SUPERFAMILY 1.75 HMM library and genome assignments server

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Platelet-derived growth factor-like family

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Small proteins [ 56992] (90)
Fold:   Cystine-knot cytokines [ 57500]
Superfamily:   Cystine-knot cytokines [ 57501] (7)
Family:   Platelet-derived growth factor-like [ 57502] (3)

Family statistics
Genomes (63) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 361 1,131 13
Proteins 361 1,131 13

Disease Ontology (DO)

show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)organ system cancer0.08532Least InformativeInherited
Disease Ontology (DO)benign neoplasm0.00003174Moderately InformativeDirect
Disease Ontology (DO)artery disease0.001071Moderately InformativeInherited
Disease Ontology (DO)lower respiratory tract disease0.002453Moderately InformativeInherited
Disease Ontology (DO)gastrointestinal system cancer0.02076Moderately InformativeInherited
Disease Ontology (DO)hypersensitivity reaction type II disease0.02139Moderately InformativeInherited
Disease Ontology (DO)cell type cancer0.02213Moderately InformativeInherited
Disease Ontology (DO)connective tissue disease0.06102Moderately InformativeInherited
Disease Ontology (DO)cell type benign neoplasm0.000001247InformativeDirect
Disease Ontology (DO)atherosclerosis0.0001749InformativeDirect
Disease Ontology (DO)scleroderma0.0002352InformativeDirect
Disease Ontology (DO)osteosarcoma0.0005552InformativeDirect
Disease Ontology (DO)lung carcinoma0.0006487InformativeDirect
Disease Ontology (DO)liver carcinoma0.0006574InformativeDirect
Disease Ontology (DO)endocrine gland cancer0.02469InformativeInherited
Disease Ontology (DO)bile duct adenocarcinoma0.00008657Highly InformativeDirect
Disease Ontology (DO)thyroid carcinoma0.0002962Highly InformativeDirect
Disease Ontology (DO)nasopharynx carcinoma0.0003858Highly InformativeDirect
Disease Ontology (DO)hemangioma0.01462Highly InformativeInherited

Document: DO annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)cardiovascular system phenotype0.0005232Least InformativeDirect
Mammalian Phenotype (MP)immune system phenotype0.09455Least InformativeInherited
Mammalian Phenotype (MP)abnormal homeostasis0.5414Least InformativeInherited
Mammalian Phenotype (MP)abnormal renal/urinary system morphology0.00408Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal heart morphology0.2466Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal fluid regulation0.0008498InformativeDirect
Mammalian Phenotype (MP)abnormal heart size0.09202InformativeInherited
Mammalian Phenotype (MP)enlarged heart0.0004985Highly InformativeDirect
Mammalian Phenotype (MP)abnormal heart right ventricle morphology0.02596Highly InformativeInherited

Document: MP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)anatomical group0Least InformativeDirect

Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details)
ZA termFDR (all)SDZA levelAnnotation (direct or inherited)
Zebrafish Anatomy (ZA)nervous system0Least InformativeDirect
Zebrafish Anatomy (ZA)organism subdivision0Least InformativeDirect
Zebrafish Anatomy (ZA)multi-tissue structure0Least InformativeDirect
Zebrafish Anatomy (ZA)cavitated compound organ0Least InformativeDirect
Zebrafish Anatomy (ZA)cell0Least InformativeDirect
Zebrafish Anatomy (ZA)cardiovascular system0Moderately InformativeDirect
Zebrafish Anatomy (ZA)central nervous system0Moderately InformativeDirect
Zebrafish Anatomy (ZA)head0Moderately InformativeDirect
Zebrafish Anatomy (ZA)vasculature0InformativeDirect
Zebrafish Anatomy (ZA)post-vent region0.07413InformativeInherited
Zebrafish Anatomy (ZA)trunk0.1224InformativeInherited
Zebrafish Anatomy (ZA)vein0.00005916Highly InformativeDirect
Zebrafish Anatomy (ZA)cranial vasculature0.0001166Highly InformativeDirect
Zebrafish Anatomy (ZA)post-vent vasculature0.02562Highly InformativeInherited
Zebrafish Anatomy (ZA)trunk vasculature0.04874Highly InformativeInherited

Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details) Document: XA annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Disease Ontology (DO) · Mouse Phenotype (MP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) ]

Internal database links

Superfamily level     Family level

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.

Superfamily level     Family level

Alignments of sequences to 43 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.

Superfamily level

Browse and view proteins in genomes which have different domain combinations including a Cystine-knot cytokines domain.

Superfamily level     Family level

Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.

Jump to [ Top of page · SCOP classification · Disease Ontology (DO) · Mouse Phenotype (MP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Internal database links ]