Transforming growth factor (TGF)-beta family

SCOP classification

• Root: SCOP hierarchy in SUPERFAMILY [ 0] (11)
• Class: Small proteins [ 56992] (90)
• Fold: Cystine-knot cytokines [ 57500]
• Superfamily: Cystine-knot cytokines [ 57501] (7)
• Family: Transforming growth factor (TGF)-beta [ 57507] (7)

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Family statistics

	Genomes (140)	Uniprot 2018_03 genome	PDB chains (SCOP 1.75)
Domains	1,930	6,046	10
Proteins	1,929	6,040	10

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Disease Ontology (DO)

Highlighted in gray are those with FDR_all>0.001

	DO term	FDR (all)	IC level	SDDO level	Annotation (direct or inherited)
Disease Ontology (DO)	neurilemmoma	0.00000001576	2.513	--	DIRECT
Disease Ontology (DO)	neuroma	0.00000002792	2.513	--	DIRECT
Disease Ontology (DO)	ankylosis	0.000000126	2.513	--	DIRECT
Disease Ontology (DO)	otosclerosis	0.000000294	2.513	--	DIRECT
Disease Ontology (DO)	corneal edema	0.0000005881	2.513	--	DIRECT
Disease Ontology (DO)	keratopathy	0.0000005881	2.513	--	DIRECT
Disease Ontology (DO)	Hirschsprung's disease	0.00001326	2.513	--	DIRECT
Disease Ontology (DO)	colonic disease	0.0000884	2.513	--	DIRECT
Disease Ontology (DO)	hypogonadism	0.0001284	2.513	--	DIRECT
Disease Ontology (DO)	reproductive organ cancer	0.0004047	1.367	--	DIRECT
Disease Ontology (DO)	reproductive system disease	0.0004808	1.399	--	DIRECT
Disease Ontology (DO)	prostate cancer	0.0008779	1.735	--	DIRECT
Disease Ontology (DO)	basal cell carcinoma	0.000973	2.212	--	DIRECT
Disease Ontology (DO)	nervous system benign neoplasm	0.002005	2.513	--	INHERITED FROM: neuroma || neurilemmoma
Disease Ontology (DO)	bone disease	0.002516	1.171	--	INHERITED FROM: ankylosis
Disease Ontology (DO)	skin carcinoma	0.002896	2.212	--	INHERITED FROM: basal cell carcinoma
Disease Ontology (DO)	ovarian disease	0.006718	2.212	--	INHERITED FROM: premature ovarian failure
Disease Ontology (DO)	disease of cellular proliferation	0.007064	0.2322	--	INHERITED FROM: basal cell carcinoma || neurilemmoma || reproductive organ cancer || prostate cancer || benign neoplasm || neuroma
Disease Ontology (DO)	disease of anatomical entity	0.01465	0.2414	--	INHERITED FROM: keratopathy || ankylosis || hypogonadism || otosclerosis || reproductive system disease || colonic disease || Hirschsprung's disease || premature ovarian failure || corneal edema || hypertension
Disease Ontology (DO)	auditory system disease	0.02096	2.036	--	INHERITED FROM: otosclerosis
Disease Ontology (DO)	musculoskeletal system disease	0.03059	0.89	--	INHERITED FROM: ankylosis
Disease Ontology (DO)	sensory system disease	0.03066	1.399	--	INHERITED FROM: keratopathy || otosclerosis || corneal edema
Disease Ontology (DO)	intestinal disease	0.0417	1.399	--	INHERITED FROM: Hirschsprung's disease || colonic disease
Disease Ontology (DO)	cardiovascular system disease	0.04367	0.7889	--	INHERITED FROM: hypertension
Disease Ontology (DO)	endocrine system disease	0.1103	1.309	--	INHERITED FROM: hypogonadism
Disease Ontology (DO)	bone inflammation disease	0.244	1.309	--	INHERITED FROM: ankylosis
Disease Ontology (DO)	vascular disease	0.2447	0.832	--	INHERITED FROM: hypertension
Disease Ontology (DO)	eye and adnexa disease	0.6588	1.472	--	INHERITED FROM: keratopathy || corneal edema
Disease Ontology (DO)	cancer	0.8064	0.2555	--	INHERITED FROM: prostate cancer || reproductive organ cancer || basal cell carcinoma
Disease Ontology (DO)	megacolon	1	2.513	--	INHERITED FROM: Hirschsprung's disease
Disease Ontology (DO)	skin cancer	1	2.212	--	INHERITED FROM: basal cell carcinoma
Disease Ontology (DO)	organ system cancer	0.3275	0.4879	Least Informative	INHERITED FROM: basal cell carcinoma || reproductive organ cancer || prostate cancer
Disease Ontology (DO)	nervous system disease	0.8355	0.7279	Least Informative	INHERITED FROM: keratopathy || corneal edema || otosclerosis
Disease Ontology (DO)	benign neoplasm	0.00002999	1.191	Moderately Informative	DIRECT
Disease Ontology (DO)	syndrome	0.01516	1.151	Moderately Informative	INHERITED FROM: polycystic ovary syndrome
Disease Ontology (DO)	artery disease	0.3183	0.9817	Moderately Informative	INHERITED FROM: hypertension
Disease Ontology (DO)	connective tissue disease	0.6457	1.022	Moderately Informative	INHERITED FROM: ankylosis
Disease Ontology (DO)	gastrointestinal system disease	0.7203	0.8797	Moderately Informative	INHERITED FROM: Hirschsprung's disease || colonic disease
Disease Ontology (DO)	hypertension	0.0001539	1.434	Informative	DIRECT
Disease Ontology (DO)	physical disorder	0.000375	1.559	Informative	DIRECT
Disease Ontology (DO)	organ system benign neoplasm	0.008517	1.559	Informative	INHERITED FROM: neurilemmoma || neuroma
Disease Ontology (DO)	eye disease	0.0539	1.472	Informative	INHERITED FROM: corneal edema || keratopathy
Disease Ontology (DO)	female reproductive system disease	0.06972	1.472	Informative	INHERITED FROM: premature ovarian failure
Disease Ontology (DO)	arthropathy	0.07017	1.735	Informative	INHERITED FROM: ankylosis
Disease Ontology (DO)	male reproductive organ cancer	0.2212	1.61	Informative	INHERITED FROM: prostate cancer
Disease Ontology (DO)	premature ovarian failure	0.0000005094	2.212	Highly Informative	DIRECT
Disease Ontology (DO)	polycystic ovary syndrome	0.000755	1.814	Highly Informative	DIRECT
Disease Ontology (DO)	inner ear disease	0.00132	2.036	Highly Informative	INHERITED FROM: otosclerosis
Disease Ontology (DO)	gonadal disease	0.006323	2.036	Highly Informative	INHERITED FROM: hypogonadism
Disease Ontology (DO)	corneal disease	0.008565	2.212	Highly Informative	INHERITED FROM: corneal edema || keratopathy
Disease Ontology (DO)	integumentary system cancer	0.01935	1.814	Highly Informative	INHERITED FROM: basal cell carcinoma

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Human Phenotype (HP)

Highlighted in gray are those with FDR_all>0.001

	HP term	FDR (all)	IC level	SDHP level	Annotation (direct or inherited)
Phenotypic Abnormality (PA)	Spondylolisthesis	0.0002488	2.462	--	DIRECT
Phenotypic Abnormality (PA)	Short middle phalanx of finger	0.0003121	2.462	--	DIRECT
Phenotypic Abnormality (PA)	Aplasia/Hypoplasia of the middle phalanges of the hand	0.000595	2.462	--	DIRECT
Phenotypic Abnormality (PA)	Transient ischemic attack	0.0006543	2.161	--	DIRECT
Phenotypic Abnormality (PA)	Abnormal middle phalanx morphology of the hand	0.0006543	2.462	--	DIRECT
Phenotypic Abnormality (PA)	Intestinal obstruction	0.0008054	2.462	--	DIRECT
Phenotypic Abnormality (PA)	Gastrointestinal obstruction	0.003319	2.462	--	INHERITED FROM: Intestinal obstruction
Phenotypic Abnormality (PA)	Abnormal appendicular skeleton morphology	0.003526	0.8289	--	INHERITED FROM: Aplasia/Hypoplasia of the middle phalanges of the hand || Abnormal middle phalanx morphology of the hand || Short middle phalanx of finger
Phenotypic Abnormality (PA)	Abnormality of limb bone	0.006726	0.9572	--	INHERITED FROM: Short middle phalanx of finger || Abnormal middle phalanx morphology of the hand || Aplasia/Hypoplasia of the middle phalanges of the hand
Phenotypic Abnormality (PA)	Short phalanx of finger	0.03037	2.161	--	INHERITED FROM: Short middle phalanx of finger
Phenotypic Abnormality (PA)	Arterial stenosis	0.03488	1.86	--	INHERITED FROM: Transient ischemic attack
Phenotypic Abnormality (PA)	Abnormality of cardiovascular system morphology	0.03728	0.8391	--	INHERITED FROM: Transient ischemic attack
Phenotypic Abnormality (PA)	Abnormal cerebral artery morphology	0.0639	1.985	--	INHERITED FROM: Transient ischemic attack
Phenotypic Abnormality (PA)	Morphological abnormality of the central nervous system	0.06506	0.533	--	INHERITED FROM: Transient ischemic attack
Phenotypic Abnormality (PA)	Abnormality of the upper limb	0.06753	0.9183	--	INHERITED FROM: Short middle phalanx of finger || Abnormal middle phalanx morphology of the hand || Aplasia/Hypoplasia of the middle phalanges of the hand
Phenotypic Abnormality (PA)	Abnormality of finger	0.09062	1.258	--	INHERITED FROM: Abnormal middle phalanx morphology of the hand || Aplasia/Hypoplasia of the middle phalanges of the hand || Short middle phalanx of finger
Phenotypic Abnormality (PA)	Abnormality of the vasculature	0.1863	0.7142	--	INHERITED FROM: Transient ischemic attack
Phenotypic Abnormality (PA)	Abnormality of the skeletal system	0.189	0.4712	--	INHERITED FROM: Abnormal middle phalanx morphology of the hand || Spondylolisthesis || Short middle phalanx of finger || Aplasia/Hypoplasia of the middle phalanges of the hand
Phenotypic Abnormality (PA)	Short finger	0.2289	2.161	--	INHERITED FROM: Short middle phalanx of finger
Phenotypic Abnormality (PA)	Abnormality of the nervous system	0.2427	0.2371	--	INHERITED FROM: Transient ischemic attack
Phenotypic Abnormality (PA)	Morphological abnormality of the gastrointestinal tract	0.2671	1.184	--	INHERITED FROM: Intestinal obstruction
Phenotypic Abnormality (PA)	Aplasia/hypoplasia of the extremities	0.3411	1.462	--	INHERITED FROM: Short middle phalanx of finger
Phenotypic Abnormality (PA)	Abnormal digit morphology	0.3546	1.14	--	INHERITED FROM: Short middle phalanx of finger || Abnormal middle phalanx morphology of the hand || Aplasia/Hypoplasia of the middle phalanges of the hand
Phenotypic Abnormality (PA)	Abnormality of brain morphology	0.3858	0.6631	--	INHERITED FROM: Transient ischemic attack
Phenotypic Abnormality (PA)	Aplasia/hypoplasia involving bones of the upper limbs	0.389	1.559	--	INHERITED FROM: Short middle phalanx of finger
Phenotypic Abnormality (PA)	Abnormal axial skeleton morphology	0.4587	0.6771	--	INHERITED FROM: Spondylolisthesis
Phenotypic Abnormality (PA)	Aplasia/hypoplasia involving bones of the hand	0.6186	1.684	--	INHERITED FROM: Short middle phalanx of finger
Phenotypic Abnormality (PA)	Aplasia/hypoplasia involving the skeleton	0.6704	1.383	--	INHERITED FROM: Short middle phalanx of finger
Phenotypic Abnormality (PA)	Abnormality of the digestive system	0.041	0.5759	Least Informative	INHERITED FROM: Intestinal obstruction
Phenotypic Abnormality (PA)	Abnormality of limbs	0.07124	0.6429	Least Informative	INHERITED FROM: Short middle phalanx of finger || Abnormal middle phalanx morphology of the hand || Aplasia/Hypoplasia of the middle phalanges of the hand
Phenotypic Abnormality (PA)	Abnormality of skeletal morphology	0.147	0.513	Least Informative	INHERITED FROM: Aplasia/Hypoplasia of the middle phalanges of the hand || Abnormal middle phalanx morphology of the hand || Spondylolisthesis || Short middle phalanx of finger
Phenotypic Abnormality (PA)	Abnormality of nervous system morphology	0.1806	0.4756	Least Informative	INHERITED FROM: Transient ischemic attack
Phenotypic Abnormality (PA)	Abnormality of the cardiovascular system	0.2477	0.5179	Least Informative	INHERITED FROM: Transient ischemic attack
Phenotypic Abnormality (PA)	Abnormality of the vertebral column	0.01209	1.031	Moderately Informative	INHERITED FROM: Spondylolisthesis
Phenotypic Abnormality (PA)	Abnormality of the gastrointestinal tract	0.0236	1.031	Moderately Informative	INHERITED FROM: Intestinal obstruction
Phenotypic Abnormality (PA)	Abnormality of digestive system morphology	0.03217	1.184	Moderately Informative	INHERITED FROM: Intestinal obstruction
Phenotypic Abnormality (PA)	Abnormal vascular morphology	0.05078	1.207	Moderately Informative	INHERITED FROM: Transient ischemic attack
Phenotypic Abnormality (PA)	Abnormality of limb bone morphology	0.4948	0.9572	Moderately Informative	INHERITED FROM: Abnormal middle phalanx morphology of the hand || Short middle phalanx of finger || Aplasia/Hypoplasia of the middle phalanges of the hand
Phenotypic Abnormality (PA)	Abnormality of the hand	0.5942	1.031	Moderately Informative	INHERITED FROM: Aplasia/Hypoplasia of the middle phalanges of the hand || Abnormal middle phalanx morphology of the hand || Short middle phalanx of finger
Phenotypic Abnormality (PA)	Abnormality of digestive system physiology	0.7734	0.9572	Moderately Informative	INHERITED FROM: Intestinal obstruction
Phenotypic Abnormality (PA)	Abnormality of the cerebral vasculature	0.04045	1.462	Informative	INHERITED FROM: Transient ischemic attack
Phenotypic Abnormality (PA)	Functional abnormality of the gastrointestinal tract	0.05724	1.421	Informative	INHERITED FROM: Intestinal obstruction
Phenotypic Abnormality (PA)	Abnormal systemic arterial morphology	0.2437	1.421	Informative	INHERITED FROM: Transient ischemic attack
Phenotypic Abnormality (PA)	Abnormal intestine morphology	0.5967	1.421	Informative	INHERITED FROM: Intestinal obstruction
Phenotypic Abnormality (PA)	Aplasia/hypoplasia involving bones of the extremities	0.6203	1.508	Informative	INHERITED FROM: Short middle phalanx of finger
Phenotypic Abnormality (PA)	Abnormal finger phalanx morphology	0.9359	1.508	Informative	INHERITED FROM: Short middle phalanx of finger || Abnormal middle phalanx morphology of the hand || Aplasia/Hypoplasia of the middle phalanges of the hand
Phenotypic Abnormality (PA)	Aplasia/Hypoplasia of the phalanges of the hand	0.04175	1.86	Highly Informative	INHERITED FROM: Short middle phalanx of finger || Aplasia/Hypoplasia of the middle phalanges of the hand
Phenotypic Abnormality (PA)	Stroke	0.0966	2.161	Highly Informative	INHERITED FROM: Transient ischemic attack
Phenotypic Abnormality (PA)	Cerebral ischemia	0.2579	1.985	Highly Informative	INHERITED FROM: Transient ischemic attack
Phenotypic Abnormality (PA)	Abnormal hand morphology	0.3555	1.985	Highly Informative	INHERITED FROM: Short middle phalanx of finger
Phenotypic Abnormality (PA)	Short digit	0.3662	1.86	Highly Informative	INHERITED FROM: Short middle phalanx of finger
Phenotypic Abnormality (PA)	Aplasia/Hypoplasia of fingers	0.4298	1.985	Highly Informative	INHERITED FROM: Short middle phalanx of finger

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Mouse Phenotype (MP)

Highlighted in gray are those with FDR_all>0.001

	MP term	FDR (all)	IC level	SDMP level	Annotation (direct or inherited)
Mammalian Phenotype (MP)	absent alisphenoid bone	0.000000008616	2.603	--	DIRECT
Mammalian Phenotype (MP)	increased ovary weight	0.00000001817	2.603	--	DIRECT
Mammalian Phenotype (MP)	absent mandibular angle	0.00000001817	2.603	--	DIRECT
Mammalian Phenotype (MP)	large anterior fontanelle	0.00000006055	2.603	--	DIRECT
Mammalian Phenotype (MP)	abnormal interdigital cell death	0.000001131	2.603	--	DIRECT
Mammalian Phenotype (MP)	complete atrioventricular septal defect	0.000001189	2.603	--	DIRECT
Mammalian Phenotype (MP)	abnormal mandibular condyloid process morphology	0.000001987	2.603	--	DIRECT
Mammalian Phenotype (MP)	increased skeletal muscle weight	0.000002019	2.603	--	DIRECT
Mammalian Phenotype (MP)	abnormal anterior visceral endoderm cell migration	0.000002019	2.603	--	DIRECT
Mammalian Phenotype (MP)	absent oocytes	0.00000249	2.603	--	DIRECT
Mammalian Phenotype (MP)	small interparietal bone	0.000003095	2.603	--	DIRECT
Mammalian Phenotype (MP)	abnormal mandibular coronoid process morphology	0.000003095	2.302	--	DIRECT
Mammalian Phenotype (MP)	absent squamosal bone	0.000003264	2.603	--	DIRECT
Mammalian Phenotype (MP)	reproductive system phenotype	0.000003362	0.8397	--	DIRECT
Mammalian Phenotype (MP)	abnormal female genitalia morphology	0.000004273	1.261	--	DIRECT
Mammalian Phenotype (MP)	small zygomatic bone	0.000005002	2.603	--	DIRECT
Mammalian Phenotype (MP)	increased muscle weight	0.000007318	2.603	--	DIRECT
Mammalian Phenotype (MP)	broad limb buds	0.000007318	2.603	--	DIRECT
Mammalian Phenotype (MP)	abnormal digit morphology	0.000007755	1.603	--	DIRECT
Mammalian Phenotype (MP)	increased skeletal muscle size	0.00001033	2.603	--	DIRECT
Mammalian Phenotype (MP)	absent zygomatic bone	0.00001033	2.603	--	DIRECT
Mammalian Phenotype (MP)	abnormal alisphenoid bone morphology	0.00001121	2.603	--	DIRECT
Mammalian Phenotype (MP)	granulomatous inflammation	0.00001308	2.302	--	DIRECT
Mammalian Phenotype (MP)	abnormal internal male genitalia morphology	0.00002566	1.373	--	DIRECT
Mammalian Phenotype (MP)	increased circulating follicle stimulating hormone level	0.00002958	2.603	--	DIRECT
Mammalian Phenotype (MP)	embryonic-extraembryonic boundary constriction	0.00003077	2.603	--	DIRECT
Mammalian Phenotype (MP)	abnormal cranium morphology	0.00003941	1.205	--	DIRECT
Mammalian Phenotype (MP)	abnormal forelimb morphology	0.00003975	1.758	--	DIRECT
Mammalian Phenotype (MP)	absent vitelline blood vessels	0.00004097	2.302	--	DIRECT
Mammalian Phenotype (MP)	abnormal sex gland morphology	0.00004258	1.141	--	DIRECT
Mammalian Phenotype (MP)	abnormal visceral endoderm physiology	0.00004452	2.603	--	DIRECT
Mammalian Phenotype (MP)	absent tympanic ring	0.00004759	2.603	--	DIRECT
Mammalian Phenotype (MP)	small nasal bone	0.00005235	2.302	--	DIRECT
Mammalian Phenotype (MP)	decreased tympanic ring size	0.00005804	2.603	--	DIRECT
Mammalian Phenotype (MP)	abnormal mandibular angle morphology	0.00006902	2.603	--	DIRECT
Mammalian Phenotype (MP)	increased skeletal muscle mass	0.00006967	2.603	--	DIRECT
Mammalian Phenotype (MP)	decreased cornea thickness	0.00009797	2.302	--	DIRECT
Mammalian Phenotype (MP)	absent allantois	0.0001144	2.603	--	DIRECT
Mammalian Phenotype (MP)	decreased nephron number	0.0001536	2.603	--	DIRECT
Mammalian Phenotype (MP)	abnormal skeletal muscle weight	0.0001767	2.302	--	DIRECT
Mammalian Phenotype (MP)	atrioventricular septal defect	0.0001833	2.603	--	DIRECT
Mammalian Phenotype (MP)	abnormal oocyte number	0.0001973	2.126	--	DIRECT
Mammalian Phenotype (MP)	abnormal anus morphology	0.0002015	2.603	--	DIRECT
Mammalian Phenotype (MP)	digestive/alimentary phenotype	0.0002072	0.9404	--	DIRECT
Mammalian Phenotype (MP)	abnormal basal metabolism	0.0002559	2.302	--	DIRECT
Mammalian Phenotype (MP)	abnormal retroperitoneal fat pad morphology	0.0002876	2.603	--	DIRECT
Mammalian Phenotype (MP)	abnormal metanephric mesenchyme morphology	0.0003216	2.302	--	DIRECT
Mammalian Phenotype (MP)	abnormal heart position or orientation	0.0003348	2.603	--	DIRECT
Mammalian Phenotype (MP)	abnormal apical ectodermal ridge morphology	0.000398	2.603	--	DIRECT
Mammalian Phenotype (MP)	abnormal fontanelle morphology	0.000491	2.603	--	DIRECT
Mammalian Phenotype (MP)	absent maxilla	0.0004929	2.603	--	DIRECT
Mammalian Phenotype (MP)	epididymis degeneration	0.0005017	2.603	--	DIRECT
Mammalian Phenotype (MP)	abnormal enteric neuron morphology	0.0005179	2.603	--	DIRECT
Mammalian Phenotype (MP)	decreased circulating follicle stimulating hormone level	0.0005293	2.302	--	DIRECT
Mammalian Phenotype (MP)	atrial septal defect	0.0005766	2.302	--	DIRECT
Mammalian Phenotype (MP)	abnormal pituitary hormone level	0.0005949	1.758	--	DIRECT
Mammalian Phenotype (MP)	chronic inflammation	0.0006103	2.302	--	DIRECT
Mammalian Phenotype (MP)	abnormal amniotic cavity morphology	0.0006149	2.603	--	DIRECT
Mammalian Phenotype (MP)	abnormal enteric nervous system morphology	0.0006301	2.603	--	DIRECT
Mammalian Phenotype (MP)	absent somites	0.0006301	2.302	--	DIRECT
Mammalian Phenotype (MP)	abnormal limb long bone morphology	0.0006646	1.649	--	DIRECT
Mammalian Phenotype (MP)	abnormal incisor morphology	0.000674	2.302	--	DIRECT
Mammalian Phenotype (MP)	asymmetric rib joints	0.0007453	2.603	--	DIRECT
Mammalian Phenotype (MP)	abnormal oocyte morphology	0.0008651	2.126	--	DIRECT
Mammalian Phenotype (MP)	craniofacial phenotype	0.0008853	1.047	--	DIRECT
Mammalian Phenotype (MP)	abnormal skeleton morphology	0.0009347	0.8323	--	DIRECT
Mammalian Phenotype (MP)	enlarged ovary	0.0009668	2.603	--	DIRECT
Mammalian Phenotype (MP)	failure of somite differentiation	0.001093	2.302	--	INHERITED FROM: absent somites
Mammalian Phenotype (MP)	abnormal digit development	0.001468	2.302	--	INHERITED FROM: abnormal interdigital cell death
Mammalian Phenotype (MP)	abnormal palate morphology	0.00164	1.758	--	INHERITED FROM: cleft palate
Mammalian Phenotype (MP)	abnormal gland morphology	0.001883	0.7519	--	INHERITED FROM: increased ovary weight || enlarged ovary || abnormal sex gland morphology
Mammalian Phenotype (MP)	skeleton phenotype	0.001911	0.8038	--	INHERITED FROM: small interparietal bone || abnormal bone ossification || asymmetric rib joints || abnormal mandibular coronoid process morphology || abnormal cranium morphology || abnormal limb long bone morphology || abnormal mandibular condyloid process morphology || abnormal incisor morphology || abnormal skeleton morphology || abnormal fontanelle morphology || small nasal bone || absent maxilla || absent squamosal bone || absent zygomatic bone || abnormal alisphenoid bone morphology || absent alisphenoid bone || large anterior fontanelle || small zygomatic bone || absent mandibular angle || abnormal mandibular angle morphology
Mammalian Phenotype (MP)	abnormal mandibule ramus morphology	0.002005	2.302	--	INHERITED FROM: abnormal mandibular condyloid process morphology || abnormal mandibular coronoid process morphology
Mammalian Phenotype (MP)	abnormal limb morphology	0.002077	1.281	--	INHERITED FROM: abnormal interdigital cell death || abnormal limb long bone morphology || abnormal apical ectodermal ridge morphology || abnormal forelimb morphology || abnormal digit morphology || broad limb buds
Mammalian Phenotype (MP)	embryo phenotype	0.002149	0.8708	--	INHERITED FROM: absent vitelline blood vessels || broad limb buds || absent allantois || abnormal apical ectodermal ridge morphology || abnormal amniotic cavity morphology || embryonic-extraembryonic boundary constriction || abnormal anterior visceral endoderm cell migration || absent somites || abnormal visceral endoderm physiology
Mammalian Phenotype (MP)	abnormal embryonic-extraembryonic boundary morphology	0.002751	2.302	--	INHERITED FROM: embryonic-extraembryonic boundary constriction
Mammalian Phenotype (MP)	abnormal heart atrium and ventricle connection	0.003845	1.904	--	INHERITED FROM: abnormal atrioventricular valve morphology
Mammalian Phenotype (MP)	abnormal skeletal muscle size	0.004	2.126	--	INHERITED FROM: increased skeletal muscle weight || increased skeletal muscle size || abnormal skeletal muscle weight
Mammalian Phenotype (MP)	abnormal nephron number	0.004033	2.603	--	INHERITED FROM: decreased nephron number
Mammalian Phenotype (MP)	renal/urinary system phenotype	0.00475	0.931	--	INHERITED FROM: abnormal metanephric mesenchyme morphology || abnormal renal/urinary system morphology || decreased nephron number
Mammalian Phenotype (MP)	abnormal muscle weight	0.006264	2.302	--	INHERITED FROM: increased muscle weight || abnormal skeletal muscle weight || increased skeletal muscle weight
Mammalian Phenotype (MP)	abnormal atrioventricular septum morphology	0.008341	2.603	--	INHERITED FROM: complete atrioventricular septal defect || atrioventricular septal defect
Mammalian Phenotype (MP)	abnormal ovary weight	0.009772	2.603	--	INHERITED FROM: increased ovary weight
Mammalian Phenotype (MP)	abnormal interparietal bone morphology	0.01166	2.603	--	INHERITED FROM: small interparietal bone
Mammalian Phenotype (MP)	abnormal anal canal morphology	0.0119	2.302	--	INHERITED FROM: abnormal anus morphology
Mammalian Phenotype (MP)	abnormal facial morphology	0.01221	1.348	--	INHERITED FROM: abnormal incisor morphology || cleft palate
Mammalian Phenotype (MP)	abnormal ear morphology	0.01223	1.281	--	INHERITED FROM: decreased tympanic ring size || absent tympanic ring
Mammalian Phenotype (MP)	abnormal craniofacial bone morphology	0.01231	1.205	--	INHERITED FROM: absent mandibular angle || abnormal mandibular condyloid process morphology || abnormal incisor morphology || abnormal mandibular angle morphology || small nasal bone || abnormal fontanelle morphology || abnormal mandibular coronoid process morphology || large anterior fontanelle || small zygomatic bone || abnormal cranium morphology || small interparietal bone || absent alisphenoid bone || absent maxilla || absent squamosal bone || absent zygomatic bone || abnormal alisphenoid bone morphology
Mammalian Phenotype (MP)	vision/eye phenotype	0.01245	0.8789	--	INHERITED FROM: decreased cornea thickness
Mammalian Phenotype (MP)	abnormal interatrial septum morphology	0.01248	2.302	--	INHERITED FROM: atrial septal defect
Mammalian Phenotype (MP)	abnormal cell morphology	0.0127	1.324	--	INHERITED FROM: absent oocytes || abnormal oocyte number || abnormal oocyte morphology
Mammalian Phenotype (MP)	abnormal cornea thickness	0.02496	2.302	--	INHERITED FROM: decreased cornea thickness
Mammalian Phenotype (MP)	increased follicle stimulating hormone level	0.02863	2.603	--	INHERITED FROM: increased circulating follicle stimulating hormone level
Mammalian Phenotype (MP)	abnormal fetal atrioventricular canal morphology	0.02902	2.001	--	INHERITED FROM: abnormal atrioventricular cushion morphology
Mammalian Phenotype (MP)	abnormal heart valve morphology	0.0291	1.904	--	INHERITED FROM: abnormal atrioventricular valve morphology
Mammalian Phenotype (MP)	decreased oocyte number	0.03437	2.603	--	INHERITED FROM: absent oocytes
Mammalian Phenotype (MP)	abnormal zygomatic bone morphology	0.04298	2.603	--	INHERITED FROM: small zygomatic bone || absent zygomatic bone
Mammalian Phenotype (MP)	abnormal nasal bone morphology	0.05052	2.302	--	INHERITED FROM: small nasal bone
Mammalian Phenotype (MP)	abnormal kidney development	0.05116	2.126	--	INHERITED FROM: abnormal metanephric mesenchyme morphology
Mammalian Phenotype (MP)	abnormal female reproductive system morphology	0.05587	1.261	--	INHERITED FROM: enlarged ovary || increased ovary weight || abnormal female genitalia morphology
Mammalian Phenotype (MP)	abnormal joint morphology	0.05678	1.825	--	INHERITED FROM: asymmetric rib joints
Mammalian Phenotype (MP)	abnormal kidney mesenchyme morphology	0.05936	2.302	--	INHERITED FROM: abnormal metanephric mesenchyme morphology
Mammalian Phenotype (MP)	abnormal extraembryonic tissue morphology	0.06121	1.348	--	INHERITED FROM: absent allantois || absent vitelline blood vessels || abnormal amniotic cavity morphology
Mammalian Phenotype (MP)	abnormal embryonic tissue morphology	0.06399	1.281	--	INHERITED FROM: broad limb buds || abnormal apical ectodermal ridge morphology || absent somites
Mammalian Phenotype (MP)	abnormal vascular development	0.06648	1.223	--	INHERITED FROM: absent vitelline blood vessels
Mammalian Phenotype (MP)	abnormal cardiovascular system morphology	0.0741	0.7902	--	INHERITED FROM: absent vitelline blood vessels || atrioventricular septal defect || complete atrioventricular septal defect || abnormal atrioventricular valve morphology || atrial septal defect || abnormal atrioventricular cushion morphology || abnormal heart position or orientation
Mammalian Phenotype (MP)	abnormal sphenoid bone morphology	0.07828	2.603	--	INHERITED FROM: abnormal alisphenoid bone morphology || absent alisphenoid bone
Mammalian Phenotype (MP)	abnormal litter size	0.08146	1.649	--	INHERITED FROM: decreased litter size
Mammalian Phenotype (MP)	abnormal appendicular skeleton morphology	0.08422	1.373	--	INHERITED FROM: abnormal limb long bone morphology
Mammalian Phenotype (MP)	absent germ cells	0.09167	1.825	--	INHERITED FROM: absent oocytes
Mammalian Phenotype (MP)	abnormal circulating hormone level	0.09202	1.241	--	INHERITED FROM: abnormal circulating pituitary hormone level || decreased circulating follicle stimulating hormone level || increased circulating follicle stimulating hormone level || abnormal circulating gonadotropin level
Mammalian Phenotype (MP)	muscle phenotype	0.09309	0.8473	--	INHERITED FROM: abnormal skeletal muscle weight || increased skeletal muscle size || increased skeletal muscle mass || increased muscle weight || increased skeletal muscle weight
Mammalian Phenotype (MP)	abnormal viscerocranium morphology	0.09447	1.399	--	INHERITED FROM: absent zygomatic bone || abnormal mandibular coronoid process morphology || small zygomatic bone || absent maxilla || small nasal bone || abnormal mandibular angle morphology || abnormal incisor morphology || abnormal mandibular condyloid process morphology || absent mandibular angle
Mammalian Phenotype (MP)	abnormal nervous system morphology	0.158	0.5861	--	INHERITED FROM: abnormal enteric nervous system morphology || abnormal enteric neuron morphology
Mammalian Phenotype (MP)	abnormal limb bud morphology	0.1616	2.302	--	INHERITED FROM: broad limb buds || abnormal apical ectodermal ridge morphology
Mammalian Phenotype (MP)	abnormal allantois morphology	0.1624	2.603	--	INHERITED FROM: absent allantois
Mammalian Phenotype (MP)	abnormal skeleton physiology	0.1712	1.302	--	INHERITED FROM: abnormal bone ossification
Mammalian Phenotype (MP)	abnormal tympanic ring morphology	0.1716	2.302	--	INHERITED FROM: absent tympanic ring || decreased tympanic ring size
Mammalian Phenotype (MP)	abnormal ectoderm morphology	0.1895	2.603	--	INHERITED FROM: abnormal apical ectodermal ridge morphology
Mammalian Phenotype (MP)	abnormal apoptosis	0.1913	1.023	--	INHERITED FROM: abnormal interdigital cell death
Mammalian Phenotype (MP)	abnormal fertility/fecundity	0.2016	1.302	--	INHERITED FROM: decreased litter size
Mammalian Phenotype (MP)	abnormal gametogenesis	0.2269	1.324	--	INHERITED FROM: abnormal oocyte number || absent oocytes || abnormal oocyte morphology
Mammalian Phenotype (MP)	decreased follicle stimulating hormone level	0.2383	2.302	--	INHERITED FROM: decreased circulating follicle stimulating hormone level
Mammalian Phenotype (MP)	abnormal ovary size	0.245	2.302	--	INHERITED FROM: increased ovary weight || enlarged ovary
Mammalian Phenotype (MP)	abnormal squamosal bone morphology	0.2666	2.126	--	INHERITED FROM: absent squamosal bone
Mammalian Phenotype (MP)	abnormal neurocranium morphology	0.2688	1.904	--	INHERITED FROM: absent squamosal bone || abnormal alisphenoid bone morphology || abnormal fontanelle morphology || small interparietal bone || large anterior fontanelle || absent alisphenoid bone
Mammalian Phenotype (MP)	abnormal female reproductive gland morphology	0.305	1.427	--	INHERITED FROM: enlarged ovary || increased ovary weight
Mammalian Phenotype (MP)	increased circulating pituitary hormone level	0.3291	2.302	--	INHERITED FROM: increased circulating follicle stimulating hormone level
Mammalian Phenotype (MP)	increased circulating gonadotropin level	0.3422	2.603	--	INHERITED FROM: increased circulating follicle stimulating hormone level
Mammalian Phenotype (MP)	increased pituitary hormone level	0.3652	2.302	--	INHERITED FROM: increased circulating follicle stimulating hormone level
Mammalian Phenotype (MP)	abnormal male reproductive system morphology	0.389	1.348	--	INHERITED FROM: abnormal internal male genitalia morphology || epididymis degeneration
Mammalian Phenotype (MP)	abnormal blood homeostasis	0.3891	0.6893	--	INHERITED FROM: decreased circulating follicle stimulating hormone level || increased circulating follicle stimulating hormone level || abnormal circulating pituitary hormone level || abnormal circulating gonadotropin level
Mammalian Phenotype (MP)	abnormal somite development	0.4193	1.904	--	INHERITED FROM: absent somites
Mammalian Phenotype (MP)	abnormal nephron morphology	0.4262	1.261	--	INHERITED FROM: decreased nephron number
Mammalian Phenotype (MP)	abnormal adipose tissue morphology	0.4646	1.223	--	INHERITED FROM: abnormal retroperitoneal fat pad morphology
Mammalian Phenotype (MP)	decreased circulating pituitary hormone level	0.4721	2.302	--	INHERITED FROM: decreased circulating follicle stimulating hormone level
Mammalian Phenotype (MP)	abnormal kidney morphology	0.5049	1.156	--	INHERITED FROM: decreased nephron number || abnormal metanephric mesenchyme morphology
Mammalian Phenotype (MP)	homeostasis/metabolism phenotype	0.5273	0.3626	--	INHERITED FROM: abnormal follicle stimulating hormone level || abnormal circulating gonadotropin level || increased circulating follicle stimulating hormone level || abnormal basal metabolism || abnormal pituitary hormone level || abnormal circulating pituitary hormone level || decreased circulating follicle stimulating hormone level
Mammalian Phenotype (MP)	decreased germ cell number	0.5432	1.562	--	INHERITED FROM: absent oocytes
Mammalian Phenotype (MP)	decreased pituitary hormone level	0.5593	2.302	--	INHERITED FROM: decreased circulating follicle stimulating hormone level
Mammalian Phenotype (MP)	decreased circulating gonadotropin level	0.597	2.302	--	INHERITED FROM: decreased circulating follicle stimulating hormone level
Mammalian Phenotype (MP)	abnormal internal female genitalia morphology	0.8421	1.281	--	INHERITED FROM: increased ovary weight || enlarged ovary
Mammalian Phenotype (MP)	abnormal immune system physiology	0.8618	0.6789	--	INHERITED FROM: granulomatous inflammation || chronic inflammation
Mammalian Phenotype (MP)	abnormal gametes	0.9811	1.825	--	INHERITED FROM: absent oocytes
Mammalian Phenotype (MP)	abnormal cell physiology	0.9959	0.6209	--	INHERITED FROM: abnormal anterior visceral endoderm cell migration || abnormal interdigital cell death
Mammalian Phenotype (MP)	abnormal male genitalia morphology	1	1.348	--	INHERITED FROM: epididymis degeneration || abnormal internal male genitalia morphology
Mammalian Phenotype (MP)	endocrine/exocrine gland phenotype	0.004396	0.6947	Least Informative	INHERITED FROM: increased ovary weight || enlarged ovary || abnormal sex gland morphology
Mammalian Phenotype (MP)	growth/size/body region phenotype	0.03496	0.6254	Least Informative	INHERITED FROM: abnormal incisor morphology || cleft palate
Mammalian Phenotype (MP)	cellular phenotype	0.04697	0.5387	Least Informative	INHERITED FROM: abnormal oocyte morphology || abnormal interdigital cell death || abnormal oocyte number || absent oocytes || abnormal anterior visceral endoderm cell migration
Mammalian Phenotype (MP)	cardiovascular system phenotype	0.105	0.6737	Least Informative	INHERITED FROM: abnormal heart position or orientation || abnormal atrioventricular cushion morphology || atrial septal defect || abnormal atrioventricular valve morphology || complete atrioventricular septal defect || atrioventricular septal defect || absent vitelline blood vessels
Mammalian Phenotype (MP)	immune system phenotype	0.1329	0.5462	Least Informative	INHERITED FROM: granulomatous inflammation || chronic inflammation
Mammalian Phenotype (MP)	nervous system phenotype	0.2946	0.4959	Least Informative	INHERITED FROM: abnormal enteric neuron morphology || abnormal enteric nervous system morphology
Mammalian Phenotype (MP)	abnormal homeostasis	0.3815	0.4926	Least Informative	INHERITED FROM: abnormal circulating gonadotropin level || abnormal follicle stimulating hormone level || increased circulating follicle stimulating hormone level || abnormal pituitary hormone level || abnormal circulating pituitary hormone level || decreased circulating follicle stimulating hormone level
Mammalian Phenotype (MP)	abnormal renal/urinary system morphology	0.0006643	1.047	Moderately Informative	DIRECT
Mammalian Phenotype (MP)	abnormal craniofacial morphology	0.0008564	1.047	Moderately Informative	DIRECT
Mammalian Phenotype (MP)	abnormal head morphology	0.0037	1.241	Moderately Informative	INHERITED FROM: cleft palate || abnormal incisor morphology
Mammalian Phenotype (MP)	limbs/digits/tail phenotype	0.009871	1.188	Moderately Informative	INHERITED FROM: broad limb buds || abnormal digit morphology || abnormal forelimb morphology || abnormal apical ectodermal ridge morphology || abnormal interdigital cell death || abnormal limb long bone morphology
Mammalian Phenotype (MP)	abnormal cardiovascular development	0.02371	1.059	Moderately Informative	INHERITED FROM: abnormal atrioventricular cushion morphology || absent vitelline blood vessels
Mammalian Phenotype (MP)	abnormal reproductive system morphology	0.02441	0.9404	Moderately Informative	INHERITED FROM: abnormal female genitalia morphology || increased ovary weight || absent oocytes || abnormal oocyte morphology || enlarged ovary || abnormal oocyte number || abnormal internal male genitalia morphology || epididymis degeneration || abnormal sex gland morphology
Mammalian Phenotype (MP)	abnormal blood vessel morphology	0.04725	1.023	Moderately Informative	INHERITED FROM: absent vitelline blood vessels
Mammalian Phenotype (MP)	abnormal muscle morphology	0.07344	1.112	Moderately Informative	INHERITED FROM: increased skeletal muscle size || increased skeletal muscle mass || abnormal skeletal muscle weight || increased muscle weight || increased skeletal muscle weight
Mammalian Phenotype (MP)	hearing/vestibular/ear phenotype	0.07388	1.223	Moderately Informative	INHERITED FROM: absent tympanic ring || decreased tympanic ring size
Mammalian Phenotype (MP)	abnormal digestive system morphology	0.0757	1.023	Moderately Informative	INHERITED FROM: cleft palate || abnormal anus morphology
Mammalian Phenotype (MP)	abnormal axial skeleton morphology	0.08123	1.001	Moderately Informative	INHERITED FROM: absent alisphenoid bone || small interparietal bone || asymmetric rib joints || absent maxilla || abnormal alisphenoid bone morphology || absent zygomatic bone || absent squamosal bone || abnormal mandibular condyloid process morphology || absent mandibular angle || abnormal mandibular angle morphology || abnormal incisor morphology || abnormal fontanelle morphology || small nasal bone || large anterior fontanelle || small zygomatic bone || abnormal mandibular coronoid process morphology || abnormal cranium morphology
Mammalian Phenotype (MP)	abnormal inflammatory response	0.1187	1.023	Moderately Informative	INHERITED FROM: chronic inflammation || granulomatous inflammation
Mammalian Phenotype (MP)	abnormal hormone level	0.1489	1.141	Moderately Informative	INHERITED FROM: abnormal follicle stimulating hormone level || abnormal pituitary hormone level || abnormal circulating pituitary hormone level || decreased circulating follicle stimulating hormone level || abnormal circulating gonadotropin level || increased circulating follicle stimulating hormone level
Mammalian Phenotype (MP)	abnormal heart morphology	0.32	0.9597	Moderately Informative	INHERITED FROM: abnormal heart position or orientation || atrial septal defect || abnormal atrioventricular cushion morphology || abnormal atrioventricular valve morphology || complete atrioventricular septal defect || atrioventricular septal defect
Mammalian Phenotype (MP)	abnormal cell death	0.3564	0.9904	Moderately Informative	INHERITED FROM: abnormal interdigital cell death
Mammalian Phenotype (MP)	abnormal embryo morphology	0.4375	1.112	Moderately Informative	INHERITED FROM: broad limb buds || abnormal apical ectodermal ridge morphology || absent somites || embryonic-extraembryonic boundary constriction
Mammalian Phenotype (MP)	adipose tissue phenotype	0.4817	1.205	Moderately Informative	INHERITED FROM: abnormal retroperitoneal fat pad morphology
Mammalian Phenotype (MP)	abnormal eye morphology	0.5021	0.9129	Moderately Informative	INHERITED FROM: decreased cornea thickness
Mammalian Phenotype (MP)	abnormal neuron morphology	0.5168	0.8323	Moderately Informative	INHERITED FROM: abnormal enteric neuron morphology
Mammalian Phenotype (MP)	abnormal reproductive system physiology	0.7369	1.012	Moderately Informative	INHERITED FROM: decreased litter size
Mammalian Phenotype (MP)	abnormal bone ossification	0.0004243	1.562	Informative	DIRECT
Mammalian Phenotype (MP)	decreased litter size	0.0007369	1.649	Informative	DIRECT
Mammalian Phenotype (MP)	abnormal germ cell morphology	0.001128	1.524	Informative	INHERITED FROM: absent oocytes || abnormal oocyte number || abnormal oocyte morphology
Mammalian Phenotype (MP)	abnormal autopod morphology	0.00454	1.524	Informative	INHERITED FROM: abnormal digit morphology
Mammalian Phenotype (MP)	abnormal heart septum morphology	0.04958	1.427	Informative	INHERITED FROM: complete atrioventricular septal defect || atrial septal defect || atrioventricular septal defect
Mammalian Phenotype (MP)	abnormal limb bone morphology	0.07023	1.649	Informative	INHERITED FROM: abnormal limb long bone morphology
Mammalian Phenotype (MP)	abnormal mouth morphology	0.07275	1.489	Informative	INHERITED FROM: abnormal incisor morphology || cleft palate
Mammalian Phenotype (MP)	abnormal heart development	0.07537	1.562	Informative	INHERITED FROM: abnormal atrioventricular cushion morphology
Mammalian Phenotype (MP)	abnormal fat pad morphology	0.08437	1.524	Informative	INHERITED FROM: abnormal retroperitoneal fat pad morphology
Mammalian Phenotype (MP)	abnormal skeleton development	0.1612	1.457	Informative	INHERITED FROM: large anterior fontanelle || abnormal fontanelle morphology
Mammalian Phenotype (MP)	abnormal anterior eye segment morphology	0.2066	1.489	Informative	INHERITED FROM: decreased cornea thickness
Mammalian Phenotype (MP)	abnormal thoracic cage morphology	0.2314	1.649	Informative	INHERITED FROM: asymmetric rib joints
Mammalian Phenotype (MP)	abnormal ovary morphology	0.2747	1.457	Informative	INHERITED FROM: enlarged ovary || increased ovary weight
Mammalian Phenotype (MP)	abnormal skeletal muscle morphology	0.3082	1.427	Informative	INHERITED FROM: abnormal skeletal muscle weight || increased skeletal muscle mass || increased skeletal muscle size || increased skeletal muscle weight
Mammalian Phenotype (MP)	abnormal cell migration	0.4272	1.399	Informative	INHERITED FROM: abnormal anterior visceral endoderm cell migration
Mammalian Phenotype (MP)	abnormal metabolism	0.4464	1.281	Informative	INHERITED FROM: abnormal basal metabolism
Mammalian Phenotype (MP)	abnormal long bone morphology	0.4851	1.489	Informative	INHERITED FROM: abnormal limb long bone morphology
Mammalian Phenotype (MP)	abnormal jaw morphology	0.7194	1.427	Informative	INHERITED FROM: abnormal mandibular coronoid process morphology || abnormal mandibular angle morphology || abnormal incisor morphology || abnormal mandibular condyloid process morphology || absent mandibular angle || absent maxilla
Mammalian Phenotype (MP)	cleft palate	0.0000004094	1.904	Highly Informative	DIRECT
Mammalian Phenotype (MP)	abnormal follicle stimulating hormone level	0.000004654	2.001	Highly Informative	DIRECT
Mammalian Phenotype (MP)	abnormal circulating gonadotropin level	0.00001856	1.825	Highly Informative	DIRECT
Mammalian Phenotype (MP)	abnormal circulating pituitary hormone level	0.0004006	1.904	Highly Informative	DIRECT
Mammalian Phenotype (MP)	abnormal atrioventricular valve morphology	0.0006074	1.904	Highly Informative	DIRECT
Mammalian Phenotype (MP)	abnormal atrioventricular cushion morphology	0.0008235	2.001	Highly Informative	DIRECT
Mammalian Phenotype (MP)	abnormal germ layer morphology	0.002354	2.126	Highly Informative	INHERITED FROM: abnormal apical ectodermal ridge morphology
Mammalian Phenotype (MP)	impaired somite development	0.00972	2.001	Highly Informative	INHERITED FROM: absent somites
Mammalian Phenotype (MP)	abnormal autonomic nervous system morphology	0.01269	1.904	Highly Informative	INHERITED FROM: abnormal enteric neuron morphology || abnormal enteric nervous system morphology
Mammalian Phenotype (MP)	abnormal limb development	0.0135	2.126	Highly Informative	INHERITED FROM: broad limb buds || abnormal interdigital cell death || abnormal apical ectodermal ridge morphology
Mammalian Phenotype (MP)	abnormal middle ear morphology	0.01606	1.904	Highly Informative	INHERITED FROM: decreased tympanic ring size || absent tympanic ring
Mammalian Phenotype (MP)	abnormal cornea morphology	0.01772	1.758	Highly Informative	INHERITED FROM: decreased cornea thickness
Mammalian Phenotype (MP)	abnormal heart atrium morphology	0.02066	2.001	Highly Informative	INHERITED FROM: atrial septal defect
Mammalian Phenotype (MP)	abnormal temporal bone morphology	0.02476	2.001	Highly Informative	INHERITED FROM: absent squamosal bone
Mammalian Phenotype (MP)	abnormal abdominal fat pad morphology	0.05342	1.825	Highly Informative	INHERITED FROM: abnormal retroperitoneal fat pad morphology
Mammalian Phenotype (MP)	abnormal vitelline vasculature morphology	0.06979	2.001	Highly Informative	INHERITED FROM: absent vitelline blood vessels
Mammalian Phenotype (MP)	abnormal epididymis morphology	0.07188	2.126	Highly Informative	INHERITED FROM: epididymis degeneration
Mammalian Phenotype (MP)	abnormal urinary system development	0.09327	1.904	Highly Informative	INHERITED FROM: abnormal metanephric mesenchyme morphology
Mammalian Phenotype (MP)	abnormal skeletal muscle mass	0.1201	2.001	Highly Informative	INHERITED FROM: increased skeletal muscle weight || increased skeletal muscle size || abnormal skeletal muscle weight || increased skeletal muscle mass
Mammalian Phenotype (MP)	abnormal female germ cell morphology	0.1481	2.126	Highly Informative	INHERITED FROM: absent oocytes || abnormal oocyte morphology || abnormal oocyte number
Mammalian Phenotype (MP)	abnormal rib joint	0.1549	2.126	Highly Informative	INHERITED FROM: asymmetric rib joints
Mammalian Phenotype (MP)	abnormal maxilla morphology	0.1666	2.001	Highly Informative	INHERITED FROM: absent maxilla
Mammalian Phenotype (MP)	abnormal oogenesis	0.1783	2.001	Highly Informative	INHERITED FROM: absent oocytes || abnormal oocyte number || abnormal oocyte morphology
Mammalian Phenotype (MP)	absent gametes	0.2629	2.126	Highly Informative	INHERITED FROM: absent oocytes
Mammalian Phenotype (MP)	abnormal mandible morphology	0.2943	2.126	Highly Informative	INHERITED FROM: absent mandibular angle || abnormal mandibular angle morphology || abnormal mandibular coronoid process morphology || abnormal mandibular condyloid process morphology
Mammalian Phenotype (MP)	abnormal tooth morphology	0.5355	2.001	Highly Informative	INHERITED FROM: abnormal incisor morphology

---

Worm Phenotype (WP)

Highlighted in gray are those with FDR_all>0.001

	WP term	FDR (all)	IC level	SDWP level	Annotation (direct or inherited)
Worm Phenotype (WP)	embryonic lethal	0	0.046	--	DIRECT
Worm Phenotype (WP)	lethal	0	0.00521	--	DIRECT
Worm Phenotype (WP)	fertility variant	0	0.05937	--	DIRECT
Worm Phenotype (WP)	development variant	0	0.001482	--	DIRECT
Worm Phenotype (WP)	morphology variant	0	0.046	--	DIRECT
Worm Phenotype (WP)	organism development variant	0	0.00297	--	DIRECT
Worm Phenotype (WP)	organism morphology variant	0	0.1372	--	DIRECT
Worm Phenotype (WP)	organ system physiology variant	0	0.04518	--	DIRECT
Worm Phenotype (WP)	reproductive system physiology variant	0	0.05515	--	DIRECT
Worm Phenotype (WP)	maternal sterile	0	0.1213	--	DIRECT
Worm Phenotype (WP)	hermaphrodite sterile	0	0.1203	--	DIRECT
Worm Phenotype (WP)	embryonic development variant	0	0.04518	--	DIRECT
Worm Phenotype (WP)	hermaphrodite fertility variant	0	0.0947	--	DIRECT
Worm Phenotype (WP)	hermaphrodite fertility reduced	0	0.1193	--	DIRECT
Worm Phenotype (WP)	fertility reduced	0	0.06449	--	DIRECT
Worm Phenotype (WP)	levamisole response variant	0.000000364	2.769	--	DIRECT
Worm Phenotype (WP)	vulva uterus connection defective	0.0000004701	1.866	--	DIRECT
Worm Phenotype (WP)	nicotine response variant	0.0000005754	1.814	--	DIRECT
Worm Phenotype (WP)	nervous system morphology variant	0.0004016	1.321	--	DIRECT
Worm Phenotype (WP)	reproductive system development variant	0.0006488	1.156	--	DIRECT
Worm Phenotype (WP)	body length variant	0.0006648	1.292	--	DIRECT
Worm Phenotype (WP)	drug response variant	0.0009062	1.135	--	DIRECT
Worm Phenotype (WP)	body width variant	0.0009474	1.237	--	DIRECT
Worm Phenotype (WP)	body size variant	0.001474	1.189	--	INHERITED FROM: body width variant || body length variant
Worm Phenotype (WP)	body morphology variant	0.001947	1.145	--	INHERITED FROM: body width variant || body length variant
Worm Phenotype (WP)	transgene expression variant	0.0067	0.773	--	INHERITED FROM: transgene expression reduced || level of transgene expression variant
Worm Phenotype (WP)	cell component morphology variant	0.0107	0.8392	--	INHERITED FROM: synapse morphology variant
Worm Phenotype (WP)	gene expression variant	0.0129	0.6256	--	INHERITED FROM: level of transgene expression variant || transgene expression reduced
Worm Phenotype (WP)	organ system morphology variant	0.0216	0.7516	--	INHERITED FROM: synapse morphology variant || nervous system morphology variant
Worm Phenotype (WP)	cell morphology variant	0.02291	0.7558	--	INHERITED FROM: synapse morphology variant
Worm Phenotype (WP)	behavior variant	0.06264	0.6859	--	INHERITED FROM: egg laying defective || egg laying variant
Worm Phenotype (WP)	organism homeostasis metabolism variant	0.6893	0.1444	--	INHERITED FROM: drug response variant || nicotine response variant || level of transgene expression variant || transgene expression reduced || levamisole response variant
Worm Phenotype (WP)	organism physiology variant	0.7034	0.1342	--	INHERITED FROM: drug response variant || nicotine response variant || level of transgene expression variant || transgene expression reduced || levamisole response variant
Worm Phenotype (WP)	physiology variant	1	0	--	INHERITED FROM: hermaphrodite fertility variant || reproductive system physiology variant || egg laying variant || transgene expression reduced || lethal || anchor cell invasion variant || development variant || levamisole response variant || reproductive system development variant || hermaphrodite sterile || egg laying defective || nicotine response variant || drug response variant || hermaphrodite fertility reduced || embryonic development variant || embryonic lethal || vulva uterus connection defective || fertility variant || organ system physiology variant || maternal sterile || organism development variant || level of transgene expression variant || fertility reduced
Worm Phenotype (WP)	sterile	1	0.1135	--	INHERITED FROM: hermaphrodite sterile || maternal sterile
Worm Phenotype (WP)	organism metabolism processing variant	0.02517	0.4899	Least Informative	INHERITED FROM: transgene expression reduced || level of transgene expression variant
Worm Phenotype (WP)	organism environmental stimulus response variant	0.04547	0.6614	Least Informative	INHERITED FROM: nicotine response variant || drug response variant || levamisole response variant
Worm Phenotype (WP)	organism behavior variant	0.06178	0.6859	Least Informative	INHERITED FROM: egg laying defective || egg laying variant
Worm Phenotype (WP)	level of transgene expression variant	0.0003908	1.125	Moderately Informative	DIRECT
Worm Phenotype (WP)	organism segment morphology variant	0.003612	1.087	Moderately Informative	INHERITED FROM: body length variant || body width variant
Worm Phenotype (WP)	body region morphology variant	0.003656	1.087	Moderately Informative	INHERITED FROM: body width variant || body length variant
Worm Phenotype (WP)	organ system development variant	0.005433	0.9113	Moderately Informative	INHERITED FROM: reproductive system development variant || vulva uterus connection defective || anchor cell invasion variant
Worm Phenotype (WP)	chemical response variant	0.00606	0.9053	Moderately Informative	INHERITED FROM: nicotine response variant || drug response variant || levamisole response variant
Worm Phenotype (WP)	transgene expression reduced	0.0000211	1.623	Informative	DIRECT
Worm Phenotype (WP)	egg laying variant	0.0009685	1.513	Informative	DIRECT
Worm Phenotype (WP)	synapse morphology variant	0.0000001951	2.07	Highly Informative	DIRECT
Worm Phenotype (WP)	anchor cell invasion variant	0.0000003329	1.866	Highly Informative	DIRECT
Worm Phenotype (WP)	egg laying defective	0.00005515	1.99	Highly Informative	DIRECT

---

Fly Phenotype (FP)

Highlighted in gray are those with FDR_all>0.001

	FP term	FDR (all)	IC level	SDFP level	Annotation (direct or inherited)
Fly Phenotype (FP)	phenotype	0	0.06546	--	DIRECT
Fly Phenotype (FP)	circadian rhythm defective	0	1.607	Informative	DIRECT

---

Fly Anatomy (FA)

Highlighted in gray are those with FDR_all>0.001

	FA term	FDR (all)	IC level	SDFA level	Annotation (direct or inherited)
Fly Anatomy (FA)	organism	0	0.06695	--	DIRECT
Fly Anatomy (FA)	organ system	0	0.1823	--	DIRECT
Fly Anatomy (FA)	cell	0	0.4069	--	DIRECT
Fly Anatomy (FA)	multicellular structure	0	0.008955	--	DIRECT
Fly Anatomy (FA)	embryonic/larval posterior spiracle	0.0001297	2.389	--	DIRECT
Fly Anatomy (FA)	stigmatophore	0.000147	2.389	--	DIRECT
Fly Anatomy (FA)	embryonic/larval spiracle	0.0001855	2.389	--	DIRECT
Fly Anatomy (FA)	spiracle	0.0004538	2.389	--	DIRECT
Fly Anatomy (FA)	abdominal segment	0.00844	1.243	--	INHERITED FROM: stigmatophore || embryonic/larval posterior spiracle
Fly Anatomy (FA)	tracheal system	0.01364	1.611	--	INHERITED FROM: embryonic/larval spiracle || embryonic/larval posterior spiracle || spiracle
Fly Anatomy (FA)	neuromuscular junction	0.02534	1.787	--	INHERITED FROM: embryonic/larval neuromuscular junction
Fly Anatomy (FA)	embryonic/larval nervous system	0.06229	0.7171	--	INHERITED FROM: embryonic/larval neuromuscular junction
Fly Anatomy (FA)	organism subdivision	0.09782	0.5027	--	INHERITED FROM: embryonic/larval posterior spiracle || stigmatophore
Fly Anatomy (FA)	embryo	0.227	0.8978	--	INHERITED FROM: embryonic/larval spiracle || embryonic/larval posterior spiracle
Fly Anatomy (FA)	integumentary system	0.3799	0.8094	--	INHERITED FROM: stigmatophore || spiracle || embryonic/larval posterior spiracle || embryonic/larval spiracle
Fly Anatomy (FA)	region of integument	0.4341	0.884	--	INHERITED FROM: spiracle || stigmatophore || embryonic/larval posterior spiracle || embryonic/larval spiracle
Fly Anatomy (FA)	anatomical structure	1	0	--	INHERITED FROM: organism || embryonic/larval posterior spiracle || embryonic/larval neuromuscular junction || adult || spiracle || stigmatophore || larva || somatic cell || cell || organ system subdivision || embryonic/larval spiracle || organ system || multicellular structure
Fly Anatomy (FA)	material anatomical entity	1	0	--	INHERITED FROM: organ system || multicellular structure || embryonic/larval spiracle || organ system subdivision || cell || stigmatophore || spiracle || larva || somatic cell || adult || organism || embryonic/larval posterior spiracle || embryonic/larval neuromuscular junction
Fly Anatomy (FA)	anterior-posterior subdivision of organism	1	0.5027	--	INHERITED FROM: embryonic/larval posterior spiracle || stigmatophore
Fly Anatomy (FA)	larva	0	0.3763	Least Informative	DIRECT
Fly Anatomy (FA)	adult	0	0.4496	Least Informative	DIRECT
Fly Anatomy (FA)	organ system subdivision	0	0.4301	Least Informative	DIRECT
Fly Anatomy (FA)	somatic cell	0	0.4861	Least Informative	DIRECT
Fly Anatomy (FA)	nervous system	0.05579	0.6333	Least Informative	INHERITED FROM: embryonic/larval neuromuscular junction
Fly Anatomy (FA)	tagma	0.113	0.5027	Least Informative	INHERITED FROM: embryonic/larval posterior spiracle || stigmatophore
Fly Anatomy (FA)	segment	0.3453	0.6568	Least Informative	INHERITED FROM: embryonic/larval posterior spiracle || stigmatophore
Fly Anatomy (FA)	peripheral nervous system	0.0301	0.8978	Moderately Informative	INHERITED FROM: embryonic/larval neuromuscular junction
Fly Anatomy (FA)	abdomen	0.03211	1.185	Moderately Informative	INHERITED FROM: stigmatophore || embryonic/larval posterior spiracle
Fly Anatomy (FA)	late embryo	0.07825	1.088	Moderately Informative	INHERITED FROM: embryonic/larval posterior spiracle || embryonic/larval spiracle
Fly Anatomy (FA)	embryonic/larval tracheal system	0.01329	1.611	Informative	INHERITED FROM: embryonic/larval posterior spiracle || embryonic/larval spiracle
Fly Anatomy (FA)	embryonic/larval peripheral nervous system	0.01361	1.544	Informative	INHERITED FROM: embryonic/larval neuromuscular junction
Fly Anatomy (FA)	cell component	0.01936	1.544	Informative	INHERITED FROM: embryonic/larval neuromuscular junction
Fly Anatomy (FA)	embryonic/larval neuromuscular junction	0.0002608	2.088	Highly Informative	DIRECT
Fly Anatomy (FA)	integumentary specialisation	0.005081	1.787	Highly Informative	INHERITED FROM: embryonic/larval spiracle || embryonic/larval posterior spiracle || stigmatophore || spiracle
Fly Anatomy (FA)	abdominal segment 8	0.04271	2.088	Highly Informative	INHERITED FROM: stigmatophore || embryonic/larval posterior spiracle

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Zebrafish Anatomy (ZA)

Highlighted in gray are those with FDR_all>0.001

	ZA term	FDR (all)	IC level	SDZA level	Annotation (direct or inherited)
Zebrafish Anatomy (ZA)	whole organism	0	0.00147	--	DIRECT
Zebrafish Anatomy (ZA)	spermatogenic cyst	0.00006654	2.471	--	DIRECT
Zebrafish Anatomy (ZA)	pineal complex	0.0003026	2.471	--	DIRECT
Zebrafish Anatomy (ZA)	notochord	0.0006333	2.471	--	DIRECT
Zebrafish Anatomy (ZA)	epithalamus	0.001266	2.471	--	INHERITED FROM: pineal complex
Zebrafish Anatomy (ZA)	reproductive system	0.002981	1.869	--	INHERITED FROM: spermatogenic cyst
Zebrafish Anatomy (ZA)	testis	0.03221	2.471	--	INHERITED FROM: spermatogenic cyst
Zebrafish Anatomy (ZA)	forebrain	0.1498	1.471	--	INHERITED FROM: pineal complex
Zebrafish Anatomy (ZA)	anatomical system	0.156	0.1857	--	INHERITED FROM: floor plate || spermatogenic cyst || pineal complex
Zebrafish Anatomy (ZA)	anatomical group	0.189	0.1532	--	INHERITED FROM: floor plate || pineal complex || spermatogenic cyst
Zebrafish Anatomy (ZA)	compound organ	0.2527	0.4299	--	INHERITED FROM: spermatogenic cyst || pineal complex
Zebrafish Anatomy (ZA)	brain	0.5574	1.193	--	INHERITED FROM: pineal complex
Zebrafish Anatomy (ZA)	anatomical structure	1	0	--	INHERITED FROM: female organism || floor plate || notochord || spermatogenic cyst || embryonic structure || whole organism || male organism || pineal complex
Zebrafish Anatomy (ZA)	multi-tissue structure	0.4692	0.5848	Least Informative	INHERITED FROM: pineal complex || floor plate
Zebrafish Anatomy (ZA)	anatomical cluster	0.4893	0.7389	Least Informative	INHERITED FROM: spermatogenic cyst
Zebrafish Anatomy (ZA)	cavitated compound organ	0.8595	0.5123	Least Informative	INHERITED FROM: spermatogenic cyst || pineal complex
Zebrafish Anatomy (ZA)	nervous system	0.999	0.7079	Least Informative	INHERITED FROM: pineal complex || floor plate
Zebrafish Anatomy (ZA)	portion of tissue	0.07487	0.7637	Moderately Informative	INHERITED FROM: notochord || spermatogenic cyst
Zebrafish Anatomy (ZA)	central nervous system	0.7551	1.04	Moderately Informative	INHERITED FROM: pineal complex || floor plate
Zebrafish Anatomy (ZA)	embryonic structure	0.000455	1.626	Informative	DIRECT
Zebrafish Anatomy (ZA)	endocrine system	0.00364	1.693	Informative	INHERITED FROM: spermatogenic cyst
Zebrafish Anatomy (ZA)	diencephalon	0.04342	1.471	Informative	INHERITED FROM: pineal complex
Zebrafish Anatomy (ZA)	pleuroperitoneal region	0.09693	1.517	Informative	INHERITED FROM: spermatogenic cyst
Zebrafish Anatomy (ZA)	floor plate	0.0002028	1.994	Highly Informative	DIRECT
Zebrafish Anatomy (ZA)	male organism	0.0004193	1.869	Highly Informative	DIRECT
Zebrafish Anatomy (ZA)	female organism	0.0008398	1.869	Highly Informative	DIRECT
Zebrafish Anatomy (ZA)	gonad	0.006474	1.994	Highly Informative	INHERITED FROM: spermatogenic cyst

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Xenopus Anatomy (XA)

Highlighted in gray are those with FDR_all>0.001

	XA term	FDR (all)	IC level	SDXA level	Annotation (direct or inherited)
Xenopus ANatomical entity (XAN)	anatomical structure	0	0	--	DIRECT
Xenopus ANatomical entity (XAN)	multicellular anatomical structure	0	0.1131	--	DIRECT
Xenopus ANatomical entity (XAN)	secondary heart field	0.000000004529	2.865	--	DIRECT
Xenopus ANatomical entity (XAN)	primary heart field	0.00000009167	2.564	--	DIRECT
Xenopus ANatomical entity (XAN)	involuting marginal zone mesenchymal layer	0.0000001249	2.865	--	DIRECT
Xenopus ANatomical entity (XAN)	dorsal aorta	0.0000002822	2.564	--	DIRECT
Xenopus ANatomical entity (XAN)	bottle cell	0.0000006451	2.865	--	DIRECT
Xenopus ANatomical entity (XAN)	aorta	0.0000007966	2.564	--	DIRECT
Xenopus ANatomical entity (XAN)	axial mesoderm	0.0000009951	2.263	--	DIRECT
Xenopus ANatomical entity (XAN)	vegetal endoderm	0.000002071	2.865	--	DIRECT
Xenopus ANatomical entity (XAN)	mouth primordium	0.00000328	2.388	--	DIRECT
Xenopus ANatomical entity (XAN)	early embryonic cell	0.000005359	2.263	--	DIRECT
Xenopus ANatomical entity (XAN)	branchial arch 3	0.000006134	2.865	--	DIRECT
Xenopus ANatomical entity (XAN)	hindlimb	0.000007008	2.263	--	DIRECT
Xenopus ANatomical entity (XAN)	endoderm	0.000009038	1.751	--	DIRECT
Xenopus ANatomical entity (XAN)	appendage	0.000009371	2.166	--	DIRECT
Xenopus ANatomical entity (XAN)	dorsal marginal zone	0.000009888	2.263	--	DIRECT
Xenopus ANatomical entity (XAN)	branchial arch 2	0.00001121	2.865	--	DIRECT
Xenopus ANatomical entity (XAN)	trunk vasculature	0.0000218	2.263	--	DIRECT
Xenopus ANatomical entity (XAN)	prechordal plate	0.00003056	2.388	--	DIRECT
Xenopus ANatomical entity (XAN)	regenerating tissue	0.00004713	1.962	--	DIRECT
Xenopus ANatomical entity (XAN)	circumblastoporal collar	0.00005173	2.02	--	DIRECT
Xenopus ANatomical entity (XAN)	heart	0.0001062	1.689	--	DIRECT
Xenopus ANatomical entity (XAN)	ventral mesoderm	0.0001514	2.564	--	DIRECT
Xenopus ANatomical entity (XAN)	heart primordium	0.0001825	2.388	--	DIRECT
Xenopus ANatomical entity (XAN)	hindlimb bud	0.0002429	2.564	--	DIRECT
Xenopus ANatomical entity (XAN)	branchial arch 1	0.0003416	2.865	--	DIRECT
Xenopus ANatomical entity (XAN)	branchial arch 4	0.0003416	2.865	--	DIRECT
Xenopus ANatomical entity (XAN)	involuting marginal zone	0.0007955	2.263	--	DIRECT
Xenopus ANatomical entity (XAN)	gastrocoel roof plate	0.0007963	2.388	--	DIRECT
Xenopus ANatomical entity (XAN)	early distal tubule	0.0009576	2.263	--	DIRECT
Xenopus ANatomical entity (XAN)	pharyngeal arch	0.001361	1.689	--	INHERITED FROM: branchial arch 3 || branchial arch 2 || branchial arch 1 || branchial arch 4
Xenopus ANatomical entity (XAN)	distal tubule	0.001837	2.263	--	INHERITED FROM: early distal tubule
Xenopus ANatomical entity (XAN)	blood vessel	0.002617	2.263	--	INHERITED FROM: dorsal aorta || aorta
Xenopus ANatomical entity (XAN)	cranial placode	0.003229	1.719	--	INHERITED FROM: neurogenic placode
Xenopus ANatomical entity (XAN)	gastrula cell	0.005329	2.865	--	INHERITED FROM: bottle cell
Xenopus ANatomical entity (XAN)	artery	0.01542	2.564	--	INHERITED FROM: aorta || dorsal aorta
Xenopus ANatomical entity (XAN)	embryonic kidney	0.04202	1.719	--	INHERITED FROM: early distal tubule
Xenopus ANatomical entity (XAN)	primary germ layer	0.05467	0.6748	--	INHERITED FROM: neurogenic placode || endoderm || mouth primordium || vegetal endoderm || head mesoderm || gastrocoel roof plate || ventral mesoderm || mesoderm
Xenopus ANatomical entity (XAN)	coelom	0.05715	1.661	--	INHERITED FROM: early distal tubule
Xenopus ANatomical entity (XAN)	branchial arch	0.0983	2.263	--	INHERITED FROM: branchial arch 3 || branchial arch 4 || branchial arch 1 || branchial arch 2
Xenopus ANatomical entity (XAN)	pronephric nephron	0.1098	2.087	--	INHERITED FROM: early distal tubule
Xenopus ANatomical entity (XAN)	pronephric kidney	0.4088	1.824	--	INHERITED FROM: early distal tubule
Xenopus ANatomical entity (XAN)	kidney	0.6106	1.564	--	INHERITED FROM: early distal tubule
Xenopus ANatomical entity (XAN)	marginal zone	0.6949	1.786	--	INHERITED FROM: dorsal marginal zone || involuting marginal zone mesenchymal layer || involuting marginal zone
Xenopus ANatomical entity (XAN)	head region	1	0.4759	--	INHERITED FROM: head mesoderm || periocular region || branchial arch 3 || branchial arch 2 || branchial arch 1 || branchial arch 4 || head mesenchyme
Xenopus ANatomical entity (XAN)	trunk region	1	0.388	--	INHERITED FROM: heart || trunk vasculature || dorsal aorta || early distal tubule
Xenopus ANatomical entity (XAN)	anatomical group	1	0.1408	--	INHERITED FROM: mouth primordium || cardiovascular system || aorta || early distal tubule || secondary heart field || circulatory system || primary heart field || dorsal aorta || trunk vasculature || heart primordium || heart
Xenopus ANatomical entity (XAN)	anatomical system	1	0.283	--	INHERITED FROM: mouth primordium || cardiovascular system || early distal tubule || aorta || secondary heart field || primary heart field || circulatory system || dorsal aorta || trunk vasculature || heart primordium || heart
Xenopus ANatomical entity (XAN)	whole organism	1	0.0884	--	INHERITED FROM: circumblastoporal collar || gastrocoel roof plate || branchial arch 4 || secondary heart field || aorta || head mesenchyme || early distal tubule || hindlimb bud || limb bud || involuting marginal zone || involuting marginal zone mesenchymal layer || regenerating tissue || prechordal plate || animal hemisphere || involuted dorsal mesoderm || circulatory system || hindlimb || primary heart field || endoderm || axial mesoderm || bottle cell || mouth primordium || multicellular anatomical structure || vegetal hemisphere || head mesoderm || cardiovascular system || periocular region || mesoderm || branchial arch 2 || branchial arch 1 || appendage || ventral mesoderm || blastema || heart || branchial arch 3 || notochord || anatomical space || vegetal endoderm || early embryonic cell || mesenchyme || trunk vasculature || dorsal marginal zone || neurogenic placode || pelvic appendage || dorsal aorta || embryonic structure || heart primordium
Xenopus ANatomical entity (XAN)	cell	1	0.8608	--	INHERITED FROM: bottle cell || early embryonic cell
Xenopus ANatomical entity (XAN)	organism subdivision	1	0.1679	--	INHERITED FROM: branchial arch 3 || heart || hindlimb || branchial arch 4 || limb bud || hindlimb bud || early distal tubule || head mesenchyme || branchial arch 2 || branchial arch 1 || head mesoderm || appendage || trunk vasculature || dorsal aorta || pelvic appendage
Xenopus ANatomical entity (XAN)	compound organ	1	0.2177	--	INHERITED FROM: heart || early distal tubule
Xenopus ANatomical entity (XAN)	anatomical region	1	0.1803	--	INHERITED FROM: animal hemisphere || heart || branchial arch 3 || branchial arch 4 || early distal tubule || head mesenchyme || branchial arch 2 || branchial arch 1 || head mesoderm || periocular region || trunk vasculature || vegetal hemisphere || dorsal aorta
Xenopus ANatomical entity (XAN)	paired appendage	1	2.166	--	INHERITED FROM: hindlimb || pelvic appendage
Xenopus ANatomical entity (XAN)	embryo	0.004645	0.5979	Least Informative	INHERITED FROM: embryonic structure || early distal tubule || bottle cell || mouth primordium || vegetal hemisphere || involuting marginal zone || involuting marginal zone mesenchymal layer || neurogenic placode || dorsal marginal zone || ventral mesoderm || gastrocoel roof plate || circumblastoporal collar || axial mesoderm || vegetal endoderm || early embryonic cell || endoderm || animal hemisphere || mesoderm || involuted dorsal mesoderm || head mesoderm || prechordal plate || heart primordium
Xenopus ANatomical entity (XAN)	tissue	0.07301	0.4672	Least Informative	INHERITED FROM: ventral mesoderm || secondary heart field || gastrocoel roof plate || early distal tubule || involuting marginal zone mesenchymal layer || head mesenchyme || involuted dorsal mesoderm || regenerating tissue || blastema || notochord || vegetal endoderm || primary heart field || endoderm || mesenchyme || mouth primordium || neurogenic placode || mesoderm || head mesoderm
Xenopus ANatomical entity (XAN)	urogenital system	1	0.4777	Least Informative	INHERITED FROM: early distal tubule
Xenopus ANatomical entity (XAN)	head	1	0.4777	Least Informative	INHERITED FROM: branchial arch 4 || head mesenchyme || branchial arch 3 || head mesoderm || branchial arch 2 || branchial arch 1
Xenopus ANatomical entity (XAN)	trunk	1	0.3894	Least Informative	INHERITED FROM: trunk vasculature || heart || dorsal aorta || early distal tubule
Xenopus ANatomical entity (XAN)	anatomical cluster	1	0.7159	Least Informative	INHERITED FROM: heart
Xenopus ANatomical entity (XAN)	cavitated compound organ	1	0.2685	Least Informative	INHERITED FROM: heart || early distal tubule
Xenopus ANatomical entity (XAN)	embryonic structure	0.0000005824	1.149	Moderately Informative	DIRECT
Xenopus ANatomical entity (XAN)	multi-tissue structure	0.003022	1.066	Moderately Informative	INHERITED FROM: branchial arch 3 || branchial arch 1 || branchial arch 2 || dorsal aorta || aorta || mouth primordium || early distal tubule || branchial arch 4 || trunk vasculature
Xenopus ANatomical entity (XAN)	ectoderm	0.6869	0.9357	Moderately Informative	INHERITED FROM: mouth primordium || neurogenic placode
Xenopus ANatomical entity (XAN)	alimentary system	1	0.8739	Moderately Informative	INHERITED FROM: mouth primordium
Xenopus ANatomical entity (XAN)	viscus	1	0.8828	Moderately Informative	INHERITED FROM: heart
Xenopus ANatomical entity (XAN)	anatomical direction	0.00000000002519	1.661	Informative	DIRECT
Xenopus ANatomical entity (XAN)	cardiovascular system	0.000003252	1.586	Informative	DIRECT
Xenopus ANatomical entity (XAN)	anatomical space	0.00000402	1.503	Informative	DIRECT
Xenopus ANatomical entity (XAN)	mesoderm	0.000004979	1.285	Informative	DIRECT
Xenopus ANatomical entity (XAN)	notochord	0.00002647	1.689	Informative	DIRECT
Xenopus ANatomical entity (XAN)	mesenchyme	0.0002439	1.586	Informative	DIRECT
Xenopus ANatomical entity (XAN)	animal hemisphere	0.0009509	1.689	Informative	DIRECT
Xenopus ANatomical entity (XAN)	pharyngeal region	0.002148	1.467	Informative	INHERITED FROM: branchial arch 4 || branchial arch 3 || branchial arch 1 || branchial arch 2
Xenopus ANatomical entity (XAN)	neuroectoderm	0.007455	1.374	Informative	INHERITED FROM: neurogenic placode
Xenopus ANatomical entity (XAN)	surface structure	0.4212	1.418	Informative	INHERITED FROM: limb bud || hindlimb bud
Xenopus ANatomical entity (XAN)	urinary system	0.4452	1.523	Informative	INHERITED FROM: early distal tubule
Xenopus ANatomical entity (XAN)	limb	0.8501	1.635	Informative	INHERITED FROM: hindlimb
Xenopus ANatomical entity (XAN)	head mesenchyme	0.00000000588	2.166	Highly Informative	DIRECT
Xenopus ANatomical entity (XAN)	head mesoderm	0.0000001282	2.087	Highly Informative	DIRECT
Xenopus ANatomical entity (XAN)	involuted dorsal mesoderm	0.000001741	2.02	Highly Informative	DIRECT
Xenopus ANatomical entity (XAN)	pelvic appendage	0.000007008	2.166	Highly Informative	DIRECT
Xenopus ANatomical entity (XAN)	blastema	0.00001585	1.962	Highly Informative	DIRECT
Xenopus ANatomical entity (XAN)	neurogenic placode	0.00002023	1.824	Highly Informative	DIRECT
Xenopus ANatomical entity (XAN)	periocular region	0.00002972	2.02	Highly Informative	DIRECT
Xenopus ANatomical entity (XAN)	circulatory system	0.00004465	2.02	Highly Informative	DIRECT
Xenopus ANatomical entity (XAN)	vegetal hemisphere	0.00007272	2.087	Highly Informative	DIRECT
Xenopus ANatomical entity (XAN)	limb bud	0.0007467	2.166	Highly Informative	DIRECT
Xenopus ANatomical entity (XAN)	lateral plate mesoderm	0.01882	1.824	Highly Informative	INHERITED FROM: ventral mesoderm
Xenopus ANatomical entity (XAN)	pronephric tubule	0.02421	2.087	Highly Informative	INHERITED FROM: early distal tubule
Xenopus ANatomical entity (XAN)	primordium	0.05337	1.751	Highly Informative	INHERITED FROM: heart primordium
Xenopus ANatomical entity (XAN)	archenteron	0.1525	2.087	Highly Informative	INHERITED FROM: gastrocoel roof plate
Xenopus DEvelopment stage (XDE)	NF stage	0	0.01895	--	DIRECT
Xenopus DEvelopment stage (XDE)	blastula stage	0.0004073	2.785	--	DIRECT
Xenopus DEvelopment stage (XDE)	embryonic stage	0.00733	1.006	Moderately Informative	INHERITED FROM: blastula stage

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