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Inhibitor of apoptosis (IAP) repeat superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Small proteins [ 56992] (90)
Fold:   Inhibitor of apoptosis (IAP) repeat [ 57923]
Superfamily:   Inhibitor of apoptosis (IAP) repeat [ 57924]
Families:   Inhibitor of apoptosis (IAP) repeat [ 57925] (6)

Superfamily statistics
Genomes (356) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 2,482 8,117 23
Proteins 1,377 4,814 23

Functional annotation
General category Processes_IC
Detailed category Cell cycle, Apoptosis

Function annotation of SCOP domain superfamilies

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)nervous system disease0.007533Least InformativeInherited
Disease Ontology (DO)organ system cancer0.1365Least InformativeInherited
Disease Ontology (DO)hematologic cancer0.0001254Moderately InformativeDirect
Disease Ontology (DO)neurodegenerative disease0.004807Moderately InformativeInherited
Disease Ontology (DO)benign neoplasm0.02195Moderately InformativeInherited
Disease Ontology (DO)multiple sclerosis0.00005997InformativeDirect
Disease Ontology (DO)female reproductive organ cancer0.003411InformativeInherited
Disease Ontology (DO)cell type benign neoplasm0.00512InformativeInherited
Disease Ontology (DO)ovary epithelial cancer0.0009057Highly InformativeDirect

Document: DO annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)cellular phenotype0Least InformativeDirect
Mammalian Phenotype (MP)immune system phenotype0.008901Least InformativeInherited
Mammalian Phenotype (MP)hematopoietic system phenotype0.05297Least InformativeInherited
Mammalian Phenotype (MP)cardiovascular system phenotype0.08399Least InformativeInherited
Mammalian Phenotype (MP)abnormal homeostasis0.9224Least InformativeInherited
Mammalian Phenotype (MP)abnormal cell death0Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal leukocyte physiology0.001926Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cardiovascular system physiology0.02085Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal muscle physiology0.0252Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal immune system organ morphology0.2264Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal heart morphology0.4344Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal professional antigen presenting cell physiology0.6231Moderately InformativeInherited
Mammalian Phenotype (MP)normal phenotype0.0005132InformativeDirect
Mammalian Phenotype (MP)hemorrhage0.0005999InformativeDirect
Mammalian Phenotype (MP)impaired muscle contractility0.001186InformativeInherited
Mammalian Phenotype (MP)abnormal fluid regulation0.001587InformativeInherited
Mammalian Phenotype (MP)abnormal lymph node morphology0.002214InformativeInherited
Mammalian Phenotype (MP)abnormal cardiac muscle contractility0.01065InformativeInherited
Mammalian Phenotype (MP)abnormal lymph organ size0.02758InformativeInherited
Mammalian Phenotype (MP)enlarged pericardium0.000004041Highly InformativeDirect
Mammalian Phenotype (MP)internal hemorrhage0.00005637Highly InformativeDirect
Mammalian Phenotype (MP)abnormal pericardial cavity morphology0.0001097Highly InformativeDirect
Mammalian Phenotype (MP)abnormal heart atrium morphology0.0003938Highly InformativeDirect
Mammalian Phenotype (MP)congestive heart failure0.0004551Highly InformativeDirect
Mammalian Phenotype (MP)abnormal B cell apoptosis0.0009025Highly InformativeDirect

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details) Document: WP annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)urogenital system0Least InformativeDirect

Document: XA annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Aminoacyltransferases0Moderately InformativeDirect
Enzyme Commission (EC)RING-type E3 ubiquitin transferase0InformativeDirect

Document: EC annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Disease Ontology (DO) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Xenopus Anatomy (XA) · Enzyme Commission (EC) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.

Alignments of sequences to 13 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.

Browse and view proteins in genomes which have different domain combinations including a Inhibitor of apoptosis (IAP) repeat domain.

Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.

Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 13 hidden Markov models representing the Inhibitor of apoptosis (IAP) repeat superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.

Jump to [ Top of page · SCOP classification · Functional annotation · Disease Ontology (DO) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Xenopus Anatomy (XA) · Enzyme Commission (EC) · Internal database links ]