Triple coiled coil domain of C-type lectins superfamily

SCOP classification

• Root: SCOP hierarchy in SUPERFAMILY [ 0] (11)
• Class: Coiled coil proteins [ 57942] (7)
• Fold: Parallel coiled-coil [ 57943] (34)
• Superfamily: Triple coiled coil domain of C-type lectins [ 57944]
• Families: Triple coiled coil domain of C-type lectins [ 57945] (3)

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Superfamily statistics

	Genomes (62)	Uniprot 2018_03 genome	PDB chains (SCOP 1.75)
Domains	196	430	16
Proteins	196	429	16

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Functional annotation

• General category: Other
• Detailed category: Unknown function

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Disease Ontology (DO)

Highlighted in gray are those with FDR_all>0.001

	DO term	FDR (all)	IC level	SDDO level	Annotation (direct or inherited)
Disease Ontology (DO)	disease of cellular proliferation	0	0.2812	--	DIRECT
Disease Ontology (DO)	cancer	0	0.3104	--	DIRECT
Disease Ontology (DO)	nasal cavity disease	0.00000002394	1.468	--	DIRECT
Disease Ontology (DO)	nose disease	0.00000003283	1.468	--	DIRECT
Disease Ontology (DO)	upper respiratory tract disease	0.00000006061	1.371	--	DIRECT
Disease Ontology (DO)	lung disease	0.00002173	1.225	--	DIRECT
Disease Ontology (DO)	respiratory system disease	0.0001547	0.9087	--	DIRECT
Disease Ontology (DO)	autosomal genetic disease	0.002337	1.141	--	INHERITED FROM: cystic fibrosis || autosomal recessive disease
Disease Ontology (DO)	monogenic disease	0.002709	1.141	--	INHERITED FROM: cystic fibrosis || autosomal recessive disease
Disease Ontology (DO)	bacterial infectious disease	0.01019	1.225	--	INHERITED FROM: tuberculosis || primary bacterial infectious disease
Disease Ontology (DO)	disease of anatomical entity	0.1453	0.2157	--	INHERITED FROM: nasal cavity disease || allergic rhinitis || upper respiratory tract disease || interstitial lung disease || lower respiratory tract disease || nose disease || lung disease || asthma || respiratory system disease
Disease Ontology (DO)	bronchial disease	0.2154	1.141	--	INHERITED FROM: asthma
Disease Ontology (DO)	rhinitis	1	1.468	--	INHERITED FROM: allergic rhinitis
Disease Ontology (DO)	lower respiratory tract disease	0.0001253	0.9731	Moderately Informative	DIRECT
Disease Ontology (DO)	disease by infectious agent	0.002242	0.8029	Moderately Informative	INHERITED FROM: tuberculosis || primary bacterial infectious disease
Disease Ontology (DO)	genetic disease	0.004258	1.092	Moderately Informative	INHERITED FROM: cystic fibrosis || autosomal recessive disease
Disease Ontology (DO)	allergic rhinitis	0.00000002159	1.468	Informative	DIRECT
Disease Ontology (DO)	interstitial lung disease	0.0000003965	1.672	Informative	DIRECT
Disease Ontology (DO)	primary bacterial infectious disease	0.0001043	1.33	Informative	DIRECT
Disease Ontology (DO)	autosomal recessive disease	0.0002888	1.371	Informative	DIRECT
Disease Ontology (DO)	asthma	0.0004575	1.257	Informative	DIRECT
Disease Ontology (DO)	cystic fibrosis	0.00001722	2.07	Highly Informative	DIRECT
Disease Ontology (DO)	tuberculosis	0.00002638	2.07	Highly Informative	DIRECT

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Mouse Phenotype (MP)

Highlighted in gray are those with FDR_all>0.001

	MP term	FDR (all)	IC level	SDMP level	Annotation (direct or inherited)
Mammalian Phenotype (MP)	abnormal monocyte cell number	0.00002076	2.508	--	DIRECT
Mammalian Phenotype (MP)	abnormal monocyte morphology	0.00002365	2.508	--	DIRECT
Mammalian Phenotype (MP)	abnormal cytokine level	0.0001821	1.466	--	DIRECT
Mammalian Phenotype (MP)	abnormal intercellular signaling peptide or protein level	0.0002002	1.429	--	DIRECT
Mammalian Phenotype (MP)	abnormal macrophage morphology	0.0002123	1.73	--	DIRECT
Mammalian Phenotype (MP)	altered susceptibility to infection	0.0004326	1.253	--	DIRECT
Mammalian Phenotype (MP)	abnormal response to infection	0.0005412	1.253	--	DIRECT
Mammalian Phenotype (MP)	abnormal mononuclear phagocyte morphology	0.0006211	1.73	--	DIRECT
Mammalian Phenotype (MP)	abnormal myeloid leukocyte morphology	0.00217	1.466	--	INHERITED FROM: abnormal monocyte morphology || abnormal macrophage morphology || abnormal monocyte cell number || abnormal mononuclear phagocyte morphology
Mammalian Phenotype (MP)	abnormal professional antigen presenting cell morphology	0.002566	1.277	--	INHERITED FROM: abnormal macrophage morphology
Mammalian Phenotype (MP)	abnormal leukocyte cell number	0.01272	1.045	--	INHERITED FROM: abnormal monocyte cell number
Mammalian Phenotype (MP)	abnormal leukocyte morphology	0.01766	0.9397	--	INHERITED FROM: abnormal monocyte morphology || abnormal mononuclear phagocyte morphology || abnormal monocyte cell number || abnormal macrophage morphology
Mammalian Phenotype (MP)	abnormal immune system cell morphology	0.01814	0.9281	--	INHERITED FROM: abnormal mononuclear phagocyte morphology || abnormal monocyte cell number || abnormal monocyte morphology || abnormal macrophage morphology
Mammalian Phenotype (MP)	abnormal immune system physiology	0.03014	0.737	--	INHERITED FROM: increased susceptibility to infection || abnormal cytokine level || altered susceptibility to infection || abnormal response to infection
Mammalian Phenotype (MP)	abnormal immune system morphology	0.0316	0.8003	--	INHERITED FROM: abnormal macrophage morphology || abnormal monocyte morphology || abnormal monocyte cell number || abnormal mononuclear phagocyte morphology
Mammalian Phenotype (MP)	abnormal hematopoietic cell morphology	0.03738	0.8177	--	INHERITED FROM: abnormal macrophage morphology || abnormal mononuclear phagocyte morphology || abnormal monocyte cell number || abnormal monocyte morphology
Mammalian Phenotype (MP)	abnormal hematopoietic system morphology/development	0.05118	0.7444	--	INHERITED FROM: abnormal macrophage morphology || abnormal monocyte morphology || abnormal mononuclear phagocyte morphology || abnormal monocyte cell number
Mammalian Phenotype (MP)	homeostasis/metabolism phenotype	0.168	0.3617	--	INHERITED FROM: abnormal cytokine level || abnormal intercellular signaling peptide or protein level
Mammalian Phenotype (MP)	hematopoietic system phenotype	0.07256	0.6505	Least Informative	INHERITED FROM: abnormal monocyte morphology || abnormal mononuclear phagocyte morphology || abnormal monocyte cell number || abnormal macrophage morphology
Mammalian Phenotype (MP)	immune system phenotype	0.07585	0.627	Least Informative	INHERITED FROM: abnormal monocyte cell number || increased susceptibility to infection || abnormal cytokine level || altered susceptibility to infection || abnormal mononuclear phagocyte morphology || abnormal monocyte morphology || abnormal response to infection || abnormal macrophage morphology
Mammalian Phenotype (MP)	abnormal homeostasis	0.1212	0.495	Least Informative	INHERITED FROM: abnormal cytokine level || abnormal intercellular signaling peptide or protein level
Mammalian Phenotype (MP)	abnormal protein level	0.003164	1.146	Moderately Informative	INHERITED FROM: abnormal intercellular signaling peptide or protein level || abnormal cytokine level
Mammalian Phenotype (MP)	abnormal immune serum protein physiology	0.003548	1.11	Moderately Informative	INHERITED FROM: abnormal cytokine level
Mammalian Phenotype (MP)	abnormal myeloid cell morphology	0.01165	1.229	Moderately Informative	INHERITED FROM: abnormal monocyte morphology || abnormal macrophage morphology || abnormal monocyte cell number || abnormal mononuclear phagocyte morphology
Mammalian Phenotype (MP)	abnormal mononuclear cell morphology	0.01191	0.9764	Moderately Informative	INHERITED FROM: abnormal mononuclear phagocyte morphology || abnormal monocyte cell number || abnormal monocyte morphology || abnormal macrophage morphology
Mammalian Phenotype (MP)	abnormal hematopoietic cell number	0.01863	0.9764	Moderately Informative	INHERITED FROM: abnormal monocyte cell number
Mammalian Phenotype (MP)	increased susceptibility to infection	0.0002356	1.466	Informative	DIRECT
Mammalian Phenotype (MP)	abnormal phagocyte morphology	0.001301	1.508	Informative	INHERITED FROM: abnormal mononuclear phagocyte morphology || abnormal monocyte morphology || abnormal macrophage morphology || abnormal monocyte cell number

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