SUPERFAMILY 1.75 HMM library and genome assignments server

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TB module/8-cys domain family

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Small proteins [ 56992] (90)
Fold:   TB module/8-cys domain [ 57580]
Superfamily:   TB module/8-cys domain [ 57581]
Family:   TB module/8-cys domain [ 57582] (2)

Family statistics
Genomes (67) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 501 1,418 3
Proteins 366 1,030 3

Human Phenotype (HP)

show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of the face0Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the cardiovascular system0Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of skeletal morphology0Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of nervous system physiology0Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of limbs0Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the eye0.147Least InformativeInherited
Phenotypic Abnormality (PA)Abnormal heart morphology0Moderately InformativeDirect
Phenotypic Abnormality (PA)Abnormality of limb bone morphology0Moderately InformativeDirect
Phenotypic Abnormality (PA)Abnormality of skeletal physiology0Moderately InformativeDirect
Phenotypic Abnormality (PA)Abnormal respiratory system morphology0.005065Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the hand0.008326Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal vascular morphology0.1381Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal anterior eye segment morphology0.1691Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal cardiovascular system physiology0.3384Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal heart valve physiology0.0009991InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the lens0.01229InformativeInherited
Phenotypic Abnormality (PA)Abnormal heart valve morphology0.04986InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the upper respiratory tract0.05959InformativeInherited
Phenotypic Abnormality (PA)Ectopia lentis0.0000007368Highly InformativeDirect
Phenotypic Abnormality (PA)Mitral valve prolapse0.00001287Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormal trachea morphology0.00005447Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormal atrioventricular valve physiology0.00009766Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormal thumb morphology0.0008116Highly InformativeDirect
Phenotypic Abnormality (PA)Limitation of joint mobility0.02235Highly InformativeInherited

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)cardiovascular system phenotype0.0005232Least InformativeDirect
Mammalian Phenotype (MP)growth/size/body region phenotype0.05384Least InformativeInherited
Mammalian Phenotype (MP)mortality/aging0.126Least InformativeInherited
Mammalian Phenotype (MP)abnormal muscle morphology0.00003464Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal craniofacial morphology0.007695Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal head morphology0.07881Moderately InformativeInherited
Mammalian Phenotype (MP)lethality during fetal growth through weaning0.1293Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal blood vessel morphology0.1953Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal axial skeleton morphology0.2332Moderately InformativeInherited
Mammalian Phenotype (MP)prenatal lethality0.2369Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal systemic artery morphology0.00003531InformativeDirect
Mammalian Phenotype (MP)abnormal jaw morphology0.0002435InformativeDirect
Mammalian Phenotype (MP)abnormal mouth morphology0.005289InformativeInherited
Mammalian Phenotype (MP)lethality throughout fetal growth and development0.03001InformativeInherited
Mammalian Phenotype (MP)abnormal vertebral column morphology0.2426InformativeInherited
Mammalian Phenotype (MP)abnormal aorta tunica media morphology0.00000295Highly InformativeDirect
Mammalian Phenotype (MP)abnormal tooth morphology0.04957Highly InformativeInherited

Document: MP annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)trunk0Least InformativeDirect
Xenopus ANatomical entity (XAN)anatomical cluster0Least InformativeDirect
Xenopus ANatomical entity (XAN)cavitated compound organ0Least InformativeDirect
Xenopus DEvelopment stage (XDE)post-embryonic stage0Least InformativeDirect
Xenopus DEvelopment stage (XDE)NF stage 660InformativeDirect

Document: XA annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Human Phenotype (HP) · Mouse Phenotype (MP) · Xenopus Anatomy (XA) ]

Internal database links

Superfamily level     Family level

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.

Superfamily level     Family level

Alignments of sequences to 3 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.

Superfamily level

Browse and view proteins in genomes which have different domain combinations including a TB module/8-cys domain domain.

Superfamily level     Family level

Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.

Jump to [ Top of page · SCOP classification · Human Phenotype (HP) · Mouse Phenotype (MP) · Xenopus Anatomy (XA) · Internal database links ]