SUPERFAMILY 1.75 HMM library and genome assignments server

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Inhibitor of apoptosis (IAP) repeat family

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Small proteins [ 56992] (90)
Fold:   Inhibitor of apoptosis (IAP) repeat [ 57923]
Superfamily:   Inhibitor of apoptosis (IAP) repeat [ 57924]
Family:   Inhibitor of apoptosis (IAP) repeat [ 57925] (6)

Family statistics
Genomes (120) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 856 2,326 23
Proteins 631 1,768 23

Disease Ontology (DO)

show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)nervous system disease0.005953Least InformativeInherited
Disease Ontology (DO)organ system cancer0.1178Least InformativeInherited
Disease Ontology (DO)hematologic cancer0.0000953Moderately InformativeDirect
Disease Ontology (DO)neurodegenerative disease0.003855Moderately InformativeInherited
Disease Ontology (DO)benign neoplasm0.01851Moderately InformativeInherited
Disease Ontology (DO)multiple sclerosis0.00004547InformativeDirect
Disease Ontology (DO)female reproductive organ cancer0.002553InformativeInherited
Disease Ontology (DO)cell type benign neoplasm0.004055InformativeInherited

Document: DO annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)cellular phenotype0Least InformativeDirect
Mammalian Phenotype (MP)hematopoietic system phenotype0.01279Least InformativeInherited
Mammalian Phenotype (MP)immune system phenotype0.01399Least InformativeInherited
Mammalian Phenotype (MP)cardiovascular system phenotype0.03408Least InformativeInherited
Mammalian Phenotype (MP)mortality/aging0.06982Least InformativeInherited
Mammalian Phenotype (MP)abnormal homeostasis0.9022Least InformativeInherited
Mammalian Phenotype (MP)abnormal cell death0Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal leukocyte physiology0.0003017Moderately InformativeDirect
Mammalian Phenotype (MP)prenatal lethality0.002491Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cardiovascular system physiology0.007479Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal muscle physiology0.01139Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal immune system organ morphology0.1989Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal heart morphology0.3954Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal professional antigen presenting cell physiology0.5954Moderately InformativeInherited
Mammalian Phenotype (MP)normal phenotype0InformativeDirect
Mammalian Phenotype (MP)hemorrhage0.0001557InformativeDirect
Mammalian Phenotype (MP)impaired muscle contractility0.0004213InformativeDirect
Mammalian Phenotype (MP)abnormal fluid regulation0.0004546InformativeDirect
Mammalian Phenotype (MP)abnormal lymph node morphology0.0008215InformativeDirect
Mammalian Phenotype (MP)abnormal cardiac muscle contractility0.007073InformativeInherited
Mammalian Phenotype (MP)abnormal lymph organ size0.01231InformativeInherited
Mammalian Phenotype (MP)enlarged pericardium0.000001353Highly InformativeDirect
Mammalian Phenotype (MP)internal hemorrhage0.00001339Highly InformativeDirect
Mammalian Phenotype (MP)abnormal heart atrium morphology0.0001094Highly InformativeDirect
Mammalian Phenotype (MP)congestive heart failure0.0002777Highly InformativeDirect
Mammalian Phenotype (MP)abnormal B cell apoptosis0.0005089Highly InformativeDirect

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details) Document: WP annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)urogenital system0Least InformativeDirect

Document: XA annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferases0Least InformativeDirect
Enzyme Commission (EC)Acyltransferases0Moderately InformativeDirect
Enzyme Commission (EC)Aminoacyltransferases0InformativeDirect

Document: EC annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Disease Ontology (DO) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Xenopus Anatomy (XA) · Enzyme Commission (EC) ]

Internal database links

Superfamily level     Family level

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.

Superfamily level     Family level

Alignments of sequences to 13 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.

Superfamily level

Browse and view proteins in genomes which have different domain combinations including a Inhibitor of apoptosis (IAP) repeat domain.

Superfamily level     Family level

Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.

Jump to [ Top of page · SCOP classification · Disease Ontology (DO) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Xenopus Anatomy (XA) · Enzyme Commission (EC) · Internal database links ]