GLA-domain family

SCOP classification

• Root: SCOP hierarchy in SUPERFAMILY [ 0] (11)
• Class: Small proteins [ 56992] (90)
• Fold: GLA-domain [ 57629]
• Superfamily: GLA-domain [ 57630]
• Family: GLA-domain [ 57631] (6)

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Family statistics

	Genomes (37)	Uniprot 2018_03 genome	PDB chains (SCOP 1.75)
Domains	93	213	15
Proteins	93	213	15

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Enzyme Commission (EC)

Highlighted in gray are those with FDR_all>0.001

	EC term	FDR (all)	IC level	SDEO level	Annotation (direct or inherited)
Enzyme Commission (EC)	Hydrolases	0	0.01852	--	DIRECT
Enzyme Commission (EC)	Coagulation factor Xa	0	2.264	--	DIRECT
Enzyme Commission (EC)	Coagulation factor VIIa	0.00000000002775	2.44	--	DIRECT
Enzyme Commission (EC)	Coagulation factor IXa	0.00000000005606	2.264	--	DIRECT
Enzyme Commission (EC)	Thrombin	0.0000000004636	2.264	--	DIRECT
Enzyme Commission (EC)	Protein C (activated)	0.000000000922	2.264	--	DIRECT
Enzyme Commission (EC)	Acting on peptide bonds (peptide hydrolases)	0	0.5709	Least Informative	DIRECT
Enzyme Commission (EC)	Serine endopeptidases	0	1.139	Moderately Informative	DIRECT

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Disease Ontology (DO)

Highlighted in gray are those with FDR_all>0.001

	DO term	FDR (all)	IC level	SDDO level	Annotation (direct or inherited)
Disease Ontology (DO)	disease of anatomical entity	0	0.2414	--	DIRECT
Disease Ontology (DO)	blood coagulation disease	0.0000000002668	1.258	--	DIRECT
Disease Ontology (DO)	acute pancreatitis	0.00000832	2.212	--	DIRECT
Disease Ontology (DO)	vascular disease	0.000008621	0.832	--	DIRECT
Disease Ontology (DO)	kidney disease	0.00001302	1.066	--	DIRECT
Disease Ontology (DO)	arteriosclerotic cardiovascular disease	0.00004246	1.367	--	DIRECT
Disease Ontology (DO)	cardiovascular system disease	0.001861	0.7889	--	INHERITED FROM: acute myocardial infarction || vascular disease || atherosclerosis || Behcet's disease || arteriosclerotic cardiovascular disease
Disease Ontology (DO)	endocrine system disease	0.005039	1.309	--	INHERITED FROM: pancreatitis || acute pancreatitis
Disease Ontology (DO)	arteriosclerosis	0.0431	1.367	--	INHERITED FROM: atherosclerosis || arteriosclerotic cardiovascular disease
Disease Ontology (DO)	myocardial infarction	0.8747	1.559	--	INHERITED FROM: acute myocardial infarction
Disease Ontology (DO)	hematopoietic system disease	0.00001429	1.051	Moderately Informative	DIRECT
Disease Ontology (DO)	syndrome	0.0002034	1.151	Moderately Informative	DIRECT
Disease Ontology (DO)	urinary system disease	0.0003826	1.051	Moderately Informative	DIRECT
Disease Ontology (DO)	artery disease	0.4446	0.9817	Moderately Informative	INHERITED FROM: atherosclerosis || acute myocardial infarction || arteriosclerotic cardiovascular disease
Disease Ontology (DO)	inherited blood coagulation disease	0.00002756	1.735	Informative	DIRECT
Disease Ontology (DO)	atherosclerosis	0.00004171	1.367	Informative	DIRECT
Disease Ontology (DO)	vasculitis	0.03026	1.668	Informative	INHERITED FROM: Behcet's disease
Disease Ontology (DO)	coronary artery disease	0.04066	1.472	Informative	INHERITED FROM: acute myocardial infarction
Disease Ontology (DO)	pancreas disease	0.1238	1.668	Informative	INHERITED FROM: acute pancreatitis || pancreatitis
Disease Ontology (DO)	Behcet's disease	0.00005782	1.814	Highly Informative	DIRECT
Disease Ontology (DO)	acute myocardial infarction	0.00008768	2.212	Highly Informative	DIRECT
Disease Ontology (DO)	pancreatitis	0.0001617	2.036	Highly Informative	DIRECT

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Human Phenotype (HP)

Highlighted in gray are those with FDR_all>0.001

	HP term	FDR (all)	IC level	SDHP level	Annotation (direct or inherited)
	Variable expressivity	0	0.04347	--	DIRECT
	Phenotypic variability	1	0	--	INHERITED FROM: Variable expressivity
Phenotypic Abnormality (PA)	Abnormality of the coagulation cascade	0.0000000003643	1.684	--	DIRECT
Phenotypic Abnormality (PA)	Post-partum hemorrhage	0.00000001174	2.462	--	DIRECT
Phenotypic Abnormality (PA)	Venous thrombosis	0.000002479	1.763	--	DIRECT
Phenotypic Abnormality (PA)	Abnormal bleeding	0.000002607	1.286	--	DIRECT
Phenotypic Abnormality (PA)	Abnormal prothrombin time	0.000003068	2.161	--	DIRECT
Phenotypic Abnormality (PA)	Abnormality of pulmonary circulation	0.000009735	2.462	--	DIRECT
Phenotypic Abnormality (PA)	Abnormal vascular physiology	0.0008989	2.462	--	DIRECT
Phenotypic Abnormality (PA)	Abnormal thrombosis	0.001037	1.763	--	INHERITED FROM: Venous thrombosis || Deep venous thrombosis
Phenotypic Abnormality (PA)	Abnormality of blood circulation	0.001292	1.421	--	INHERITED FROM: Internal hemorrhage || Joint hemorrhage
Phenotypic Abnormality (PA)	Abnormal oral mucosa morphology	0.004295	1.258	--	INHERITED FROM: Abnormality of the gingiva
Phenotypic Abnormality (PA)	Abnormality of skin morphology	0.008841	0.7722	--	INHERITED FROM: Aplasia/Hypoplasia of the skin
Phenotypic Abnormality (PA)	Abnormality of the skin	0.01343	0.722	--	INHERITED FROM: Aplasia/Hypoplasia of the skin
Phenotypic Abnormality (PA)	Abnormality of brain morphology	0.02147	0.6631	--	INHERITED FROM: Abnormality of the cerebral vasculature
Phenotypic Abnormality (PA)	Morphological abnormality of the central nervous system	0.03714	0.533	--	INHERITED FROM: Abnormality of the cerebral vasculature
Phenotypic Abnormality (PA)	Abnormality of the respiratory system	0.1384	0.9183	--	INHERITED FROM: Abnormality of pulmonary circulation
Phenotypic Abnormality (PA)	Abnormality of the vasculature	0.1527	0.7142	--	INHERITED FROM: Abnormality of the cerebral vasculature || Abnormal vascular physiology || Abnormality of pulmonary circulation
Phenotypic Abnormality (PA)	Abnormality of prothrombin	0.1595	2.161	--	INHERITED FROM: Abnormal prothrombin time || Prolonged prothrombin time
Phenotypic Abnormality (PA)	Abnormal oral morphology	0.189	0.7381	--	INHERITED FROM: Abnormality of the gingiva
Phenotypic Abnormality (PA)	Abnormality of the mouth	0.2241	0.7065	--	INHERITED FROM: Abnormality of the gingiva
Phenotypic Abnormality (PA)	Abnormality of the nervous system	0.2421	0.2371	--	INHERITED FROM: Abnormality of the cerebral vasculature
Phenotypic Abnormality (PA)	Abnormality of the skeletal system	0.273	0.4712	--	INHERITED FROM: Joint hemorrhage
Phenotypic Abnormality (PA)	Abnormality of the head	0.5575	0.4538	--	INHERITED FROM: Abnormality of the gingiva
Phenotypic Abnormality (PA)	Abnormality of head or neck	0.5667	0.4454	--	INHERITED FROM: Abnormality of the gingiva
Phenotypic Abnormality (PA)	Abnormality of the cardiovascular system	0	0.5179	Least Informative	DIRECT
Phenotypic Abnormality (PA)	Abnormality of the integument	0.03431	0.6235	Least Informative	INHERITED FROM: Aplasia/Hypoplasia of the skin
Phenotypic Abnormality (PA)	Abnormality of nervous system morphology	0.06104	0.4756	Least Informative	INHERITED FROM: Abnormality of the cerebral vasculature
Phenotypic Abnormality (PA)	Abnormality of skeletal morphology	0.2394	0.513	Least Informative	INHERITED FROM: Joint hemorrhage
Phenotypic Abnormality (PA)	Abnormality of the face	0.4592	0.533	Least Informative	INHERITED FROM: Abnormality of the gingiva
Phenotypic Abnormality (PA)	Abnormality of the musculature	0.6828	0.5433	Least Informative	INHERITED FROM: Intramuscular hematoma
Phenotypic Abnormality (PA)	Abnormal cardiovascular system physiology	0	0.9309	Moderately Informative	DIRECT
Phenotypic Abnormality (PA)	Abnormality of blood and blood-forming tissues	0.001407	0.9183	Moderately Informative	INHERITED FROM: Post-partum hemorrhage || Abnormal prothrombin time || Deep venous thrombosis || Internal hemorrhage || Prolonged prothrombin time || Abnormality of the coagulation cascade || Abnormal bleeding || Venous thrombosis || Prolonged bleeding following procedure || Abnormality of coagulation || Joint hemorrhage
Phenotypic Abnormality (PA)	Abnormal joint morphology	0.03353	1.101	Moderately Informative	INHERITED FROM: Joint hemorrhage
Phenotypic Abnormality (PA)	Abnormal skeletal muscle morphology	0.3069	0.9061	Moderately Informative	INHERITED FROM: Intramuscular hematoma
Phenotypic Abnormality (PA)	Localized skin lesion	0.4293	1.161	Moderately Informative	INHERITED FROM: Aplasia/Hypoplasia of the skin
Phenotypic Abnormality (PA)	Abnormal oral cavity morphology	1	0.8289	Moderately Informative	INHERITED FROM: Abnormality of the gingiva
Phenotypic Abnormality (PA)	Abnormality of coagulation	0.000000005783	1.617	Informative	DIRECT
Phenotypic Abnormality (PA)	Internal hemorrhage	0.0000001401	1.421	Informative	DIRECT
Phenotypic Abnormality (PA)	Abnormality of the cerebral vasculature	0.00002998	1.462	Informative	DIRECT
Phenotypic Abnormality (PA)	Abnormality of the gingiva	0.0008993	1.617	Informative	DIRECT
Phenotypic Abnormality (PA)	Functional respiratory abnormality	0.04573	1.348	Informative	INHERITED FROM: Abnormality of pulmonary circulation
Phenotypic Abnormality (PA)	Deep venous thrombosis	0.00000000101	2.161	Highly Informative	DIRECT
Phenotypic Abnormality (PA)	Intramuscular hematoma	0.00000001174	2.161	Highly Informative	DIRECT
Phenotypic Abnormality (PA)	Joint hemorrhage	0.0000001034	2.161	Highly Informative	DIRECT
Phenotypic Abnormality (PA)	Prolonged prothrombin time	0.000002623	2.161	Highly Informative	DIRECT
Phenotypic Abnormality (PA)	Prolonged bleeding following procedure	0.0006221	2.161	Highly Informative	DIRECT
Phenotypic Abnormality (PA)	Aplasia/Hypoplasia of the skin	0.0008767	1.86	Highly Informative	DIRECT

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Mouse Phenotype (MP)

Highlighted in gray are those with FDR_all>0.001

	MP term	FDR (all)	IC level	SDMP level	Annotation (direct or inherited)
Mammalian Phenotype (MP)	homeostasis/metabolism phenotype	0	0.3626	--	DIRECT
Mammalian Phenotype (MP)	abnormal blood homeostasis	0	0.6893	--	DIRECT
Mammalian Phenotype (MP)	abnormal hemostasis	0.000004455	1.399	--	DIRECT
Mammalian Phenotype (MP)	abnormal trabecular bone thickness	0.000107	2.603	--	DIRECT
Mammalian Phenotype (MP)	abnormal blood circulation	0.007766	1.261	--	INHERITED FROM: hemorrhage
Mammalian Phenotype (MP)	skeleton phenotype	0.03769	0.8038	--	INHERITED FROM: abnormal trabecular bone thickness
Mammalian Phenotype (MP)	abnormal adipose tissue morphology	0.08094	1.223	--	INHERITED FROM: increased total body fat amount
Mammalian Phenotype (MP)	abnormal skeleton morphology	0.7784	0.8323	--	INHERITED FROM: abnormal trabecular bone thickness
Mammalian Phenotype (MP)	abnormal homeostasis	0	0.4926	Least Informative	DIRECT
Mammalian Phenotype (MP)	cardiovascular system phenotype	0.001282	0.6737	Least Informative	INHERITED FROM: hemorrhage || abnormal cardiovascular system physiology
Mammalian Phenotype (MP)	abnormal cardiovascular system physiology	0.0000441	0.9499	Moderately Informative	DIRECT
Mammalian Phenotype (MP)	abnormal bone structure	0.0534	1.241	Moderately Informative	INHERITED FROM: abnormal trabecular bone thickness
Mammalian Phenotype (MP)	adipose tissue phenotype	0.08536	1.205	Moderately Informative	INHERITED FROM: increased total body fat amount
Mammalian Phenotype (MP)	abnormal blood coagulation	0.0000000003223	1.399	Informative	DIRECT
Mammalian Phenotype (MP)	hemorrhage	0.0000002558	1.348	Informative	DIRECT
Mammalian Phenotype (MP)	abnormal adipose tissue amount	0.03994	1.489	Informative	INHERITED FROM: increased total body fat amount
Mammalian Phenotype (MP)	abnormal trabecular bone morphology	0.04594	1.489	Informative	INHERITED FROM: abnormal trabecular bone thickness
Mammalian Phenotype (MP)	increased total body fat amount	0.000585	2.001	Highly Informative	DIRECT

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Zebrafish Anatomy (ZA)

Highlighted in gray are those with FDR_all>0.001

	ZA term	FDR (all)	IC level	SDZA level	Annotation (direct or inherited)
Zebrafish Anatomy (ZA)	whole organism	0	0.00147	--	DIRECT
Zebrafish Anatomy (ZA)	anatomical system	0	0.1857	--	DIRECT
Zebrafish Anatomy (ZA)	anatomical group	0	0.1532	--	DIRECT
Zebrafish Anatomy (ZA)	anatomical structure	1	0	--	INHERITED FROM: anatomical system || anatomical group || whole organism

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Xenopus Anatomy (XA)

Highlighted in gray are those with FDR_all>0.001

	XA term	FDR (all)	IC level	SDXA level	Annotation (direct or inherited)
Xenopus ANatomical entity (XAN)	anatomical structure	0	0	--	DIRECT
Xenopus ANatomical entity (XAN)	anatomical group	0	0.1408	--	DIRECT
Xenopus ANatomical entity (XAN)	organism subdivision	0	0.1679	--	DIRECT
Xenopus ANatomical entity (XAN)	compound organ	0	0.2177	--	DIRECT
Xenopus ANatomical entity (XAN)	multicellular anatomical structure	0	0.1131	--	DIRECT
Xenopus ANatomical entity (XAN)	whole organism	1	0.0884	--	INHERITED FROM: anatomical group || multicellular anatomical structure || compound organ || organism subdivision
Xenopus DEvelopment stage (XDE)	NF stage	0	0.01895	--	DIRECT

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Enzyme Commission (EC)

Highlighted in gray are those with FDR_all>0.001

	EC term	FDR (all)	IC level	SDEC level	Annotation (direct or inherited)
Enzyme Commission (EC)	Coagulation factor Xa	0	2.753	--	DIRECT
Enzyme Commission (EC)	Coagulation factor IXa	0.000000000001115	2.753	--	DIRECT
Enzyme Commission (EC)	Coagulation factor VIIa	0.00000000002163	2.753	--	DIRECT
Enzyme Commission (EC)	Thrombin	0.0000000003727	2.753	--	DIRECT
Enzyme Commission (EC)	Protein C (activated)	0.0000000007181	2.753	--	DIRECT
Enzyme Commission (EC)	Hydrolases	0	0.4043	Least Informative	DIRECT
Enzyme Commission (EC)	Acting on peptide bonds (peptidases)	0	1.004	Moderately Informative	DIRECT
Enzyme Commission (EC)	Serine endopeptidases	0	1.576	Informative	DIRECT

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