SUPERFAMILY 1.75 HMM library and genome assignments server

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Triple coiled coil domain of C-type lectins superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Coiled coil proteins [ 57942] (7)
Fold:   Parallel coiled-coil [ 57943] (34)
Superfamily:   Triple coiled coil domain of C-type lectins [ 57944]
Families:   Triple coiled coil domain of C-type lectins [ 57945] (3)

Superfamily statistics
Genomes (62) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 196 430 16
Proteins 196 429 16

Functional annotation
General category Other
Detailed category Unknown function

Function annotation of SCOP domain superfamilies

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)lower respiratory tract disease0.0001253Moderately InformativeDirect
Disease Ontology (DO)disease by infectious agent0.002242Moderately InformativeInherited
Disease Ontology (DO)genetic disease0.004258Moderately InformativeInherited
Disease Ontology (DO)allergic rhinitis0.00000002159InformativeDirect
Disease Ontology (DO)interstitial lung disease0.0000003965InformativeDirect
Disease Ontology (DO)primary bacterial infectious disease0.0001043InformativeDirect
Disease Ontology (DO)autosomal recessive disease0.0002888InformativeDirect
Disease Ontology (DO)asthma0.0004575InformativeDirect
Disease Ontology (DO)cystic fibrosis0.00001722Highly InformativeDirect
Disease Ontology (DO)tuberculosis0.00002638Highly InformativeDirect

Document: DO annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)hematopoietic system phenotype0.07256Least InformativeInherited
Mammalian Phenotype (MP)immune system phenotype0.07585Least InformativeInherited
Mammalian Phenotype (MP)abnormal homeostasis0.1212Least InformativeInherited
Mammalian Phenotype (MP)abnormal protein level0.003164Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal immune serum protein physiology0.003548Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal myeloid cell morphology0.01165Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal mononuclear cell morphology0.01191Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal hematopoietic cell number0.01863Moderately InformativeInherited
Mammalian Phenotype (MP)increased susceptibility to infection0.0002356InformativeDirect
Mammalian Phenotype (MP)abnormal phagocyte morphology0.001301InformativeInherited

Document: MP annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Disease Ontology (DO) · Mouse Phenotype (MP) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.

Alignments of sequences to 6 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.

Browse and view proteins in genomes which have different domain combinations including a Triple coiled coil domain of C-type lectins domain.

Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.

Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 6 hidden Markov models representing the Triple coiled coil domain of C-type lectins superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.

Jump to [ Top of page · SCOP classification · Functional annotation · Disease Ontology (DO) · Mouse Phenotype (MP) · Internal database links ]