1.814	--	DIRECT
Disease Ontology (DO)	myocardial infarction	0.0002714	1.559	--	DIRECT
Disease Ontology (DO)	arteriosclerotic cardiovascular disease	0.0006022	1.367	--	DIRECT
Disease Ontology (DO)	connective tissue cancer	0.0006112	1.367	--	DIRECT
Disease Ontology (DO)	head and neck squamous cell carcinoma	0.0006577	1.668	--	DIRECT
Disease Ontology (DO)	arteriosclerosis	0.0006722	1.367	--	DIRECT
Disease Ontology (DO)	thyroid cancer	0.0007959	1.911	--	DIRECT
Disease Ontology (DO)	larynx cancer	0.003991	1.911	--	INHERITED FROM: laryngeal carcinoma
Disease Ontology (DO)	autosomal genetic disease	0.004487	1.133	--	INHERITED FROM: autosomal recessive disease
Disease Ontology (DO)	monogenic disease	0.0053	1.115	--	INHERITED FROM: autosomal recessive disease
Disease Ontology (DO)	musculoskeletal system cancer	0.009045	1.283	--	INHERITED FROM: osteosarcoma || bone cancer || connective tissue cancer
Disease Ontology (DO)	bone marrow cancer	0.009205	1.399	--	INHERITED FROM: myeloid neoplasm
Disease Ontology (DO)	head and neck cancer	0.009595	1.513	--	INHERITED FROM: head and neck squamous cell carcinoma
Disease Ontology (DO)	respiratory system cancer	0.01763	1.434	--	INHERITED FROM: laryngeal carcinoma
Disease Ontology (DO)	vascular disease	0.0379	0.832	--	INHERITED FROM: arteriosclerotic cardiovascular disease || coronary artery disease || myocardial infarction || arteriosclerosis || acute myocardial infarction || atherosclerosis || aortic disease
Disease Ontology (DO)	cardiovascular system disease	0.06438	0.7889	--	INHERITED FROM: acute myocardial infarction || aortic disease || atherosclerosis || arteriosclerotic cardiovascular disease || myocardial infarction || coronary artery disease || arteriosclerosis
Disease Ontology (DO)	immune system cancer	0.1415	0.89	--	INHERITED FROM: Hodgkin's lymphoma || myeloid neoplasm || thymoma || thymus cancer
Disease Ontology (DO)	cancer	0.2011	0.2555	--	INHERITED FROM: connective tissue cancer || thyroid cancer || Hodgkin's lymphoma || myeloid neoplasm || bone cancer || osteosarcoma || head and neck squamous cell carcinoma || thyroid carcinoma || thymus cancer || laryngeal carcinoma || thymoma
Disease Ontology (DO)	disease of cellular proliferation	0.2193	0.2322	--	INHERITED FROM: connective tissue cancer || thymoma || osteosarcoma || thymus cancer || thyroid carcinoma || thyroid cancer || head and neck squamous cell carcinoma || laryngeal carcinoma || bone cancer || Hodgkin's lymphoma || myeloid neoplasm
Disease Ontology (DO)	disease of anatomical entity	0.4605	0.2414	--	INHERITED FROM: atherosclerosis || acute myocardial infarction || arteriosclerosis || coronary artery disease || aortic disease || arteriosclerotic cardiovascular disease || myocardial infarction
Disease Ontology (DO)	organ system cancer	0.01527	0.4879	Least Informative	INHERITED FROM: thymoma || laryngeal carcinoma || thymus cancer || thyroid carcinoma || osteosarcoma || head and neck squamous cell carcinoma || bone cancer || myeloid neoplasm || Hodgkin's lymphoma || thyroid cancer || connective tissue cancer
Disease Ontology (DO)	genetic disease	0.008847	1.066	Moderately Informative	INHERITED FROM: autosomal recessive disease
Disease Ontology (DO)	hematologic cancer	0.01722	0.89	Moderately Informative	INHERITED FROM: myeloid neoplasm || Hodgkin's lymphoma
Disease Ontology (DO)	artery disease	0.02292	0.9817	Moderately Informative	INHERITED FROM: aortic disease || atherosclerosis || arteriosclerosis || coronary artery disease || acute myocardial infarction || myocardial infarction || arteriosclerotic cardiovascular disease
Disease Ontology (DO)	osteosarcoma	0.00008702	1.61	Informative	DIRECT
Disease Ontology (DO)	autosomal recessive disease	0.0003377	1.472	Informative	DIRECT
Disease Ontology (DO)	atherosclerosis	0.0005936	1.367	Informative	DIRECT
Disease Ontology (DO)	coronary artery disease	0.0006371	1.472	Informative	DIRECT
Disease Ontology (DO)	myeloid neoplasm	0.0007153	1.399	Informative	DIRECT
Disease Ontology (DO)	head and neck carcinoma	0.001747	1.513	Informative	INHERITED FROM: head and neck squamous cell carcinoma
Disease Ontology (DO)	lymphoma	0.005317	1.668	Informative	INHERITED FROM: Hodgkin's lymphoma
Disease Ontology (DO)	endocrine gland cancer	0.03937	1.337	Informative	INHERITED FROM: thyroid carcinoma || thyroid cancer
Disease Ontology (DO)	acute myocardial infarction	0.000002239	2.212	Highly Informative	DIRECT
Disease Ontology (DO)	Hodgkin's lymphoma	0.00002977	2.212	Highly Informative	DIRECT
Disease Ontology (DO)	laryngeal carcinoma	0.00005199	1.911	Highly Informative	DIRECT
Disease Ontology (DO)	thyroid carcinoma	0.000731	1.911	Highly Informative	DIRECT

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Human Phenotype (HP)

Highlighted in gray are those with FDR_all>0.001

	HP term	FDR (all)	IC level	SDHP level	Annotation (direct or inherited)
Phenotypic Abnormality (PA)	Abnormality of the metaphysis	0.0001851	1.763	--	DIRECT
Phenotypic Abnormality (PA)	Abnormality of limb bone	0.08015	0.9572	--	INHERITED FROM: Abnormality of the metaphysis
Phenotypic Abnormality (PA)	Abnormal appendicular skeleton morphology	0.09917	0.8289	--	INHERITED FROM: Abnormality of the metaphysis
Phenotypic Abnormality (PA)	Abnormality of the skeletal system	0.4634	0.4712	--	INHERITED FROM: Abnormality of the metaphysis
Phenotypic Abnormality (PA)	Abnormality of limbs	0.1879	0.6429	Least Informative	INHERITED FROM: Abnormality of the metaphysis
Phenotypic Abnormality (PA)	Abnormality of skeletal morphology	0.4277	0.513	Least Informative	INHERITED FROM: Abnormality of the metaphysis
Phenotypic Abnormality (PA)	Abnormality of limb bone morphology	0.08015	0.9572	Moderately Informative	INHERITED FROM: Abnormality of the metaphysis
Phenotypic Abnormality (PA)	Abnormality of long bone morphology	0.006948	1.462	Informative	INHERITED FROM: Abnormality of the metaphysis

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Mouse Phenotype (MP)

Highlighted in gray are those with FDR_all>0.001

	MP term	FDR (all)	IC level	SDMP level	Annotation (direct or inherited)
Mammalian Phenotype (MP)	homeostasis/metabolism phenotype	0.04251	0.3626	--	INHERITED FROM: altered response to CNS ischemic injury
Mammalian Phenotype (MP)	abnormal response to infection	0.06474	1.112	--	INHERITED FROM: decreased susceptibility to infection
Mammalian Phenotype (MP)	abnormal immune system physiology	0.08185	0.6789	--	INHERITED FROM: decreased susceptibility to infection
Mammalian Phenotype (MP)	abnormal nervous system physiology	0.1647	0.825	--	INHERITED FROM: altered response to CNS ischemic injury
Mammalian Phenotype (MP)	abnormal sensitivity to induced morbidity/mortality	0.4505	1.302	--	INHERITED FROM: increased sensitivity to induced morbidity/mortality
Mammalian Phenotype (MP)	mortality/aging	0.05843	0.5424	Least Informative	INHERITED FROM: increased sensitivity to induced morbidity/mortality
Mammalian Phenotype (MP)	nervous system phenotype	0.2306	0.4959	Least Informative	INHERITED FROM: altered response to CNS ischemic injury
Mammalian Phenotype (MP)	immune system phenotype	0.2326	0.5462	Least Informative	INHERITED FROM: decreased susceptibility to infection
Mammalian Phenotype (MP)	abnormal induced morbidity/mortality	0.001645	1.241	Moderately Informative	INHERITED FROM: increased sensitivity to induced morbidity/mortality
Mammalian Phenotype (MP)	altered susceptibility to infection	0.01621	1.112	Moderately Informative	INHERITED FROM: decreased susceptibility to infection
Mammalian Phenotype (MP)	increased sensitivity to induced morbidity/mortality	0.0004934	1.649	Informative	DIRECT
Mammalian Phenotype (MP)	abnormal response to injury	0.01039	1.261	Informative	INHERITED FROM: altered response to CNS ischemic injury
Mammalian Phenotype (MP)	altered response to CNS ischemic injury	0.0000481	2.001	Highly Informative	DIRECT
Mammalian Phenotype (MP)	decreased susceptibility to infection	0.0006248	2.001	Highly Informative	DIRECT

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Zebrafish Anatomy (ZA)

Highlighted in gray are those with FDR_all>0.001

	ZA term	FDR (all)	IC level	SDZA level	Annotation (direct or inherited)
Zebrafish Anatomy (ZA)	whole organism	0	0.00147	--	DIRECT
Zebrafish Anatomy (ZA)	anatomical system	0	0.1857	--	DIRECT
Zebrafish Anatomy (ZA)	anatomical group	0	0.1532	--	DIRECT
Zebrafish Anatomy (ZA)	anatomical structure	1	0	--	INHERITED FROM: anatomical system || anatomical group || whole organism

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Xenopus Anatomy (XA)

Highlighted in gray are those with FDR_all>0.001

	XA term	FDR (all)	IC level	SDXA level	Annotation (direct or inherited)
Xenopus ANatomical entity (XAN)	trunk region	0	0.388	--	DIRECT
Xenopus ANatomical entity (XAN)	anatomical structure	0	0	--	DIRECT
Xenopus ANatomical entity (XAN)	anatomical group	0	0.1408	--	DIRECT
Xenopus ANatomical entity (XAN)	organism subdivision	0	0.1679	--	DIRECT
Xenopus ANatomical entity (XAN)	compound organ	0	0.2177	--	DIRECT
Xenopus ANatomical entity (XAN)	anatomical region	0	0.1803	--	DIRECT
Xenopus ANatomical entity (XAN)	multicellular anatomical structure	0	0.1131	--	DIRECT
Xenopus ANatomical entity (XAN)	anatomical system	1	0.283	--	INHERITED FROM: alimentary system
Xenopus ANatomical entity (XAN)	whole organism	1	0.0884	--	INHERITED FROM: alimentary system || anatomical group || multicellular anatomical structure || compound organ || trunk || anatomical region || epithelium || trunk region || anatomical cluster || viscus || mesenchyme || organism subdivision
Xenopus ANatomical entity (XAN)	trunk	0	0.3894	Least Informative	DIRECT
Xenopus ANatomical entity (XAN)	anatomical cluster	0	0.7159	Least Informative	DIRECT
Xenopus ANatomical entity (XAN)	tissue	0.6306	0.4672	Least Informative	INHERITED FROM: epithelium || mesenchyme
Xenopus ANatomical entity (XAN)	alimentary system	0	0.8739	Moderately Informative	DIRECT
Xenopus ANatomical entity (XAN)	viscus	0	0.8828	Moderately Informative	DIRECT
Xenopus ANatomical entity (XAN)	mesenchyme	0.0007962	1.586	Informative	DIRECT
Xenopus ANatomical entity (XAN)	epithelium	0.0008281	1.586	Informative	DIRECT

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Enzyme Commission (EC)

Highlighted in gray are those with FDR_all>0.001

	EC term	FDR (all)	IC level	SDEC level	Annotation (direct or inherited)
Enzyme Commission (EC)	Coagulation factor XIIa	0	2.753	--	DIRECT
Enzyme Commission (EC)	Gelatinase A	0.0000000002936	2.628	--	DIRECT
Enzyme Commission (EC)	Gelatinase B	0.0000000002936	2.628	--	DIRECT
Enzyme Commission (EC)	Hydrolases	0	0.4043	Least Informative	DIRECT
Enzyme Commission (EC)	Acting on peptide bonds (peptidases)	0	1.004	Moderately Informative	DIRECT
Enzyme Commission (EC)	Serine endopeptidases	0.3855	1.576	Informative	INHERITED FROM: Coagulation factor XIIa
Enzyme Commission (EC)	Metalloendopeptidases	0.000000000002757	1.753	Highly Informative	DIRECT

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