TNF receptor-like superfamily

SCOP classification

• Root: SCOP hierarchy in SUPERFAMILY [ 0] (11)
• Class: Small proteins [ 56992] (90)
• Fold: TNF receptor-like [ 57585]
• Superfamily: TNF receptor-like [ 57586] (2)
• Families:
  • TNF receptor-like [ 57587] (5)
  • BAFF receptor-like [ 90174] (3)

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Superfamily statistics

	Genomes (117)	Uniprot 2018_03 genome	PDB chains (SCOP 1.75)
Domains	3,273	9,605	36
Proteins	1,709	5,117	16

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Functional annotation

• General category: Processes_EC
• Detailed category: Immune response

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Disease Ontology (DO)

Highlighted in gray are those with FDR_all>0.001

	DO term	FDR (all)	IC level	SDDO level	Annotation (direct or inherited)
Disease Ontology (DO)	disease of anatomical entity	0	0.2157	--	DIRECT
Disease Ontology (DO)	bone inflammation disease	0.0000000000001691	1.195	--	DIRECT
Disease Ontology (DO)	kidney disease	0.0000001163	1.092	--	DIRECT
Disease Ontology (DO)	musculoskeletal system disease	0.0000002159	0.9087	--	DIRECT
Disease Ontology (DO)	breast carcinoma	0.00009003	1.672	--	DIRECT
Disease Ontology (DO)	immune system cancer	0.00009548	0.8797	--	DIRECT
Disease Ontology (DO)	pancreatic adenocarcinoma	0.0001306	1.769	--	DIRECT
Disease Ontology (DO)	bone resorption disease	0.0001456	2.371	--	DIRECT
Disease Ontology (DO)	vascular disease	0.0003119	0.8029	--	DIRECT
Disease Ontology (DO)	hypotrichosis	0.0003247	1.672	--	DIRECT
Disease Ontology (DO)	immune system disease	0.0003369	0.78	--	DIRECT
Disease Ontology (DO)	arteriosclerotic cardiovascular disease	0.0007648	1.257	--	DIRECT
Disease Ontology (DO)	integumentary system disease	0.0009267	0.8939	--	DIRECT
Disease Ontology (DO)	B cell deficiency	0.003425	1.894	--	INHERITED FROM: agammaglobulinemia
Disease Ontology (DO)	demyelinating disease	0.004391	1.417	--	INHERITED FROM: multiple sclerosis
Disease Ontology (DO)	thoracic cancer	0.01512	1.371	--	INHERITED FROM: breast cancer || breast carcinoma
Disease Ontology (DO)	bone marrow cancer	0.02552	1.371	--	INHERITED FROM: myeloid neoplasm
Disease Ontology (DO)	cancer	0.03867	0.3104	--	INHERITED FROM: pancreatic adenocarcinoma || immune system cancer || myeloid neoplasm || hematologic cancer || breast carcinoma || breast cancer
Disease Ontology (DO)	disease of cellular proliferation	0.04617	0.2812	--	INHERITED FROM: immune system cancer || pancreatic adenocarcinoma || breast cancer || hematologic cancer || breast carcinoma || myeloid neoplasm
Disease Ontology (DO)	hair disease	0.04923	1.672	--	INHERITED FROM: hypotrichosis || alopecia
Disease Ontology (DO)	arteriosclerosis	0.06922	1.257	--	INHERITED FROM: atherosclerosis || arteriosclerotic cardiovascular disease
Disease Ontology (DO)	cardiovascular system disease	0.07165	0.7583	--	INHERITED FROM: vascular disease || atherosclerosis || arteriosclerotic cardiovascular disease
Disease Ontology (DO)	pancreatic cancer	0.1147	1.769	--	INHERITED FROM: pancreatic adenocarcinoma
Disease Ontology (DO)	central nervous system disease	0.1644	0.8526	--	INHERITED FROM: multiple sclerosis
Disease Ontology (DO)	bone disease	0.1719	1.092	--	INHERITED FROM: bone inflammation disease || spondyloarthropathy || bone resorption disease || arthritis
Disease Ontology (DO)	hypersensitivity reaction disease	0.1957	0.827	--	INHERITED FROM: lupus erythematosus || hypersensitivity reaction type II disease
Disease Ontology (DO)	pancreatic carcinoma	1	1.769	--	INHERITED FROM: pancreatic adenocarcinoma
Disease Ontology (DO)	organ system cancer	0.002958	0.5515	Least Informative	INHERITED FROM: breast cancer || breast carcinoma || hematologic cancer || myeloid neoplasm || immune system cancer || pancreatic adenocarcinoma
Disease Ontology (DO)	nervous system disease	0.8136	0.6635	Least Informative	INHERITED FROM: multiple sclerosis
Disease Ontology (DO)	connective tissue disease	0.000000000000258	1.009	Moderately Informative	DIRECT
Disease Ontology (DO)	hypersensitivity reaction type II disease	0.00000008045	0.8526	Moderately Informative	DIRECT
Disease Ontology (DO)	hematologic cancer	0.0000001167	0.8939	Moderately Informative	DIRECT
Disease Ontology (DO)	disease by infectious agent	0.000001618	0.8029	Moderately Informative	DIRECT
Disease Ontology (DO)	urinary system disease	0.00005411	1.07	Moderately Informative	DIRECT
Disease Ontology (DO)	endocrine system disease	0.0006238	1.225	Moderately Informative	DIRECT
Disease Ontology (DO)	neurodegenerative disease	0.02235	0.9909	Moderately Informative	INHERITED FROM: multiple sclerosis
Disease Ontology (DO)	artery disease	0.7184	0.9087	Moderately Informative	INHERITED FROM: atherosclerosis || arteriosclerotic cardiovascular disease
Disease Ontology (DO)	arthritis	0.00000000000006044	1.371	Informative	DIRECT
Disease Ontology (DO)	myeloid neoplasm	0.000001666	1.371	Informative	DIRECT
Disease Ontology (DO)	alopecia	0.0002046	1.672	Informative	DIRECT
Disease Ontology (DO)	multiple sclerosis	0.000399	1.468	Informative	DIRECT
Disease Ontology (DO)	breast cancer	0.0004218	1.371	Informative	DIRECT
Disease Ontology (DO)	atherosclerosis	0.0007536	1.257	Informative	DIRECT
Disease Ontology (DO)	primary immunodeficiency disease	0.01628	1.593	Informative	INHERITED FROM: agammaglobulinemia
Disease Ontology (DO)	endocrine gland cancer	0.02287	1.526	Informative	INHERITED FROM: pancreatic adenocarcinoma
Disease Ontology (DO)	arthropathy	0.1741	1.672	Informative	INHERITED FROM: spondyloarthropathy
Disease Ontology (DO)	lupus erythematosus	0.00000000001601	1.769	Highly Informative	DIRECT
Disease Ontology (DO)	agammaglobulinemia	0.00000005029	1.894	Highly Informative	DIRECT
Disease Ontology (DO)	spondyloarthropathy	0.00007139	1.894	Highly Informative	DIRECT
Disease Ontology (DO)	bone remodeling disease	0.2232	1.894	Highly Informative	INHERITED FROM: bone resorption disease

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Human Phenotype (HP)

Highlighted in gray are those with FDR_all>0.001

	HP term	FDR (all)	IC level	SDHP level	Annotation (direct or inherited)
	Variable expressivity	0	0.01931	--	DIRECT
	Phenotypic variability	1	0	--	INHERITED FROM: Variable expressivity
Phenotypic Abnormality (PA)	Abnormality of B cell physiology	0.000001689	1.708	--	DIRECT
Phenotypic Abnormality (PA)	Abnormal cellular phenotype	0.00002286	1.407	--	DIRECT
Phenotypic Abnormality (PA)	Abnormal spleen morphology	0.00002286	1.561	--	DIRECT
Phenotypic Abnormality (PA)	Conjunctivitis	0.0001806	1.804	--	DIRECT
Phenotypic Abnormality (PA)	Red eye	0.0001806	1.804	--	DIRECT
Phenotypic Abnormality (PA)	Abnormality of abdomen morphology	0.0003899	1.628	--	DIRECT
Phenotypic Abnormality (PA)	Abnormality of humoral immunity	0.0004328	1.293	--	DIRECT
Phenotypic Abnormality (PA)	Recurrent pneumonia	0.0005209	2.407	--	DIRECT
Phenotypic Abnormality (PA)	Abnormal cellular immune system morphology	0.0005883	1.407	--	DIRECT
Phenotypic Abnormality (PA)	Abnormal lymphocyte physiology	0.0005989	1.708	--	DIRECT
Phenotypic Abnormality (PA)	Abnormal conjunctiva morphology	0.001935	1.804	--	INHERITED FROM: Conjunctivitis
Phenotypic Abnormality (PA)	Abnormality of the spleen	0.004948	1.561	--	INHERITED FROM: Splenomegaly || Abnormal spleen morphology
Phenotypic Abnormality (PA)	Neoplasm by anatomical site	0.008493	1.151	--	INHERITED FROM: Lymphoma
Phenotypic Abnormality (PA)	Abnormal immune system morphology	0.009052	1.365	--	INHERITED FROM: Abnormal cellular immune system morphology
Phenotypic Abnormality (PA)	Recurrent lower respiratory tract infections	0.0159	2.407	--	INHERITED FROM: Recurrent pneumonia
Phenotypic Abnormality (PA)	Hematological neoplasm	0.02168	2.106	--	INHERITED FROM: Lymphoma
Phenotypic Abnormality (PA)	Abnormality of the immune system	0.02714	0.8268	--	INHERITED FROM: Abnormality of the lymphatic system || Abnormality of humoral immunity || Conjunctivitis || Abnormality of B cell physiology || Recurrent pneumonia || Abnormal spleen morphology || Abnormal immunoglobulin level || Splenomegaly || Abnormal cellular immune system morphology || Abnormal lymphocyte physiology
Phenotypic Abnormality (PA)	Pneumonia	0.04547	2.407	--	INHERITED FROM: Recurrent pneumonia
Phenotypic Abnormality (PA)	Abnormal respiratory system morphology	0.07155	1.106	--	INHERITED FROM: Recurrent pneumonia
Phenotypic Abnormality (PA)	Abnormality of the ocular adnexa	0.1328	1.176	--	INHERITED FROM: Conjunctivitis
Phenotypic Abnormality (PA)	Unusual infection	0.1513	1.23	--	INHERITED FROM: Recurrent pneumonia
Phenotypic Abnormality (PA)	Abnormality of the orbital region	0.2319	1.176	--	INHERITED FROM: Conjunctivitis
Phenotypic Abnormality (PA)	Abnormality of the face	0.2342	0.5614	--	INHERITED FROM: Conjunctivitis
Phenotypic Abnormality (PA)	Respiratory tract infection	0.3141	2.106	--	INHERITED FROM: Recurrent pneumonia
Phenotypic Abnormality (PA)	Abnormal vascular morphology	0.3427	1.23	--	INHERITED FROM: Vasculitis
Phenotypic Abnormality (PA)	Abnormality of head or neck	0.3604	0.472	--	INHERITED FROM: Conjunctivitis
Phenotypic Abnormality (PA)	Abnormal eye morphology	0.535	0.8155	--	INHERITED FROM: Conjunctivitis || Red eye
Phenotypic Abnormality (PA)	Abnormal inflammatory response	0.5739	1.176	--	INHERITED FROM: Conjunctivitis || Recurrent pneumonia
Phenotypic Abnormality (PA)	Increased inflammatory response	1	1.23	--	INHERITED FROM: Recurrent pneumonia || Conjunctivitis
Phenotypic Abnormality (PA)	Abnormality of the cardiovascular system	0.01635	0.6284	Least Informative	INHERITED FROM: Abnormality of the lymphatic system || Vasculitis || Conjunctivitis || Red eye || Splenomegaly || Abnormal spleen morphology
Phenotypic Abnormality (PA)	Abnormality of metabolism/homeostasis	0.04442	0.5315	Least Informative	INHERITED FROM: Abnormality of B cell physiology || Abnormal cellular physiology || Abnormal immunoglobulin level || Abnormal lymphocyte physiology
Phenotypic Abnormality (PA)	Abnormality of the head	0.3494	0.4771	Least Informative	INHERITED FROM: Conjunctivitis
Phenotypic Abnormality (PA)	Abnormality of the digestive system	0.3682	0.5805	Least Informative	INHERITED FROM: Abnormality of abdomen morphology || Splenomegaly || Visceromegaly || Abnormal spleen morphology
Phenotypic Abnormality (PA)	Abnormality of the eye	0.8275	0.6004	Least Informative	INHERITED FROM: Conjunctivitis || Red eye
Phenotypic Abnormality (PA)	Abnormality of blood and blood-forming tissues	0.00406	1.026	Moderately Informative	INHERITED FROM: Lymphoma
Phenotypic Abnormality (PA)	Abnormality of immune system physiology	0.006122	0.9441	Moderately Informative	INHERITED FROM: Abnormal lymphocyte physiology || Abnormal immunoglobulin level || Abnormality of humoral immunity || Abnormality of B cell physiology || Recurrent pneumonia || Conjunctivitis
Phenotypic Abnormality (PA)	Abnormality of the abdominal organs	0.009419	0.9752	Moderately Informative	INHERITED FROM: Splenomegaly || Abnormal spleen morphology
Phenotypic Abnormality (PA)	Neoplasm	0.01102	1.106	Moderately Informative	INHERITED FROM: Lymphoma
Phenotypic Abnormality (PA)	Abnormal ocular adnexa morphology	0.1258	1.176	Moderately Informative	INHERITED FROM: Conjunctivitis
Phenotypic Abnormality (PA)	Abnormality of the vasculature	0.2131	0.8625	Moderately Informative	INHERITED FROM: Vasculitis || Splenomegaly || Abnormal spleen morphology || Conjunctivitis || Red eye || Abnormality of the lymphatic system
Phenotypic Abnormality (PA)	Abnormality of the respiratory system	0.2877	0.9294	Moderately Informative	INHERITED FROM: Recurrent pneumonia
Phenotypic Abnormality (PA)	Abnormal eye physiology	0.754	0.8751	Moderately Informative	INHERITED FROM: Conjunctivitis
Phenotypic Abnormality (PA)	Abnormality of cardiovascular system morphology	0.9758	0.9441	Moderately Informative	INHERITED FROM: Vasculitis
Phenotypic Abnormality (PA)	Abnormality of the lymphatic system	0.00001298	1.452	Informative	DIRECT
Phenotypic Abnormality (PA)	Abnormal cellular physiology	0.0001789	1.407	Informative	DIRECT
Phenotypic Abnormality (PA)	Visceromegaly	0.0002003	1.628	Informative	DIRECT
Phenotypic Abnormality (PA)	Inflammatory abnormality of the eye	0.002795	1.628	Informative	INHERITED FROM: Conjunctivitis
Phenotypic Abnormality (PA)	Abnormality of the vasculature of the eye	0.02644	1.628	Informative	INHERITED FROM: Conjunctivitis || Red eye
Phenotypic Abnormality (PA)	Abnormal lung morphology	0.03819	1.365	Informative	INHERITED FROM: Recurrent pneumonia
Phenotypic Abnormality (PA)	Recurrent infections	0.9629	1.628	Informative	INHERITED FROM: Recurrent pneumonia
Phenotypic Abnormality (PA)	Abnormal immunoglobulin level	0.00000155	1.929	Highly Informative	DIRECT
Phenotypic Abnormality (PA)	Splenomegaly	0.000003253	1.804	Highly Informative	DIRECT
Phenotypic Abnormality (PA)	Lymphoma	0.00002069	2.106	Highly Informative	DIRECT
Phenotypic Abnormality (PA)	Vasculitis	0.00004564	1.804	Highly Informative	DIRECT
Phenotypic Abnormality (PA)	Recurrent respiratory infections	0.2088	2.106	Highly Informative	INHERITED FROM: Recurrent pneumonia

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Mouse Phenotype (MP)

Highlighted in gray are those with FDR_all>0.001

	MP term	FDR (all)	IC level	SDMP level	Annotation (direct or inherited)
Mammalian Phenotype (MP)	abnormal spleen secondary B follicle morphology	0	1.906	--	DIRECT
Mammalian Phenotype (MP)	abnormal spleen B cell follicle morphology	0.00000000000008677	1.906	--	DIRECT
Mammalian Phenotype (MP)	abnormal spleen white pulp morphology	0.0000000001237	1.73	--	DIRECT
Mammalian Phenotype (MP)	abnormal lymphocyte cell number	0.0000000002452	1.253	--	DIRECT
Mammalian Phenotype (MP)	abnormal lymphocyte physiology	0.000000000527	1.186	--	DIRECT
Mammalian Phenotype (MP)	abnormal leukocyte morphology	0.000000009813	0.9397	--	DIRECT
Mammalian Phenotype (MP)	abnormal immune system cell morphology	0.00000001144	0.9281	--	DIRECT
Mammalian Phenotype (MP)	abnormal blood cell physiology	0.0000001436	0.9281	--	DIRECT
Mammalian Phenotype (MP)	decreased acute inflammation	0.0000005675	2.207	--	DIRECT
Mammalian Phenotype (MP)	abnormal hematopoietic cell morphology	0.0000007516	0.8177	--	DIRECT
Mammalian Phenotype (MP)	absent lymph node germinal center	0.000001611	2.508	--	DIRECT
Mammalian Phenotype (MP)	increased susceptibility to autoimmune disorder	0.000005808	2.508	--	DIRECT
Mammalian Phenotype (MP)	abnormal self tolerance	0.000006234	1.466	--	DIRECT
Mammalian Phenotype (MP)	abnormal interferon-gamma secretion	0.000006655	1.73	--	DIRECT
Mammalian Phenotype (MP)	abnormal definitive hematopoiesis	0.000008144	1.128	--	DIRECT
Mammalian Phenotype (MP)	abnormal IgG2b level	0.000008781	2.508	--	DIRECT
Mammalian Phenotype (MP)	abnormal negative T cell selection	0.00001005	2.508	--	DIRECT
Mammalian Phenotype (MP)	abnormal T cell proliferation	0.00002562	2.508	--	DIRECT
Mammalian Phenotype (MP)	abnormal lymph node germinal center morphology	0.00003309	2.508	--	DIRECT
Mammalian Phenotype (MP)	pulmonary fibrosis	0.00007097	2.508	--	DIRECT
Mammalian Phenotype (MP)	decreased susceptibility to experimental autoimmune encephalomyelitis	0.0000924	2.508	--	DIRECT
Mammalian Phenotype (MP)	cortical renal glomerulopathies	0.000104	1.663	--	DIRECT
Mammalian Phenotype (MP)	abnormal bronchial provocation	0.0001505	1.809	--	DIRECT
Mammalian Phenotype (MP)	abnormal gut-associated lymphoid tissue morphology	0.000427	1.73	--	DIRECT
Mammalian Phenotype (MP)	abnormal plasma cell number	0.0005617	2.508	--	DIRECT
Mammalian Phenotype (MP)	enlarged thymus	0.0007066	2.508	--	DIRECT
Mammalian Phenotype (MP)	abnormal bone structure	0.0008166	1.277	--	DIRECT
Mammalian Phenotype (MP)	abnormal renal glomerulus morphology	0.001242	1.554	--	INHERITED FROM: cortical renal glomerulopathies
Mammalian Phenotype (MP)	altered susceptibility to infection	0.002692	1.253	--	INHERITED FROM: increased susceptibility to bacterial infection
Mammalian Phenotype (MP)	abnormal hepatobiliary system physiology	0.008428	1.304	--	INHERITED FROM: abnormal liver physiology
Mammalian Phenotype (MP)	abnormal immunoglobulin level	0.009327	1.605	--	INHERITED FROM: abnormal IgG2b level || abnormal IgG1 level || abnormal IgG2a level
Mammalian Phenotype (MP)	abnormal hematopoietic system physiology	0.01197	0.9168	--	INHERITED FROM: abnormal leukocyte physiology || abnormal cytotoxic T cell physiology || abnormal IgG1 level || abnormal lymphocyte physiology || abnormal T cell proliferation || abnormal blood cell physiology || abnormal IgG2b level || abnormal IgG2a level
Mammalian Phenotype (MP)	abnormal immune tolerance	0.01352	1.466	--	INHERITED FROM: increased susceptibility to autoimmune disorder || decreased susceptibility to experimental autoimmune encephalomyelitis || autoimmune response || abnormal self tolerance || increased anti-nuclear antigen antibody level
Mammalian Phenotype (MP)	abnormal kidney morphology	0.01435	1.093	--	INHERITED FROM: cortical renal glomerulopathies
Mammalian Phenotype (MP)	abnormal endocrine gland morphology	0.01855	1.304	--	INHERITED FROM: abnormal thymus medulla morphology || enlarged thymus || abnormal thymus epithelium morphology
Mammalian Phenotype (MP)	abnormal immune system physiology	0.01894	0.737	--	INHERITED FROM: abnormal interferon-gamma secretion || increased susceptibility to autoimmune disorder || abnormal IgG1 level || autoimmune response || abnormal T cell proliferation || increased anti-nuclear antigen antibody level || abnormal humoral immune response || abnormal self tolerance || abnormal IgG2b level || abnormal IgG2a level || increased susceptibility to bacterial infection || decreased acute inflammation || abnormal lymphocyte physiology || decreased susceptibility to experimental autoimmune encephalomyelitis || abnormal cytotoxic T cell physiology || abnormal leukocyte physiology
Mammalian Phenotype (MP)	abnormal immune system morphology	0.02379	0.8003	--	INHERITED FROM: abnormal spleen white pulp morphology || abnormal mononuclear cell morphology || enlarged spleen || enlarged lymph nodes || abnormal Peyer's patch morphology || abnormal lymphocyte cell number || abnormal thymus epithelium morphology || abnormal lymph node germinal center morphology || abnormal spleen secondary B follicle morphology || abnormal immune system cell morphology || abnormal lymph node B cell domain morphology || abnormal leukocyte morphology || abnormal thymus medulla morphology || abnormal spleen germinal center morphology || abnormal plasma cell number || abnormal phagocyte morphology || absent lymph node germinal center || abnormal spleen B cell follicle morphology || abnormal gut-associated lymphoid tissue morphology || abnormal negative T cell selection || enlarged thymus
Mammalian Phenotype (MP)	abnormal B cell physiology	0.02546	1.229	--	INHERITED FROM: abnormal IgG2b level || abnormal IgG1 level || abnormal IgG2a level
Mammalian Phenotype (MP)	abnormal hemopoiesis	0.02812	1.11	--	INHERITED FROM: abnormal negative T cell selection || abnormal definitive hematopoiesis
Mammalian Phenotype (MP)	homeostasis/metabolism phenotype	0.03152	0.3617	--	INHERITED FROM: abnormal body temperature homeostasis
Mammalian Phenotype (MP)	abnormal immune cell physiology	0.03303	0.9638	--	INHERITED FROM: abnormal leukocyte physiology || abnormal cytotoxic T cell physiology || abnormal IgG1 level || abnormal T cell proliferation || abnormal lymphocyte physiology || abnormal IgG2b level || abnormal IgG2a level
Mammalian Phenotype (MP)	abnormal cell-mediated immunity	0.03553	0.9638	--	INHERITED FROM: abnormal IgG1 level || abnormal cytotoxic T cell physiology || abnormal leukocyte physiology || abnormal IgG2a level || abnormal IgG2b level || abnormal lymphocyte physiology || abnormal T cell proliferation
Mammalian Phenotype (MP)	abnormal adaptive immunity	0.04112	0.9516	--	INHERITED FROM: abnormal cytotoxic T cell physiology || abnormal leukocyte physiology || abnormal IgG1 level || abnormal lymphocyte physiology || abnormal T cell proliferation || abnormal IgG2a level || abnormal IgG2b level
Mammalian Phenotype (MP)	abnormal kidney cortex morphology	0.05116	1.508	--	INHERITED FROM: cortical renal glomerulopathies
Mammalian Phenotype (MP)	abnormal lymph node cortex morphology	0.05187	2.207	--	INHERITED FROM: absent lymph node germinal center || abnormal lymph node germinal center morphology || abnormal lymph node B cell domain morphology
Mammalian Phenotype (MP)	renal/urinary system phenotype	0.05388	0.8951	--	INHERITED FROM: cortical renal glomerulopathies
Mammalian Phenotype (MP)	endocrine/exocrine gland phenotype	0.05695	0.8003	--	INHERITED FROM: abnormal thymus epithelium morphology || abnormal thymus medulla morphology || enlarged thymus
Mammalian Phenotype (MP)	abnormal leukocyte cell number	0.08588	1.045	--	INHERITED FROM: abnormal lymphocyte cell number
Mammalian Phenotype (MP)	abnormal leukopoiesis	0.08724	1.229	--	INHERITED FROM: abnormal negative T cell selection
Mammalian Phenotype (MP)	skeleton phenotype	0.09352	0.8451	--	INHERITED FROM: abnormal bone structure
Mammalian Phenotype (MP)	abnormal plasma cell morphology	0.113	2.508	--	INHERITED FROM: abnormal plasma cell number
Mammalian Phenotype (MP)	abnormal lymphocyte morphology	0.1174	1.061	--	INHERITED FROM: abnormal negative T cell selection || abnormal plasma cell number || abnormal lymphocyte cell number
Mammalian Phenotype (MP)	abnormal nephron morphology	0.1283	1.229	--	INHERITED FROM: cortical renal glomerulopathies
Mammalian Phenotype (MP)	abnormal thymus lobule morphology	0.1326	1.906	--	INHERITED FROM: abnormal thymus medulla morphology
Mammalian Phenotype (MP)	abnormal lymph node size	0.1434	1.663	--	INHERITED FROM: enlarged lymph nodes
Mammalian Phenotype (MP)	abnormal CD8-positive, alpha-beta T cell physiology	0.1631	2.031	--	INHERITED FROM: abnormal cytotoxic T cell physiology
Mammalian Phenotype (MP)	abnormal skin morphology	0.1912	1.229	--	INHERITED FROM: skin lesions
Mammalian Phenotype (MP)	abnormal respiratory system physiology	0.2057	1.332	--	INHERITED FROM: abnormal airway responsiveness || abnormal bronchial provocation
Mammalian Phenotype (MP)	abnormal hematopoietic system morphology/development	0.2314	0.7444	--	INHERITED FROM: abnormal spleen secondary B follicle morphology || abnormal thymus epithelium morphology || abnormal mononuclear cell morphology || enlarged spleen || abnormal spleen white pulp morphology || abnormal lymphocyte cell number || abnormal spleen B cell follicle morphology || enlarged thymus || abnormal negative T cell selection || abnormal spleen germinal center morphology || abnormal definitive hematopoiesis || abnormal leukocyte morphology || abnormal thymus medulla morphology || abnormal plasma cell number || abnormal hematopoietic cell morphology || abnormal phagocyte morphology
Mammalian Phenotype (MP)	abnormal lymph node secondary follicle morphology	0.2635	2.508	--	INHERITED FROM: absent lymph node germinal center || abnormal lymph node germinal center morphology
Mammalian Phenotype (MP)	abnormal B cell morphology	0.2658	1.253	--	INHERITED FROM: abnormal plasma cell number
Mammalian Phenotype (MP)	abnormal respiration	0.2853	1.429	--	INHERITED FROM: abnormal airway responsiveness || abnormal bronchial provocation
Mammalian Phenotype (MP)	abnormal response to infection	0.2923	1.253	--	INHERITED FROM: increased susceptibility to bacterial infection
Mammalian Phenotype (MP)	increased autoantibody level	0.3028	2.207	--	INHERITED FROM: increased anti-nuclear antigen antibody level
Mammalian Phenotype (MP)	abnormal lymphopoiesis	0.3124	1.229	--	INHERITED FROM: abnormal negative T cell selection
Mammalian Phenotype (MP)	abnormal IgG2 level	0.3237	1.906	--	INHERITED FROM: abnormal IgG2b level || abnormal IgG2a level
Mammalian Phenotype (MP)	abnormal myeloid leukocyte morphology	0.3419	1.466	--	INHERITED FROM: abnormal phagocyte morphology
Mammalian Phenotype (MP)	abnormal cytokine secretion	0.4243	1.277	--	INHERITED FROM: abnormal interferon-gamma secretion
Mammalian Phenotype (MP)	decreased susceptibility to autoimmune disorder	0.4308	2.508	--	INHERITED FROM: decreased susceptibility to experimental autoimmune encephalomyelitis
Mammalian Phenotype (MP)	abnormal respiratory system morphology	0.4869	1.165	--	INHERITED FROM: pulmonary fibrosis
Mammalian Phenotype (MP)	abnormal spleen size	0.64	2.207	--	INHERITED FROM: enlarged spleen
Mammalian Phenotype (MP)	abnormal IgG level	0.7105	1.73	--	INHERITED FROM: abnormal IgG2a level || abnormal IgG1 level || abnormal IgG2b level
Mammalian Phenotype (MP)	abnormal thymus size	0.7222	2.508	--	INHERITED FROM: enlarged thymus
Mammalian Phenotype (MP)	abnormal T cell morphology	0.9365	1.362	--	INHERITED FROM: abnormal negative T cell selection
Mammalian Phenotype (MP)	hematopoietic system phenotype	0.000002469	0.6505	Least Informative	DIRECT
Mammalian Phenotype (MP)	immune system phenotype	0.000003248	0.627	Least Informative	DIRECT
Mammalian Phenotype (MP)	nervous system phenotype	0.6055	0.5166	Least Informative	INHERITED FROM: abnormal nervous system regeneration
Mammalian Phenotype (MP)	abnormal homeostasis	0.6203	0.495	Least Informative	INHERITED FROM: abnormal body temperature homeostasis
Mammalian Phenotype (MP)	abnormal mononuclear cell morphology	0.0000000009162	0.9764	Moderately Informative	DIRECT
Mammalian Phenotype (MP)	abnormal leukocyte physiology	0.00000004616	0.9764	Moderately Informative	DIRECT
Mammalian Phenotype (MP)	abnormal immune serum protein physiology	0.001485	1.11	Moderately Informative	INHERITED FROM: abnormal IgG1 level || abnormal interferon-gamma secretion || abnormal IgG2a level || abnormal IgG2b level
Mammalian Phenotype (MP)	abnormal renal/urinary system morphology	0.02019	1.016	Moderately Informative	INHERITED FROM: cortical renal glomerulopathies
Mammalian Phenotype (MP)	liver/biliary system phenotype	0.02512	0.9397	Moderately Informative	INHERITED FROM: abnormal liver physiology
Mammalian Phenotype (MP)	abnormal blood cell morphology/development	0.05644	1.093	Moderately Informative	INHERITED FROM: abnormal definitive hematopoiesis || abnormal negative T cell selection
Mammalian Phenotype (MP)	abnormal hematopoietic cell number	0.07066	0.9764	Moderately Informative	INHERITED FROM: abnormal lymphocyte cell number
Mammalian Phenotype (MP)	abnormal skeleton morphology	0.07286	0.8951	Moderately Informative	INHERITED FROM: abnormal bone structure
Mammalian Phenotype (MP)	abnormal immune system organ morphology	0.08282	1.186	Moderately Informative	INHERITED FROM: abnormal spleen B cell follicle morphology || abnormal lymph node B cell domain morphology || enlarged spleen || abnormal gut-associated lymphoid tissue morphology || abnormal lymph node germinal center morphology || abnormal spleen germinal center morphology || abnormal spleen secondary B follicle morphology || absent lymph node germinal center || abnormal thymus medulla morphology || abnormal spleen white pulp morphology || abnormal thymus epithelium morphology || enlarged thymus || abnormal Peyer's patch morphology || enlarged lymph nodes
Mammalian Phenotype (MP)	respiratory system phenotype	0.1006	0.9893	Moderately Informative	INHERITED FROM: abnormal airway responsiveness || pulmonary fibrosis || abnormal bronchial provocation
Mammalian Phenotype (MP)	integument phenotype	0.1207	0.8451	Moderately Informative	INHERITED FROM: skin lesions
Mammalian Phenotype (MP)	abnormal nervous system physiology	0.1451	0.8744	Moderately Informative	INHERITED FROM: abnormal nervous system regeneration
Mammalian Phenotype (MP)	abnormal professional antigen presenting cell physiology	0.2002	1.11	Moderately Informative	INHERITED FROM: abnormal IgG2a level || abnormal IgG1 level || abnormal IgG2b level
Mammalian Phenotype (MP)	abnormal blood cell morphology	0.4275	1.016	Moderately Informative	INHERITED FROM: abnormal definitive hematopoiesis || abnormal negative T cell selection
Mammalian Phenotype (MP)	abnormal inflammatory response	0.6454	1.076	Moderately Informative	INHERITED FROM: decreased acute inflammation
Mammalian Phenotype (MP)	abnormal gland morphology	0.6632	0.8644	Moderately Informative	INHERITED FROM: abnormal thymus epithelium morphology || abnormal thymus medulla morphology || enlarged thymus
Mammalian Phenotype (MP)	abnormal myeloid cell morphology	0.9726	1.229	Moderately Informative	INHERITED FROM: abnormal phagocyte morphology
Mammalian Phenotype (MP)	abnormal Peyer's patch morphology	0.00000008209	1.73	Informative	DIRECT
Mammalian Phenotype (MP)	autoimmune response	0.000005964	1.466	Informative	DIRECT
Mammalian Phenotype (MP)	abnormal humoral immune response	0.0004017	1.508	Informative	DIRECT
Mammalian Phenotype (MP)	abnormal liver physiology	0.000494	1.394	Informative	DIRECT
Mammalian Phenotype (MP)	abnormal phagocyte morphology	0.0006643	1.508	Informative	DIRECT
Mammalian Phenotype (MP)	abnormal renal corpuscle morphology	0.001763	1.508	Informative	INHERITED FROM: cortical renal glomerulopathies
Mammalian Phenotype (MP)	abnormal lymph node morphology	0.009388	1.508	Informative	INHERITED FROM: abnormal lymph node B cell domain morphology || enlarged lymph nodes || abnormal lymph node germinal center morphology || absent lymph node germinal center
Mammalian Phenotype (MP)	abnormal spleen morphology	0.02066	1.508	Informative	INHERITED FROM: abnormal spleen germinal center morphology || abnormal spleen secondary B follicle morphology || abnormal spleen white pulp morphology || enlarged spleen || abnormal spleen B cell follicle morphology
Mammalian Phenotype (MP)	abnormal thymus morphology	0.03532	1.508	Informative	INHERITED FROM: abnormal thymus epithelium morphology || enlarged thymus || abnormal thymus medulla morphology
Mammalian Phenotype (MP)	abnormal interferon secretion	0.1431	1.554	Informative	INHERITED FROM: abnormal interferon-gamma secretion
Mammalian Phenotype (MP)	abnormal skin appearance	0.1501	1.663	Informative	INHERITED FROM: skin lesions
Mammalian Phenotype (MP)	altered susceptibility to bacterial infection	0.1742	1.73	Informative	INHERITED FROM: increased susceptibility to bacterial infection
Mammalian Phenotype (MP)	abnormal lung morphology	0.368	1.332	Informative	INHERITED FROM: pulmonary fibrosis
Mammalian Phenotype (MP)	abnormal respiratory function	0.4233	1.508	Informative	INHERITED FROM: abnormal airway responsiveness || abnormal bronchial provocation
Mammalian Phenotype (MP)	increased susceptibility to infection	0.502	1.466	Informative	INHERITED FROM: increased susceptibility to bacterial infection
Mammalian Phenotype (MP)	abnormal lymph organ size	0.5289	1.663	Informative	INHERITED FROM: enlarged lymph nodes || enlarged spleen || enlarged thymus
Mammalian Phenotype (MP)	abnormal T cell differentiation	0.5799	1.605	Informative	INHERITED FROM: abnormal negative T cell selection
Mammalian Phenotype (MP)	abnormal T cell physiology	0.7024	1.605	Informative	INHERITED FROM: abnormal T cell proliferation || abnormal cytotoxic T cell physiology
Mammalian Phenotype (MP)	abnormal spleen germinal center morphology	0	2.031	Highly Informative	DIRECT
Mammalian Phenotype (MP)	abnormal IgG1 level	0.000000003211	2.207	Highly Informative	DIRECT
Mammalian Phenotype (MP)	abnormal lymph node B cell domain morphology	0.000008833	2.207	Highly Informative	DIRECT
Mammalian Phenotype (MP)	enlarged spleen	0.00002868	2.207	Highly Informative	DIRECT
Mammalian Phenotype (MP)	abnormal nervous system regeneration	0.00003568	2.207	Highly Informative	DIRECT
Mammalian Phenotype (MP)	abnormal IgG2a level	0.00003614	1.906	Highly Informative	DIRECT
Mammalian Phenotype (MP)	abnormal airway responsiveness	0.0001396	1.809	Highly Informative	DIRECT
Mammalian Phenotype (MP)	enlarged lymph nodes	0.0001839	1.906	Highly Informative	DIRECT
Mammalian Phenotype (MP)	increased anti-nuclear antigen antibody level	0.000236	2.207	Highly Informative	DIRECT
Mammalian Phenotype (MP)	abnormal thymus medulla morphology	0.0002454	1.906	Highly Informative	DIRECT
Mammalian Phenotype (MP)	skin lesions	0.0003316	2.207	Highly Informative	DIRECT
Mammalian Phenotype (MP)	increased susceptibility to bacterial infection	0.0006858	2.031	Highly Informative	DIRECT
Mammalian Phenotype (MP)	abnormal thymus epithelium morphology	0.0006978	2.207	Highly Informative	DIRECT
Mammalian Phenotype (MP)	abnormal cytotoxic T cell physiology	0.0009049	2.031	Highly Informative	DIRECT
Mammalian Phenotype (MP)	abnormal body temperature homeostasis	0.000911	2.031	Highly Informative	DIRECT
Mammalian Phenotype (MP)	decreased inflammatory response	0.001009	1.906	Highly Informative	INHERITED FROM: decreased acute inflammation
Mammalian Phenotype (MP)	abnormal acute inflammation	0.003214	1.906	Highly Informative	INHERITED FROM: decreased acute inflammation
Mammalian Phenotype (MP)	abnormal T cell selection	0.007686	2.207	Highly Informative	INHERITED FROM: abnormal negative T cell selection
Mammalian Phenotype (MP)	abnormal T cell activation	0.1587	2.031	Highly Informative	INHERITED FROM: abnormal T cell proliferation
Mammalian Phenotype (MP)	altered susceptibility to autoimmune disorder	0.6476	2.207	Highly Informative	INHERITED FROM: decreased susceptibility to experimental autoimmune encephalomyelitis || increased susceptibility to autoimmune disorder

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Zebrafish Anatomy (ZA)

Highlighted in gray are those with FDR_all>0.001

	ZA term	FDR (all)	IC level	SDZA level	Annotation (direct or inherited)
Zebrafish Anatomy (ZA)	whole organism	0	0.004764	--	DIRECT
Zebrafish Anatomy (ZA)	anatomical group	0	0.1889	--	DIRECT
Zebrafish Anatomy (ZA)	anatomical structure	1	0	--	INHERITED FROM: anatomical group || whole organism

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Xenopus Anatomy (XA)

Highlighted in gray are those with FDR_all>0.001

	XA term	FDR (all)	IC level	SDXA level	Annotation (direct or inherited)
Xenopus ANatomical entity (XAN)	head region	0	0.5108	--	DIRECT
Xenopus ANatomical entity (XAN)	trunk region	0	0.4287	--	DIRECT
Xenopus ANatomical entity (XAN)	central nervous system	0	0.6506	--	DIRECT
Xenopus ANatomical entity (XAN)	anatomical structure	0	0	--	DIRECT
Xenopus ANatomical entity (XAN)	anatomical group	0	0.1442	--	DIRECT
Xenopus ANatomical entity (XAN)	organism subdivision	0	0.1871	--	DIRECT
Xenopus ANatomical entity (XAN)	compound organ	0	0.24	--	DIRECT
Xenopus ANatomical entity (XAN)	anatomical region	0	0.193	--	DIRECT
Xenopus ANatomical entity (XAN)	multicellular anatomical structure	0	0.1217	--	DIRECT
Xenopus ANatomical entity (XAN)	anatomical system	1	0.3094	--	INHERITED FROM: nervous system || central nervous system
Xenopus ANatomical entity (XAN)	whole organism	1	0.09747	--	INHERITED FROM: head region || nervous system || anatomical group || cavitated compound organ || multicellular anatomical structure || compound organ || trunk || anatomical region || central nervous system || trunk region || organism subdivision || head
Xenopus ANatomical entity (XAN)	nervous system	0	0.6341	Least Informative	DIRECT
Xenopus ANatomical entity (XAN)	head	0	0.5108	Least Informative	DIRECT
Xenopus ANatomical entity (XAN)	trunk	0	0.4308	Least Informative	DIRECT
Xenopus ANatomical entity (XAN)	cavitated compound organ	0	0.3033	Least Informative	DIRECT
Xenopus DEvelopment stage (XDE)	NF stage	0	0.02327	--	DIRECT

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