SUPERFAMILY 1.75 HMM library and genome assignments server

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Blood coagulation inhibitor (disintegrin) family

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Small proteins [ 56992] (90)
Fold:   Blood coagulation inhibitor (disintegrin) [ 57551]
Superfamily:   Blood coagulation inhibitor (disintegrin) [ 57552]
Family:   Blood coagulation inhibitor (disintegrin) [ 57553] (6)

Family statistics
Genomes (11) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 20 659 13
Proteins 20 658 13

Enzyme Commission (EC)

show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on peptide bonds (peptide hydrolases)0Least InformativeDirect
Enzyme Commission (EC)Metalloendopeptidases0InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)organ system cancer0.00267Least InformativeInherited
Disease Ontology (DO)artery disease0.0006899Moderately InformativeDirect
Disease Ontology (DO)atherosclerosis0.00001777InformativeDirect
Disease Ontology (DO)breast carcinoma0.0009358InformativeDirect
Disease Ontology (DO)integumentary system cancer0.003991Highly InformativeInherited

Document: DO annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)cardiovascular system phenotype0.419Least InformativeInherited
Mammalian Phenotype (MP)mortality/aging0.8449Least InformativeInherited
Mammalian Phenotype (MP)abnormal heart morphology0.06978Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal reproductive system physiology0.1042Moderately InformativeInherited
Mammalian Phenotype (MP)lethality during fetal growth through weaning0.1142Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal eye morphology0.2961Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal eyelid morphology0.002184InformativeInherited
Mammalian Phenotype (MP)abnormal heart septum morphology0.00362InformativeInherited
Mammalian Phenotype (MP)perinatal lethality0.02609InformativeInherited
Mammalian Phenotype (MP)abnormal semilunar valve morphology0.0000009028Highly InformativeDirect
Mammalian Phenotype (MP)abnormal heart ventricle outflow tract morphology0.000001054Highly InformativeDirect
Mammalian Phenotype (MP)abnormal atrioventricular valve morphology0.000001137Highly InformativeDirect
Mammalian Phenotype (MP)abnormal heart right ventricle morphology0.00005201Highly InformativeDirect
Mammalian Phenotype (MP)ventricular septal defect0.0001618Highly InformativeDirect
Mammalian Phenotype (MP)double outlet right ventricle0.0001833Highly InformativeDirect
Mammalian Phenotype (MP)abnormal heart left ventricle morphology0.0006149Highly InformativeDirect

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)slow growth0Least InformativeDirect
Worm Phenotype (WP)larval lethal0Least InformativeDirect
Worm Phenotype (WP)larval arrest0Least InformativeDirect
Worm Phenotype (WP)progeny variant0Least InformativeDirect
Worm Phenotype (WP)cell development variant0Least InformativeDirect
Worm Phenotype (WP)pericellular component development variant0Moderately InformativeDirect

Document: WP annotation of SCOP domains

Fly Phenotype (FP)

(show details) Document: FP annotation of SCOP domains

Xenopus Anatomy (XA)

(show details) Document: XA annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Hydrolases0Least InformativeDirect
Enzyme Commission (EC)Acting on peptide bonds (peptidases)0Moderately InformativeDirect
Enzyme Commission (EC)Metalloendopeptidases0Highly InformativeDirect

Document: EC annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Enzyme Commission (EC) · Disease Ontology (DO) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Xenopus Anatomy (XA) · Enzyme Commission (EC) ]

Internal database links

Superfamily level     Family level

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.

Superfamily level     Family level

Alignments of sequences to 17 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.

Superfamily level

Browse and view proteins in genomes which have different domain combinations including a Blood coagulation inhibitor (disintegrin) domain.

Superfamily level     Family level

Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.

Jump to [ Top of page · SCOP classification · Enzyme Commission (EC) · Disease Ontology (DO) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Xenopus Anatomy (XA) · Enzyme Commission (EC) · Internal database links ]