Platelet-derived growth factor-like family

SCOP classification

• Root: SCOP hierarchy in SUPERFAMILY [ 0] (11)
• Class: Small proteins [ 56992] (90)
• Fold: Cystine-knot cytokines [ 57500]
• Superfamily: Cystine-knot cytokines [ 57501] (7)
• Family: Platelet-derived growth factor-like [ 57502] (3)

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Family statistics

	Genomes (63)	Uniprot 2018_03 genome	PDB chains (SCOP 1.75)
Domains	361	1,131	13
Proteins	361	1,131	13

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Disease Ontology (DO)

Highlighted in gray are those with FDR_all>0.001

	DO term	FDR (all)	IC level	SDDO level	Annotation (direct or inherited)
Disease Ontology (DO)	disease of cellular proliferation	0	0.2322	--	DIRECT
Disease Ontology (DO)	cancer	0	0.2555	--	DIRECT
Disease Ontology (DO)	arteriovenous malformation	0.000000003904	2.513	--	DIRECT
Disease Ontology (DO)	follicular thyroid carcinoma	0.00000367	2.513	--	DIRECT
Disease Ontology (DO)	malignant mesothelioma	0.00002075	2.513	--	DIRECT
Disease Ontology (DO)	papillary thyroid carcinoma	0.00003129	2.513	--	DIRECT
Disease Ontology (DO)	arteriosclerotic cardiovascular disease	0.0001773	1.367	--	DIRECT
Disease Ontology (DO)	connective tissue cancer	0.0001795	1.367	--	DIRECT
Disease Ontology (DO)	rheumatic disease	0.0002352	1.513	--	DIRECT
Disease Ontology (DO)	collagen disease	0.0002787	1.472	--	DIRECT
Disease Ontology (DO)	thyroid cancer	0.0003251	1.911	--	DIRECT
Disease Ontology (DO)	non-small cell lung carcinoma	0.0003748	1.735	--	DIRECT
Disease Ontology (DO)	lung disease	0.000503	1.258	--	DIRECT
Disease Ontology (DO)	carcinoma	0.0006213	1.098	--	DIRECT
Disease Ontology (DO)	lung cancer	0.0006552	1.513	--	DIRECT
Disease Ontology (DO)	biliary tract cancer	0.0008561	1.911	--	DIRECT
Disease Ontology (DO)	vascular disease	0.002123	0.832	--	INHERITED FROM: arteriosclerotic cardiovascular disease || atherosclerosis
Disease Ontology (DO)	musculoskeletal system cancer	0.004571	1.283	--	INHERITED FROM: osteosarcoma || connective tissue cancer
Disease Ontology (DO)	respiratory system cancer	0.009236	1.434	--	INHERITED FROM: non-small cell lung carcinoma || lung carcinoma || lung cancer
Disease Ontology (DO)	respiratory system disease	0.01151	0.9334	--	INHERITED FROM: lung disease
Disease Ontology (DO)	pharynx cancer	0.01661	2.212	--	INHERITED FROM: nasopharynx carcinoma
Disease Ontology (DO)	cardiovascular system disease	0.02076	0.7889	--	INHERITED FROM: atherosclerosis || arteriosclerotic cardiovascular disease
Disease Ontology (DO)	arteriosclerosis	0.02685	1.367	--	INHERITED FROM: atherosclerosis || arteriosclerotic cardiovascular disease
Disease Ontology (DO)	disease of anatomical entity	0.03569	0.2414	--	INHERITED FROM: atherosclerosis || scleroderma || collagen disease || arteriosclerotic cardiovascular disease || lung disease || rheumatic disease
Disease Ontology (DO)	immune system disease	0.03823	0.8411	--	INHERITED FROM: rheumatic disease || scleroderma
Disease Ontology (DO)	liver cancer	0.0887	1.668	--	INHERITED FROM: liver carcinoma
Disease Ontology (DO)	musculoskeletal system disease	0.2412	0.89	--	INHERITED FROM: collagen disease || scleroderma
Disease Ontology (DO)	bone cancer	0.3208	1.61	--	INHERITED FROM: osteosarcoma
Disease Ontology (DO)	bile duct cancer	0.5402	1.911	--	INHERITED FROM: bile duct adenocarcinoma
Disease Ontology (DO)	hypersensitivity reaction disease	0.6459	0.8505	--	INHERITED FROM: scleroderma || rheumatic disease
Disease Ontology (DO)	bile duct carcinoma	1	1.911	--	INHERITED FROM: bile duct adenocarcinoma
Disease Ontology (DO)	organ system cancer	0.08532	0.4879	Least Informative	INHERITED FROM: thyroid carcinoma || osteosarcoma || lung cancer || non-small cell lung carcinoma || nasopharynx carcinoma || follicular thyroid carcinoma || thyroid cancer || papillary thyroid carcinoma || biliary tract cancer || liver carcinoma || bile duct adenocarcinoma || lung carcinoma || connective tissue cancer
Disease Ontology (DO)	benign neoplasm	0.00003174	1.191	Moderately Informative	DIRECT
Disease Ontology (DO)	artery disease	0.001071	0.9817	Moderately Informative	INHERITED FROM: atherosclerosis || arteriosclerotic cardiovascular disease
Disease Ontology (DO)	lower respiratory tract disease	0.002453	0.9947	Moderately Informative	INHERITED FROM: lung disease
Disease Ontology (DO)	gastrointestinal system cancer	0.02076	1.151	Moderately Informative	INHERITED FROM: bile duct adenocarcinoma || nasopharynx carcinoma || liver carcinoma || biliary tract cancer
Disease Ontology (DO)	hypersensitivity reaction type II disease	0.02139	0.8797	Moderately Informative	INHERITED FROM: rheumatic disease || scleroderma
Disease Ontology (DO)	cell type cancer	0.02213	0.9112	Moderately Informative	INHERITED FROM: malignant mesothelioma || carcinoma
Disease Ontology (DO)	connective tissue disease	0.06102	1.022	Moderately Informative	INHERITED FROM: scleroderma || collagen disease
Disease Ontology (DO)	cell type benign neoplasm	0.000001247	1.337	Informative	DIRECT
Disease Ontology (DO)	atherosclerosis	0.0001749	1.367	Informative	DIRECT
Disease Ontology (DO)	scleroderma	0.0002352	1.513	Informative	DIRECT
Disease Ontology (DO)	osteosarcoma	0.0005552	1.61	Informative	DIRECT
Disease Ontology (DO)	lung carcinoma	0.0006487	1.513	Informative	DIRECT
Disease Ontology (DO)	liver carcinoma	0.0006574	1.668	Informative	DIRECT
Disease Ontology (DO)	endocrine gland cancer	0.02469	1.337	Informative	INHERITED FROM: papillary thyroid carcinoma || follicular thyroid carcinoma || thyroid carcinoma || thyroid cancer
Disease Ontology (DO)	bile duct adenocarcinoma	0.00008657	1.911	Highly Informative	DIRECT
Disease Ontology (DO)	thyroid carcinoma	0.0002962	1.911	Highly Informative	DIRECT
Disease Ontology (DO)	nasopharynx carcinoma	0.0003858	2.212	Highly Informative	DIRECT
Disease Ontology (DO)	hemangioma	0.01462	1.911	Highly Informative	INHERITED FROM: arteriovenous malformation

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Mouse Phenotype (MP)

Highlighted in gray are those with FDR_all>0.001

	MP term	FDR (all)	IC level	SDMP level	Annotation (direct or inherited)
Mammalian Phenotype (MP)	abnormal lymphatic vessel morphology	0.00001367	2.302	--	DIRECT
Mammalian Phenotype (MP)	edema	0.00002128	1.7	--	DIRECT
Mammalian Phenotype (MP)	increased heart right ventricle size	0.00003974	2.603	--	DIRECT
Mammalian Phenotype (MP)	abnormal heart right ventricle size	0.00006819	2.603	--	DIRECT
Mammalian Phenotype (MP)	abnormal kidney cortex morphology	0.0001494	1.399	--	DIRECT
Mammalian Phenotype (MP)	abnormal kidney morphology	0.002982	1.156	--	INHERITED FROM: abnormal kidney cortex morphology
Mammalian Phenotype (MP)	renal/urinary system phenotype	0.00983	0.931	--	INHERITED FROM: abnormal kidney cortex morphology
Mammalian Phenotype (MP)	homeostasis/metabolism phenotype	0.01995	0.3626	--	INHERITED FROM: abnormal fluid regulation || edema
Mammalian Phenotype (MP)	increased heart ventricle size	0.03703	2.302	--	INHERITED FROM: increased heart right ventricle size
Mammalian Phenotype (MP)	abnormal heart ventricle morphology	0.09516	1.261	--	INHERITED FROM: increased heart right ventricle size || abnormal heart right ventricle size
Mammalian Phenotype (MP)	abnormal cardiovascular system morphology	0.3012	0.7902	--	INHERITED FROM: enlarged heart || abnormal heart right ventricle size || increased heart right ventricle size
Mammalian Phenotype (MP)	abnormal immune system morphology	0.3282	0.7223	--	INHERITED FROM: abnormal lymphatic vessel morphology
Mammalian Phenotype (MP)	cardiovascular system phenotype	0.0005232	0.6737	Least Informative	DIRECT
Mammalian Phenotype (MP)	immune system phenotype	0.09455	0.5462	Least Informative	INHERITED FROM: abnormal lymphatic vessel morphology
Mammalian Phenotype (MP)	abnormal homeostasis	0.5414	0.4926	Least Informative	INHERITED FROM: abnormal fluid regulation || edema
Mammalian Phenotype (MP)	abnormal renal/urinary system morphology	0.00408	1.047	Moderately Informative	INHERITED FROM: abnormal kidney cortex morphology
Mammalian Phenotype (MP)	abnormal heart morphology	0.2466	0.9597	Moderately Informative	INHERITED FROM: increased heart right ventricle size || abnormal heart right ventricle size || enlarged heart
Mammalian Phenotype (MP)	abnormal fluid regulation	0.0008498	1.373	Informative	DIRECT
Mammalian Phenotype (MP)	abnormal heart size	0.09202	1.603	Informative	INHERITED FROM: enlarged heart
Mammalian Phenotype (MP)	enlarged heart	0.0004985	2.001	Highly Informative	DIRECT
Mammalian Phenotype (MP)	abnormal heart right ventricle morphology	0.02596	2.001	Highly Informative	INHERITED FROM: increased heart right ventricle size || abnormal heart right ventricle size

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Fly Anatomy (FA)

Highlighted in gray are those with FDR_all>0.001

	FA term	FDR (all)	IC level	SDFA level	Annotation (direct or inherited)
Fly Anatomy (FA)	multicellular structure	0	0.008955	--	DIRECT
Fly Anatomy (FA)	anatomical structure	1	0	--	INHERITED FROM: multicellular structure
Fly Anatomy (FA)	material anatomical entity	1	0	--	INHERITED FROM: anatomical group || multicellular structure
Fly Anatomy (FA)	anatomical group	0	0.6816	Least Informative	DIRECT

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Zebrafish Anatomy (ZA)

Highlighted in gray are those with FDR_all>0.001

	ZA term	FDR (all)	IC level	SDZA level	Annotation (direct or inherited)
Zebrafish Anatomy (ZA)	brain	0	1.193	--	DIRECT
Zebrafish Anatomy (ZA)	compound organ	0	0.4299	--	DIRECT
Zebrafish Anatomy (ZA)	whole organism	0	0.00147	--	DIRECT
Zebrafish Anatomy (ZA)	anatomical system	0	0.1857	--	DIRECT
Zebrafish Anatomy (ZA)	anatomical group	0	0.1532	--	DIRECT
Zebrafish Anatomy (ZA)	cranial blood vessel	0.0000003307	2.471	--	DIRECT
Zebrafish Anatomy (ZA)	intersegmental vessel	0.0002624	2.17	--	DIRECT
Zebrafish Anatomy (ZA)	blood vasculature	0.007952	1.626	--	INHERITED FROM: intersegmental vessel || vein || cranial blood vessel
Zebrafish Anatomy (ZA)	blood vessel	0.00978	1.626	--	INHERITED FROM: vein || cranial blood vessel || intersegmental vessel
Zebrafish Anatomy (ZA)	anatomical structure	1	0	--	INHERITED FROM: vasculature || cell || intersegmental vessel || brain || anatomical system || multi-tissue structure || cranial blood vessel || cranial vasculature || anatomical group || whole organism || cardiovascular system || organism subdivision || compound organ || vein || central nervous system || cavitated compound organ || head || nervous system
Zebrafish Anatomy (ZA)	nervous system	0	0.7079	Least Informative	DIRECT
Zebrafish Anatomy (ZA)	organism subdivision	0	0.614	Least Informative	DIRECT
Zebrafish Anatomy (ZA)	multi-tissue structure	0	0.5848	Least Informative	DIRECT
Zebrafish Anatomy (ZA)	cavitated compound organ	0	0.5123	Least Informative	DIRECT
Zebrafish Anatomy (ZA)	cell	0	0.6388	Least Informative	DIRECT
Zebrafish Anatomy (ZA)	cardiovascular system	0	1.216	Moderately Informative	DIRECT
Zebrafish Anatomy (ZA)	central nervous system	0	1.04	Moderately Informative	DIRECT
Zebrafish Anatomy (ZA)	head	0	0.9398	Moderately Informative	DIRECT
Zebrafish Anatomy (ZA)	vasculature	0	1.471	Informative	DIRECT
Zebrafish Anatomy (ZA)	post-vent region	0.07413	1.568	Informative	INHERITED FROM: intersegmental vessel
Zebrafish Anatomy (ZA)	trunk	0.1224	1.568	Informative	INHERITED FROM: intersegmental vessel
Zebrafish Anatomy (ZA)	vein	0.00005916	2.17	Highly Informative	DIRECT
Zebrafish Anatomy (ZA)	cranial vasculature	0.0001166	2.17	Highly Informative	DIRECT
Zebrafish Anatomy (ZA)	post-vent vasculature	0.02562	1.869	Highly Informative	INHERITED FROM: intersegmental vessel
Zebrafish Anatomy (ZA)	trunk vasculature	0.04874	1.772	Highly Informative	INHERITED FROM: intersegmental vessel

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Xenopus Anatomy (XA)

Highlighted in gray are those with FDR_all>0.001

	XA term	FDR (all)	IC level	SDXA level	Annotation (direct or inherited)
Xenopus ANatomical entity (XAN)	anatomical structure	0	0	--	DIRECT
Xenopus DEvelopment stage (XDE)	NF stage	0	0.01895	--	DIRECT

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