SUPERFAMILY 1.75 HMM library and genome assignments server

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GLA-domain family

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Small proteins [ 56992] (90)
Fold:   GLA-domain [ 57629]
Superfamily:   GLA-domain [ 57630]
Family:   GLA-domain [ 57631] (6)

Family statistics
Genomes (37) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 93 213 15
Proteins 93 213 15

Enzyme Commission (EC)

show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on peptide bonds (peptide hydrolases)0Least InformativeDirect
Enzyme Commission (EC)Serine endopeptidases0Moderately InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)hematopoietic system disease0.00001429Moderately InformativeDirect
Disease Ontology (DO)syndrome0.0002034Moderately InformativeDirect
Disease Ontology (DO)urinary system disease0.0003826Moderately InformativeDirect
Disease Ontology (DO)artery disease0.4446Moderately InformativeInherited
Disease Ontology (DO)inherited blood coagulation disease0.00002756InformativeDirect
Disease Ontology (DO)atherosclerosis0.00004171InformativeDirect
Disease Ontology (DO)vasculitis0.03026InformativeInherited
Disease Ontology (DO)coronary artery disease0.04066InformativeInherited
Disease Ontology (DO)pancreas disease0.1238InformativeInherited
Disease Ontology (DO)Behcet's disease0.00005782Highly InformativeDirect
Disease Ontology (DO)acute myocardial infarction0.00008768Highly InformativeDirect
Disease Ontology (DO)pancreatitis0.0001617Highly InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of the cardiovascular system0Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the integument0.03431Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of nervous system morphology0.06104Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of skeletal morphology0.2394Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the face0.4592Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the musculature0.6828Least InformativeInherited
Phenotypic Abnormality (PA)Abnormal cardiovascular system physiology0Moderately InformativeDirect
Phenotypic Abnormality (PA)Abnormality of blood and blood-forming tissues0.001407Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal joint morphology0.03353Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal skeletal muscle morphology0.3069Moderately InformativeInherited
Phenotypic Abnormality (PA)Localized skin lesion0.4293Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal oral cavity morphology1Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of coagulation0.000000005783InformativeDirect
Phenotypic Abnormality (PA)Internal hemorrhage0.0000001401InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the cerebral vasculature0.00002998InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the gingiva0.0008993InformativeDirect
Phenotypic Abnormality (PA)Functional respiratory abnormality0.04573InformativeInherited
Phenotypic Abnormality (PA)Deep venous thrombosis0.00000000101Highly InformativeDirect
Phenotypic Abnormality (PA)Intramuscular hematoma0.00000001174Highly InformativeDirect
Phenotypic Abnormality (PA)Joint hemorrhage0.0000001034Highly InformativeDirect
Phenotypic Abnormality (PA)Prolonged prothrombin time0.000002623Highly InformativeDirect
Phenotypic Abnormality (PA)Prolonged bleeding following procedure0.0006221Highly InformativeDirect
Phenotypic Abnormality (PA)Aplasia/Hypoplasia of the skin0.0008767Highly InformativeDirect

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)abnormal homeostasis0Least InformativeDirect
Mammalian Phenotype (MP)cardiovascular system phenotype0.001282Least InformativeInherited
Mammalian Phenotype (MP)abnormal cardiovascular system physiology0.0000441Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal bone structure0.0534Moderately InformativeInherited
Mammalian Phenotype (MP)adipose tissue phenotype0.08536Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal blood coagulation0.0000000003223InformativeDirect
Mammalian Phenotype (MP)hemorrhage0.0000002558InformativeDirect
Mammalian Phenotype (MP)abnormal adipose tissue amount0.03994InformativeInherited
Mammalian Phenotype (MP)abnormal trabecular bone morphology0.04594InformativeInherited
Mammalian Phenotype (MP)increased total body fat amount0.000585Highly InformativeDirect

Document: MP annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details) Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details) Document: XA annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Hydrolases0Least InformativeDirect
Enzyme Commission (EC)Acting on peptide bonds (peptidases)0Moderately InformativeDirect
Enzyme Commission (EC)Serine endopeptidases0InformativeDirect

Document: EC annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Enzyme Commission (EC) ]

Internal database links

Superfamily level     Family level

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.

Superfamily level     Family level

Alignments of sequences to 10 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.

Superfamily level

Browse and view proteins in genomes which have different domain combinations including a GLA-domain domain.

Superfamily level     Family level

Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.

Jump to [ Top of page · SCOP classification · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Enzyme Commission (EC) · Internal database links ]