SUPERFAMILY 1.75 HMM library and genome assignments server

SUPERFAMILY 2 can be accessed from supfam.org. Please contact us if you experience any problems.

  Home > SCOP hierarchy > FnI-like domain superfamily


FnI-like domain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Small proteins [ 56992] (90)
Fold:   FnI-like domain [ 57602]
Superfamily:   FnI-like domain [ 57603] (2)
Families:   Fibronectin type I module [ 57604] (2)
  VWC domain [ 118264]

 Superfamily statistics
Genomes (147) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 10,295 27,002 13
Proteins 3,823 10,540 9

 Functional annotation
General category Processes_EC
Detailed category Cell adhesion

Document: Function annotation of SCOP domain superfamilies

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on peptide bonds (peptide hydrolases)0.00000000009655Least InformativeDirect
Enzyme Commission (EC)Oxidoreductases0.007355Least InformativeInherited
Enzyme Commission (EC)Serine endopeptidases0.000000000000004396Moderately InformativeDirect
Enzyme Commission (EC)Peroxidases0.0000000001346InformativeDirect
Enzyme Commission (EC)T-plasminogen activator0Highly InformativeDirect
Enzyme Commission (EC)Peroxidase0.000000000000001637Highly InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)organ system cancer0.1039Least InformativeInherited
Disease Ontology (DO)lower respiratory tract disease0.003425Moderately InformativeInherited
Disease Ontology (DO)connective tissue disease0.2757Moderately InformativeInherited
Disease Ontology (DO)nervous system cancer0.3437Moderately InformativeInherited
Disease Ontology (DO)arthritis0.00001555InformativeDirect
Disease Ontology (DO)collagen disease0.05242InformativeInherited
Disease Ontology (DO)peripheral nervous system neoplasm0.06883InformativeInherited
Disease Ontology (DO)neurofibroma0.000002421Highly InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of limbs0.05965Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of skeletal morphology0.182Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the cardiovascular system0.3139Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the digestive system0.401Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the integument0.4707Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the eye0.6896Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the musculature0.7564Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the vasculature0.05351Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal anterior eye segment morphology0.06429Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of connective tissue0.1125Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of cardiovascular system morphology0.2255Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of skin morphology0.3326Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal posterior eye segment morphology0.3376Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the lower limb0.3675Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal skeletal muscle morphology0.3999Moderately InformativeInherited
Phenotypic Abnormality (PA)Growth abnormality0.4417Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal eye physiology0.5676Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of limb bone morphology0.6242Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal morphology of the great vessels0.005456InformativeInherited
Phenotypic Abnormality (PA)Abnormal heart valve morphology0.01012InformativeInherited
Phenotypic Abnormality (PA)Localized skin lesion0.05034InformativeInherited
Phenotypic Abnormality (PA)Hernia0.05832InformativeInherited
Phenotypic Abnormality (PA)Abnormal cornea morphology0.07379InformativeInherited
Phenotypic Abnormality (PA)Abnormal retinal morphology0.1109InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the lens0.119InformativeInherited
Phenotypic Abnormality (PA)Abnormal lower limb bone morphology0.2054InformativeInherited
Phenotypic Abnormality (PA)Short stature0.2107InformativeInherited
Phenotypic Abnormality (PA)Abnormality of long bone morphology0.3014InformativeInherited
Phenotypic Abnormality (PA)Abnormal systemic arterial morphology0.3382InformativeInherited
Phenotypic Abnormality (PA)Mitral valve prolapse0.000007928Highly InformativeDirect
Phenotypic Abnormality (PA)Ectopia lentis0.0001935Highly InformativeDirect
Phenotypic Abnormality (PA)Dermal atrophy0.002094Highly InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the abdominal wall0.01666Highly InformativeInherited
Phenotypic Abnormality (PA)Proportionate short stature0.01992Highly InformativeInherited
Phenotypic Abnormality (PA)Abnormality of femur morphology0.048Highly InformativeInherited
Phenotypic Abnormality (PA)Aortic aneurysm0.07042Highly InformativeInherited
Phenotypic Abnormality (PA)Abnormality of epiphysis morphology0.2228Highly InformativeInherited

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)cardiovascular system phenotype0.0007162Least InformativeDirect
Mammalian Phenotype (MP)cellular phenotype0.1053Least InformativeInherited
Mammalian Phenotype (MP)growth/size/body region phenotype0.1863Least InformativeInherited
Mammalian Phenotype (MP)respiratory system phenotype0.00002228Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal skeleton morphology0.0007745Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal craniofacial morphology0.004564Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal blood vessel morphology0.005379Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cardiovascular system physiology0.009076Moderately InformativeInherited
Mammalian Phenotype (MP)integument phenotype0.01534Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal digestive system morphology0.2301Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal renal/urinary system morphology0.2443Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal eye morphology0.5465Moderately InformativeInherited
Mammalian Phenotype (MP)hemorrhage0.000001179InformativeDirect
Mammalian Phenotype (MP)abnormal angiogenesis0.00002811InformativeDirect
Mammalian Phenotype (MP)abnormal response to injury0.0002953InformativeDirect
Mammalian Phenotype (MP)abnormal head morphology0.009249InformativeInherited
Mammalian Phenotype (MP)abnormal skin physiology0.01366InformativeInherited
Mammalian Phenotype (MP)abnormal compact bone morphology0.03064InformativeInherited
Mammalian Phenotype (MP)abnormal thoracic cage morphology0.109InformativeInherited
Mammalian Phenotype (MP)abnormal bone ossification0.1236InformativeInherited
Mammalian Phenotype (MP)abnormal trabecular bone morphology0.1341InformativeInherited
Mammalian Phenotype (MP)abnormal lung morphology0.247InformativeInherited
Mammalian Phenotype (MP)abnormal vertebrae morphology0.3961InformativeInherited
Mammalian Phenotype (MP)abnormal respiratory function0.6452InformativeInherited
Mammalian Phenotype (MP)abnormal kidney corticomedullary boundary morphology0.000001592Highly InformativeDirect
Mammalian Phenotype (MP)abnormal rib morphology0.00007545Highly InformativeDirect
Mammalian Phenotype (MP)microphthalmia0.0003317Highly InformativeDirect
Mammalian Phenotype (MP)abnormal secondary palate development0.0004084Highly InformativeDirect
Mammalian Phenotype (MP)abnormal compact bone thickness0.0004258Highly InformativeDirect
Mammalian Phenotype (MP)abnormal breathing pattern0.0009888Highly InformativeDirect
Mammalian Phenotype (MP)abnormal pulmonary alveolus morphology0.004163Highly InformativeInherited
Mammalian Phenotype (MP)abnormal skin tensile strength0.004923Highly InformativeInherited
Mammalian Phenotype (MP)abnormal kidney size0.05474Highly InformativeInherited
Mammalian Phenotype (MP)abnormal pulmonary circulation0.0608Highly InformativeInherited
Mammalian Phenotype (MP)abnormal respiratory epithelium morphology0.1061Highly InformativeInherited
Mammalian Phenotype (MP)internal hemorrhage0.5945Highly InformativeInherited

Document: MP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)viable0Least InformativeDirect

Document: FP annotation of SCOP domains

Fly Anatomy (FA)

(show details) Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details)
ZA termFDR (all)SDZA levelAnnotation (direct or inherited)
Zebrafish Anatomy (ZA)compound organ0.0498Least InformativeInherited
Zebrafish Anatomy (ZA)organism subdivision0.1431Least InformativeInherited
Zebrafish Anatomy (ZA)multi-tissue structure0.4091Least InformativeInherited
Zebrafish Anatomy (ZA)head0.1245Moderately InformativeInherited
Zebrafish Anatomy (ZA)anatomical cluster0.1352Moderately InformativeInherited
Zebrafish Anatomy (ZA)skeletal system0.00001235InformativeDirect
Zebrafish Anatomy (ZA)pharyngeal arch0.02916InformativeInherited
Zebrafish Anatomy (ZA)surface structure0.1387InformativeInherited
Zebrafish Anatomy (ZA)pectoral fin0.0004876Highly InformativeDirect
Zebrafish Anatomy (ZA)suspensorium0.001913Highly InformativeInherited
Zebrafish Anatomy (ZA)mandibular arch skeleton0.003419Highly InformativeInherited
Zebrafish Anatomy (ZA)oral region0.02291Highly InformativeInherited
Zebrafish Anatomy (ZA)bone element0.1937Highly InformativeInherited
Zebrafish Anatomy (ZA)pharyngeal arch cartilage0.3082Highly InformativeInherited

Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)tissue0.5777Least InformativeInherited
Xenopus ANatomical entity (XAN)embryo0.7081Least InformativeInherited
Xenopus ANatomical entity (XAN)embryonic structure0.2788Moderately InformativeInherited
Xenopus ANatomical entity (XAN)musculoskeletal system0.3373Moderately InformativeInherited
Xenopus ANatomical entity (XAN)endoderm0.00001756InformativeDirect
Xenopus ANatomical entity (XAN)cardiovascular system0.000122InformativeDirect
Xenopus ANatomical entity (XAN)notochord0.0004066InformativeDirect
Xenopus ANatomical entity (XAN)mesoderm0.002106InformativeInherited
Xenopus ANatomical entity (XAN)epithelium0.02222InformativeInherited
Xenopus ANatomical entity (XAN)hypochord0.00000006246Highly InformativeDirect
Xenopus ANatomical entity (XAN)circulatory system0.00007175Highly InformativeDirect
Xenopus ANatomical entity (XAN)somite0.0007911Highly InformativeDirect
Xenopus ANatomical entity (XAN)epithelial cell0.0008861Highly InformativeDirect
Xenopus ANatomical entity (XAN)axial mesoderm0.006176Highly InformativeInherited

Document: XA annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Hydrolases0.0002467Least InformativeDirect
Enzyme Commission (EC)Oxidoreductases0.005838Least InformativeInherited
Enzyme Commission (EC)Acting on peptide bonds (peptidases)0.00000000006555Moderately InformativeDirect
Enzyme Commission (EC)Serine endopeptidases0.000000000000003019InformativeDirect
Enzyme Commission (EC)Acting on a peroxide as acceptor0.0000000001242InformativeDirect

Document: EC annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Enzyme Commission (EC) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.

Alignments of sequences to 8 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a FnI-like domain domain.

Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 8 hidden Markov models representing the FnI-like domain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Enzyme Commission (EC) · Internal database links ]
Please cite: Gough, J., Karplus, K., Hughey, R. and Chothia, C. (2001). "Assignment of Homology to Genome Sequences using a Library of Hidden Markov Models that Represent all Proteins of Known Structure." J. Mol. Biol., 313(4), 903-919.

Please send feedback, comments or questions to superfamily@cs.bris.ac.uk or use the feedback form.

© Copyright 2013 The SUPERFAMILY authors and Julian Gough.