B-box zinc-binding domain superfamily

SCOP classification

• Root: SCOP hierarchy in SUPERFAMILY [ 0] (11)
• Class: Small proteins [ 56992] (90)
• Fold: B-box zinc-binding domain [ 57844]
• Superfamily: B-box zinc-binding domain [ 57845]
• Families: B-box zinc-binding domain [ 57846] (7)

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Superfamily statistics

	Genomes (407)	Uniprot 2018_03 genome	PDB chains (SCOP 1.75)
Domains	9,656	21,902	7
Proteins	9,553	21,699	7

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Functional annotation

• General category: General
• Detailed category: Ion binding

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Mouse Phenotype (MP)

Highlighted in gray are those with FDR_all>0.001

	MP term	FDR (all)	IC level	SDMP level	Annotation (direct or inherited)
Mammalian Phenotype (MP)	abnormal skeletal muscle fiber size	0.0008282	2.207	--	DIRECT
Mammalian Phenotype (MP)	abnormal muscle fiber morphology	0.04197	1.906	--	INHERITED FROM: abnormal skeletal muscle fiber size
Mammalian Phenotype (MP)	abnormal skeletal muscle morphology	0.1953	1.332	--	INHERITED FROM: abnormal skeletal muscle fiber size
Mammalian Phenotype (MP)	muscle phenotype	0.2163	0.8177	--	INHERITED FROM: abnormal skeletal muscle fiber size
Mammalian Phenotype (MP)	abnormal muscle morphology	0.06649	1.061	Moderately Informative	INHERITED FROM: abnormal skeletal muscle fiber size
Mammalian Phenotype (MP)	abnormal skeletal muscle fiber morphology	0.02612	2.031	Highly Informative	INHERITED FROM: abnormal skeletal muscle fiber size

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Worm Phenotype (WP)

Highlighted in gray are those with FDR_all>0.001

	WP term	FDR (all)	IC level	SDWP level	Annotation (direct or inherited)
Worm Phenotype (WP)	embryonic lethal	0	0.07108	--	DIRECT
Worm Phenotype (WP)	lethal	0	0.01121	--	DIRECT
Worm Phenotype (WP)	fertility variant	0	0.08329	--	DIRECT
Worm Phenotype (WP)	development variant	0	0.001706	--	DIRECT
Worm Phenotype (WP)	morphology variant	0	0.06117	--	DIRECT
Worm Phenotype (WP)	organism development variant	0	0.004279	--	DIRECT
Worm Phenotype (WP)	organism morphology variant	0	0.2011	--	DIRECT
Worm Phenotype (WP)	organ system physiology variant	0	0.05921	--	DIRECT
Worm Phenotype (WP)	reproductive system physiology variant	0	0.07209	--	DIRECT
Worm Phenotype (WP)	maternal sterile	0	0.171	--	DIRECT
Worm Phenotype (WP)	hermaphrodite sterile	0	0.1685	--	DIRECT
Worm Phenotype (WP)	embryonic development variant	0	0.06709	--	DIRECT
Worm Phenotype (WP)	hermaphrodite fertility variant	0	0.1278	--	DIRECT
Worm Phenotype (WP)	hermaphrodite fertility reduced	0	0.1672	--	DIRECT
Worm Phenotype (WP)	fertility reduced	0	0.09267	--	DIRECT
Worm Phenotype (WP)	protein aggregation variant	0.000000000808	1.074	--	DIRECT
Worm Phenotype (WP)	protein protein interaction variant	0.000000001071	1.064	--	DIRECT
Worm Phenotype (WP)	cell migration variant	0.0000006044	1.327	--	DIRECT
Worm Phenotype (WP)	transgene subcellular localization variant	0.0000006992	1.23	--	DIRECT
Worm Phenotype (WP)	transgene expression variant	0.00003681	0.7938	--	DIRECT
Worm Phenotype (WP)	gene expression variant	0.0002035	0.6038	--	DIRECT
Worm Phenotype (WP)	physiology variant	1	0	--	INHERITED FROM: neuron migration variant || hermaphrodite fertility variant || protein protein interaction variant || reproductive system physiology variant || transgene expression variant || cell migration variant || gene expression variant || lethal || protein interaction variant || transgene subcellular localization variant || development variant || hermaphrodite sterile || hermaphrodite fertility reduced || embryonic development variant || embryonic lethal || fertility variant || protein aggregation variant || organ system physiology variant || maternal sterile || organism development variant || fertility reduced || cell development variant
Worm Phenotype (WP)	organism physiology variant	1	0.1405	--	INHERITED FROM: transgene expression variant || transgene subcellular localization variant || gene expression variant || protein protein interaction variant || protein aggregation variant || protein interaction variant
Worm Phenotype (WP)	organism homeostasis metabolism variant	1	0.1501	--	INHERITED FROM: gene expression variant || transgene expression variant || transgene subcellular localization variant || protein interaction variant || protein protein interaction variant || protein aggregation variant
Worm Phenotype (WP)	sterile	1	0.161	--	INHERITED FROM: hermaphrodite sterile || maternal sterile
Worm Phenotype (WP)	cell development variant	0.0000183	0.632	Least Informative	DIRECT
Worm Phenotype (WP)	organism metabolism processing variant	0.001105	0.4572	Least Informative	INHERITED FROM: gene expression variant || protein interaction variant || transgene subcellular localization variant || transgene expression variant || protein aggregation variant || protein protein interaction variant
Worm Phenotype (WP)	protein interaction variant	0.0000001309	1.035	Moderately Informative	DIRECT
Worm Phenotype (WP)	pattern of transgene expression variant	0.03291	1.017	Moderately Informative	INHERITED FROM: transgene subcellular localization variant
Worm Phenotype (WP)	neuron migration variant	0.000000000000008505	1.531	Informative	DIRECT

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Fly Phenotype (FP)

Highlighted in gray are those with FDR_all>0.001

	FP term	FDR (all)	IC level	SDFP level	Annotation (direct or inherited)
Fly Phenotype (FP)	phenotype	0	0.05522	--	DIRECT
Fly Phenotype (FP)	increased mortality during development	0	0.6799	--	DIRECT
Fly Phenotype (FP)	viable	0	0.735	Least Informative	DIRECT
Fly Phenotype (FP)	increased mortality	0	0.5628	Least Informative	DIRECT
Fly Phenotype (FP)	lethal	0	0.798	Moderately Informative	DIRECT

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Fly Anatomy (FA)

Highlighted in gray are those with FDR_all>0.001

	FA term	FDR (all)	IC level	SDFA level	Annotation (direct or inherited)
Fly Anatomy (FA)	organism	0	0.07918	--	DIRECT
Fly Anatomy (FA)	organ system	0	0.2279	--	DIRECT
Fly Anatomy (FA)	multicellular structure	0	0.009143	--	DIRECT
Fly Anatomy (FA)	anatomical structure	1	0	--	INHERITED FROM: organism || cell || organ system || multicellular structure
Fly Anatomy (FA)	material anatomical entity	1	0	--	INHERITED FROM: organ system || multicellular structure || cell || organism
Fly Anatomy (FA)	cell	0	0.4937	Least Informative	DIRECT

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Zebrafish Anatomy (ZA)

Highlighted in gray are those with FDR_all>0.001

	ZA term	FDR (all)	IC level	SDZA level	Annotation (direct or inherited)
Zebrafish Anatomy (ZA)	whole organism	0	0.004764	--	DIRECT
Zebrafish Anatomy (ZA)	anatomical structure	1	0	--	INHERITED FROM: whole organism

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Xenopus Anatomy (XA)

Highlighted in gray are those with FDR_all>0.001

	XA term	FDR (all)	IC level	SDXA level	Annotation (direct or inherited)
Xenopus ANatomical entity (XAN)	anatomical structure	0	0	--	DIRECT

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Enzyme Commission (EC)

Highlighted in gray are those with FDR_all>0.001

	EC term	FDR (all)	IC level	SDEC level	Annotation (direct or inherited)
Enzyme Commission (EC)	Transferases	0	0.3035	--	DIRECT
Enzyme Commission (EC)	Acyltransferases	0	0.8446	--	DIRECT
Enzyme Commission (EC)	Aminoacyltransferases	0	1.166	Moderately Informative	DIRECT
Enzyme Commission (EC)	RING-type E3 ubiquitin transferase	0	1.384	Informative	DIRECT

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