SUPERFAMILY 1.75 HMM library and genome assignments server

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Thyroglobulin type-1 domain family

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Small proteins [ 56992] (90)
Fold:   Thyroglobulin type-1 domain [ 57609]
Superfamily:   Thyroglobulin type-1 domain [ 57610]
Family:   Thyroglobulin type-1 domain [ 57611] (4)

Family statistics
Genomes (63) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 204 416 4
Proteins 204 416 4

Disease Ontology (DO)

show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)organ system cancer0.1859Least InformativeInherited
Disease Ontology (DO)nervous system cancer0.06705Moderately InformativeInherited
Disease Ontology (DO)retinal cell cancer0.0009206InformativeDirect
Disease Ontology (DO)urinary system cancer0.001585InformativeInherited
Disease Ontology (DO)thyroid gland disease0.0007944Highly InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details) Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)endocrine/exocrine gland phenotype0.273Least InformativeInherited
Mammalian Phenotype (MP)abnormal homeostasis0.8077Least InformativeInherited
Mammalian Phenotype (MP)abnormal hormone level0.06776Moderately InformativeInherited
Mammalian Phenotype (MP)adipose tissue phenotype0.1468Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal muscle morphology0.3572Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal fat pad morphology0.006911InformativeInherited
Mammalian Phenotype (MP)abnormal pancreas physiology0.01064InformativeInherited
Mammalian Phenotype (MP)abnormal endocrine gland physiology0.02InformativeInherited
Mammalian Phenotype (MP)abnormal skeletal muscle morphology0.02801InformativeInherited
Mammalian Phenotype (MP)decreased circulating insulin-like growth factor I level0.00006967Highly InformativeDirect
Mammalian Phenotype (MP)abnormal hypaxial muscle morphology0.001481Highly InformativeInherited
Mammalian Phenotype (MP)abnormal insulin secretion0.001749Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)slow growth0Least InformativeDirect
Worm Phenotype (WP)larval arrest0Least InformativeDirect
Worm Phenotype (WP)pericellular component development variant0.0001097Moderately InformativeDirect

Document: WP annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details) Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus DEvelopment stage (XDE)post-embryonic stage0Least InformativeDirect

Document: XA annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) ]

Internal database links

Superfamily level     Family level

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.

Superfamily level     Family level

Alignments of sequences to 5 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.

Superfamily level

Browse and view proteins in genomes which have different domain combinations including a Thyroglobulin type-1 domain domain.

Superfamily level     Family level

Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.

Jump to [ Top of page · SCOP classification · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Internal database links ]